ID LoVo AC CVCL_0399 SY LOVO DR BTO; BTO_0000666 DR CLO; CLO_0007377 DR CLO; CLO_0007378 DR CLO; CLO_0050632 DR EFO; EFO_0006639 DR MCCL; MCC:0000293 DR CLDB; cl3248 DR CLDB; cl3249 DR CLDB; cl3250 DR CLDB; cl4981 DR AddexBio; C0009011/380 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CCL-229 DR BCRC; 60148 DR BCRJ; 0332 DR BioGRID_ORCS_Cell_line; 405 DR BioSample; SAMN03470964 DR BioSample; SAMN03471476 DR BioSample; SAMN03472104 DR BioSample; SAMN03472362 DR BioSample; SAMN03473360 DR BioSample; SAMN05292432 DR BioSample; SAMN10988310 DR cancercelllines; CVCL_0399 DR CCLV; CCLV-RIE 1151 DR CCRID; 1101HUM-PUMC000164 DR CCRID; 3101HUMSCSP514 DR CCRID; 3101HUMTCHu82 DR CCRID; 4201HUM-CCTCC00646 DR CCTCC; GDC0186 DR Cell_Model_Passport; SIDM00839 DR ChEMBL-Cells; CHEMBL3307691 DR ChEMBL-Targets; CHEMBL614721 DR CLS; 300266 DR ColonAtlas; LOVO DR Cosmic; 711256 DR Cosmic; 720330 DR Cosmic; 724842 DR Cosmic; 738931 DR Cosmic; 873702 DR Cosmic; 876724 DR Cosmic; 887220 DR Cosmic; 889534 DR Cosmic; 897741 DR Cosmic; 905003 DR Cosmic; 907790 DR Cosmic; 913886 DR Cosmic; 948858 DR Cosmic; 985997 DR Cosmic; 995396 DR Cosmic; 1043567 DR Cosmic; 1057754 DR Cosmic; 1066209 DR Cosmic; 1122327 DR Cosmic; 1132566 DR Cosmic; 1132691 DR Cosmic; 1184084 DR Cosmic; 1184329 DR Cosmic; 1187308 DR Cosmic; 1223145 DR Cosmic; 1312303 DR Cosmic; 1466817 DR Cosmic; 1479597 DR Cosmic; 1482522 DR Cosmic; 1486133 DR Cosmic; 1524331 DR Cosmic; 1552182 DR Cosmic; 1571770 DR Cosmic; 1609489 DR Cosmic; 1676729 DR Cosmic; 1708412 DR Cosmic; 1803948 DR Cosmic; 1927244 DR Cosmic; 1945867 DR Cosmic; 1995488 DR Cosmic; 2267319 DR Cosmic; 2301996 DR Cosmic; 2389574 DR Cosmic; 2588707 DR Cosmic; 2646767 DR Cosmic; 2651865 DR Cosmic; 2664049 DR Cosmic; 2667975 DR Cosmic; 2760062 DR Cosmic; 2787548 DR Cosmic; 2800576 DR Cosmic-CLP; 907790 DR DepMap; ACH-000950 DR DSMZ; ACC-350 DR DSMZCellDive; ACC-350 DR ECACC; 87060101 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR ENCODE; ENCBS024NHD DR ENCODE; ENCBS080BPN DR GDSC; 907790 DR GEO; GSM206517 DR GEO; GSM274719 DR GEO; GSM274720 DR GEO; GSM274729 DR GEO; GSM513820 DR GEO; GSM514296 DR GEO; GSM741268 DR GEO; GSM784014 DR GEO; GSM887274 DR GEO; GSM888349 DR GEO; GSM1346882 DR GEO; GSM1374627 DR GEO; GSM1374628 DR GEO; GSM1374629 DR GEO; GSM1374630 DR GEO; GSM1448163 DR GEO; GSM1670055 DR GEO; GSM2550007 DR GEO; GSM3591765 DR IARC_TP53; 21485 DR ICLC; HTL99028 DR IZSLER; BS TCL 205 DR JCRB; IFO50067 DR JCRB; JCRB9083 DR KCB; KCB 200718YJ DR KCLB; 10229 DR LiGeA; CCLE_421 DR LINCS_LDP; LCL-1181 DR Lonza; 1021 DR MetaboLights; MTBLS227 DR NCI-DTP; LOVO DR PharmacoDB; LoVo_856_2019 DR PRIDE; PXD005235 DR PRIDE; PXD005354 DR PRIDE; PXD005355 DR PRIDE; PXD030304 DR Progenetix; CVCL_0399 DR PubChem_Cell_line; CVCL_0399 DR RCB; RCB1639 DR SKY/M-FISH/CGH; 2878 DR TKG; TKG 0344 DR Ubigene; YC-C137 DR Wikidata; Q54902894 RX PubMed=1260746; RX PubMed=3335022; RX PubMed=7104989; RX PubMed=7651727; RX PubMed=8197130; RX PubMed=8464898; RX PubMed=9000147; RX PubMed=9000572; RX PubMed=9290701; RX PubMed=9294210; RX PubMed=9515795; RX PubMed=9715273; RX PubMed=10612807; RX PubMed=10674020; RX PubMed=10737795; RX PubMed=11226274; RX PubMed=11314036; RX PubMed=11414198; RX PubMed=11416159; RX PubMed=11526487; RX PubMed=11668190; RX PubMed=12068308; RX PubMed=12584437; RX PubMed=12615714; RX PubMed=12661003; RX PubMed=15771911; RX PubMed=15900046; RX PubMed=16418264; RX PubMed=16854228; RX PubMed=18258742; RX PubMed=19927377; RX PubMed=19941903; RX PubMed=20164919; RX PubMed=20570890; RX PubMed=20606684; RX PubMed=20831567; RX PubMed=22460905; RX PubMed=24042735; RX PubMed=24755471; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25926053; RX PubMed=25944804; RX PubMed=25984343; RX PubMed=26537799; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=28683746; RX PubMed=28854368; RX PubMed=29101300; RX PubMed=29444439; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=32172478; RX PubMed=34320349; RX