ID NCI-H157 AC CVCL_0463 SY NCl-H157; NCI H157; H157; H-157; NCI-157; NCIH157DM; H157DM DR BTO; BTO_0002283 DR CLO; CLO_0037032 DR EFO; EFO_0003118 DR MCCL; MCC:0000360 DR ArrayExpress; E-MTAB-783 DR ATCC; CRL-5802 DR BioSample; SAMN03151855 DR BioSample; SAMN03471738 DR cancercelllines; CVCL_0463 DR CCRID; 1101HUM-PUMC000113 DR ChEMBL-Cells; CHEMBL3307706 DR ChEMBL-Targets; CHEMBL614783 DR CLS; 300387 DR Cosmic; 722053 DR Cosmic; 724867 DR Cosmic; 801588 DR Cosmic; 844816 DR Cosmic; 852006 DR Cosmic; 876171 DR Cosmic; 877258 DR Cosmic; 903569 DR Cosmic; 911847 DR Cosmic; 917987 DR Cosmic; 929971 DR Cosmic; 930486 DR Cosmic; 932921 DR Cosmic; 934546 DR Cosmic; 949208 DR Cosmic; 953987 DR Cosmic; 980960 DR Cosmic; 1028954 DR Cosmic; 1032432 DR Cosmic; 1146881 DR Cosmic; 1219061 DR Cosmic; 1239910 DR Cosmic; 1320185 DR Cosmic; 2560227 DR Cosmic; 2648437 DR Cosmic; 2668267 DR Cosmic; 2668329 DR DepMap; ACH-000921 DR GEO; GSM62967 DR GEO; GSM108815 DR GEO; GSM108816 DR GEO; GSM253365 DR GEO; GSM434267 DR GEO; GSM784238 DR GEO; GSM794274 DR GEO; GSM817068 DR IARC_TP53; 495 DR IARC_TP53; 28242 DR IARC_TP53; 28453 DR IGRhCellID; H157GEO DR KCB; KCB 200814YJ DR KCLB; 90157 DR LINCS_LDP; LCL-1596 DR PRIDE; PXD002556 DR Progenetix; CVCL_0463 DR PubChem_Cell_line; CVCL_0463 DR Wikidata; Q54907822 RX PubMed=1311061; RX PubMed=1563005; RX PubMed=3940644; RX PubMed=6148444; RX PubMed=6270685; RX PubMed=6272398; RX PubMed=6713399; RX PubMed=7972006; RX PubMed=8626706; RX PubMed=8806092; RX PubMed=9649128; RX PubMed=10536175; RX PubMed=11005564; RX PubMed=11369051; RX PubMed=12068308; RX PubMed=12820372; RX PubMed=16187286; RX PubMed=19472407; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20557307; RX PubMed=20624269; RX PubMed=22961666; RX PubMed=23381221; RX PubMed=25120651; RX PubMed=26361996; RX PubMed=29681454; RX PubMed=30038707; RX PubMed=31803961; RX PubMed=38180245; WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/cross-contamination-of-atcc-crl-5802-and-atcc-crl-5860 WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/misidentified-cell-lines-atcc-crl-5802-and-atcc-crl-5860 WW Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx CC Problematic cell line: Contaminated. NCI-H157 and NCI-H1264 have been shown to be identical. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00412. CC Doubling time: 53 hours (Note=In RPMI 1640 + 10% FBS), 90 hours (Note=In ACL-3 + BSA) (PubMed=3940644); 20.8 hours (PubMed=29681454). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Homozygous (PubMed=30038707; DepMap=ACH-000921). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Arg (c.34G>C); ClinVar=VCV000012579; Zygosity=Heterozygous (PubMed=1311061; PubMed=12068308; DepMap=ACH-000921). CC Sequence variation: Mutation; HGNC; HGNC:11100; SMARCA4; Simple; p.Thr58Profs*36 (c.171del); Zygosity=Homozygous (DepMap=ACH-000921). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu35Phefs*8 (c.102_103insT) (c.103_104insT); Zygosity=Heterozygous (PubMed=10536175; PubMed=20557307; DepMap=ACH-000921). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu298Ter (c.892G>T); ClinVar=VCV000093323; Zygosity=Heterozygous (PubMed=1311061; PubMed=10536175; PubMed=20557307; DepMap=ACH-000921). