ID   Neuro-2a
AC   CVCL_0470
SY   NEURO-2A; Neuro 2a; Neuro2a; Neuro2A; N-2a; N2a; N2A; Nb2a; NB2a
DR   BTO; BTO_0001976
DR   CLO; CLO_0008154
DR   CLO; CLO_0050180
DR   EFO; EFO_0022756
DR   MCCL; MCC:0000368
DR   CLDB; cl3682
DR   CLDB; cl3683
DR   CLDB; cl3684
DR   CLDB; cl3685
DR   CLDB; cl4956
DR   CLDB; cl5236
DR   Abcam; ab279975
DR   ATCC; CCL-131
DR   BCRC; 60026
DR   BCRJ; 0189
DR   BioGRID_ORCS_Cell_line; 1373
DR   CCLV; CCLV-RIE 0132
DR   CCRID; 1101MOU-PUMC000291
DR   CCRID; 3101MOUSCSP5035
DR   CCRID; 3101MOUTCM29
DR   CCRID; 4201MOU-CCTCC00162
DR   CCTCC; GDC0162
DR   ChEMBL-Cells; CHEMBL3307521
DR   ChEMBL-Targets; CHEMBL614062
DR   CLS; 400394
DR   DSMZ; ACC-148
DR   DSMZCellDive; ACC-148
DR   ECACC; 89121404
DR   ICLC; ATL99007
DR   IZSLER; BS TCL 128
DR   JCRB; IFO50081
DR   KCB; KCB 2014025YJ
DR   Lonza; 451
DR   PRIDE; PXD000065
DR   PRIDE; PXD002290
DR   PRIDE; PXD018875
DR   PubChem_Cell_line; CVCL_0470
DR   RCB; RCB2639
DR   TKG; TKG 0509
DR   TOKU-E; 2746
DR   TOKU-E; 3552
DR   TOKU-E; 3563
DR   Wikidata; Q18391478
RX   DOI=10.5352/JLS.2009.19.4.449;
RX   PubMed=11470893;
RX   PubMed=14504404;
RX   PubMed=19903493;
RX   PubMed=25193168;
RX   PubMed=25277546;
RX   PubMed=25565633;
RX   PubMed=35339896;
RX   PubMed=39594637;
WW   Info; ResearchGate; -; https://www.researchgate.net/post/What_are_the_details_of_N2A_cell_differentiation_methods
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-213.html
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-384.html
WW   Info; Wikipedia; -; https://en.wikipedia.org/wiki/N2a_cell
CC   Characteristics: Capable of differentiating into various types of neurons.
CC   Doubling time: ~70 hours (DSMZ=ACC-148).
CC   Karyotypic information: Has a hyper-tetraploid karyotype. Has lost chromosome Y (PubMed=39594637).
CC   Omics: Proteomics.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: STR profile from personal communication of Rodriguez-Tarduchy Segovia, Gemma.
CC   Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
CC   Cell type: Neural crest derived neuroblast; CL=CL_0002676.
CC   Breed/subspecies: A/J.
ST   Source(s): Direct_author_submission; PubMed=35339896
ST   Mouse STR 1-1: 11
ST   Mouse STR 1-2: 17,18
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 12,13,14
ST   Mouse STR 4-2: 21.3,22.3
ST   Mouse STR 5-5: 15,17
ST   Mouse STR 6-4: 18,19 (Direct_author_submission)
ST   Mouse STR 6-4: 18,20 (PubMed=35339896)
ST   Mouse STR 6-7: 12 (Direct_author_submission)
ST   Mouse STR 6-7: 15 (PubMed=35339896)
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 16,17
ST   Mouse STR 11-2: 15
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 16.2,17.2
ST   Mouse STR 15-3: 21.3,22.3,23.3
ST   Mouse STR 17-2: 16
ST   Mouse STR 18-3: 22 (Direct_author_submission)
ST   Mouse STR 18-3: 22,23 (PubMed=35339896)
ST   Mouse STR 19-2: 12
ST   Mouse STR X-1: 26,27
DI   NCIt; C21993; Mouse neuroblastoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4343 ! C-1300
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   DOI=10.5352/JLS.2009.19.4.449;
RA   Do J.H., Kim I.S., Ko H.M., Choi D.-K.;
RT   "High resolution genomic profile of Neuro2a murine neuroblastoma cell
RT   line by array-based comparative genomic hybridization.";
RL   J. Life Sci. 19:449-456(2009).