PubMed=35839778; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/LoVo.html WW Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544586 WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/l/cell-lines-detail-208.html WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/lovo-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: KuDOS 95 cell line panel. CC Part of: MD Anderson Cell Lines Project. CC Part of: NCI RAS program mutant KRAS cell line panel. CC Population: Caucasian. CC Doubling time: 37 hours (PubMed=1260746); 33.16 hours (PubMed=25944804); 52 hours (PubMed=25984343); ~48 hours (DSMZ=ACC-350); ~34 hours (PBCF). CC HLA typing: A*01:01,32:01; B*27:08,57:01; C*06:02,06:02; DQA1*03:02,05:02; DQB1*06:13,06:13; DRB1*09:07,13:10 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-high) (PubMed=9000147; PubMed=10674020; PubMed=12661003; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746; PubMed=31068700; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (PubMed=12615714; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (PubMed=8197130; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12068308; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (PubMed=24755471; Cosmic-CLP=907790; DepMap=ACH-000950). CC Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (PubMed=12615714). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9715273; PubMed=15900046; PubMed=16418264). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Glycomics; N-glycan profiling. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0%; East Asian, North=0%; East Asian, South=0%; South Asian=0.96%; European, North=71.69%; European, South=27.34% (PubMed=30894373). CC Discontinued: TKG; TKG 0344; probable. CC Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. ST Source(s): AddexBio=C0009011/380; ATCC=CCL-229; CCRID; CLS=300266; Cosmic-CLP=907790; DSMZ=ACC-350; ECACC=87060101; JCRB=IFO50067; JCRB=JCRB9083; KCLB=10229; PubMed=11416159; PubMed=15771911; PubMed=25877200; PubMed=25926053; RCB=RCB1639 ST Amelogenin: X,Y ST CSF1PO: 10,11,13,14 (AddexBio=C0009011/380; CCRID; CLS=300266; PubMed=25877200) ST CSF1PO: 10,14 (KCLB=10229) ST CSF1PO: 11,12,13 (RCB=RCB1639) ST CSF1PO: 11,12,13,14,15 (DSMZ=ACC-350) ST CSF1PO: 11,13,14 (ATCC=CCL-229; ECACC=87060101; JCRB=IFO50067; JCRB=JCRB9083; PubMed=25926053) ST CSF1PO: 11,14 (Cosmic-CLP=907790) ST D13S317: 8,11 ST D16S539: 9,11,12 (DSMZ=ACC-350) ST D16S539: 9,12 (AddexBio=C0009011/380; ATCC=CCL-229; CCRID; CLS=300266; Cosmic-CLP=907790; ECACC=87060101; JCRB=IFO50067; JCRB=JCRB9083; PubMed=15771911; PubMed=25877200; PubMed=25926053; RCB=RCB1639) ST D18S51: 13,17,18 (DSMZ=ACC-350; PubMed=11416159) ST D18S51: 13,18 (ATCC=CCL-229; CCRID; CLS=300266; PubMed=15771911; PubMed=25877200) ST D19S433: 14,15 (ATCC=CCL-229; CCRID; DSMZ=ACC-350; PubMed=25877200) ST D19S433: 15 (PubMed=15771911) ST D21S11: 29,31.2 (ATCC=CCL-229; CCRID; DSMZ=ACC-350; PubMed=15771911; PubMed=25877200; PubMed=25926053) ST D21S11: 29,31.2,32.2 (CLS=300266) ST D2S1338: 16,17,18 (DSMZ=ACC-350; PubMed=15771911) ST D2S1338: 17,18 (ATCC=CCL-229; CCRID; PubMed=25877200) ST D3S1358: 14,15,16,17 (ATCC=CCL-229) ST D3S1358: 14,16 (PubMed=15771911) ST D3S1358: 14,16,17 (DSMZ=ACC-350) ST D3S1358: 14,16,17,18 (CCRID) ST D3S1358: 14,17 (PubMed=25877200_130903) ST D3S1358: 14,18 (KCLB=10229; PubMed=25877200_584429) ST D5S818: 11,12,13 (AddexBio=C0009011/380; ATCC=CCL-229; DSMZ=ACC-350; JCRB=IFO50067; JCRB=JCRB9083; PubMed=25926053; RCB=RCB1639) ST D5S818: 11,13 (CCRID; CLS=300266; Cosmic-CLP=907790; ECACC=87060101; KCLB=10229; PubMed=25877200) ST D7S820: 9.3,10,11 (AddexBio=C0009011/380; ATCC=CCL-229; CCRID; DSMZ=ACC-350; JCRB=IFO50067; PubMed=25877200; PubMed=25926053) ST D7S820: 10,11 (CLS=300266; Cosmic-CLP=907790; ECACC=87060101; JCRB=JCRB9083; KCLB=10229; RCB=RCB1639) ST D8S1179: 9,10 (DSMZ=ACC-350; PubMed=15771911) ST D8S1179: 10 (ATCC=CCL-229; CCRID; PubMed=25877200) ST FGA: 18,19,20 (DSMZ=ACC-350; PubMed=15771911) ST FGA: 18,20 (ATCC=CCL-229; CCRID; CLS=300266; PubMed=11416159; PubMed=25877200) ST