ID   MCF7mp53
AC   CVCL_0415
SY   MCF7 mp53; MCF-7-mp53; MCF-7mp53
DR   MCCL; MCC:0000311
DR   cancercelllines; CVCL_0415
DR   Wikidata; Q54904475
RX   PubMed=11278253;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11998; TP53 (Note=With p.Arg273His).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 23
//
RX   PubMed=11278253; DOI=10.1074/jbc.C100025200;
RA   Gupta, Sanjeev
RA   Radha, Vegesna
RA   Furukawa, Yusuke
RA   Swarup, Ghanshyam
RT   "Direct transcriptional activation of human caspase-1 by tumor
RT   suppressor p53.";
RL   J. Biol. Chem. 276:10585-10588(2001).
//