ID   LAMA-84
AC   CVCL_0388
SY   Lama-84; LAMA84; Lama84
DR   BTO; BTO_0004465
DR   CLO; CLO_0007238
DR   MCCL; MCC:0000283
DR   CLDB; cl3168
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473363
DR   BioSample; SAMN10988484
DR   cancercelllines; CVCL_0388
DR   CCRID; 1101HUM-PUMC000685
DR   Cell_Model_Passport; SIDM00346
DR   ChEMBL-Cells; CHEMBL3308267
DR   ChEMBL-Targets; CHEMBL2366090
DR   CLS; 300261
DR   Cosmic; 787500
DR   Cosmic; 907783
DR   Cosmic; 1012081
DR   Cosmic; 1019834
DR   Cosmic; 1026569
DR   Cosmic; 1078729
DR   Cosmic-CLP; 907783
DR   DepMap; ACH-000301
DR   DSMZ; ACC-168
DR   DSMZCellDive; ACC-168
DR   EGA; EGAS00001000978
DR   GDSC; 907783
DR   GEO; GSM887262
DR   GEO; GSM888337
DR   GEO; GSM1670031
DR   IARC_TP53; 21457
DR   LiGeA; CCLE_403
DR   LINCS_LDP; LCL-1109
DR   Lonza; 961
DR   Millipore; SCC140
DR   PharmacoDB; LAMA84_818_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0388
DR   PubChem_Cell_line; CVCL_0388
DR   Wikidata; Q54901914
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=3476310;
RX   PubMed=7996872;
RX   PubMed=8693292;
RX   PubMed=9257809;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=15843827;
RX   PubMed=16408098;
RX   PubMed=20164919;
RX   PubMed=20809971;
RX   PubMed=22460905;
RX   PubMed=25984343;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Doubling time: 48 hours (PubMed=3476310); 36 hours (PubMed=25984343); ~50 hours (DSMZ=ACC-168).
CC   HLA typing: A*02:01:01,25:01:01; B*18:01:01,44:02:01; C*05:01:01,12:03:01; DPA1*01:03:01,02:01:01; DQB1*06:02:01,06:02:01; DRA*01:01:01,01:02:03; DRB1*15:01:01,15:01:01 (DSMZCellDive=ACC-168).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827; PubMed=20809971; DepMap=ACH-000301).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Lys319Ter (c.955A>T); Zygosity=Homozygous (Cosmic-CLP=907783; DepMap=ACH-000301).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=14.08%; Native American=0%; East Asian, North=1.13%; East Asian, South=1.46%; South Asian=1.64%; European, North=29.64%; European, South=52.05% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): CCRID=1101HUM-PUMC000685; CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168; Millipore=SCC140
ST   Amelogenin: X
ST   CSF1PO: 8,11,12 (DSMZ=ACC-168)
ST   CSF1PO: 11,12 (CCRID=1101HUM-PUMC000685; Cosmic-CLP=907783; Millipore=SCC140)
ST   CSF1PO: 11,12,13 (CLS=300261)
ST   D12S391: 18,24
ST   D13S317: 11 (CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168; Millipore=SCC140)
ST   D13S317: 11,12 (CCRID=1101HUM-PUMC000685)
ST   D16S539: 11
ST   D18S51: 13
ST   D19S433: 13
ST   D1S1656: 15,15.3
ST   D21S11: 29,30,31 (CLS=300261; DSMZ=ACC-168)
ST   D21S11: 29,31 (CCRID=1101HUM-PUMC000685; Millipore=SCC140)
ST   D2S1338: 17 (CLS=300261; DSMZ=ACC-168)
ST   D2S1338: 17,19 (CCRID=1101HUM-PUMC000685)
ST   D3S1358: 14,17
ST   D5S818: 11,12
ST   D6S1043: 10,20
ST   D7S820: 11
ST   D8S1179: 10,15
ST   FGA: 21,22
ST   Penta D: 10
ST   Penta E: 7
ST   TH01: 6,7
ST   TPOX: 10 (CLS=300261; Cosmic-CLP=907783; DSMZ=ACC-168)
ST   TPOX: 10,11 (CCRID=1101HUM-PUMC000685; Millipore=SCC140)
ST   vWA: 14,17
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   29Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 44
CH   CVCL_1826 ! LAMA-87
CH   CVCL_9540 ! LAMA-88
CH   CVCL_DP57 ! LAMA84-r
CH   CVCL_DP54 ! LAMA84-rn
CH   CVCL_UE08 ! LAMA84-s
CH   CVCL_AE17 ! LAMA84R
//
RX   PubMed=3476310;
RA   Seigneurin, Daniel
RA   Champelovier, Pierre
RA   Mouchiroud, Guy
RA   Berthier, Rolande
RA   Leroux, Dominique
RA   Prenant, Michel
RA   McGregor, John
RA   Starck, Joelle
RA   Morle, Francois
RA   Micouin, Claude
RA   Pietrantuono, Annie
RA   Kolodie, Lucien
RT   "Human chronic myeloid leukemic cell line with positive Philadelphia
RT   chromosome exhibits megakaryocytic and erythroid characteristics.";
RL   Exp. Hematol. 15:822-832(1987).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=9257809;
RA   Champelovier, Pierre
RA   Fixe, Philippe
RA   Valiron, Odile
RA   Feige, Jean-Jacques
RA   Praloran, Vincent
RA   Seigneurin, Daniel
RT   "Proliferation of LAMA-84 and LAMA-87 cell lines is modulated by
RT   autocrine loops involving M-CSF and TGF-beta.";
RL   Exp. Hematol. 25:958-965(1997).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125;
RA   Virgili, Anna
RA   Nacheva, Elisabeth
RT   "Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in
RT   chronic myeloid leukaemia: a FISH mapping study of CML patients and
RT   cell lines.";
RL   Mol. Cytogenet. 3:15.1-15.12(2010).
//
RX   PubMed=8693292; DOI=10.1046/j.1365-3083.1996.d01-84.x;
RA   Blom, Thomas
RA   Nilsson, Gunnar
RA   Sundstrom, Christer
RA   Nilsson, Kenneth
RA   Hellman, Lars
RT   "Characterization of a human basophil-like cell line (LAMA-84).";
RL   Scand. J. Immunol. 44:54-61(1996).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier, Hilmar
RA   MacLeod, Roderick A.F.
RA   Zaborski, Margarete
RA   Drexler, Hans Gunther
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=7996872; DOI=10.1016/0145-2126(94)90102-3;
RA   Champelovier, Pierre
RA   Valiron, Odile
RA   Jacrot, Michele
RA   Leroux, Dominique
RA   Seigneurin, Daniel
RT   "Selection and characterization of an erythroeosinophilic subclone
RT   (LAMA-87) and an eosinophilic subclone (LAMA-88) from the
RT   multipotential cell line LAMA-84.";
RL   Leuk. Res. 18:903-918(1994).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//