Penta D: 9,10,14 (CLS=300266) ST Penta D: 10,14 (ATCC=CCL-229; DSMZ=ACC-350; PubMed=25877200) ST Penta E: 9,16 (DSMZ=ACC-350) ST Penta E: 10,16 (ATCC=CCL-229; CLS=300266; PubMed=25877200) ST SE33: 19.2,20.2,25.2 ST TH01: 9.3 ST TPOX: 8,9 ST vWA: 16,17,18,19 (DSMZ=ACC-350) ST vWA: 17,18 (AddexBio=C0009011/380; ATCC=CCL-229; CCRID; CLS=300266; Cosmic-CLP=907790; ECACC=87060101; JCRB=IFO50067; JCRB=JCRB9083; KCLB=10229; PubMed=11416159; PubMed=25877200; PubMed=25926053; RCB=RCB1639) ST vWA: 17,19 (PubMed=15771911) DI NCIt; C4349; Colon adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 56Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 50 // RX PubMed=1260746; RA Drewinko B., Romsdahl M.M., Yang L.-Y., Ahearn M.J., Trujillo J.M.; RT "Establishment of a human carcinoembryonic antigen-producing colon RT adenocarcinoma cell line."; RL Cancer Res. 36:467-475(1976). // RX PubMed=3335022; RA Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., RA Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.; RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0; RA Chen T.-R., Hay R.J., Macy M.L.; RT "Karyotype consistency in human colorectal carcinoma cell lines RT established in vitro."; RL Cancer Genet. Cytogenet. 6:93-117(1982). // RX PubMed=7651727; RA Kastrinakis W.V., Ramchurren N., Rieger K.M., Hess D.T., Loda M., RA Steele G., Summerhayes I.C.; RT "Increased incidence of p53 mutations is associated with hepatic RT metastasis in colorectal neoplastic progression."; RL Oncogene 11:647-652(1995). // RX PubMed=8197130; DOI=10.1073/pnas.91.11.4751; PMCID=PMC43866; RA Bicknell D.C., Rowan A.J., Bodmer W.F.; RT "Beta 2-microglobulin gene mutations: a study of established RT colorectal cell lines and fresh tumors."; RL Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994). // RX PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192; RA Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G., RA Bodmer W.F.; RT "Tissue typing the HLA-A locus from genomic DNA by sequence-specific RT PCR: comparison of HLA genotype and surface expression on colorectal RT tumor cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993). // RX PubMed=9000147; RA Cottu P.-H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D., RA Thomas G., Hamelin R.; RT "Inverse correlation between RER+ status and p53 mutation in RT colorectal cancer cell lines."; RL Oncogene 13:2727-2730(1996). // RX PubMed=9000572; RA Hoang J.-M., Cottu P.-H., Thuille B., Salmon R.J., Thomas G., RA Hamelin R.; RT "BAT-26, an indicator of the replication error phenotype in colorectal RT cancers and cell lines."; RL Cancer Res. 57:300-303(1997). // RX PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D; RA Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., RA Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., RA Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.; RT "Screening the p53 status of human cell lines using a yeast functional RT assay."; RL Mol. Carcinog. 19:243-253(1997). // RX PubMed=9294210; DOI=10.1073/pnas.94.19.10330; PMCID=PMC23362; RA Ilyas M., Tomlinson I.P.M., Rowan A.J., Pignatelli M., Bodmer W.F.; RT "Beta-catenin mutations in cell lines established from human RT colorectal cancers."; RL Proc. Natl. Acad. Sci. U.S.A. 94:10330-10334(1997). // RX PubMed=9515795; RA Sparks A.B., Morin P.J., Vogelstein B., Kinzler K.W.; RT "Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal RT cancer."; RL Cancer Res. 58:1130-1134(1998). // RX PubMed=9715273; DOI=10.1038/sj.onc.1201986; RA Eshleman J.R., Casey G., Kochera M.E., Sedwick W.D., Swinler S.E., RA Veigl M.L., Willson J.K.V., Schwartz S., Markowitz S.D.; RT "Chromosome number and structure both are markedly stable in RER RT colorectal cancers and are not destabilized by mutation of p53."; RL Oncogene 17:719-725(1998). // RX PubMed=10612807; DOI=10.1002/(SICI)1098-2264(200002)27:2<183::AID-GCC10>3.0.CO;2-P; PMCID=PMC4721570; RA Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schrock E., RA Neumann T., Jauho