ID   UW228-3
AC   CVCL_0573
DR   BTO; BTO_0004332
DR   MCCL; MCC:0000478
DR   cancercelllines; CVCL_0573
DR   Wikidata; Q54992375
RX   PubMed=8674085;
RX   PubMed=8866661;
RX   PubMed=15814657;
CC   Doubling time: 29.0 +- 2.0 hours (PubMed=8866661).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
DI   NCIt; C129442; Medulloblastoma, SHH-activated, TP53-mutant
DI   ORDO; Orphanet_616; Medulloblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8585 ! UW228
SX   Female
AG   9Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=15814657; DOI=10.1158/1078-0432.CCR-04-2045;
RA   Bobola, Michael S.
RA   Silber, John R.
RA   Ellenbogen, Richard G.
RA   Geyer, J. Russell
RA   Blank, A.
RA   Goff, Ryan David
RT   "O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and
RT   resistance to clinical alkylators in pediatric primary brain tumor
RT   cell lines.";
RL   Clin. Cancer Res. 11:2747-2755(2005).
//
RX   PubMed=8674085; DOI=10.1007/BF00819500;
RA   Srinivasan, Jayashree
RA   Berger, Mitchel Stuart
RA   Silber, John R.
RT   "p53 expression in four human medulloblastoma-derived cell lines.";
RL   Childs Nerv. Syst. 12:76-80(1996).
//
RX   PubMed=8866661;
RA   Keles, Guven Evren
RA   Berger, Mitchel Stuart
RA   Srinivasan, Jayashree
RA   Kolstoe, Douglas D.
RA   Bobola, Michael S.
RA   Silber, John R.
RT   "Establishment and characterization of four human
RT   medulloblastoma-derived cell lines.";
RL   Oncol. Res. 7:493-503(1995).
//