ID   NCI-H295A
AC   CVCL_0457
SY   H295A; H-295A
DR   BTO; BTO:0005669
DR   MCCL; MCC:0000354
DR   cancercelllines; CVCL_0457
DR   Wikidata; Q54908017
RX   PubMed=9024219;
RX   PubMed=15541570;
RX   PubMed=18000308;
RX   PubMed=21924324;
RX   PubMed=22266826;
CC   Characteristics: Grows as monolayer.
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
DI   NCIt; C9325; Adrenal cortex carcinoma
DI   ORDO; Orphanet_1501; Adrenocortical carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0456 ! NCI-H295
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 17
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RX   PubMed=9024219; DOI=10.1210/jcem.82.2.3721;
RA   Rodriguez H., Hum D.W., Staels B., Miller W.L.;
RT   "Transcription of the human genes for cytochrome P450scc and P450c17
RT   is regulated differently in human adrenal NCI-H295 cells than in mouse
RT   adrenal Y1 cells.";
RL   J. Clin. Endocrinol. Metab. 82:365-371(1997).
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RX   PubMed=15541570; DOI=10.1016/j.mce.2003.12.020;
RA   Rainey W.E., Saner K., Schimmer B.P.;
RT   "Adrenocortical cell lines.";
RL   Mol. Cell. Endocrinol. 228:23-38(2004).
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RX   PubMed=18000308; DOI=10.1677/JOE-07-0166;
RA   Samandari E., Kempna P., Nuoffer J.-M., Hofer G., Mullis P.-E.,
RA   Fluck C.E.;
RT   "Human adrenal corticocarcinoma NCI-H295R cells produce more androgens
RT   than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase
RT   type 2 and 17,20 lyase activities.";
RL   J. Endocrinol. 195:459-472(2007).
//
RX   PubMed=21924324; DOI=10.1016/j.mce.2011.08.041;
RA   Wang T., Rainey W.E.;
RT   "Human adrenocortical carcinoma cell lines.";
RL   Mol. Cell. Endocrinol. 351:58-65(2012).
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RX   PubMed=22266826; DOI=10.1055/s-0031-1298019;
RA   Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.;
RT   "Comparison of aldosterone production among human adrenocortical cell
RT   lines.";
RL   Horm. Metab. Res. 44:245-250(2012).
//