ID NCTC clone 929 AC CVCL_0462 SY NCTC 929; NCTC-929; NCTC929; NCTC-929L; L cell; L cells; L-cell; L-cells; L cell line; L; Strain L-929; L-929; L 929; L929; L929(NCTC); Clone 929; Earles's cells; Earle's L cells DR BTO; BTO_0000331 DR CLO; CLO_0007144 DR CLO; CLO_0007219 DR CLO; CLO_0007220 DR CLO; CLO_0007221 DR CLO; CLO_0008140 DR CLO; CLO_0050233 DR CLO; CLO_0050234 DR CLO; CLO_0050235 DR MCCL; MCC:0000359 DR CLDB; cl3154 DR CLDB; cl3156 DR CLDB; cl3157 DR CLDB; cl3158 DR CLDB; cl3159 DR CLDB; cl3160 DR CLDB; cl3673 DR CLDB; cl3674 DR CLDB; cl3675 DR CLDB; cl3676 DR AddexBio; P0011012/5025 DR ATCC; CCL-1 DR ATCC; CRL-6364 DR BCRC; 60091 DR BCRJ; 0188 DR BioGRID_ORCS_Cell_line; 1749 DR BioSample; SAMN11397622 DR CCLV; CCLV-RIE 0014 DR CCLV; CCLV-RIE 0287 DR CCRID; 1101MOU-PUMC000403 DR CCRID; 1102MOU-NIFDC00019 DR CCRID; 3101MOUGNM28 DR CCRID; 3101MOUSCSP5039 DR CCRID; 4201MOU-CCTCC00034 DR CCRID; 5301MOU-KCB92012YJ DR CCTCC; GDC0034 DR ChEMBL-Cells; CHEMBL3307946 DR ChEMBL-Targets; CHEMBL612266 DR ChEMBL-Targets; CHEMBL612267 DR CLS; 400260 DR DSMZ; ACC-2 DR DSMZCellDive; ACC-2 DR ECACC; 85011425 DR ECACC; 85103115 DR ECACC; 88102702 DR FCS-free; 8-5-530-1-3-3 DR FCS-free; 8-5-9-1-3-3 DR IBRC; C10102 DR ICLC; ATL95001 DR IZSLER; BS CL 56 DR JCRB; IFO50409 DR JCRB; JCRB9003 DR KCB; KCB 92012YJ DR KCLB; 10001 DR Lonza; 32 DR Lonza; 937 DR MeSH; D007739 DR NCBI_Iran; C161 DR PubChem_Cell_line; CVCL_0462 DR RCB; RCB0081 DR RCB; RCB1422 DR RCB; RCB1451 DR RCB; RCB2619 DR TKG; TKG 0217 DR TOKU-E; 3695 DR Ubigene; YC-C091 DR Wikidata; Q28335098 RX DOI=10.1007/BF02618370; RX DOI=10.4051/ibc.2010.2.4.0014; RX DOI=10.5897/IJBMBR2013.0154; RX PubMed=4328993; RX PubMed=4471172; RX PubMed=4560675; RX PubMed=6298990; RX PubMed=13293658; RX PubMed=13431913; RX PubMed=13587550; RX PubMed=14185313; RX PubMed=18105872; RX PubMed=23430347; RX PubMed=31220119; RX PubMed=32218446; RX PubMed=33389257; RX PubMed=34737324; WW Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=L929 WW Info; ResearchGate; -; https://www.researchgate.net/post/Is_L929_normal_or_cancer_cell_line WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-125.html WW Provider; Vircell; -; https://www.vircell.com/en/products/l-929-cell-line CC Group: Space-flown cell line (cellonaut). CC Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). CC Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257). CC Doubling time: 28 hours (Note=From cell counting), 32 hours (Note=From absorbance) (DOI=10.5897/IJBMBR2013.0154); ~25 hours (CLS=400260); ~21-24 hours (DSMZ=ACC-2). CC Omics: Proteomics; Quantitative. CC Anecdotal: First established continuous cell line. CC Miscellaneous: PubMed=23430347 has a different value for STR 6-4 (16) than that of NIST (17,18) due to a change in the marker motif (personal communication of Almeida, Jamie L.). CC Discontinued: ATCC; CRL-6364; true. CC Discontinued: RCB; RCB0081; true. CC Derived from site: In situ; Connective tissue; UBERON=UBERON_0002384. CC Cell type: Fibroblast; CL=CL_0000057. CC Breed/subspecies: C3H/An. ST Source(s): DSMZ=ACC-2; PubMed=23430347; PubMed=31220119; Ubigene=YC-C091 ST Mouse STR 1-1: 10 ST Mouse STR 1-2: 17 ST Mouse STR 2-1: 9 ST Mouse STR 