ID   OVCA433
AC   CVCL_0475
SY   OvCa433; OVCA 433; OvCa 433; OVCA-433; OVCA433_Bast; OVCAR-433; OVCAR 433; OVCAR433; SKOV-433; SK-OV-433; OV433
DR   BTO; BTO_0002566
DR   EFO; EFO_0006723
DR   MCCL; MCC:0000373
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03473291
DR   cancercelllines; CVCL_0475
DR   Cell_Model_Passport; SIDM00966
DR   Cosmic; 924148
DR   Cosmic; 927568
DR   Cosmic; 1175882
DR   Cosmic; 1524355
DR   Cosmic; 1709258
DR   Cosmic-CLP; 1480367
DR   DepMap; ACH-002182
DR   EGA; EGAS00001000610
DR   GDSC; 1480367
DR   GEO; GSM95433
DR   GEO; GSM711706
DR   GEO; GSM851931
DR   GEO; GSM1670316
DR   GEO; GSM2474992
DR   PharmacoDB; OVCA433_1216_2019
DR   PRIDE; PXD003668
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0475
DR   Wikidata; Q54936989
RX   PubMed=1536252;
RX   PubMed=6346879;
RX   PubMed=7028788;
RX   PubMed=10318951;
RX   PubMed=10972993;
RX   PubMed=11793438;
RX   PubMed=16382445;
RX   PubMed=19926575;
RX   PubMed=22328975;
RX   PubMed=22585861;
RX   PubMed=22710073;
RX   PubMed=23415752;
RX   PubMed=24434149;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=27561551;
RX   PubMed=28273451;
RX   PubMed=30894373;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Doubling time: 102.24 hours (JWGray panel).
CC   HLA typing: A*01:01,26:01; B*15:17,39:01; C*07:01,12:03 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Proteomics; Subcellular; Exosome.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.31%; Native American=1.3%; East Asian, North=0.31%; East Asian, South=0%; South Asian=0%; European, North=59.83%; European, South=38.24% (PubMed=30894373).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): Cosmic-CLP=1480367; PubMed=22710073; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 7,12
ST   D16S539: 12
ST   D18S51: 14
ST   D19S433: 13
ST   D21S11: 30
ST   D2S1338: 19,20
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 14,15
ST   FGA: 24
ST   Penta D: 13,14
ST   Penta E: 7,12
ST   TH01: 9
ST   TPOX: 9,11
ST   vWA: 16,18
DI   NCIt; C7550; Ovarian serous adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_IQ32 ! LAZ-444
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
CH   CVCL_DA01 ! OVCA433/T40
CH   CVCL_DA00 ! OVCA433/TxT50
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028;
RA   Medrano, Mauricio
RA   Communal, Laudine
RA   Brown, Kevin R.
RA   Iwanicki, Marcin
RA   Normand, Josee
RA   Paterson, Joshua
RA   Sircoulomb, Fabrice
RA   Krzyzanowski, Paul M.
RA   Novak, Marian
RA   Doodnauth, Sasha A.
RA   Suarez Saiz, Fernando Jose
RA   Cullis, Jane
RA   Al-awar, Rima
RA   Neel, Benjamin G.
RA   McPherson, John
RA   Drapkin, Ronny I.
RA   Ailles, Laurie
RA   Mes-Masson, Anne-Marie
RA   Rottapel, Robert
RT   "Interrogation of functional cell-surface markers identifies CD151
RT   dependency in high-grade serous ovarian cancer.";
RL   Cell Rep. 18:2343-2358(2017).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte, Richard
RA   Brown, Kevin R.
RA   Suarez Saiz, Fernando Jose
RA   Sayad, Azin
RA   Karamboulas, Konstantina
RA   Krzyzanowski, Paul M.
RA   Sircoulomb, Fabrice
RA   Medrano, Mauricio
RA   Fedyshyn, Yaroslav
RA   Koh, Judice Lie-Yong
RA   van Dyk, Dewald
RA   Fedyshyn, Bohdana
RA   Luhova, Marianna
RA   Brito, Glauber C.
RA   Vizeacoumar, Franco J.
RA   Vizeacoumar, Frederick S.
RA   Datti, Alessandro
RA   Kasimer, Dahlia
RA   Buzina, Alla
RA   Mero, Patricia
RA   Misquitta, Christine
RA   Normand, Josee
RA   Haider, Maliha
RA   Ketela, Troy
RA   Wrana, Jeffrey L.
RA   Rottapel, Robert
RA   Neel, Benjamin G.
RA   Moffat, Jason
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
RX   PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023;
RA   Stordal, Britta
RA   Timms, Kirsten
RA   Farrelly, Angela
RA   Gallagher, Danielle
RA   Busschots, Steven
RA   Renaud, Mickael
RA   Thery, Julien
RA   Williams, Deborah
RA   Potter, Jennifer
RA   Tran, Thanh
RA   Korpanty, Greg
RA   Cremona, Mattia
RA   Carey, Mark S.
RA   Li, Jie
RA   Li, Yang
RA   Aslan, Ozlem
RA   O'Leary, John J.
RA   Mills, Gordon B.
RA   Hennessy, Bryan T.
RT   "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one
RT   functionally deleterious BRCA1 mutation.";
RL   Mol. Oncol. 7:567-579(2013).
//
RX   PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821;
RA   Hanrahan, Aphrothiti J.
RA   Schultz, Nikolaus
RA   Westfal, Maggie L.
RA   Sakr, Rita A.
RA   Giri, Dilip D.
RA   Scarperi, Stefano
RA   Janakiraman, Manickam
RA   Olvera, Narciso
RA   Stevens, Ellen V.
