ID MRC-5 AC CVCL_0440 SY MRC5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5 DR BTO; BTO_0001590 DR CLO; CLO_0007865 DR CLO; CLO_0050055 DR EFO; EFO_0002835 DR MCCL; MCC:0000336 DR CLDB; cl3563 DR CLDB; cl3564 DR CLDB; cl3566 DR CLDB; cl3567 DR CLDB; cl3568 DR CLDB; cl5168 DR AddexBio; T0016002/4922 DR ATCC; CCL-171 DR BCRC; 60023 DR BCRJ; 0180 DR BioSample; SAMN01821580 DR BioSample; SAMN01821702 DR BioSample; SAMN01821735 DR BioSample; SAMN03473183 DR CCRID; 1101HUM-PUMC000044 DR CCRID; 1102HUM-NIFDC00002 DR CCRID; 3101HUMGNHu41 DR CCRID; 3101HUMSCSP5040 DR CCRID; 4201HUM-CCTCC00032 DR CCRID; 5301HUM-KCB89023YJ DR CCTCC; GDC0032 DR ChEMBL-Cells; CHEMBL3308499 DR ChEMBL-Targets; CHEMBL614181 DR CLS; 300395 DR ECACC; 97112601 DR FCS-free; 179-2-338-1-16-3 DR GEO; GSM248209 DR GEO; GSM248210 DR GEO; GSM520665 DR GEO; GSM520666 DR GEO; GSM520667 DR GEO; GSM579888 DR GEO; GSM579889 DR GEO; GSM607969 DR GEO; GSM3738752 DR GEO; GSM3738753 DR IBRC; C10313 DR ICLC; HL95001 DR IZSLER; BS CL 68 DR JCRB; IFO50073 DR JCRB; JCRB9008 DR KCB; KCB 200412YJ DR KCB; KCB 89023YJ DR KCLB; 10171 DR Lonza; 52 DR NCBI_Iran; C125 DR PRIDE; PXD001909 DR PRIDE; PXD013120 DR PRIDE; PXD023286 DR PubChem_Cell_line; CVCL_0440 DR RCB; RCB0211 DR RCB; RCB0218 DR Wikidata; Q3273166 RX CelloPub=CLPUB00391; RX CelloPub=CLPUB00783; RX PubMed=113411; RX PubMed=211143; RX PubMed=932048; RX PubMed=1031681; RX PubMed=1193162; RX PubMed=1756776; RX PubMed=1965304; RX PubMed=3335022; RX PubMed=4316953; RX PubMed=6538202; RX PubMed=6971834; RX PubMed=7065527; RX PubMed=10752125; RX PubMed=11416159; RX PubMed=17395773; RX PubMed=19657000; RX PubMed=21637780; RX PubMed=25877200; RX PubMed=25903999; RX PubMed=26477663; RX PubMed=31869419; RX PubMed=33389257; WW Info; -; -; https://micro.magnet.fsu.edu/primer/techniques/fluorescence/gallery/cells/mrc5/mrc5cells.html WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/number-of-population-doublings-pdl-for-atcc-ccl-171 WW Info; Evident; -; https://evidentscientific.com/en/microscope-resource/image-gallery/confocal/fibroblastindex WW Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=68 WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/m/cell-lines-detail-380.html WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/MRC-5 WW Provider; Vircell; -; https://www.vircell.com/en/products/mrc-5-cell-line WW Provider; WHO; -; https://www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/norms-and-standards/who-reference-cell-banks CC Group: Vaccine production cell line. CC Biotechnology: Used for the production of the Human Diploid Cell Vaccine (HDCV) against rabies (Trade name: Imovax Rabies). CC Biotechnology: Used for the production of the Hepatitis A vaccines Avaxim, Epaxal, Havrix and Vaqta. CC Biotechnology: Used for the production of the live varicella virus vaccine (Trade name: Varivax). CC Biotechnology: Used for the production of the live zoster vaccine (Trade name: Zostavax). CC Senescence: Capable of attaining 42-46 population doublings before the onset of senescence (ATCC=CCL-171). Senesces at 26 PDL (PubMed=17395773). CC Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257). CC Doubling time: 45 hours (Note=Lot 08072009), ~40 hours (Note=Lot 02272015) (JCRB=IFO50073); 36 hours (Note=Lot 041392), ~5 days (Note=Lot 031098), ~2 days (Note=Lot 05192003), ~1.5 days (Note=Lot 05202005), ~34 hours (Note=Lot 06022011), ~38 hours (Note=Lot 04212016) (JCRB=JCRB9008). CC HLA typing: A*02:01,29:02; B*07:02,44:02; C*05:01,07:02 (PubMed=31869419). CC HLA typing: A*02:01:01,29:02:01; B*07:02:01,44:02:01; C*05:01:01,07:02:01; DPB1*04:01:01; DQA1*01:02:01,03:03:01; DQB1*03:01:01,06:02:01; DRB1*04:08:01,15:01:01G (CLS=300395). CC Omics: Genomics; DNA methylation analysis. CC Omics: Glycomics; Glycosphingolipids. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; 2DE. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Misspelling: MCR-5; Note=Occasionally. CC Discontinued: ECACC; 97112601; true. CC Derived from site: In situ; Fetal lung; UBERON=UBERON_0005597. CC Cell type: Fibroblast of lung; CL=CL_0002553. ST Source(s): AddexBio=T0016002/4922; ATCC=CCL-171; CCRID; CLS=300395; JCRB=IFO50073; JCRB=JCRB9008; KCLB=10171; PubMed=11416159; PubMed=21637780; PubMed=25877200; RCB=RCB0211 ST Amelogenin: X,Y ST CSF1PO: 11,12 ST D12S391: 20,22 ST D13S317: 11,14 ST D16S539: 9,11 ST D18S51: 15,21 ST D19S433: 14,15 ST D21S11: 31.2 ST D2S1338: 20 ST D3S1358: 15,17 ST D5S818: 11,12 ST D6S1043: 11,19 ST D7S820: 10,11 ST D8S1179: 13 ST FGA: 21,23 ST Penta D: 12 ST Penta E: 12,16 ST TH01: 8 ST TPOX: 8 ST vWA: 15 OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 14FW CA Finite cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 44 CH CVCL_2264 ! 1221 CH CVCL_2837 ! A9(Neo1) CH CVCL_2838 ! A9(Neo11) CH CVCL_2844 ! A9(Neo19) CH CVCL_2846 ! A9(Neo20) CH CVCL_2848 ! A9(Neo4) CH CVCL_WT86 ! AG27415 CH CVCL_F664 ! Flow13000 CH CVCL_JG29 ! HuS-L12/10 CH CVCL_4W54 ! HuSI-L23 CH CVCL_D0JB ! iPS-14 CH CVCL_D0JC ! iPS-27 CH CVCL_D0JD ! iPS-49 CH CVCL_D0JE ! iPS-50 CH CVCL_D0JF ! iPS-51 CH CVCL_D0JG ! iPS-59 CH CVCL_D0JH ! iPS-60 CH CVCL_D0JI ! iPS-62 CH CVCL_D0JJ ! iPS-71 CH CVCL_D0JK ! iPS-72 CH CVCL_D0JL ! iPS-76 CH CVCL_RG58 ! iPSC D1 CH CVCL_RG59 ! iPSC D4 CH CVCL_RB14 ! IRR-MRC-5 CH CVCL_4W64 ! L12.28-1/1 CH CVCL_U651 ! L12.9-2(1) CH CVCL_U661 ! L23immo CH CVCL_E260 ! MRC-5 CV1 CH CVCL_2621 ! MRC-5 pd13 CH CVCL_2622 ! MRC-5 pd19 CH CVCL_2623 ! MRC-5 pd25 CH CVCL_2624 ! MRC-5 pd30 CH CVCL_JF54 ! MRC-5 PDL12 CH CVCL_H749 ! MRC-5 PDL27 CH CVCL_H748 ! MRC-5 PDL40 CH CVCL_8B13 ! MRC-5 PDL5.51 CH CVCL_2625 ! MRC-5 SV1 TG1 CH CVCL_2626 ! MRC-5 SV1 TG2 CH CVCL_3027 ! MRC-5-30 CH CVCL_3028 ! MRC-5-40 CH CVCL_3029 ! MRC-5-50 CH CVCL_D690 ! MRC-5V1 CH CVCL_2627 ! MRC-5V2 CH CVCL_D923 ! MRC-iPS-1 CH CVCL_D924 ! MRC-iPS-10 CH CVCL_D925 ! MRC-iPS-100 CH CVCL_D926 ! MRC-iPS-101 CH CVCL_8343 ! MRC-iPS-11 CH CVCL_D927 ! MRC-iPS-12 CH CVCL_D928 ! MRC-iPS-13 CH CVCL_D929 ! MRC-iPS-14 CH CVCL_D930 ! MRC-iPS-15 CH CVCL_D931 ! MRC-iPS-16 CH CVCL_D932 ! MRC-iPS-17 CH CVCL_8367 ! MRC-iPS-18 CH CVCL_D933 ! MRC-iPS-19 CH CVCL_D934 ! MRC-iPS-2 CH CVCL_D935 ! MRC-iPS-20 CH