ID RL95-2 AC CVCL_0505 SY RL95_2; RL-95-2; RL-952; RL952; RL95 DR BTO; BTO_0004491 DR CLO; CLO_0008830 DR EFO; EFO_0002320 DR MCCL; MCC:0000402 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-1671 DR BCRC; 60103 DR BCRJ; 0366 DR BioGRID_ORCS_Cell_line; 999 DR BioSample; SAMN03473219 DR BioSample; SAMN10987787 DR cancercelllines; CVCL_0505 DR CCRID; 3101HUMTCHu198 DR CCRID; 4201HUM-CCTCC00113 DR CCTCC; GDC0113 DR Cell_Model_Passport; SIDM01088 DR ChEMBL-Cells; CHEMBL3308843 DR ChEMBL-Targets; CHEMBL2366168 DR CLS; 305062 DR Cosmic; 713477 DR Cosmic; 713489 DR Cosmic; 809132 DR Cosmic; 846175 DR Cosmic; 871556 DR Cosmic; 889117 DR Cosmic; 930082 DR Cosmic; 980637 DR Cosmic; 1007165 DR Cosmic; 1066226 DR Cosmic; 1070808 DR Cosmic; 1102377 DR Cosmic; 1177623 DR Cosmic; 1223487 DR Cosmic; 1576464 DR Cosmic; 1622899 DR Cosmic; 1696756 DR Cosmic; 2030481 DR Cosmic; 2301551 DR Cosmic; 2646617 DR Cosmic; 2702441 DR Cosmic-CLP; 930082 DR DepMap; ACH-000965 DR EGA; EGAS00001000978 DR GDSC; 930082 DR GEO; GSM374977 DR GEO; GSM375436 DR GEO; GSM844677 DR GEO; GSM887542 DR GEO; GSM888625 DR GEO; GSM1670382 DR GEO; GSM3161728 DR GEO; GSM3161729 DR IARC_TP53; 1114 DR IGRhCellID; RL952 DR KCB; KCB 2013033YJ DR LiGeA; CCLE_166 DR LINCS_LDP; LCL-1506 DR Lonza; 1501 DR PharmacoDB; RL952_1319_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0505 DR PubChem_Cell_line; CVCL_0505 DR Wikidata; Q54950589 RX PubMed=1541432; RX PubMed=2436984; RX PubMed=6339371; RX PubMed=7798295; RX PubMed=8123477; RX PubMed=9887230; RX PubMed=12893190; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20944090; RX PubMed=22460905; RX PubMed=22710073; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31395879; RX PubMed=33174010; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Part of: TCGA-110-CL cell line panel. CC Population: Caucasian. CC Doubling time: 22 hours (PubMed=1541432). CC HLA typing: A*02:10,24:02; B*55:01,55:01; C*03:03,03:03; DQA1*01:02,05:02; DQB1*05:03,05:03; DRB1*14:01,14:01 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11110; ARID1A; Simple; p.Arg693Ter (c.2077C>T); Zygosity=Heterozygous (Cosmic-CLP=930082; DepMap=ACH-000965). CC Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61His (c.183G>T); ClinVar=VCV000376318; Zygosity=Heterozygous (ATCC=CRL-1671; Cosmic-CLP=930082; DepMap=ACH-000965). CC Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (Cosmic-CLP=930082; DepMap=ACH-000965). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323fs*2 (c.968_969insA); Zygosity=Heterozygous (PubMed=20944090). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn323Metfs*21 (c.968delA); ClinVar=VCV000653412; Zygosity=Heterozygous (PubMed=20944090). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (PubMed=9887230; Cosmic-CLP=930082; DepMap=ACH-000965). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Heterozygous (PubMed=9887230; Cosmic-CLP=930082; DepMap=ACH-000965). CC Omics: Genomics; Chromatin accessibility; ATAC-seq. CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.33%; East Asian, North=1.49%; East Asian, South=0%; South Asian=1.52%; European, North=68.38%; European, South=28.28% (PubMed=30894373). CC Derived from site: In situ; Endometrium; UBERON=UBERON_0001295. ST Source(s): ATCC=CRL-1671; Cosmic-CLP=930082; PubMed=25877200; PubMed=33174010; Technion Genomics Center ST Amelogenin: X ST CSF1PO: 10,11 ST D10S1248: 14,15 ST D12S391: 15,21 ST D13S317: 8,12 ST D16S539: 11,13 ST D18S51: 10,14 ST D19S433: 15 ST D1S1656: 13,19.3 ST D21S11: 28,29 ST D22S1045: 15 ST D2S1338: 22,23 ST D2S441: 11,14 ST D3S1358: 14,16 ST D5S818: 10,11 ST D7S820: 10 ST D8S1179: 10,14 ST FGA: 20,22 ST Penta D: 9 ST Penta E: 5,11 ST TH01: 9,9.3 ST TPOX: 8 ST vWA: 16,20 DI NCIt; C114656; Endometrial adenosquamous carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 65Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 44 // RX PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677; RA Korch, Christopher T. RA Spillman, Monique Ann RA Jackson, Twila A. RA Jacobsen, Britta M. RA Murphy, Susan K. RA Lessey, Bruce Arthur RA Jordan, Virgil Craig RA Bradford, Andrew Peter RT "DNA profiling analysis of endometrial and ovarian cell lines reveals RT misidentification, redundancy and contamination."; RL Gynecol. Oncol. 