ID   PC12
AC   CVCL_0481
SY   PC-12; PC 12; PC12.1
DR   BTO; BTO:0001009
DR   CLO; CLO_0008392
DR   CLO; CLO_0050821
DR   EFO; EFO_0001225
DR   MCCL; MCC:0000379
DR   CLDB; cl3876
DR   CLDB; cl3877
DR   CLDB; cl3878
DR   CLDB; cl4922
DR   CLDB; cl5245
DR   Abcam; ab279978
DR   AddexBio; C0032001/4927
DR   ATCC; CRL-1721
DR   BCRC; 60048
DR   BCRJ; 0203
DR   CCRID; 1101RAT-PUMC000024
DR   CCRID; 4201RAT-CCTCC00006
DR   CCRID; 5301RAT-KCB07036YJ
DR   ChEMBL-Cells; CHEMBL3307976
DR   ChEMBL-Targets; CHEMBL612556
DR   CLS; 500311
DR   DSMZ; ACC-159
DR   DSMZCellDive; ACC-159
DR   ECACC; 88022401
DR   ICLC; ATL98004
DR   JCRB; IFO50278
DR   KCB; KCB 93033YJ
DR   KCB; KCB 200735YJ
DR   KCB; KCB 200736YJ
DR   KCLB; 21721
DR   Lonza; 124
DR   MeSH; D016716
DR   NCBI_Iran; C153
DR   PubChem_Cell_line; CVCL_0481
DR   RCB; RCB0009
DR   TOKU-E; 2867
DR   TOKU-E; 3554
DR   Ubigene; YC-C047
DR   Wikidata; Q7118481
RX   PubMed=682602;
RX   PubMed=1065897;
RX   PubMed=2187480;
RX   PubMed=2493070;
RX   PubMed=2759161;
RX   PubMed=6500171;
RX   PubMed=9886495;
RX   PubMed=15541571;
RX   PubMed=16223334;
RX   PubMed=18005394;
RX   PubMed=22538498;
RX   PubMed=33171774;
RX   PubMed=34348336;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Responds reversibly to NGF by induction of a neuronal phenotype.
CC   Doubling time: 40 hours (PubMed=9886495); 92 hours (CLS=500311; ECACC=88022401); ~50-60 hours (DSMZ=ACC-159).
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
CC   Breed/subspecies: NEDH.
DI   NCIt; C121568; Rat adrenal gland pheochromocytoma
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 32
RX   PubMed=682602;
RA   Tischler A.S., Greene L.A.;
RT   "Morphologic and cytochemical properties of a clonal line of rat
RT   adrenal pheochromocytoma cells which respond to nerve growth factor.";
RL   Lab. Invest. 39:77-89(1978).
RX   PubMed=1065897; DOI=10.1073/pnas.73.7.2424;
RA   Greene L.A., Tischler A.S.;
RT   "Establishment of a noradrenergic clonal line of rat adrenal
RT   pheochromocytoma cells which respond to nerve growth factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 73:2424-2428(1976).
RX   PubMed=2187480; DOI=10.1089/dna.1990.9.221;
RA   Muller S.R., Sullivan P.D., Clegg D.O., Feinstein S.C.;
RT   "Efficient transfection and expression of heterologous genes in PC12
RT   cells.";
RL   DNA Cell Biol. 9:221-229(1990).
RX   PubMed=2493070; DOI=10.1111/j.1471-4159.1989.tb02538.x;
RA   Katoh-Semba R., Oohira A., Sano M., Watanabe K., Kitajima S.,
RA   Kashiwamata S.;
RT   "Glycosaminoglycan composition of PC12 pheochromocytoma cells: a
RT   comparison with PC12D cells, a new subline of PC12 cells.";
RL   J. Neurochem. 52:889-895(1989).
RX   PubMed=2759161; DOI=10.1016/0277-5379(89)90388-X;
RA   Chelmicka-Schorr E., Checinski M.E., Arnason B.G.W.;
RT   "PC12 pheochromocytoma and sympathetic nervous system derived trophic
RT   factors augment growth of neuroblastoma.";
RL   Eur. J. Cancer Clin. Oncol. 25:1057-1059(1989).
RX   PubMed=6500171; DOI=10.1016/0303-7207(84)90102-3;
RA   Bethea C.L., Kozak S.L.;
RT   "Effect of extracellular matrix on PC 12 cell shape and dopamine
RT   processing.";
RL   Mol. Cell. Endocrinol. 37:319-329(1984).
RX   PubMed=9886495; DOI=10.1002/(SICI)1097-4652(199901)178:1<93::AID-JCP12>3.0.CO;2-U;
RA   Dwyer D.S., Liu Y., Bradley R.J.;
RT   "An ethanol-sensitive variant of the PC12 neuronal cell line:
RT   sensitivity to alcohol is associated with increased cell adhesion and
RT   decreased glucose accumulation.";
RL   J. Cell. Physiol. 178:93-101(1999).
RX   PubMed=15541571; DOI=10.1016/j.mce.2003.02.001;
RA   Eaton M.J., Duplan H.;
RT   "Useful cell lines derived from the adrenal medulla.";
RL   Mol. Cell. Endocrinol. 228:39-52(2004).
RX   PubMed=16223334; DOI=10.1290/0411077.1;
RA   Dixon D.N., Loxley R.A., Barron A., Cleary S., Phillips J.K.;
RT   "Comparative studies of PC12 and mouse pheochromocytoma-derived rodent
RT   cell lines as models for the study of neuroendocrine systems.";
RL   In Vitro Cell. Dev. Biol. Anim. 41:197-206(2005).
RX   PubMed=18005394; DOI=10.1111/j.1748-1716.2007.01805.x;
RA   Westerink R.H.S., Ewing A.G.;
RT   "The PC12 cell as model for neurosecretion.";
RL   Acta Physiol. 192:273-285(2008).
RX   PubMed=22538498; DOI=10.1159/000338793;
RA   Grozinsky-Glasberg S., Shimon I., Rubinfeld H.;
RT   "The role of cell lines in the study of neuroendocrine tumors.";
RL   Neuroendocrinology 96:173-187(2012).
RX   PubMed=33171774; DOI=10.3390/ijms21218356;
RA   Kudo T.-a., Tominami K., Izumi S., Hayashi Y., Noguchi T.,
RA   Matsuzawa A., Hong G., Nakai J.;
RT   "Characterization of PC12 cell subclones with different sensitivities
RT   to programmed thermal stimulation.";
RL   Int. J. Mol. Sci. 21:8356.1-8356.15(2020).
RX   PubMed=34348336; DOI=10.1159/000518337;
RA   Delage C., Breard-Mellin L., Theresine C., Simioneck S., Lefranc B.,
RA   Leprince J., Benard M., Vaudry D.;
RT   "The heterogeneity of response of PC12 cells from different
RT   laboratories to nerve growth factor and pituitary adenylate
RT   cyclase-activating polypeptide questions the reproducibility of
RT   studies carried out with tumor cell lines.";
RL   Neuroendocrinology 113:216-230(2023).