ID   MDCK-II
AC   CVCL_0424
SY   MDCK II; MDCKII; MDCK2; MDCK-2; MDCK Type II; MDCKII-WT
DR   BTO; BTO_0004607
DR   MCCL; MCC:0000321
DR   AddexBio; P0014001/82
DR   CCLV; CCLV-RIE 1061
DR   ChEMBL-Cells; CHEMBL3308862
DR   ChEMBL-Targets; CHEMBL4296466
DR   CLS; 305233
DR   ECACC; 00062107
DR   Lonza; 811
DR   PRIDE; PXD001130
DR   PubChem_Cell_line; CVCL_0424
DR   RCB; RCB5148
DR   Wikidata; Q54904781
RX   PubMed=1468552;
RX   PubMed=19941903;
RX   PubMed=21766308;
RX   PubMed=21982418;
RX   PubMed=24975811;
RX   PubMed=34737324;
CC   Group: Vaccine production cell line.
CC   Omics: Proteomics.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0422 ! MDCK
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=1468552; DOI=10.1016/0014-5793(92)81476-3;
RA   Grunberg J., Luginbuhl U., Sterchi E.E.;
RT   "Proteolytic processing of human intestinal lactase-phlorizin
RT   hydrolase precursor is not a prerequisite for correct sorting in
RT   Madin Darby canine kidney (MDCK) cells.";
RL   FEBS Lett. 314:224-228(1992).
//
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger A., Bettin B., Lenk M., Mettenleiter T.C.;
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
//
RX   PubMed=21766308; DOI=10.1002/jps.22674;
RA   Di L., Whitney-Pickett C., Umland J.P., Zhang H., Zhang X.,
RA   Gebhard D.F., Lai Y.-R., Federico J.J. 3rd, Davidson R.E., Smith R.,
RA   Reyner E.L., Lee C., Feng B., Rotter C., Varma M.V., Kempshall S.,
RA   Fenner K., El-Kattan A.F., Liston T.E., Troutman M.D.;
RT   "Development of a new permeability assay using low-efflux MDCKII
RT   cells.";
RL   J. Pharm. Sci. 100:4974-4985(2011).
//
RX   PubMed=21982418; DOI=10.1186/1471-2121-12-43; PMCID=PMC3209442;
RA   Dukes J.D., Whitley P., Chalmers A.D.;
RT   "The MDCK variety pack: choosing the right strain.";
RL   BMC Cell Biol. 12:43.1-43.4(2011).
//
RX   PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045; PMCID=PMC5915289;
RA   Donis R.O., Chen L.-M., Davis C.T., Foust A., Hossain M.J.,
RA   Johnson A., Klimov A., Loughlin R.F., Xu X.-Y., Tsai T., Blayer S.,
RA   Trusheim H., Colegate T., Fox J., Taylor B., Hussain A.I., Barr I.,
RA   Baas C., Louwerens J., Geuns E., Lee M.-S., Venhuizen L., Neumeier E.,
RA   Ziegler T.;
RG   Influenza Cell Culture Working Group;
RT   "Performance characteristics of qualified cell lines for isolation and
RT   propagation of influenza viruses for vaccine manufacturing.";
RL   Vaccine 32:6583-6590(2014).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163;
RA   Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657.1-21657.9(2021).
//