CVCL_D936 ! MRC-iPS-21 CH CVCL_8426 ! MRC-iPS-22 CH CVCL_D937 ! MRC-iPS-23 CH CVCL_D938 ! MRC-iPS-24 CH CVCL_8433 ! MRC-iPS-25 CH CVCL_D939 ! MRC-iPS-26 CH CVCL_8434 ! MRC-iPS-27 CH CVCL_D940 ! MRC-iPS-28 CH CVCL_D941 ! MRC-iPS-29 CH CVCL_D942 ! MRC-iPS-3 CH CVCL_D943 ! MRC-iPS-30 CH CVCL_D944 ! MRC-iPS-31 CH CVCL_D945 ! MRC-iPS-32 CH CVCL_D946 ! MRC-iPS-33 CH CVCL_D947 ! MRC-iPS-34 CH CVCL_D948 ! MRC-iPS-35 CH CVCL_D949 ! MRC-iPS-36 CH CVCL_D950 ! MRC-iPS-37 CH CVCL_D951 ! MRC-iPS-38 CH CVCL_D952 ! MRC-iPS-39 CH CVCL_D953 ! MRC-iPS-4 CH CVCL_D954 ! MRC-iPS-40 CH CVCL_D955 ! MRC-iPS-41 CH CVCL_D956 ! MRC-iPS-42 CH CVCL_D957 ! MRC-iPS-43 CH CVCL_D958 ! MRC-iPS-44 CH CVCL_D959 ! MRC-iPS-45 CH CVCL_D960 ! MRC-iPS-46 CH CVCL_D961 ! MRC-iPS-47 CH CVCL_D962 ! MRC-iPS-48 CH CVCL_D963 ! MRC-iPS-49 CH CVCL_D964 ! MRC-iPS-5 CH CVCL_D965 ! MRC-iPS-50 CH CVCL_D966 ! MRC-iPS-51 CH CVCL_D967 ! MRC-iPS-52 CH CVCL_D968 ! MRC-iPS-53 CH CVCL_D969 ! MRC-iPS-54 CH CVCL_D970 ! MRC-iPS-55 CH CVCL_D971 ! MRC-iPS-56 CH CVCL_D972 ! MRC-iPS-57 CH CVCL_D973 ! MRC-iPS-58 CH CVCL_D974 ! MRC-iPS-59 CH CVCL_D975 ! MRC-iPS-6 CH CVCL_D976 ! MRC-iPS-60 CH CVCL_D977 ! MRC-iPS-61 CH CVCL_D978 ! MRC-iPS-62 CH CVCL_D979 ! MRC-iPS-63 CH CVCL_D980 ! MRC-iPS-64 CH CVCL_D981 ! MRC-iPS-65 CH CVCL_D982 ! MRC-iPS-66 CH CVCL_D983 ! MRC-iPS-67 CH CVCL_D984 ! MRC-iPS-68 CH CVCL_D985 ! MRC-iPS-69 CH CVCL_D986 ! MRC-iPS-7 CH CVCL_D987 ! MRC-iPS-70 CH CVCL_D988 ! MRC-iPS-71 CH CVCL_D989 ! MRC-iPS-72 CH CVCL_D990 ! MRC-iPS-73 CH CVCL_D991 ! MRC-iPS-74 CH CVCL_D992 ! MRC-iPS-75 CH CVCL_D993 ! MRC-iPS-76 CH CVCL_D994 ! MRC-iPS-77 CH CVCL_D995 ! MRC-iPS-78 CH CVCL_D996 ! MRC-iPS-79 CH CVCL_D997 ! MRC-iPS-8 CH CVCL_D998 ! MRC-iPS-80 CH CVCL_D999 ! MRC-iPS-81 CH CVCL_E000 ! MRC-iPS-82 CH CVCL_E001 ! MRC-iPS-83 CH CVCL_E002 ! MRC-iPS-84 CH CVCL_E003 ! MRC-iPS-85 CH CVCL_E004 ! MRC-iPS-86 CH CVCL_E005 ! MRC-iPS-87 CH CVCL_E006 ! MRC-iPS-88 CH CVCL_E007 ! MRC-iPS-89 CH CVCL_E008 ! MRC-iPS-9 CH CVCL_E009 ! MRC-iPS-90 CH CVCL_E010 ! MRC-iPS-91 CH CVCL_E011 ! MRC-iPS-92 CH CVCL_E012 ! MRC-iPS-93 CH CVCL_E013 ! MRC-iPS-94 CH CVCL_E014 ! MRC-iPS-95 CH CVCL_E015 ! MRC-iPS-96 CH CVCL_E016 ! MRC-iPS-97 CH CVCL_E017 ! MRC-iPS-98 CH CVCL_E018 ! MRC-iPS-99 CH CVCL_C975 ! MRC5-iPS12 CH CVCL_C974 ! MRC5-iPS17 CH CVCL_V234 ! MRC5-iPS2 CH CVCL_C1XY ! MRC5-iPS7 CH CVCL_C976 ! MRC5-RiPS-1.11 CH CVCL_C977 ! MRC5-RiPS-1.2 CH CVCL_C978 ! MRC5-RiPS-1.3 CH CVCL_C979 ! MRC5-RiPS-1.8 CH CVCL_C980 ! MRC5-RiPS-1.9 CH CVCL_B0XS ! MRC5/ACE2 CH CVCL_Y625 ! SR2 // RX PubMed=1031681; RA Jacobs, J.P. RT "Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell RT strains."; RL Dev. Biol. Stand. 37:155-156(1976). // RX PubMed=6971834; DOI=10.1080/09553008114550251; RA Cooke, Alexander RA Harris, William J. RT "Pyrimidine dimer excision in ageing human cells in tissue culture."; RL Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 39:223-226(1981). // RX CelloPub=CLPUB00391; RA Wadman, Meredith RT "The vaccine race: science; politics; and the human costs of defeating RT disease."; RL (In book) ISBN 9780525427537; pp.1-436; Viking; New York; USA (2016). // RX PubMed=21637780; DOI=10.1371/journal.pgen.1002085; PMCID=PMC3102737; RA Nishino, Koichiro RA Toyoda, Masashi RA Yamazaki-Inoue, Mayu RA Fukawatase, Yoshihiro RA Chikazawa, Emi RA Sakaguchi, Hironari RA Akutsu, Hidenori RA Umezawa, Akihiro RT "DNA methylation dynamics in human induced pluripotent stem cells over RT time."; RL PLoS Genet. 