127:241-248(2012). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=9887230; DOI=10.1006/gyno.1998.5194; RA Rantanen, Virpi RA Grenman, Seija E. RA Kurvinen, Kaisa RA Hietanen, Sakari H. RA Raitanen, Misa RA Syrjanen, Stina M. RT "p53 mutations and presence of HPV DNA do not correlate with RT radiosensitivity of gynecological cancer cell lines."; RL Gynecol. Oncol. 71:352-358(1998). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8123477; DOI=10.1038/bjc.1994.87; PMCID=PMC1968845; RA Rantanen, Virpi RA Grenman, Seija E. RA Kulmala, Jarmo RA Grenman, Reidar RT "Comparative evaluation of cisplatin and carboplatin sensitivity in RT endometrial adenocarcinoma cell lines."; RL Br. J. Cancer 69:482-486(1994). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=33174010; DOI=10.3892/ijo.2020.5139; PMCID=PMC8811471; RA Devor, Eric J. RA Gonzalez-Bosquet, Jesus RA Thiel, Kristina W. RA Leslie, Kimberly K. RT "Genomic characterization of five commonly used endometrial cancer RT cell lines."; RL Int. J. Oncol. 57:1348-1357(2020). // RX PubMed=1541432; DOI=10.1016/0090-8258(92)90045-K; RA Rantanen, Virpi RA Grenman, Seija E. RA Kulmala, Jarmo RA Salmi, Tuula RA Grenman, Reidar RT "Radiation sensitivity of endometrial carcinoma in vitro."; RL Gynecol. Oncol. 44:217-222(1992). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=20944090; DOI=10.1126/scitranslmed.3001538; RA Dedes, Konstantin J. RA Wetterskog, Daniel RA Mendes-Pereira, Ana M. RA Natrajan, Rachael RA Lambros, Maryou B. RA Geyer, Felipe Correa RA Vatcheva, Radost RA Savage, Kay RA Mackay, Alan RA Lord, Christopher J. RA Ashworth, Alan RA Reis-Filho, Jorge Sergio RT "PTEN deficiency in endometrioid endometrial adenocarcinomas predicts RT sensitivity to PARP inhibitors."; RL Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010). // RX PubMed=6339371; DOI=10.1007/BF02618053; RA Way, Dennis L. RA Grosso, David S. RA Davis, John R. RA Surwit, Earl A. RA Christian, C.D. RT "Characterization of a new human endometrial carcinoma (RL95-2) RT established in tissue culture."; RL In Vitro 19:147-158(1983). // RX PubMed=2436984; DOI=10.1016/0090-8258(87)90286-1; RA Noumoff, Joel S. RA Haydock, Susan W. RA Sachdeva, Rajeev RA Heyner, Susan RA Pritchard, M. Lynn RT "Characteristics of cell lines derived from normal and malignant RT endometrial tissue."; RL Gynecol. Oncol. 27:141-149(1987). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=7798295; DOI=10.1007/BF01194268; RA Rantanen, Virpi RA Grenman, Seija E. RA Kulmala, Jarmo RA Alanen, Kalle RA Lakkala, Taina RA Grenman, Reidar RT "Sublethal damage repair after fractionated irradiation in endometrial RT cancer cell lines tested with the 96-well plate clonogenic assay."; RL J. Cancer Res. Clin. Oncol. 120:712-716(1994). // RX PubMed=12893190; DOI=10.1016/S0090-8258(03)00335-4; RA Tanaka, Ryoichi RA Saito, Tsuyoshi RA Ashihara, Koji RA Nishimura, Makoto RA Mizumoto, Hisanobu RA Kudo, Ryuichi RT "Three-dimensional coculture of endometrial cancer cells and RT fibroblasts in human placenta derived collagen sponges and expression RT matrix metalloproteinases in these cells."; RL Gynecol. Oncol. 90:297-304(2003). //