ID   UM-SCV-1A
AC   CVCL_0568
SY   UMSCV-1A; UMSCV1A; University of Michigan-Squamous cell Carcinoma of the Vulva-1A
DR   MCCL; MCC:0000473
DR   IARC_TP53; 21680
DR   Wikidata; Q54990958
RX   CelloPub=CLPUB00591;
RX   PubMed=1777413;
RX   PubMed=1958593;
RX   PubMed=2335395;
RX   PubMed=2758419;
RX   PubMed=7503188;
RX   PubMed=7599042;
RX   PubMed=8646696;
RX   PubMed=9887230;
RX   PubMed=15047230;
RX   PubMed=31654625;
CC   Doubling time: 32 hours (PubMed=15047230); 30.12 +- 0.43 hours (PubMed=31654625).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=7503188; PubMed=9887230).
CC   Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
DI   NCIt; C4052; Vulvar squamous cell carcinoma
DI   ORDO; Orphanet_494448; Vulvar squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5973 ! UM-SCV-1B
SX   Female
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 21
//
RX   PubMed=31654625; DOI=10.1016/j.yexcr.2019.111684;
RA   Dongre, Harsh Nitin
RA   Rana, Neha
RA   Fromreide, Siren
RA   Rajthala, Saroj
RA   Boe Engelsen, Ingeborg
RA   Paradis, Justine
RA   Gutkind, Jorge Silvio
RA   Vintermyr, Olav Karsten
RA   Johannessen, Anne Christine
RA   Bjorge, Line
RA   Costea, Daniela Elena
RT   "Establishment of a novel cancer cell line derived from vulvar
RT   carcinoma associated with lichen sclerosus exhibiting a
RT   fibroblast-dependent tumorigenic potential.";
RL   Exp. Cell Res. 386:111684.1-111684.9(2020).
//
RX   PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3;
RA   Hietanen, Sakari H.
RA   Kurvinen, Kaisa
RA   Syrjanen, Kari Juhani
RA   Grenman, Seija E.
RA   Carey, Thomas E.
RA   McClatchey, Kenneth Donald
RA   Syrjanen, Stina M.
RT   "Mutation of tumor suppressor gene p53 is frequently found in vulvar
RT   carcinoma cells.";
RL   Am. J. Obstet. Gynecol. 173:1477-1482(1995).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen, Virpi
RA   Grenman, Seija E.
RA   Kurvinen, Kaisa
RA   Hietanen, Sakari H.
RA   Raitanen, Misa
RA   Syrjanen, Stina M.
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   CelloPub=CLPUB00591;
RA   Seppanen, Marjo
RT   "Cytokines and gynecological cancer. In vitro effects of cytokines on
RT   ovarian, endometrial and vulvar carcinoma cells.";
RL   Thesis PhD (2000); Tampere University; Tampere; Finland.
//
RX   PubMed=1958593; DOI=10.1002/gcc.2870030406;
RA   Bradford, Carol R.
RA   Kimmel, Kathryn Anne
RA   Van Dyke, Daniel L.
RA   Worsham, Maria J.
RA   Tilley, Barbara J.
RA   Burk, David
RA   del Rosario, Fernando
RA   Lutz, Stephen
RA   Tooley, Richard
RA   Hayashida, Diana J.S.
RA   Carey, Thomas E.
RT   "11p deletions and breakpoints in squamous cell carcinoma: association
RT   with altered reactivity with the UM-E7 antibody.";
RL   Genes Chromosomes Cancer 3:272-282(1991).
//
RX   PubMed=8646696; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1940::AID-CNCR26>3.0.CO;2-Z;
RA   Jaakkola, Misa
RA   Rantanen, Virpi
RA   Grenman, Seija E.
RA   Kulmala, Jarmo
RA   Grenman, Reidar
RT   "In vitro concurrent paclitaxel and radiation of four vulvar squamous
RT   cell carcinoma cell lines.";
RL   Cancer 77:1940-1946(1996).
//
RX   PubMed=2758419;
RA   Pekkola-Heino, Kirsi
RA   Kulmala, Jarmo
RA   Grenman, Seija E.
RA   Carey, Thomas E.
RA   Grenman, Reidar
RT   "Radiation response of vulvar squamous cell carcinoma (UM-SCV-1A,
RT   UM-SCV-1B, UM-SCV-2, and A-431) cells in vitro.";
RL   Cancer Res. 49:4876-4878(1989).
//
RX   PubMed=1777413; DOI=10.1002/gcc.2870030604;
RA   Worsham, Maria J.
RA   Van Dyke, Daniel L.
RA   Grenman, Seija E.
RA   Grenman, Reidar
RA   Hopkins, Michael P.
RA   Roberts, James A.
RA   Gasser, Kathleen M.
RA   Schwartz, Donald R.
RA   Carey, Thomas E.
RT   "Consistent chromosome abnormalities in squamous cell carcinoma of the
RT   vulva.";
RL   Genes Chromosomes Cancer 3:420-432(1991).
//
RX   PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033;
RA   Raitanen, Misa
RA   Worsham, Maria J.
RA   Lakkala, Taina
RA   Carey, Thomas E.
RA   Van Dyke, Daniel L.
RA   Grenman, Reidar
RA   Klemi, Pekka
RA   Rantanen, Virpi
RA   Isola, Jorma J.
RA   Grenman, Seija E.
RT   "Characterization of 10 vulvar carcinoma cell lines by karyotyping,
RT   comparative genomic hybridization and flow cytometry.";
RL   Gynecol. Oncol. 93:155-163(2004).
//
RX   PubMed=2335395; DOI=10.1002/ijc.2910450524;
RA   Grenman, Seija E.
RA   Van Dyke, Daniel L.
RA   Worsham, Maria J.
RA   England, Barry
RA   McClatchey, Kenneth Donald
RA   Hopkins, Michael P.
RA   Babu, V. Ramesh
RA   Grenman, Reidar
RA   Carey, Thomas E.
RT   "Phenotypic characterization, karyotype analysis and in vitro
RT   tamoxifen sensitivity of new ER-negative vulvar carcinoma cell lines,
RT   UM-SCV-1A and UM-SCV-1B.";
RL   Int. J. Cancer 45:920-927(1990).
//
RX   PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151;
RA   Hietanen, Sakari H.
RA   Grenman, Seija E.
RA   Syrjanen, Kari Juhani
RA   Lappalainen, Katriina
RA   Kauppinen, Juha
RA   Carey, Thomas E.
RA   Syrjanen, Stina M.
RT   "Human papillomavirus in vulvar and vaginal carcinoma cell lines.";
RL   Br. J. Cancer 72:134-139(1995).
//