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Discontinued: ATCC; CRL-5802; true. CC Discontinued: KCLB; 90157; probable. ST Source(s): ATCC=CRL-5802; CCRID=1101HUM-PUMC000113; CLS=300387 ST Amelogenin: X ST CSF1PO: 12 ST D12S391: 20 ST D13S317: 12 ST D16S539: 12,13 ST D18S51: 13,15 ST D19S433: 11,13 ST D21S11: 32 ST D2S1338: 21,22 ST D3S1358: 17,18 ST D5S818: 10,13 ST D6S1043: 17,24 ST D7S820: 12 ST D8S1179: 14,16 ST FGA: 22,23 ST Penta D: 2.2 ST Penta E: 7 ST TH01: 7,9 ST TPOX: 6,12 ST vWA: 15 DI NCIt; C3493; Lung squamous cell carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_3970 ! NCI-H1264 SX Male AG 59Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 43 CH CVCL_VD88 ! H157R CH CVCL_E3I3 ! HyCyte NCI-H157-Luc // RX PubMed=30038707; DOI=10.18632/oncotarget.25642; PMCID=PMC6049873; RA Du, Li-Qin RA Zhao, Zhen-Ze RA Suraokar, Milind Bhalchandra RA Shelton, Spencer S. RA Ma, Xiu-Ye RA Hsiao, Tzu-Hung RA Minna, John D. RA Wistuba, Ignacio Ivan RA Pertsemlidis, Alexander RT "LMO1 functions as an oncogene by regulating TTK expression and RT correlates with neuroendocrine differentiation of lung cancer."; RL Oncotarget 9:29601-29618(2018). // RX PubMed=11369051; DOI=10.1016/S0165-4608(00)00363-0; RA Luk, Catherine RA Tsao, Ming-Sound RA Bayani, Jane RA Shepherd, Frances Alice RA Squire, Jeremy Andrew RT "Molecular cytogenetic analysis of non-small cell lung carcinoma by RT spectral karyotyping and comparative genomic hybridization."; RL Cancer Genet. Cytogenet. 125:87-99(2001). // RX PubMed=6272398; DOI=10.1126/science.6272398; RA Moody, Terry W. RA Pert, Candace Beebe RA Gazdar, Adi F. RA Carney, Desmond Niall RA Minna, John D. RT "High levels of intracellular bombesin characterize human small-cell RT lung carcinoma."; RL Science 214:1246-1248(1981). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathryn RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne Margaret RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=1563005; RA Giaccone, Giuseppe RA Battey, James RA Gazdar, Adi F. RA Oie, Herbert Kazuto RA Draoui, Muriel RA Moody, Terry W. RT "Neuromedin B is present in lung cancer cell lines."; RL Cancer Res. 52:2732s-2736s(1992). // RX PubMed=6713399; RA Rosen, Steven T. RA Mulshine, James L. RA Cuttitta, Frank RA Fedorko, Joseph RA Carney, Desmond Niall RA Gazdar, Adi F. RA Minna, John D. RT "Analysis of human small cell lung cancer differentiation antigens RT using a panel of rat monoclonal antibodies."; RL Cancer Res. 44:2052-2061(1984). // RX PubMed=12820372; RA Bergqvist, Michael RA Brattstrom, Daniel RA Gullbo, Joachim RA Hesselius, Patrik RA Brodin, Ola RA Wagenius, Gunnar RT "p53 status and its in vitro relationship to radiosensitivity and RT chemosensitivity in lung cancer."; RL Anticancer Res. 23:1207-1212(2003). // RX PubMed=8806092; DOI=10.1002/jcb.240630505; RA Phelps, Ruby M. RA Johnson, Bruce E. RA Ihde, Daniel Carlyle RA Gazdar, Adi F. RA Carbone, David P. RA McClintock, Patrick R. RA Linnoila, Ritva Ilona RA Matthews, Mary J. RA Bunn, Paul A. Jr. RA Carney, Desmond Niall RA Minna, John D. RA Mulshine, James L. RT "NCI-Navy Medical Oncology Branch cell line data base."; RL J. Cell. Biochem. Suppl. 24:32-91(1996). // RX PubMed=10536175; DOI=10.3892/ijo.15.5.927; RA Fujita, Takeshi RA Kiyama, Masaharu RA Tomizawa, Yoshio RA Kohno, Takashi RA Yokota, Jun RT "Comprehensive analysis of p53 gene mutation characteristics in lung RT carcinoma with special reference to histological subtypes."; RL Int. J. Oncol. 