A., Auer G., Ried T.; RT "Centrosome amplification and instability occurs exclusively in RT aneuploid, but not in diploid colorectal cancer cell lines, and RT correlates with numerical chromosomal aberrations."; RL Genes Chromosomes Cancer 27:183-190(2000). // RX PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3; RA Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.; RT "Mutations in hMSH6 alone are not sufficient to cause the RT microsatellite instability in colorectal cancer cell lines."; RL Eur. J. Cancer 35:1724-1729(1999). // RX PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243; RA Rowan A.J., Lamlum H., Ilyas M., Wheeler J.M.D., Straub J., RA Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.; RT "APC mutations in sporadic colorectal tumors: a mutational 'hotspot' RT and interdependence of the 'two hits'."; RL Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000). // RX PubMed=11226274; DOI=10.1073/pnas.041603298; PMCID=PMC30173; RA Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., RA Bicknell D.C., Bodmer W.F., Arends M.J., Wyllie A.H., Edwards P.A.W.; RT "Spectral karyotyping suggests additional subsets of colorectal RT cancers characterized by pattern of chromosome rearrangement."; RL Proc. Natl. Acad. Sci. U.S.A. 98:2538-2543(2001). // RX PubMed=11314036; DOI=10.1038/sj.onc.1204211; RA Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., RA Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., RA Minna J.D.; RT "Searching for microsatellite mutations in coding regions in lung, RT breast, ovarian and colorectal cancers."; RL Oncogene 20:1005-1009(2001). // RX PubMed=11414198; DOI=10.1007/s004320000207; RA Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., RA Wolf E., Gabius H.-J.; RT "Comprehensive galectin fingerprinting in a panel of 61 human tumor RT cell lines by RT-PCR and its implications for diagnostic and RT therapeutic procedures."; RL J. Cancer Res. Clin. Oncol. 127:375-386(2001). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., RA Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., RA Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.; RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). // RX PubMed=11526487; DOI=10.1038/sj.onc.1204611; RA Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.-H., RA Hamelin R.; RT "Extensive characterization of genetic alterations in a series of RT human colorectal cancer cell lines."; RL Oncogene 20:5025-5032(2001). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.; RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., RA Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., RA Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., RA Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., RA Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., RA Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., RA Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., RA Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., RA Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., RA Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.; RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=12584437; DOI=10.1159/000068544; RA Melcher R., Koehler S., Steinlein C., Schmid M., Mueller C.R., RA Luehrs H., Menzel T., Scheppach W., Moerk H., Scheurlen M., RA Koehrle J., Al-Taie O.; RT "Spectral karyotype analysis of colon cancer cell lines of the tumor RT suppressor and mutator pathway."; RL Cytogenet. Genome Res. 98:22-28(2002). // RX PubMed=12615714; RA Hempen P.M., Zhang L., Bansal R.K., Iacobuzio-Donahue C.A., RA Murphy K.M., Maitra A., Vogelstein B., Whitehead R.H., Markowitz S.D., RA Willson J.K.V., Yeo C.J., Hruban R.H., Kern S.E.; RT "Evidence of selection for clones having genetic inactivation of the RT activin A type II receptor (ACVR2) gene in gastrointestinal cancers."; RL Cancer Res. 63:994-999(2003). // RX PubMed=12661003; DOI=10.1002/gcc.10196; RA Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., RA Santibanez-Koref M.F., Schlag P.M., Scherneck S.; RT "Identification of microsatellite instability and mismatch repair gene RT mutations in breast cancer cell lines."; RL Genes Chromosomes Cancer 37:29-35(2003). // RX PubMed=15771911; DOI=10.1016/j.cancergencyto.2004.08.023; RA Melcher R., Maisch S., Koehler S., Bauer M., Steinlein C., Schmid M., RA Kudlich T., Schauber J., Luehrs H., Menzel T., Scheppach W.; RT "SKY and genetic fingerprinting reveal a cross-contamination of the RT putative normal colon epithelial cell line NCOL-1."; RL Cancer Genet. Cytogenet. 