ID SNU-475 AC CVCL_0497 SY SNU475; NCI-SNU-475 DR BTO; BTO_0003189 DR CLO; CLO_0009101 DR EFO; EFO_0002350 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2236 DR BioGRID_ORCS_Cell_line; 811 DR BioSample; SAMN03471846 DR BioSample; SAMN03473134 DR BioSample; SAMN10987958 DR cancercelllines; CVCL_0497 DR Cell_Model_Passport; SIDM01196 DR ChEMBL-Cells; CHEMBL3308787 DR ChEMBL-Targets; CHEMBL1075586 DR Cosmic; 684201 DR Cosmic; 871512 DR Cosmic; 873403 DR Cosmic; 909739 DR Cosmic; 928145 DR Cosmic; 2023871 DR Cosmic; 2162533 DR Cosmic; 2321038 DR Cosmic-CLP; 909739 DR DepMap; ACH-000422 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 909739 DR GEO; GSM481449 DR GEO; GSM565920 DR GEO; GSM887630 DR GEO; GSM888715 DR GEO; GSM936783 DR GEO; GSM1670472 DR GEO; GSM2551590 DR IARC_TP53; 6310 DR IARC_TP53; 21143 DR IGRhCellID; SNU475 DR KCLB; 00475 DR LiGeA; CCLE_299 DR LIMORE; SNU475 DR LINCS_LDP; LCL-1937 DR Lonza; 452 DR PharmacoDB; SNU475_1465_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0497 DR PubChem_Cell_line; CVCL_0497 DR Wikidata; Q54955204 RX PubMed=7543080; RX PubMed=8824565; RX PubMed=16616112; RX PubMed=19956504; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=23505090; RX PubMed=23887712; RX PubMed=25485619; RX PubMed=25574106; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=31063779; RX PubMed=31068700; RX PubMed=31378681; RX PubMed=35839778; WW Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/SNU475 WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Liver Cancer Model Repository (LIMORE). CC Part of: MD Anderson Cell Lines Project. CC Part of: Seoul National University (SNU) cell line collection. CC Population: Korean. CC Doubling time: 66 hours (PubMed=7543080); 35.6 hours (PubMed=31378681). CC HLA typing: A*02:01,11:01; B*40:02,54:01; C*03:04,03:04 (PubMed=26589293). CC Karyotypic information: Has lost chromosome Y. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn239Asp (c.715A>G); ClinVar=VCV000234036; Zygosity=Heterozygous (PubMed=8824565; Cosmic-CLP=909739; DepMap=ACH-000422). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly262Asp (c.785G>A); Zygosity=Heterozygous (Cosmic-CLP=909739; DepMap=ACH-000422). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys275Arg (c.823T>C); ClinVar=VCV000376584; Zygosity=Unspecified (PubMed=8824565). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asn288Ser (c.863A>G); Zygosity=Unspecified (PubMed=8824565). CC Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.39%; Native American=0%; East Asian, North=63.9%; East Asian, South=34.56%; South Asian=0%; European, North=0%; European, South=1.15% (PubMed=30894373). CC Derived from site: In situ; Liver; UBERON=UBERON_0002107. ST Source(s): ATCC=CRL-2236; Cosmic-CLP=909739; KCLB=00475; PubMed=25877200; PubMed=31378681 ST Amelogenin: X,Y ST CSF1PO: 11,12 ST D13S317: 8,11 ST D16S539: 12 ST D18S51: 13 ST D19S433: 14.2 ST D21S11: 28,30 ST D2S1338: 17,23 ST D3S1358: 14 ST D5S818: 10,13 ST D7S820: 7 (PubMed=25877200) ST D7S820: 7,12 (ATCC=CRL-2236; Cosmic-CLP=909739; KCLB=00475; PubMed=31378681) ST D8S1179: 13,14 ST FGA: 23 ST Penta D: 9,12 ST Penta E: 5,16 ST TH01: 7,9 ST TPOX: 8,9 ST vWA: 14 DI NCIt; C7956; Adult hepatocellular carcinoma DI ORDO; Orphanet_210159; Adult hepatocellular carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 43Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 44 CH CVCL_C9G6 ! SNU-475/Cas9-hyg // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001; RA Caruso, Stefano RA Calatayud, Anna-Line RA Pilet, Jill RA La Bella, Tiziana RA Rekik, Samia RA Imbeaud, Sandrine RA Letouze, Eric RA Meunier, Lea RA Bayard, Quentin RA Rohr-Udilova, Nataliya RA Peneau, Camille