3-2: 13,14 ST Mouse STR 4-2: 20.3 ST Mouse STR 5-5: 14 ST Mouse STR 6-4: 16,17 (DSMZ=ACC-2) ST Mouse STR 6-4: 17,18 (PubMed=23430347; PubMed=31220119; Ubigene=YC-C091) ST Mouse STR 6-7: 12 ST Mouse STR 7-1: 25,26,27 ST Mouse STR 8-1: 16 ST Mouse STR 9-2: 15 ST Mouse STR 11-2: 15,16 ST Mouse STR 12-1: 16 ST Mouse STR 13-1: 17 ST Mouse STR 15-3: 24.3,25.3,26.3 ST Mouse STR 17-2: 15 ST Mouse STR 18-3: 16 ST Mouse STR 19-2: 12 ST Mouse STR X-1: 26,27 OX NCBI_TaxID=10090; ! Mus musculus (Mouse) SX Male AG 100D CA Spontaneously immortalized cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 43 CH CVCL_DD99 ! 1R [Mouse L cells] CH CVCL_3984 ! A-9 CH CVCL_4114 ! B82 CH CVCL_8887 ! L Cells (TK+, HBS Ag+) CH CVCL_IW04 ! L-929 D CH CVCL_IW05 ! L-929 E CH CVCL_IW06 ! L-929 F CH CVCL_IW07 ! L-929 HH CH CVCL_4535 ! L-M CH CVCL_U990 ! L.P3 CH CVCL_0D72 ! L4.5 CH CVCL_AR58 ! L929/A CH CVCL_E2Z7 ! L929/CD275 CH CVCL_C5ES ! L929/CD83 CH CVCL_4237 ! L929/R CH CVCL_4238 ! L929S CH CVCL_4Z39 ! LA-9 CH CVCL_B950 ! LAG CH CVCL_WY44 ! LMCAT CH CVCL_E7GZ ! LS1 CH CVCL_E7H0 ! LS2 [Mouse fibroblast] CH CVCL_E7H1 ! LS3 CH CVCL_E7H2 ! LS4 CH CVCL_E7H3 ! LS5 CH CVCL_E7H4 ! LS6 CH CVCL_E7H5 ! LS7 CH CVCL_3742 ! McCoy CH CVCL_4255 ! NCTC 2071 CH CVCL_A0ZP ! NCTC 2168 CH CVCL_C8QV ! Wnt-LIGHT // RX PubMed=14185313; DOI=10.1126/science.146.3641.241; RG Cell Culture Collection Committee; RT "Animal cell strains. The Cell Culture Collection Committee has RT assembled and certified 23 strains of animal cells."; RL Science 146:241-243(1964). // RX PubMed=32218446; DOI=10.1038/s41597-020-0449-z; PMCID=PMC7099061; RA Zhong, Chuan-Qi RA Wu, Jian-Feng RA Qiu, Xing-Feng RA Chen, Xi RA Xie, Chang-Chuan RA Han, Jia-Huai RT "Generation of a murine SWATH-MS spectral library to quantify more RT than 11,000 proteins."; RL Sci. Data 7:104.1-104.9(2020). // RX PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163; RA Lung, Oliver RA Candlish, Rebecca C. RA Nebroski, Michelle RA Kruckiewicz, Peter RA Buchanan, Cody RA Moniwa, Mariko RT "High-throughput sequencing for species authentication and RT contamination detection of 63 cell lines."; RL Sci. Rep. 11:21657.1-21657.9(2021). // RX PubMed=4560675; RA Tsuboi, Kazuko RA Takaoka, Toshiko RA Katsuta, Hajim RT "Comparative analyses of strain L-929 and its substrain L-P3 grown in RT a protein- and lipid-free synthetic medium."; RL Jpn. J. Exp. Med. 42:361-376(1972). // RX PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308; RA Almeida, Jamie L. RA Dakic, Aleksandra RA Kindig, Karin RA Kone, Maikan RA Letham, Deborah Lee Dormady RA Langdon, Scott RA Peat, Ruth RA Holding-Pillai, Jayamalini RA Hall, Erin M. RA Ladd, Mark RA Shaffer, Megan D. RA Berg, Heath RA Li, Jin-Liang RA Wigger, Georges RA Lund, Steve RA Steffen, Carolyn R. RA Fransway, Barbara B. RA Geraghty, Bob RA Natoli, Manuela RA Bauer, Beth A. RA Gollin, Susanne M. RA Lewis, Dale W. RA Reid, Yvonne A. RT "Interlaboratory study to validate a STR profiling method for RT intraspecies identification of mouse cell lines."; RL PLoS ONE 14:e0218412.1-e0218412.24(2019). // RX PubMed=23430347; DOI=10.1007/s10616-013-9545-7; PMCID=PMC3886540; RA Almeida, Jamie L. RA Hill, Carolyn R. RA