7:e1002085.1-e1002085.14(2011). // RX PubMed=113411; DOI=10.1016/S0092-1157(79)80043-8; RA Jacobs, J.P. RA Garrett, A. John RA Merton, Rosemary RT "Characteristics of a serially propagated human diploid cell RT designated MRC-9."; RL J. Biol. Stand. 7:113-122(1979). // RX PubMed=4316953; DOI=10.1038/227168a0; RA Jacobs, J.P. RA Jones, C.M. RA Baille, J.P. RT "Characteristics of a human diploid cell designated MRC-5."; RL Nature 227:168-170(1970). // RX PubMed=6538202; DOI=10.1083/jcb.98.3.1133; PMCID=PMC2113122; RA Azzarone, Bruno RA Suarez, Horacio Guillermo RA Mingari, Maria Cristina RA Moretta, Lorenzo RA Fauci, Anthony Stephen RT "4F2 monoclonal antibody recognizes a surface antigen on spread human RT fibroblasts of embryonic but not of adult origin."; RL J. Cell Biol. 98:1133-1137(1984). // RX PubMed=17395773; DOI=10.1634/stemcells.2006-0504; RA Sudo, Kazuhiro RA Kanno, Megumi RA Miharada, Kenichi RA Ogawa, Saeri RA Hiroyama, Takashi RA Saijo, Kaoru RA Nakamura, Yukio RT "Mesenchymal progenitors able to differentiate into osteogenic, RT chondrogenic, and/or adipogenic cells in vitro are present in most RT primary fibroblast-like cell populations."; RL Stem Cells 25:1610-1617(2007). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=3335022; RA Alley, Michael C. RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=7065527; DOI=10.1164/arrd.1982.125.2.222; RA Hay, Robert J. RA Williams, Carolyn D. RA Macy, Marvin L. RA Lavappa, Kantharajapura Subbegowda RT "Cultured cell lines for research on pulmonary physiology available RT through the American Type Culture Collection."; RL Am. Rev. Respir. Dis. 125:222-232(1982). // RX CelloPub=CLPUB00783; RA Stacey, Glyn N. RA Hawkins, J. Ross RA Carter, Penny RA Hunt, Charles John RA Young, Lesley A. RT "Replacement seed stock for MRC-5 cells."; RL (In technical document) World Health Organization publication WHO/BS/07.2077; pp.1-9; WHO; Geneva; Switzerland (2007). // RX PubMed=25903999; DOI=10.1002/biot.201400388; RA Genzel, Yvonne RT "Designing cell lines for viral vaccine production: where do we RT stand?"; RL Biotechnol. J. 10:728-740(2015). // RX PubMed=1756776; DOI=10.1016/0531-5565(91)90033-i; RA Tasaki, Yoko RA Ohara, Takane RA Yamamoto, Mari RA Yamamoto, Kiyotaka RT "Isozyme polymorphisms in human diploid cell strains for research on RT cellular aging."; RL Exp. Gerontol. 26:441-451(1991). // RX PubMed=932048; DOI=10.1016/0092-1157(76)90018-4; RA Jacobs, J.P. RT "The status of human diploid cell strain MRC-5 as an approved RT substrate for the production of viral vaccines."; RL J. Biol. Stand. 4:97-99(1976). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine H. RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=31869419; DOI=10.1084/jem.20191164; PMCID=PMC7062530; RA Lubke, Maren RA Spalt, Stefanie RA Kowalewski, Daniel Johannes RA Zimmermann, Cosima RA Bauersfeld, Liane RA Nelde, Annika RA Bichmann, Leon RA Marcu, Ana RA Peper, Janet Kerstin RA Kohlbacher, Oliver RA Walz, Juliane Sarah RA Le-Trilling, Vu Thuy Khanh RA Hengel, Hartmut RA Rammensee, Hans-Georg RA Stevanovic, Stefan RA Halenius, Anne RT "Identification of HCMV-derived T cell epitopes in seropositive RT individuals through viral deletion models."; RL J. Exp. Med. 217:e20191164.1-e20191164.14(2020). // RX PubMed=1965304; DOI=10.1002/elps.1150111203; RA Celis, Julio Enrique RA Dejgaard, Kurt RA Madsen, Peder RA Leffers, Henrik RA Gesser, Borbala RA Honore, Bent RA Rasmussen, Hanne Holm RA Olsen, Eydfinnur RA Lauridsen, Jette B. RA Ratz, Gitte RA Mouritzen, Solveig RA Basse, Bodil RA Hellerup, Marianne RA Celis, Ariana RA Puype, Magda RA Van Damme, Jozef RA Vandekerckhove, Joel RT "The MRC-5 human embryonal lung fibroblast two-dimensional gel RT cellular protein database: quantitative identification of polypeptides RT whose relative abundance differs between quiescent, proliferating and RT SV40 transformed cells."; RL Electrophoresis 11:1072-1113(1990). // RX PubMed=26477663; DOI=10.1038/srep14988; PMCID=PMC4609952; RA Ojima, Takuma RA Shibata, Eri RA Saito, Shiho RA Toyoda, Masashi RA Nakajima, Hideki RA Yamazaki-Inoue, Mayu RA Miyagawa, Yoshitaka RA Kiyokawa, Nobutaka RA Fujimoto, Jun-ichiro RA Sato, Toshinori RA Umezawa, Akihiro RT "Glycolipid dynamics in generation and differentiation of induced RT pluripotent stem cells."; RL Sci. Rep. 5:14988.1-14988.13(2015). // RX PubMed=19657000; RA Rubporn, Atchara RA Srisomsap, Chantragan RA Subhasitanont, Pantipa RA Chokchaichamnankit, Daranee RA Chiablaem, Khajeelak RA Svasti, Jisnuson RA Sangvanich, Polkit RT "Comparative proteomic analysis of lung cancer cell line and lung RT fibroblast cell line."; RL Cancer Genomics Proteomics 6:229-237(2009). // RX PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494; RA Wurtz, Nathalie RA Penant, Gwilherm RA Jardot, Priscilla RA Duclos, Nathalie RA La Scola, Bernard RT "Culture of SARS-CoV-2 in a panel of laboratory cell lines, RT permissivity, and differences in growth profile."; RL Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021). // RX PubMed=10752125; RA Poljanskaia, Galina Georgievna RA Efremova, Tatiana N. RA Sakuta, Galina Anatolyevna RT "The effect of mycoplasmal contamination of human embryonic lung cell RT line MRC-5 on the karyotypic variability."; RL Tsitologiia 42:190-195(2000). // RX PubMed=211143; DOI=10.1128/jcm.7.4.368-371.1978; PMCID=PMC274969; RA Friedman, Harvey M. RA Koropchak, Celine RT "Comparison of WI-38, MRC-5, and IMR-90 cell strains for isolation of RT viruses from clinical specimens."; RL J. Clin. Microbiol. 7:368-371(1978). // RX PubMed=1193162; DOI=10.1016/s0014-4827(75)80029-2; RA Thompson, K.V.A. RA Holliday, Robin RT "Chromosome changes during the in vitro ageing of MRC-5 human RT fibroblasts."; RL Exp. Cell Res. 96:1-6(1975). //