ID   MEG-01
AC   CVCL_0425
SY   Meg-01; MEG01; Meg01
DR   BTO; BTO_0002581
DR   CLO; CLO_0007668
DR   EFO; EFO_0002232
DR   MCCL; MCC:0000322
DR   CLDB; cl3432
DR   CLDB; cl3433
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-2021
DR   BCRC; 60238
DR   BCRJ; 0262
DR   BioSample; SAMN01821577
DR   BioSample; SAMN01821648
DR   BioSample; SAMN01821734
DR   BioSample; SAMN03471278
DR   BioSample; SAMN10988184
DR   cancercelllines; CVCL_0425
DR   CCRID; 1101HUM-PUMC000521
DR   CCRID; 3101HUMTCHu197
DR   Cell_Model_Passport; SIDM00526
DR   ChEMBL-Cells; CHEMBL3308539
DR   ChEMBL-Targets; CHEMBL2366084
DR   CLS; 300482
DR   Cosmic; 787503
DR   Cosmic; 908126
DR   Cosmic; 924042
DR   Cosmic; 1026578
DR   Cosmic; 1070702
DR   Cosmic; 1078723
DR   Cosmic; 1516634
DR   Cosmic; 1523830
DR   Cosmic-CLP; 908126
DR   DepMap; ACH-000072
DR   DSMZ; ACC-364
DR   DSMZCellDive; ACC-364
DR   ECACC; 94012401
DR   EGA; EGAS00001000978
DR   FANTOM5_SSTAR; 10752-110D5
DR   GDSC; 908126
DR   GEO; GSM482498
DR   GEO; GSM887307
DR   GEO; GSM888383
DR   GEO; GSM1374669
DR   GEO; GSM1670093
DR   IARC_TP53; 21491
DR   ICLC; HTL96017
DR   IGRhCellID; MEG01
DR   JCRB; IFO50151
DR   LiGeA; CCLE_381
DR   LINCS_LDP; LCL-1110
DR   Lonza; 959
DR   PharmacoDB; MEG01_913_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0425
DR   PubChem_Cell_line; CVCL_0425
DR   Wikidata; Q54905035
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1742484;
RX   PubMed=2998511;
RX   PubMed=3332852;
RX   PubMed=9738977;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=15843827;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20809971;
RX   PubMed=22460905;
RX   PubMed=26700326;
RX   PubMed=27277069;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30332548;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=32180119;
RX   PubMed=35839778;
RX   PubMed=36982453;
WW   Info; KAKEN; 60480281; https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480281/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Japanese.
CC   Characteristics: Can be induced to differentiate into megakaryocytes after application of 12-O-tetradecanoyl-13-phorbol acetate (TPA) or valproic acid (VPA) (PubMed=1742484; PubMed=30332548).
CC   Doubling time: 36-48 hours (PubMed=2998511); ~35 hours (DSMZ=ACC-364).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827; PubMed=20809971; DepMap=ACH-000072).
CC   Sequence variation: Mutation; HGNC; HGNC:18318; ASXL1; Simple; p.Gly646Trpfs*12 (c.1934dupG); ClinVar=VCV000426927; Zygosity=Heterozygous (PubMed=26700326; DepMap=ACH-000072).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His233del (c.697_699delCAC); Zygosity=Heterozygous (Cosmic-CLP=908126; DepMap=ACH-000072).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.14%; Native American=0%; East Asian, North=79.13%; East Asian, South=17.4%; South Asian=0%; European, North=0%; European, South=2.33% (PubMed=30894373).