RA   She, Qing-Bai
RA   Aghajanian, Carol
RA   King, Tari Ann
RA   de Stanchina, Elisa
RA   Spriggs, David R.
RA   Heguy, Adriana
RA   Taylor, Barry Stephen
RA   Sander, Chris
RA   Rosen, Neal
RA   Levine, Douglas A.
RA   Solit, David B.
RT   "Genomic complexity and AKT dependence in serous ovarian cancer.";
RL   Cancer Discov. 2:56-67(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=6346879; DOI=10.1016/0002-9378(83)90999-7;
RA   Berkowitz, Ross Stuart
RA   Kabawat, Salim
RA   Lazarus, Herbert
RA   Colvin, Robert B.
RA   Knapp, Robert C.
RA   Bast, Robert Clinton Jr.
RT   "Comparison of a rabbit heteroantiserum and a murine monoclonal
RT   antibody raised against a human epithelial ovarian carcinoma cell
RT   line.";
RL   Am. J. Obstet. Gynecol. 146:607-612(1983).
//
RX   PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461;
RA   Coscia, Fabian
RA   Watters, Karen M.
RA   Curtis, Marion
RA   Eckert, Mark A.
RA   Chiang, Chun-Yi
RA   Tyanova, Stefka
RA   Montag, Anthony
RA   Lastra, Ricardo R.
RA   Lengyel, Ernst Robert
RA   Mann, Matthias
RT   "Integrative proteomic profiling of ovarian cancer cell lines reveals
RT   precursor cell associated proteins and functional status.";
RL   Nat. Commun. 7:12645.1-12645.14(2016).
//
RX   PubMed=10972993; DOI=10.1002/1098-2744(200008)28:4<236::AID-MC6>3.0.CO;2-H;
RA   Rauh-Adelmann, Christine
RA   Lau, Kin-Mang
RA   Sabeti, Nari
RA   Long, John P.
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
RT   "Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon
RT   12 deletion variant in malignant human ovarian, prostate, and breast
RT   cancer cell lines.";
RL   Mol. Carcinog. 28:236-246(2000).
//
RX   PubMed=16382445; DOI=10.1002/gcc.20300;
RA   Wang, Yan C.
RA   Juric, Dejan
RA   Francisco, Brian
RA   Yu, Ron X.
RA   Duran, George E.
RA   Chen, G. Kevin
RA   Chen, Xin
RA   Sikic, Branimir Ivan
RT   "Regional activation of chromosomal arm 7q with and without gene
RT   amplification in taxane-selected human ovarian cancer cell lines.";
RL   Genes Chromosomes Cancer 45:365-374(2006).
//
RX   PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS; PMCID=PMC3040237;
RA   DeRycke, Melissa S.
RA   Andersen, John D.
RA   Harrington, Katherine M.
RA   Pambuccian, Stefan Eduard
RA   Kalloger, Steve E.
RA   Boylan, Kristin L.M.
RA   Argenta, Peter Alexander
RA   Skubitz, Amy Patrice Norden
RT   "S100A1 expression in ovarian and endometrial endometrioid carcinomas
RT   is a prognostic indicator of relapse-free survival.";
RL   Am. J. Clin. Pathol. 132:846-856(2009).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=24434149; DOI=10.1016/j.bbrc.2013.12.070;
RA   Sinha, Ankit
RA   Ignatchenko, Vladimir
RA   Ignatchenko, Alex
RA   Mejia-Guerrero, Salvador
RA   Kislinger, Thomas
RT   "In-depth proteomic analyses of ovarian cancer cell line exosomes
RT   reveals differential enrichment of functional categories compared to
RT   the NCI 60 proteome.";
RL   Biochem. Biophys. Res. Commun. 445:694-701(2014).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=10318951; DOI=10.1073/pnas.96.10.5722; PMCID=PMC21927;
RA   Lau, Kin-Mang
RA   Mok, Samuel C.
RA   Ho, Shuk-Mei
RT   "Expression of human estrogen receptor-alpha and -beta, progesterone
RT   receptor, and androgen receptor mRNA in normal and malignant ovarian
RT   epithelial cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:5722-5727(1999).
//
RX   PubMed=1536252; DOI=10.1016/0002-9378(92)91697-9;
RA   Berchuck, Andrew
RA   Rodriguez, Gus
RA   Olt, George
RA   Whitaker, Regina
RA   Boente, Matthew P.
RA   Arrick, Bradley A.
RA   Clarke-Pearson, Daniel Lyle
RA   Bast, Robert Clinton Jr.
RT   "Regulation of growth of normal ovarian epithelial cells and ovarian
RT   cancer cell lines by transforming growth factor-beta.";
RL   Am. J. Obstet. Gynecol. 166:676-684(1992).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=7028788; DOI=10.1172/JCI110380; PMCID=PMC370929;
RA   Bast, Robert Clinton Jr.
RA   Feeney, Maryellen
RA   Lazarus, Herbert
RA   Nadler, Lee Marshall
RA   Colvin, Robert B.
RA   Knapp, Robert C.
RT   "Reactivity of a monoclonal antibody with human ovarian carcinoma.";
RL   J. Clin. Invest. 68:1331-1337(1981).
//
RX   PubMed=11793438; DOI=10.1002/gcc.1221;
RA   Rao, Pulivarthi H.
RA   Harris, Charles P.
RA   Lu, Xin-Yan
RA   Li, Xiao-Nan
RA   Mok, Samuel C.
RA   Lau, Ching C.
RT   "Multicolor spectral karyotyping of serous ovarian adenocarcinoma.";
RL   Genes Chromosomes Cancer 33:123-132(2002).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//