ID   SMMC-7721
AC   CVCL_0534
AS   CVCL_B400
SY   SMMC 7721; SMMC7721; H7721; H-7721
DR   BTO; BTO_0003227
DR   MCCL; MCC:0000433
DR   ChEMBL-Cells; CHEMBL3308059
DR   ChEMBL-Targets; CHEMBL613831
DR   Cosmic; 852773
DR   Cosmic; 1060081
DR   Cosmic; 1499248
DR   Cosmic; 2773184
DR   GEO; GSM501779
DR   GEO; GSM936777
DR   GEO; GSM1374884
DR   PubChem_Cell_line; CVCL_0534
DR   Ubigene; YC-C056
DR   Wikidata; Q54954976
RX   PubMed=12717835;
RX   PubMed=17552011;
RX   PubMed=23505090;
RX   PubMed=26116706;
RX   PubMed=28807831;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-587.html
WW   Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/smmc-7721-xenograft-model/
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706; PubMed=28807831). Originally thought to originate from a hepatocellular carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00554.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Proteomics; 2DE-MS.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: Formerly the CCRID database had 3 entries describing this cell line (3111C0001CCC000087, 3131C0001000700052, 3142C0001000000063). They were one of the sources for the STR profile of this entry.
CC   Misspelling: SMMU-7721; Note=Occasionally.
CC   Misspelling: SMCC-7721; Note=Occasionally.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): CCRID; PubMed=26116706
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D12S391: 20,25,26
ST   D13S317: 13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D6S1043: 18
ST   D7S820: 12
ST   D8S1179: 12
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=26116706; DOI=10.1096/fj.14-266718;
RA   Ye, Fang
RA   Chen, Chu-Guang
RA   Qin, Jian
RA   Liu, Jie
RA   Zheng, Cong-Yi
RT   "Genetic profiling reveals an alarming rate of cross-contamination
RT   among human cell lines used in China.";
RL   FASEB J. 29:4268-4272(2015).
//
RX   PubMed=12717835; DOI=10.3748/wjg.v9.i5.946; PMCID=PMC4611402;
RA   Ma, Xiang-Dong
RA   Ma, Xing
RA   Sui, Yan-Fang
RA   Wang, Weng-Liang
RA   Wang, Chun-Mei
RT   "Signal transduction of gap junctional genes, connexin32, connexin43
RT   in human hepatocarcinogenesis.";
RL   World J. Gastroenterol. 9:946-950(2003).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang, Kai
RA   Lim, Ho Yeong
RA   Shi, Stephanie
RA   Lee, Jeeyun
RA   Deng, Shi-Bing
RA   Xie, Tao
RA   Zhu, Zhou
RA   Wang, Yu-Li
RA   Pocalyko, David
RA   Yang, Wei Jennifer
RA   Rejto, Paul A.
RA   Mao, Mao
RA   Park, Cheol-Keun
RA   Xu, Jiang-Chun
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=28807831; DOI=10.1016/j.jhep.2017.08.002;
RA   Rebouissou, Sandra
RA   Zucman-Rossi, Jessica
RA   Moreau, Richard
RA   Qiu, Zhi-Xin
RA   Hui, Li-Jian
RT   "Note of caution: contaminations of hepatocellular cell lines.";
RL   J. Hepatol. 67:896-897(2017).
//
RX   PubMed=17552011; DOI=10.3748/wjg.v13.i18.2608; PMCID=PMC4146824;
RA   Feng, Yi
RA   Tian, Zhong-Min
RA   Wan, Ming-Xi
RA   Zheng, Zhao-Bin
RT   "Protein profile of human hepatocarcinoma cell line SMMC-7721:
RT   identification and functional analysis.";
RL   World J. Gastroenterol. 13:2608-2614(2007).
//