158:84-87(2005). // RX PubMed=15900046; DOI=10.1093/jnci/dji133; RA Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., RA Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y., RA Tomoda H., Yamori T., Tsuruo T.; RT "p53-defective tumors with a functional apoptosome-mediated pathway: a RT new therapeutic target."; RL J. Natl. Cancer Inst. 97:765-777(2005). // RX PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731; RA Liu Y., Bodmer W.F.; RT "Analysis of p53 mutations and their expression in 56 colorectal RT cancer cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006). // RX PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420; RA Bandres Elizalde E.M., Cubedo E., Agirre X., Malumbres R., Zarate R., RA Ramirez N., Abajo A., Navarro A., Moreno I., Monzo M., RA Garcia-Foncillas J.; RT "Identification by real-time PCR of 13 mature microRNAs differentially RT expressed in colorectal cancer and non-tumoral tissues."; RL Mol. Cancer 5:29.1-29.10(2006). // RX PubMed=18258742; DOI=10.1073/pnas.0712176105; PMCID=PMC2268141; RA Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.; RT "Cell growth, global phosphotyrosine elevation, and c-Met RT phosphorylation through Src family kinases in colorectal cancer RT cells."; RL Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008). // RX PubMed=19927377; DOI=10.1002/gcc.20730; PMCID=PMC2818350; RA Knutsen T., Padilla-Nash H.M., Wangsa D., Barenboim-Stapleton L., RA Camps J., McNeil N.E., Difilippantonio M.J., Ried T.; RT "Definitive molecular cytogenetic characterization of 15 colorectal RT cancer cell lines."; RL Genes Chromosomes Cancer 49:204-223(2010). // RX PubMed=19941903; DOI=10.1016/j.jviromet.2009.11.022; RA Karger A., Bettin B., Lenk M., Mettenleiter T.C.; RT "Rapid characterisation of cell cultures by matrix-assisted laser RT desorption/ionisation mass spectrometric typing."; RL J. Virol. Methods 164:116-121(2010). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., RA Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., RA Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., RA Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.; RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514; RA Janakiraman M., Vakiani E., Zeng Z.-S., Pratilas C.A., Taylor B.S., RA Chitale D., Halilovic E., Wilson M., Huberman K., Ricarte Filho J.C.M., RA Persaud Y., Levine D.A., Fagin J.A., Jhanwar S.C., Mariadason J.M., RA Lash A., Ladanyi M., Saltz L.B., Heguy A., Paty P.B., Solit D.B.; RT "Genomic and biological characterization of exon 4 KRAS mutations in RT human cancer."; RL Cancer Res. 70:5901-5911(2010). // RX PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028; RA Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.; RT "5-fluorouracil response in a large panel of colorectal cancer cell RT lines is associated with mismatch repair deficiency."; RL Br. J. Cancer 103:340-346(2010). // RX PubMed=20831567; DOI=10.1111/j.1582-4934.2010.01170.x; PMCID=PMC3918049; RA Ma Y.-L., Zhang P., Wang F., Moyer M.P., Yang J.-J., Liu Z.-H., RA Peng J.-Y., Chen H.-Q., Zhou Y.-K., Liu W.-J., Qin H.-L.; RT "Human embryonic stem cells and metastatic colorectal cancer cells RT shared the common endogenous human microRNA-26b."; RL J. Cell. Mol. Med. 15:1941-1954(2011). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., RA Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., RA Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., RA Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., RA Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., RA Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., RA Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., RA Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., RA Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., RA Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., RA Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.; RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225; RA Ahmed D., Eide P.W., Eilertsen I.A., Danielsen S.A., Eknaes M., RA Hektoen M., Lind G.E., Lothe R.A.; RT "Epigenetic and genetic features of 24 colon cancer cell lines."; RL Oncogenesis 2:e71.1-e71.8(2013). // RX PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013; RA Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., RA Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., RA O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., RA Mariadason J.M., Sieber O.M.; RT "Colorectal cancer cell lines are representative models of the main RT molecular subtypes of primary cancer."; RL Cancer Res. 74:3238-3247(2014). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., RA Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., RA Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., RA Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., RA Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., RA Settleman J., Seshagiri S., Zhang Z.-M.; RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., RA Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., RA Neve R.M.; RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=25926053; DOI=10.1038/ncomms8002; RA Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., RA Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., RA Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., RA Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.; RT "The molecular landscape of colorectal cancer cell lines unveils RT clinically actionable kinase targets."; RL Nat. Commun. 6:7002.1-7002.10(2015). // RX PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457; RA Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., RA Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., RA Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.; RT "Highly expressed genes in rapidly proliferating tumor cells as new RT targets for colorectal cancer treatment."; RL Clin. Cancer Res. 21:3695-3704(2015). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., RA East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., RA Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., RA Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., RA Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., RA Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., RA Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., RA Golub T.R., Root D.E., Hahn W.C.; RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=26537799; DOI=10.1074/mcp.M115.051235; PMCID=PMC4762531; RA Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., RA Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., RA Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.; RT "N-glycosylation profiling of colorectal cancer cell lines reveals RT association of fucosylation with differentiation and caudal type RT homebox 1 (CDX1)/villin mRNA expression."; RL Mol. Cell. Proteomics 15:124-140(2016). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., RA Loewer M., Sahin U., Castle J.C.; RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., RA Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., RA Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., RA Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., RA Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., RA Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., RA Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., RA Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.; RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., RA Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., RA Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., RA Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., RA