15:927-934(1999). // RX PubMed=16187286; DOI=10.1002/ijc.21491; RA Garnis, Cathie RA Lockwood, William W. RA Vucic, Emily RA Ge, Ying RA Girard, Luc RA Minna, John D. RA Gazdar, Adi F. RA Lam, Stephen RA MacAulay, Calum RA Lam, Wan L. RT "High resolution analysis of non-small cell lung cancer cell lines by RT whole genome tiling path array CGH."; RL Int. J. Cancer 118:1556-1564(2006). // RX PubMed=1311061; RA Mitsudomi, Tetsuya RA Steinberg, Seth M. RA Nau, Marion M. RA Carbone, David P. RA D'Amico, Domenico RA Bodner, Sara M. RA Oie, Herbert Kazuto RA Linnoila, Ritva Ilona RA Mulshine, James L. RA Minna, John D. RA Gazdar, Adi F. RT "p53 gene mutations in non-small-cell lung cancer cell lines and their RT correlation with the presence of ras mutations and clinical RT features."; RL Oncogene 7:171-180(1992). // RX PubMed=9649128; DOI=10.1038/bjc.1998.361; PMCID=PMC2150402; RA Yi, Seung RA Chen, Jing-Ru RA Viallet, Jean RA Schwall, Ralph H. RA Nakamura, Toshikazu RA Tsao, Ming-Sound RT "Paracrine effects of hepatocyte growth factor/scatter factor on RT non-small-cell lung carcinoma cell lines."; RL Br. J. Cancer 77:2162-2170(1998). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540; RA McMillan, Elizabeth A. RA Ryu, Myung-Jeom RA Diep, Caroline H. RA Mendiratta, Saurabh RA Clemenceau, Jean Rene RA Vaden, Rachel M. RA Kim, Ju-Hwa RA Motoyaji, Takashi RA Covington, Kyle R. RA Peyton, Michael RA Huffman, Kenneth RA Wu, Xiao-Feng RA Girard, Luc RA Sung, Yeojin RA Chen, Pei-Hsaun RA Mallipeddi, Prema Latha RA Lee, Joo Young RA Hanson, Jordan RA Voruganti, Sukesh RA Yu, Yunku RA Park, Sunho RA Sudderth, Jessica RA DeSevo, Christopher RA Muzny, Donna M. RA Doddapaneni, HarshaVardhan RA Gazdar, Adi F. RA Gibbs, Richard Alexander RA Hwang, Tae Hyun RA Heymach, John Victor RA Wistuba, Ignacio Ivan RA Coombes, Kevin Robert RA Williams, Noelle S. RA Wheeler, David A. RA MacMillan, John B. RA DeBerardinis, Ralph J. RA Roth, Michael G. RA Posner, Bruce Arthur RA Minna, John D. RA Kim, Hyun Seok RA White, Michael A. RT "Chemistry-first approach for nomination of personalized treatment in RT lung cancer."; RL Cell 173:864-878.e29(2018). // RX PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293; RA Kohno, Takashi RA Sato, Takako RA Takakura, Satoshi RA Takei, Kimiko RA Inoue, Kaoru RA Nishioka, Michiho RA Yokota, Jun RT "Mutation and expression of the DCC gene in human lung cancer."; RL Neoplasia 2:300-305(2000). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa, Reika RA Kohno, Takashi RA Enari, Masatoshi RA Kiyono, Tohru RA Yokota, Jun RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=23381221; DOI=10.3892/or.2013.2266; PMCID=PMC3621652; RA Suzuki, Makoto RA Shiraishi, Kenji RA Eguchi, Ayami RA Ikeda, Koei RA Mori, Takeshi RA Yoshimoto, Kentaro RA Ohba, Yasuomi RA Yamada, Tatsuya RA Ito, Takaaki RA Baba, Yoshifumi RA Baba, Hideo RT "Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small RT cell lung cancer."; RL Oncol. Rep. 29:1308-1314(2013). // RX PubMed=8626706; DOI=10.1074/jbc.271.19.11477; RA Quinn, Kathryn A. RA Treston, Anthony M. RA Unsworth, Edward J. RA Miller, Mae-Jean RA Vos, Michele RA Grimley, Chris RA Battey, James RA Mulshine, James L. RA Cuttitta, Frank RT "Insulin-like growth factor expression in human cancer cell lines."; RL J. Biol. Chem. 271:11477-11483(1996). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco, Raquel RA Iwakawa, Reika RA Tang, Mo-Ying RA Kohno, Takashi RA Angulo, Barbara RA Pio, Ruben RA Montuenga, Luis M. RA Minna, John D. RA Yokota, Jun RA Sanchez-Cespedes, Montse RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=6148444; DOI=10.1093/jnci/73.4.801; RA Morstyn, George RA Russo, Angelo RA Carney, Desmond Niall RA Karawya, Essam RA Wilson, Samuel H. Jr. RA Mitchell, James B. RT "Heterogeneity in the radiation survival curves and biochemical RT properties of human lung cancer cell lines."; RL J. Natl. Cancer Inst. 73:801-807(1984). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers, Lauren Averett RA Wang, Jing RA Nilsson, Monique B. RA Fujimoto, Junya RA Saintigny, Pierre RA Yordy, John Stuart RA Giri, Uma RA Peyton, Michael RA Fan, You-Hong RA Diao, Li-Xia RA Masrorpour, Fatemeh RA Shen, Li RA Liu, Wen-Bin RA Duchemann, Boris RA Tumula, Praveen RA Bhardwaj, Vikas RA Welsh, James RA Weber, Stephanie RA Glisson, Bonnie S. RA Kalhor, Neda RA Wistuba, Ignacio Ivan RA Girard, Luc RA Lippman, Scott M. RA Mills, Gordon B. RA Coombes, Kevin Robert RA Weinstein, John N. RA Minna, John D. RA Heymach, John Victor RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003; RA Grundner-Culemann, Kathrin RA Dybowski, J. Nikolaj RA Klammer, Martin RA Tebbe, Andreas RA Schaab, Christoph RA Daub, Henrik RT "Comparative proteome analysis across non-small cell lung cancer cell RT lines."; RL J. Proteomics 130:1-10(2016). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine, James L. RA Ujhazy, Peter RA Antman, Melissa RA Burgess, Christine M. RA Kuzmin, Igor A. RA Bunn, Paul A. Jr. RA Johnson, Bruce E. RA Roth, Jack Alan RA Pass, Harvey I. RA Ross, Sheila M. RA Aldige, Carolyn R. RA Wistuba, Ignacio Ivan RA Minna, John D. RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=20624269; DOI=10.1186/1756-9966-29-75; PMCID=PMC2907339; RA Du, Li-Qin RA Schageman, Jeoffrey J. RA Irnov, Irnov RA Girard, Luc RA Hammond, Scott M. RA Minna, John D. RA Gazdar, Adi F. RA Pertsemlidis, Alexander RT "MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells RT and suggests a possible pathological relationship between SCLCs and RT NSCLCs."; RL J. Exp. Clin. Cancer Res. 29:75.1-75.12(2010). // RX PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163; RA Okamoto, Aikou RA Demetrick, Douglas J. RA Spillare, Elisa A. RA Hagiwara, Koichi RA Hussain, S. Perwez RA Bennett, William P. RA Forrester, Kathleen RA Gerwin, Brenda Isen RA Serrano, Manuel RA Beach, David H. RA Harris, Curtis Craig RT "Mutations and altered expression of p16INK4 in human cancer."; RL Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994). // RX PubMed=3940644; RA Brower, Martin RA Carney, Desmond Niall RA Oie, Herbert Kazuto RA Gazdar, Adi F. RA Minna, John D. RT "Growth of cell lines and clinical specimens of human non-small cell RT lung cancer in a serum-free defined medium."; RL Cancer Res. 46:798-806(1986). // RX PubMed=6270685; DOI=10.1073/pnas.78.7.4591; PMCID=PMC319839; RA Cuttitta, Frank RA Rosen, Steven T. RA Gazdar, Adi F. RA Minna, John D. RT "Monoclonal antibodies that demonstrate specificity for several types RT of human lung cancer."; RL Proc. Natl. Acad. Sci. U.S.A. 78:4591-4595(1981). // RX PubMed=25120651; DOI=10.3892/ol.2014.2234; PMCID=PMC4114630; RA Suzuki, Makoto RA Ikeda, Koei RA Shiraishi, Kenji RA Eguchi, Ayami RA Mori, Takeshi RA Yoshimoto, Kentaro RA Shibata, Hidekatsu RA Ito, Takaaki RA Baba, Yoshifumi RA Baba, Hideo RT "Aberrant methylation and silencing of IRF8 expression in non-small RT cell lung cancer."; RL Oncol. Lett. 8:1025-1030(2014). // RX PubMed=38180245; DOI=10.1158/1078-0432.CCR-23-2360; PMCID=PMC11061608; RA Ng, Jin RA Cai, Ling RA Girard, Luc RA Prall, Owen W.J. RA Rajan, Neeha Sulakshi RA Khoo, Christine RA Batrouney, Ahida RA Byrne, David J. RA Boyd, Danielle K. RA Kersbergen, Ariena J. RA Christie, Michael RA Minna, John D. RA Burr, Marian L. RA Sutherland, Kate D. RT "Molecular and pathologic characterization of YAP1-expressing small RT cell lung cancer cell lines leads to reclassification as RT SMARCA4-deficient malignancies."; RL Clin. Cancer Res. 30:1846-1858(2024). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //