ID   UMNSAH/DF-1
AC   CVCL_0570
SY   UMNSAH-DF-1; UMNSAH-DF 1; UMNSAH-DF1; UMNSAH/DF1; UMNSAH/DF#1; DF-1; DF1; Douglas Foster-1
DR   BTO; BTO:0005956
DR   CLO; CLO_0009484
DR   MCCL; MCC:0000475
DR   ATCC; CRL-12203
DR   BCRJ; 0307
DR   CCLV; CCLV-RIE 1029
DR   CCRID; 1101BIR-PUMC000417
DR   CLS; 305016
DR   GEO; GSE29257
DR   IZSLER; BS CL 197
DR   KCB; KCB 2012111YJ
DR   Wikidata; Q54991087
RX   CelloPub=CLPUB00401;
RX   Patent=US6207415;
RX   Patent=US20200179507;
RX   PubMed=9721238;
RX   PubMed=9721239;
RX   PubMed=11420679;
RX   PubMed=11513975;
RX   PubMed=16313905;
RX   PubMed=18638503;
RX   PubMed=19941903;
RX   PubMed=22111699;
RX   PubMed=32005267;
RX   PubMed=33743496;
RX   PubMed=34737324;
WW   https://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/cef/cefcells.html
WW   http://license.umn.edu/technologies/95149_retrovirus-free-cell-line-for-vaccine-development
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/d/cell-lines-detail-546.html
CC   Group: Bird cell line.
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12203.
CC   Virology: Low susceptibility to infection by aquatic bird bornavirus 1 (ABBV-1) strain UoG-CG (PubMed=32005267).
CC   Doubling time: 13.22 hours (Note=In DMEM/F-12 medium), 33.64 hours (Note=In MEM medium), 15.30 hours (Note=In RPMI 1640 medium), 21.39 hours (Note=In DMEM medium) (CelloPub=CLPUB00401).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Embryo; UBERON=UBERON_0000922.
CC   Cell type: Fibroblast; CL=CL_0000057.
CC   Breed/subspecies: East Lansing Line 0 (ELL-0).
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
SX   Sex unspecified
AG   10FD
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   CelloPub=CLPUB00401;
RA   Arifin M.A., Mel M., Raus R.A., Sharifah S.H., Ideris A.;
RT   "Comparison of growth rate and viability of DF-1 cell line in
RT   different culture media.";
RL   (In) Abstracts of the 2nd International Conference on Science and Technology; pp.1-5; Universiti Teknologi MARA; Pulau Pinang (2008).
//
RX   Patent=US6207415;
RA   Foster D.N., Foster L.K.;
RT   "Immortalized cell lines protein production.";
RL   Patent number US6207415, 27-Mar-2001.
//
RX   Patent=US20200179507;
RA   Foster D.N., Foster L.K.;
RT   "Immortalized cell lines and methods of use.";
RL   Patent number US20200179507, 11-Jun-2020.
//
RX   PubMed=9721238; DOI=10.1006/viro.1998.9290;
RA   Himly M., Foster D.N., Bottoli I., Iacovoni J.S., Vogt P.K.;
RT   "The DF-1 chicken fibroblast cell line: transformation induced by
RT   diverse oncogenes and cell death resulting from infection by avian
RT   leukosis viruses.";
RL   Virology 248:295-304(1998).
//
RX   PubMed=9721239; DOI=10.1006/viro.1998.9291;
RA   Schaefer-Klein J., Givol I., Barsov E.V., Whitcomb J.M.,
RA   VanBrocklin M., Foster D.N., Federspiel M.J., Hughes S.H.;
RT   "The EV-O-derived cell line DF-1 supports the efficient replication of
RT   avian leukosis-sarcoma viruses and vectors.";
RL   Virology 248:305-311(1998).
//
RX   PubMed=11420679; DOI=10.1038/sj.onc.1204378;
RA   Kim H., You S., Kim I.-J., Foster L.K., Farris J., Ambady S.,
RA   Ponce de Leon F.A., Foster D.N.;
RT   "Alterations in p53 and E2F-1 function common to immortalized chicken
RT   embryo fibroblasts.";
RL   Oncogene 20:2671-2682(2001).
//
RX   PubMed=11513975; DOI=10.1016/s0167-4889(01)00131-8;
RA   Kim H., You S., Kong B.-W., Foster L.K., Farris J., Foster D.N.;
RT   "Necrotic cell death by hydrogen peroxide in immortal DF-1 chicken
RT   embryo fibroblast cells expressing deregulated MnSOD and catalase.";
RL   Biochim. Biophys. Acta 1540:137-146(2001).
//
RX   PubMed=16313905; DOI=10.1016/j.febslet.2005.10.066;
RA   Christman S.A., Kong B.-W., Landry M.M., Kim H., Foster D.N.;
RT   "Modulation of p53 expression and its role in the conversion to a
RT   fully immortalized chicken embryo fibroblast line.";
RL   FEBS Lett. 579:6705-6715(2005).
//
RX   PubMed=18638503; DOI=10.1016/j.jviromet.2008.06.019;
RA   Lee C.-W., Jung K., Jadhao S.J., Suarez D.L.;
RT   "Evaluation of chicken-origin (DF-1) and quail-origin (QT-6)
RT   fibroblast cell lines for replication of avian influenza viruses.";
RL   J. Virol. Methods 153:22-28(2008).
//
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger A., Bettin B., Lenk M., Mettenleiter T.C.;
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
//
RX   PubMed=22111699; DOI=10.1186/1471-2164-12-571;
RA   Kong B.-W., Lee J.Y., Bottje W.G., Lassiter K., Lee J., Foster D.N.;
RT   "Genome-wide differential gene expression in immortalized DF-1 chicken
RT   embryo fibroblast cell line.";
RL   BMC Genomics 12:571.1-571.19(2011).
//
RX   PubMed=32005267; DOI=10.1186/s12985-020-1286-6;
RA   Pham P.H., Leacy A., Deng L., Nagy E., Susta L.;
RT   "Isolation of Ontario aquatic bird bornavirus 1 and characterization
RT   of its replication in immortalized avian cell lines.";
RL   Virol. J. 17:16.1-16.12(2020).
//
RX   PubMed=33743496; DOI=10.1016/j.psj.2021.101057;
RA   Lee J., Kim D.-H., Suh Y., Lee K.;
RT   "Research note: potential usage of DF-1 cell line as a new cell model
RT   for avian adipogenesis.";
RL   Poult. Sci. 100:101057.1-101057.4(2021).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5;
RA   Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657-21657(2021).
//