Cole, Kenneth D. RT "Mouse cell line authentication."; RL Cytotechnology 66:133-147(2014). // RX DOI=10.4051/ibc.2010.2.4.0014; RA Yoshino, Kaori RA Saijo, Kaoru RA Noro, Chikako RA Nakamura, Yukio RT "Development of a simple method to determine the mouse strain from which RT cultured cell lines originated."; RL Interdisciplinary Bio Cent. 2:14.1-14.9(2010). // RX PubMed=4471172; DOI=10.1007/BF02615345; RA Ham, Richard G. RT "Nutritional requirements of primary cultures. A neglected problem of RT modern biology."; RL In Vitro 10:119-129(1974). // RX DOI=10.5897/IJBMBR2013.0154; RA Iloki Assanga, Simon Bernard RA Gil-Salido, Armida Andrea RA Lewis Lujan, Lydianis Maria RA de Jesus Rosas-Durazo, Aaron RA Acosta-Silva, Ana Lilian RA Rivera-Castaneda, Elba Griselda RA Rubio-Pino, Jose Luis RT "Cell growth curves for different cell lines and their relationship RT with biological activities."; RL Int. J. Biotechnol. Mol. Biol. Res. 4:60-70(2013). // RX DOI=10.1007/BF02618370; RA Stulberg, Cyril S. RA Coriell, Lewis Lemon RA Kniazeff, Alexis John RA Shannon, John E. RT "The animal cell culture collection."; RL In Vitro 5:1-16(1970). // RX PubMed=6298990; DOI=10.1016/0378-1135(82)90056-6; RA McPhee, Dale A. RA Parsonson, Ian Malcolm RA Della-Porta, Anthony James RT "Comparative studies on the growth of Australian bluetongue virus RT serotypes in continuous cell lines and embryonated chicken eggs."; RL Vet. Microbiol. 7:401-410(1982). // RX PubMed=13293658; RA Sanford, Katherine Koontz RA Hobbs, Gwendolyn Likely RA Earle, Wilton Robinson RT "The tumor-producing capacity of strain L mouse cells after 10 years RT in vitro."; RL Cancer Res. 16:162-166(1956). // RX PubMed=13431913; DOI=10.3181/00379727-94-23044; RA Foley, George E. RA Handler, Alfred H. RT "Differentiation of normal and neoplastic cells maintained in tissue RT culture by implantation into normal hamsters."; RL Proc. Soc. Exp. Biol. Med. 94:661-664(1957). // RX PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494; RA Wurtz, Nathalie RA Penant, Gwilherm RA Jardot, Priscilla RA Duclos, Nathalie RA La Scola, Bernard RT "Culture of SARS-CoV-2 in a panel of laboratory cell lines, RT permissivity, and differences in growth profile."; RL Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021). // RX PubMed=4328993; DOI=10.1016/0014-4827(71)90412-5; RA Takaoka, Toshiko RA Katsuta, Hajim RT "Long-term cultivation of mammalian cell strains in protein- and RT lipid-free chemically defined synthetic media."; RL Exp. Cell Res. 67:295-304(1971). // RX PubMed=13587550; DOI=10.1083/jcb.4.5.567; PMCID=PMC2224560; RA Westfall, Benton Bosworth RA Peppers, Ellison V. RA Evans, Virginia John RA Sanford, Katherine Koontz RA Hawkins, Naomi M. RA Fioramonti, Mary C. RA Kerr, Harold A. RA Hobbs, Gwendolyn Likely RA Earle, Wilton Robinson RT "The arginase and rhodanese activities of certain cell strains after RT long cultivation in vitro."; RL J. Biophys. Biochem. Cytol. 4:567-570(1958). // RX PubMed=18105872; DOI=10.1093/jnci/9.3.229; RA Sanford, Katherine Koontz RA Earle, Wilton Robinson RA Hobbs, Gwendolyn Likely RT "The growth in vitro of single isolated tissue cells."; RL J. Natl. Cancer Inst. 9:229-246(1948). //