ID   OV-2008
AC   CVCL_0473
AS   CVCL_4066
SY   OV2008; Ov2008; OV 2008; 2008; A2008
DR   BTO; BTO_0003792
DR   EFO; EFO_0022702
DR   MCCL; MCC:0000371
DR   BioSample; SAMN03151841
DR   BioSample; SAMN03151843
DR   cancercelllines; CVCL_0473
DR   ChEMBL-Cells; CHEMBL3308015
DR   ChEMBL-Targets; CHEMBL612818
DR   Cosmic; 849613
DR   Cosmic; 948293
DR   Cosmic; 988874
DR   Cosmic; 1102825
DR   Cosmic; 1524359
DR   Cosmic; 1707563
DR   Cosmic; 2582806
DR   Cosmic; 2674703
DR   GEO; GSM184384
DR   GEO; GSM184385
DR   GEO; GSM659387
DR   GEO; GSM711715
DR   GEO; GSM711718
DR   GEO; GSM851907
DR   GEO; GSM851925
DR   IARC_TP53; 25074
DR   Progenetix; CVCL_0473
DR   PubChem_Cell_line; CVCL_0473
DR   Wikidata; Q54936825
RX   PubMed=4118903;
RX   PubMed=9234707;
RX   PubMed=11314036;
RX   PubMed=19926575;
RX   PubMed=22710073;
RX   PubMed=24023729;
RX   PubMed=25846456;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/2/cell-lines-detail-62.html
CC   Problematic cell line: Contaminated. Shown to be a ME-180 derivative (PubMed=22710073). Originally thought to originate from a female patient with an ovarian serous carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00466.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (PubMed=25846456).
CC   Transformant: NCBI_TaxID; 45240; Human papillomavirus type 68 (HPV68).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Omentum; UBERON=UBERON_0003688.
ST   Source(s): PubMed=22710073
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,12
ST   D16S539: 12,13
ST   D18S51: 12
ST   D19S433: 13,15.2
ST   D21S11: 30,31
ST   D2S1338: 18
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 9,10
ST   D8S1179: 14
ST   FGA: 23
ST   TH01: 8,9.3
ST   TPOX: 8,10
ST   vWA: 15,17
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1401 ! ME-180
SX   Female
AG   66Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
CH   CVCL_0114 ! 2008/C13*5.25
CH   CVCL_W373 ! PX2
CH   CVCL_W374 ! PX24
//
RX   PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS; PMCID=PMC3040237;
RA   DeRycke, Melissa S.
RA   Andersen, John D.
RA   Harrington, Katherine M.
RA   Pambuccian, Stefan Eduard
RA   Kalloger, Steve E.
RA   Boylan, Kristin L.M.
RA   Argenta, Peter Alexander
RA   Skubitz, Amy Patrice Norden
RT   "S100A1 expression in ovarian and endometrial endometrioid carcinomas
RT   is a prognostic indicator of relapse-free survival.";
RL   Am. J. Clin. Pathol. 132:846-856(2009).
//
RX   PubMed=25846456; DOI=10.3892/ijo.2015.2951;
RA   Takenaka, Masataka
RA   Saito, Motonobu
RA   Iwakawa, Reika
RA   Yanaihara, Nozomu
RA   Saito, Misato
RA   Kato, Mamoru
RA   Ichikawa, Hitoshi
RA   Shibata, Tatsuhiro
RA   Yokota, Jun
RA   Okamoto, Aikou
RA   Kohno, Takashi
RT   "Profiling of actionable gene alterations in ovarian cancer by
RT   targeted deep sequencing.";
RL   Int. J. Oncol. 46:2389-2398(2015).
//
RX   PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677;
RA   Korch, Christopher T.
RA   Spillman, Monique Ann
RA   Jackson, Twila A.
RA   Jacobsen, Britta M.
RA   Murphy, Susan K.
RA   Lessey, Bruce Arthur
RA   Jordan, Virgil Craig
RA   Bradford, Andrew Peter
RT   "DNA profiling analysis of endometrial and ovarian cell lines reveals
RT   misidentification, redundancy and contamination.";
RL   Gynecol. Oncol. 127:241-248(2012).
//
RX   PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837;
RA   Anglesio, Michael S.
RA   Wiegand, Kimberly C.
RA   Melnyk, Nataliya
RA   Chow, Christine
RA   Salamanca, Clara M.
RA   Prentice, Leah M.
RA   Senz, Janine
RA   Yang, Winnie
RA   Spillman, Monique Ann
RA   Cochrane, Dawn R.
RA   Shumansky, Karey
RA   Shah, Sohrab P.
RA   Kalloger, Steve E.
RA   Huntsman, David G.
RT   "Type-specific cell line models for type-specific ovarian cancer
RT   research.";
RL   PLoS ONE 8:e72162.1-e72162.13(2013).
//
RX   PubMed=9234707; DOI=10.1128/mcb.17.8.4501; PMCID=PMC232303;
RA   Bullions, Linda C.
RA   Notterman, Daniel A.
RA   Chung, Lorinda S.
RA   Levine, Arnold Jay
RT   "Expression of wild-type alpha-catenin protein in cells with a mutant
RT   alpha-catenin gene restores both growth regulation and tumor
RT   suppressor activities.";
RL   Mol. Cell. Biol. 17:4501-4508(1997).
//
RX   PubMed=4118903; DOI=10.1016/0002-9378(72)90109-3;
RA   DiSaia, Philip J.
RA   Sinkovics, Joseph G.
RA   Rutledge, Felix Noah
RA   Smith, Julian P.
RT   "Cell-mediated immunity to human malignant cells. A brief review and
RT   further studies with two gynecologic tumors.";
RL   Am. J. Obstet. Gynecol. 114:979-989(1972).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs, Eva
RA   Wren, Jonathan D.
RA   Kamibayashi, Craig
RA   Kondo, Masashi
RA   Xu, Xie L.
RA   Markowitz, Sanford David
RA   Tomlinson, Gail E.
RA   Muller, Carolyn Y.
RA   Gazdar, Adi F.
RA   Garner, Harold Ray
RA   Minna, John D.
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//