ID   MDCK-II
AC   CVCL_0424
SY   MDCK II; MDCKII; MDCK2; MDCK-2; MDCK Type II; MDCKII-WT
DR   BTO; BTO_0004607
DR   MCCL; MCC:0000321
DR   AddexBio; P0014001/82
DR   CCLV; CCLV-RIE 1061
DR   ChEMBL-Cells; CHEMBL3308862
DR   ChEMBL-Targets; CHEMBL4296466
DR   CLS; 305233
DR   ECACC; 00062107
DR   Lonza; 811
DR   PRIDE; PXD001130
DR   PubChem_Cell_line; CVCL_0424
DR   RCB; RCB5148
DR   Wikidata; Q54904781
RX   PubMed=1468552;
RX   PubMed=19941903;
RX   PubMed=21766308;
RX   PubMed=21982418;
RX   PubMed=24975811;
RX   PubMed=34737324;
CC   Group: Vaccine production cell line.
CC   Omics: Proteomics.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Epithelial cell of kidney; CL=CL_0002518.
CC   Breed/subspecies: Cocker Spaniel; VBO=VBO_0200372.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
HI   CVCL_0422 ! MDCK
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
//
RX   PubMed=1468552; DOI=10.1016/0014-5793(92)81476-3;
RA   Grunberg, Jurgen
RA   Luginbuhl, Ursula
RA   Sterchi, Erwin E.
RT   "Proteolytic processing of human intestinal lactase-phlorizin
RT   hydrolase precursor is not a prerequisite for correct sorting in
RT   Madin Darby canine kidney (MDCK) cells.";
RL   FEBS Lett. 314:224-228(1992).
//
RX   PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022;
RA   Karger, Axel
RA   Bettin, Barbara
RA   Lenk, Matthias
RA   Mettenleiter, Thomas Christoph
RT   "Rapid characterisation of cell cultures by matrix-assisted laser
RT   desorption/ionisation mass spectrometric typing.";
RL   J. Virol. Methods 164:116-121(2010).
//
RX   PubMed=21766308; DOI=10.1002/jps.22674;
RA   Di, Li
RA   Whitney-Pickett, Carrie
RA   Umland, John P.
RA   Zhang, Hui
RA   Zhang, Xun
RA   Gebhard, David F.
RA   Lai, Yu-Rong
RA   Federico, James J. 3rd
RA   Davidson, Ralph E.
RA   Smith, Russ
RA   Reyner, Eric L.
RA   Lee, Caroline
RA   Feng, Bo
RA   Rotter, Charles
RA   Varma, Manthena V.
RA   Kempshall, Sarah
RA   Fenner, Katherine
RA   El-Kattan, Ayman F.
RA   Liston, Theodore E.
RA   Troutman, Matthew D.
RT   "Development of a new permeability assay using low-efflux MDCKII
RT   cells.";
RL   J. Pharm. Sci. 100:4974-4985(2011).
//
RX   PubMed=21982418; DOI=10.1186/1471-2121-12-43; PMCID=PMC3209442;
RA   Dukes, Joseph D.
RA   Whitley, Paul
RA   Chalmers, Andrew D.
RT   "The MDCK variety pack: choosing the right strain.";
RL   BMC Cell Biol. 12:43.1-43.4(2011).
//
RX   PubMed=24975811; DOI=10.1016/j.vaccine.2014.06.045; PMCID=PMC5915289;
RA   Donis, Ruben O.
RA   Chen, I-Mei
RA   Davis, C. Todd
RA   Foust, Angie
RA   Hossain, M. Jaber
RA   Johnson, Adam
RA   Klimov, Alexander
RA   Loughlin, Rosette F.
RA   Xu, Xi-Yan
RA   Tsai, Theodore
RA   Blayer, Simone
RA   Trusheim, Heidi
RA   Colegate, Tony
RA   Fox, John
RA   Taylor, Beverly
RA   Hussain, Althaf I.
RA   Barr, Ian
RA   Baas, Chantal
RA   Louwerens, Jaap
RA   Geuns, Ed
RA   Lee, Min-Shi
RA   Venhuizen, Lodewijk
RA   Neumeier, Elisabeth
RA   Ziegler, Thedi
RG   Influenza Cell Culture Working Group;
RT   "Performance characteristics of qualified cell lines for isolation and
RT   propagation of influenza viruses for vaccine manufacturing.";
RL   Vaccine 32:6583-6590(2014).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5; PMCID=PMC8569163;
RA   Lung, Oliver
RA   Candlish, Rebecca C.
RA   Nebroski, Michelle
RA   Kruckiewicz, Peter
RA   Buchanan, Cody
RA   Moniwa, Mariko
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657.1-21657.9(2021).
//