RA Grasl-Kraupp, Bettina RA de Koning, Leanne RA Ouine, Berengere RA Bioulac-Sage, Paulette RA Couchy, Gabrielle RA Calderaro, Julien RA Nault, Jean-Charles RA Zucman-Rossi, Jessica RA Rebouissou, Sandra RT "Analysis of liver cancer cell lines identifies agents with likely RT efficacy against hepatocellular carcinoma and markers of response."; RL Gastroenterology 157:760-776(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X; RA Kang, Myung-Soo RA Lee, Hong-Joo RA Lee, Jae-Ho RA Ku, Ja-Lok RA Lee, Kathreen P. RA Kelley, Michael J. RA Won, Yong-Jin RA Kim, Soo-Tae RA Park, Jae-Gahb RT "Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX RT DNA."; RL Int. J. Cancer 67:898-902(1996). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=23505090; DOI=10.1002/hep.26402; RA Wang, Kai RA Lim, Ho Yeong RA Shi, Stephanie RA Lee, Jeeyun RA Deng, Shi-Bing RA Xie, Tao RA Zhu, Zhou RA Wang, Yu-Li RA Pocalyko, David RA Yang, Wei Jennifer RA Rejto, Paul A. RA Mao, Mao RA Park, Cheol-Keun RA Xu, Jiang-Chun RT "Genomic landscape of copy number aberrations enables the RT identification of oncogenic drivers in hepatocellular carcinoma."; RL Hepatology 58:706-717(2013). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665; RA Nault, Jean-Charles RA Mallet, Maxime RA Pilati, Camilla RA Calderaro, Julien RA Bioulac-Sage, Paulette RA Laurent, Christophe RA Laurent, Alexis RA Cherqui, Daniel RA Balabaud, Charles RA Zucman-Rossi, Jessica RT "High frequency of telomerase reverse-transcriptase promoter somatic RT mutations in hepatocellular carcinoma and preneoplastic lesions."; RL Nat. Commun. 4:2218.1-2218.7(2013). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=16616112; DOI=10.1016/j.cancergencyto.2005.08.022; RA Park, Sang-Jin RA Jeong, Seon-Yong RA Kim, Hyon-Ju RT "Y chromosome loss and other genomic alterations in hepatocellular RT carcinoma cell lines analyzed by CGH and CGH array."; RL Cancer Genet. Cytogenet. 166:56-64(2006). // RX PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416; RA Ku, Ja-Lok RA Park, Jae-Gahb RT "Biology of SNU cell lines."; RL Cancer Res. Treat. 37:1-19(2005). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350; RA Cevik, Dilek RA Yildiz, Gokhan RA Ozturk, Mehmet RT "Common telomerase reverse transcriptase promoter mutations in RT hepatocellular carcinomas from different geographical locations."; RL World J. Gastroenterol. 21:311-317(2015). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, A. Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724; RA Qiu, Zhi-Xin RA Li, Hong RA Zhang, Zheng-Tao RA Zhu, Zhen-Feng RA He, Sheng RA Wang, Xu-Jun RA Wang, Peng-Cheng RA Qin, Jian-Jie RA Zhuang, Li-Ping RA Wang, Wei RA Xie, Fu-Bo RA Gu, Ying RA Zou, Ke-Ke RA Li, Chao RA Li, Chun RA Wang, Chen-Hua RA Cen, Jin RA Chen, Xiao-Tao RA Shu, Ya-Jing RA Zhang, Zhao RA Sun, Lu-Lu RA Min, Li-Hua RA Fu, Yong RA Huang, Xiao-Wu RA Lv, Hui RA Zhou, He RA Ji, Yuan RA Zhang, Zhi-Gang RA Meng, Zhi-Qiang RA Shi, Xiao-Lei RA Zhang, Hai-Bin RA Li, Yi-Xue RA Hui, Li-Jian RT "A pharmacogenomic landscape in human liver cancers."; RL Cancer Cell 36:179-193.e11(2019). // RX PubMed=7543080; DOI=10.1002/ijc.2910620308; RA Park, Jae-Gahb RA Lee, Jae-Ho RA Kang, Myung-Soo RA Park, Kyu-Joo RA Jeon, You-Me RA Lee, Hyun-Ju RA Kwon, Hae-Sung RA Park, Hyun-Sook RA Yeo, Kyong-Sook RA Lee, Kuhn-Uk RA Kim, Soo-Tae RA Chung, June-Key RA Hwang, You-Jin RA Lee, Hyo-Suk RA Kim, Chung Yong RA Lee, Young Ik RA Chen, Tchaw-Ren RA Hay, Robert J. RA Song, Sang-Yong RA Kim, Woo-Ho RA Ki, Chul-Woo RA Kim, Young-Il RT "Characterization of cell lines established from human hepatocellular RT carcinoma."; RL Int. J. Cancer 62:276-282(1995). //