CC   Misspelling: Mego-1; Note=Occasionally.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): ATCC=CRL-2021; Cosmic-CLP=908126; DSMZ=ACC-364; ECACC=94012401; JCRB=IFO50151
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 8
ST   D16S539: 9
ST   D18S51: 18,22
ST   D19S433: 14,16
ST   D21S11: 29
ST   D2S1338: 19
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 11
ST   D8S1179: 14,15
ST   FGA: 26
ST   Penta D: 11,13
ST   Penta E: 15
ST   TH01: 7
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 46
CH   CVCL_E2Q6 ! HyCyte MEG-01 hJAK2_p.V617F_c.1849G>T
CH   CVCL_3022 ! MEG-01s
CH   CVCL_VG38 ! SPYMEG
//
RX   PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125;
RA   Virgili, Anna
RA   Nacheva, Elisabeth
RT   "Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in
RT   chronic myeloid leukaemia: a FISH mapping study of CML patients and
RT   cell lines.";
RL   Mol. Cytogenet. 3:15.1-15.12(2010).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30332548; DOI=10.1080/09537104.2018.1528344;
RA   Dhenge, Ankita
RA   Kuhikar, Rutuja
RA   Kale, Vaijayanti
RA   Limaye, Lalita Shrikant
RT   "Regulation of differentiation of MEG01 to megakaryocytes and
RT   platelet-like particles by valproic acid through Notch3 mediated actin
RT   polymerization.";
RL   Platelets 30:780-795(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=32180119; DOI=10.1007/s12185-020-02853-6;
RA   Saito, Hiroshi
RA   Hayakawa, Morisada
RA   Kamoshita, Nobuhiko
RA   Yasumoto, Atsushi
RA   Suzuki-Inoue, Katsue
RA   Yatomi, Yutaka
RA   Ohmori, Tsukasa
RT   "Establishment of a megakaryoblastic cell line for conventional
RT   assessment of platelet calcium signaling.";
RL   Int. J. Hematol. 111:786-794(2020).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886;
RA   Takizawa, Jun
RA   Suzuki, Ritsuro
RA   Kuroda, Hiroyuki
RA   Utsunomiya, Atae
RA   Kagami, Yoshitoyo
RA   Joh, Tatsuroh
RA   Aizawa, Yoshifusa
RA   Ueda, Ryuzo
RA   Seto, Masao
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=26700326; DOI=10.1016/j.exphem.2015.11.011;
RA   Inoue, Daichi
RA   Matsumoto, Masaki
RA   Nagase, Reina
RA   Saika, Makoto
RA   Fujino, Takeshi
RA   Nakayama, Keiichi I.
RA   Kitamura, Toshio
RT   "Truncation mutants of ASXL1 observed in myeloid malignancies are
RT   expressed at detectable protein levels.";
RL   Exp. Hematol. 44:172-176.e1(2016).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=2998511; DOI=10.1182/blood.V66.6.1384.1384;
RA   Ogura, Michinori
RA   Morishima, Yasuo
RA   Ohno, Ryuzo
RA   Kato, Yukio
RA   Hirabayashi, Norio
RA   Nagura, Hiroshi
RA   Saito, Hidehiko
RT   "Establishment of a novel human megakaryoblastic leukemia cell line,
RT   MEG-01, with positive Philadelphia chromosome.";
RL   Blood 66:1384-1392(1985).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680;
RA   Skopek, Rafal
RA   Palusinska, Malgorzata
RA   Kaczor-Keller, Katarzyna
RA   Pingwara, Rafal
RA   Papierniak-Wygladala, Anna
RA   Schenk, Tino
RA   Lewicki, Slawomir
RA   Zelent, Artur
RA   Szymanski, Lukasz
RT   "Choosing the right cell line for acute myeloid leukemia (AML)
RT   research.";
RL   Int. J. Mol. Sci. 24:5377.1-5377.34(2023).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=1742484; DOI=10.1182/blood.V78.12.3168.3168;
RA   Murate, Takashi
RA   Hotta, Tomomitsu
RA   Tsushita, Keitaro
RA   Suzuki, Motoshi
RA   Yoshida, Tomoaki
RA   Saga, Shinsuke
RA   Saito, Hidehiko
RA   Yoshida, Shonen
RT   "Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced
RT   differentiation of a human megakaryoblastic cell line, MEG-O1.";
RL   Blood 78:3168-3177(1991).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=27277069; DOI=10.1160/TH15-11-0891; PMCID=PMC5080539;
RA   Wright, Joy R.
RA   Amisten, Stefan
RA   Goodall, Alison H.
RA   Mahaut-Smith, Martyn P.
RT   "Transcriptomic analysis of the ion channelome of human platelets and
RT   megakaryocytic cell lines.";
RL   Thromb. Haemost. 116:272-284(2016).
//
RX   PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9;
RA   Keating, Armand
RT   "Ph positive CML cell lines.";
RL   Baillieres Clin. Haematol. 1:1021-1029(1987).
//