ID   Neuro-2a
AC   CVCL_0470
SY   NEURO-2A; Neuro 2a; Neuro2a; Neuro2A; N-2a; N2a; N2A; Nb2a; NB2a
DR   BTO; BTO:0001976
DR   CLO; CLO_0008154
DR   CLO; CLO_0050180
DR   MCCL; MCC:0000368
DR   CLDB; cl3682
DR   CLDB; cl3683
DR   CLDB; cl3684
DR   CLDB; cl3685
DR   CLDB; cl4956
DR   CLDB; cl5236
DR   Abcam; ab279975
DR   ATCC; CCL-131
DR   BCRC; 60026
DR   BCRJ; 0189
DR   BioGRID_ORCS_Cell_line; 1373
DR   CCRID; 1101MOU-PUMC000291
DR   CCRID; 4201MOU-CCTCC00162
DR   ChEMBL-Cells; CHEMBL3307521
DR   ChEMBL-Targets; CHEMBL614062
DR   CLS; 400394
DR   DSMZ; ACC-148
DR   DSMZCellDive; ACC-148
DR   ECACC; 89121404
DR   ICLC; ATL99007
DR   JCRB; IFO50081
DR   KCB; KCB 2014025YJ
DR   Lonza; 451
DR   PRIDE; PXD000065
DR   PRIDE; PXD002290
DR   PRIDE; PXD018875
DR   PubChem_Cell_line; CVCL_0470
DR   RCB; RCB2639
DR   TKG; TKG 0509
DR   TOKU-E; 2746
DR   TOKU-E; 3552
DR   TOKU-E; 3563
DR   Wikidata; Q18391478
RX   PubMed=11470893;
RX   PubMed=14504404;
RX   PubMed=19903493;
RX   PubMed=25193168;
RX   PubMed=25277546;
RX   PubMed=25565633;
CC   Characteristics: Capable of differentiating into various types of neurons.
CC   Doubling time: ~70 hours (DSMZ=ACC-148).
CC   Omics: Deep proteome analysis.
CC   Omics: SNP array analysis.
CC   Miscellaneous: STR profile from personal communication of Rodriguez-Tarduchy Segovia G.
CC   Derived from site: In situ; Peripheral nervous system; UBERON=UBERON_0000010.
CC   Cell type: Neural crest derived neuroblast; CL=CL_0002676.
CC   Breed/subspecies: A/J.
ST   Source(s): Direct_author_submission
ST   Mouse STR 1-1: 11
ST   Mouse STR 1-2: 17,18
ST   Mouse STR 11-2: 15
ST   Mouse STR 12-1: 16
ST   Mouse STR 13-1: 16.2,17.2
ST   Mouse STR 15-3: 21.3,22.3,23.3
ST   Mouse STR 17-2: 16
ST   Mouse STR 18-3: 22,23
ST   Mouse STR 19-2: 12
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 12,13,14
ST   Mouse STR 4-2: 21.3,22.3
ST   Mouse STR 5-5: 15,17
ST   Mouse STR 6-4: 18,20
ST   Mouse STR 6-7: 12
ST   Mouse STR 7-1: 25.2
ST   Mouse STR 8-1: 16,17
ST   Mouse STR X-1: 26,27
DI   NCIt; C21993; Mouse neuroblastoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_4343 ! C-1300
SX   Male
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 32
RX   PubMed=11470893; DOI=10.1073/pnas.151242598;
RA   Enari M., Flechsig E., Weissmann C.;
RT   "Scrapie prion protein accumulation by scrapie-infected neuroblastoma
RT   cells abrogated by exposure to a prion protein antibody.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9295-9299(2001).
RX   PubMed=14504404; DOI=10.1073/pnas.1834432100;
RA   Klohn P.-C., Stoltze L., Flechsig E., Enari M., Weissmann C.;
RT   "A quantitative, highly sensitive cell-based infectivity assay for
RT   mouse scrapie prions.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:11666-11671(2003).
RX   PubMed=19903493; DOI=10.1016/j.jneumeth.2009.11.004;
RA   Tremblay R.G., Sikorska M., Sandhu J.K., Lanthier P.,
RA   Ribecco-Lutkiewicz M., Bani-Yaghoub M.;
RT   "Differentiation of mouse Neuro 2A cells into dopamine neurons.";
RL   J. Neurosci. Methods 186:60-67(2010).
RX   PubMed=25193168; DOI=10.1074/mcp.M113.037291;
RA   Hornburg D., Drepper C., Butter F., Meissner F., Sendtner M., Mann M.;
RT   "Deep proteomic evaluation of primary and cell line motoneuron disease
RT   models delineates major differences in neuronal characteristics.";
RL   Mol. Cell. Proteomics 13:3410-3420(2014).
RX   PubMed=25277546; DOI=10.1186/1471-2164-15-847;
RA   Didion J.P., Buus R.J., Naghashfar Z., Threadgill D.W.,
RA   Morse H.C. III, Pardo-Manuel de Villena F.;
RT   "SNP array profiling of mouse cell lines identifies their strains of
RT   origin and reveals cross-contamination and widespread aneuploidy.";
RL   BMC Genomics 15:847.1-847.11(2014).
RX   PubMed=25565633; DOI=10.1371/journal.pone.0117154;
RA   Oelschlegel A.M., Geissen M., Lenk M., Riebe R., Angermann M.,
RA   Schaetzl H., Groschup M.H.;
RT   "A bovine cell line that can be infected by natural sheep scrapie
RT   prions.";
RL   PLoS ONE 10:E0117154-E0117154(2015).