//
RX   PubMed=11470893; DOI=10.1073/pnas.151242598; PMCID=PMC55414;
RA   Enari M., Flechsig E., Weissmann C.;
RT   "Scrapie prion protein accumulation by scrapie-infected neuroblastoma
RT   cells abrogated by exposure to a prion protein antibody.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9295-9299(2001).
//
RX   PubMed=14504404; DOI=10.1073/pnas.1834432100; PMCID=PMC208815;
RA   Klohn P.-C., Stoltze L., Flechsig E., Enari M., Weissmann C.;
RT   "A quantitative, highly sensitive cell-based infectivity assay for
RT   mouse scrapie prions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:11666-11671(2003).
//
RX   PubMed=19903493; DOI=10.1016/j.jneumeth.2009.11.004;
RA   Tremblay R.G., Sikorska M., Sandhu J.K., Lanthier P.,
RA   Ribecco-Lutkiewicz M., Bani-Yaghoub M.;
RT   "Differentiation of mouse Neuro 2A cells into dopamine neurons.";
RL   J. Neurosci. Methods 186:60-67(2010).
//
RX   PubMed=25193168; DOI=10.1074/mcp.M113.037291; PMCID=PMC4256493;
RA   Hornburg D., Drepper C., Butter F., Meissner F., Sendtner M., Mann M.;
RT   "Deep proteomic evaluation of primary and cell line motoneuron disease
RT   models delineates major differences in neuronal characteristics.";
RL   Mol. Cell. Proteomics 13:3410-3420(2014).
//
RX   PubMed=25277546; DOI=10.1186/1471-2164-15-847; PMCID=PMC4198738;
RA   Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W.,
RA   Morse H.C. 3rd, Pardo-Manuel de Villena F.;
RT   "SNP array profiling of mouse cell lines identifies their strains of
RT   origin and reveals cross-contamination and widespread aneuploidy.";
RL   BMC Genomics 15:847.1-847.11(2014).
//
RX   PubMed=25565633; DOI=10.1371/journal.pone.0117154; PMCID=PMC4286239;
RA   Oelschlegel A.M., Geissen M., Lenk M., Riebe R., Angermann M.,
RA   Schaetzl H., Groschup M.H.;
RT   "A bovine cell line that can be infected by natural sheep scrapie
RT   prions.";
RL   PLoS ONE 10:e0117154.1-e0117154.15(2015).
//
RX   PubMed=35339896; DOI=10.1016/j.ebiom.2022.103970; PMCID=PMC8956943;
RA   Zhou Q.-Z., Li S.-H., Li M.-Z., Ke D., Wang Q., Yang Y., Liu G.-P.,
RA   Wang X.-C., Liu E.-J., Wang J.-Z.;
RT   "Human tau accumulation promotes glycogen synthase kinase-3beta
RT   acetylation and thus upregulates the kinase: a vicious cycle in
RT   Alzheimer neurodegeneration.";
RL   EBioMedicine 78:103970.1-103970.18(2022).
//
RX   PubMed=39594637; DOI=10.3390/cells13221889; PMCID=PMC11593031;
RA   Hergenhahn L., Padutsch N., Azawi S., Weiskirchen R., Liehr T.,
RA   Rincic M.;
RT   "Cytogenomic characterization of murine neuroblastoma cell line
RT   Neuro-2a and its two derivatives Neuro-2a TR-alpha and Neuro-2a
RT   TR-beta.";
RL   Cells 13:1889.1-1889.11(2024).
//