Liang H.; RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998; RA Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J., RA Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E., RA Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.; RT "Multi-omics of 34 colorectal cancer cell lines -- a resource for RT biomedical studies."; RL Mol. Cancer 16:116.1-116.16(2017). // RX PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010; PMCID=PMC5583477; RA Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., RA Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., RA Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., RA Guinney J.H., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., RA Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.; RT "Genomic determinants of protein abundance variation in colorectal RT cancer cells."; RL Cell Rep. 20:2201-2214(2017). // RX PubMed=29101300; DOI=10.15252/msb.20177701; PMCID=PMC5731344; RA Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., RA Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., RA Johnstone E., Domingo E., Kerr D.J., Jesinghaus M., Slotta-Huspenina J., RA Weichert W., Knapp S., Feller S.M., Kuster B.; RT "Pharmacoproteomic characterisation of human colon and rectal RT cancer."; RL Mol. Syst. Biol. 13:951-951(2017). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., RA Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D.A., RA Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., RA Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., RA Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., RA McCormick F.; RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.; RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., RA Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., RA Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., RA van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., RA Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.; RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., RA McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., RA Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., RA Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., RA Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., RA Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., RA Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., RA Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., RA Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., RA Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., RA Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., RA Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., RA Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., RA Sellers W.R.; RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=32172478; DOI=10.1007/s12253-020-00805-3; RA Xu Y.-T., Zhang L., Wang Q.-L., Zheng M.-J.; RT "Comparison of different colorectal cancer with liver metastases RT models using six colorectal cancer cell lines."; RL Pathol. Oncol. Res. 26:2177-2183(2020). // RX PubMed=34320349; DOI=10.1016/j.celrep.2021.109441; PMCID=PMC8333195; RA Jochems F., Thijssen B., De Conti G., Jansen R., Pogacar Z., Groot K., RA Wang L.-Q., Schepers A., Wang C., Jin H.-J., Beijersbergen R.L., RA Leite de Oliveira R., Wessels L.F.A., Bernards R.; RT "The cancer SENESCopedia: a delineation of cancer cell senescence."; RL Cell Rep. 36:109441.1-109441.22(2021). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., RA Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., RA Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., RA Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., RA Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., RA Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.; RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). //