ID   JHH-5
AC   CVCL_0364
AS   CVCL_0263
SY   Jhh-5; JHH5; FLC-5; FLC5; Functional Liver Cell-5
DR   EFO; EFO_0006602
DR   MCCL; MCC:0000154
DR   MCCL; MCC:0000258
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   BioGRID_ORCS_Cell_line; 633
DR   BioSample; SAMN03473192
DR   BioSample; SAMN10987783
DR   cancercelllines; CVCL_0364
DR   Cell_Model_Passport; SIDM01569
DR   Cosmic; 2023875
DR   DepMap; ACH-000734
DR   EGA; EGAS00001000610
DR   GEO; GSM887172
DR   GEO; GSM888244
DR   GEO; GSM936767
DR   GEO; GSM2551574
DR   IARC_TP53; 28347
DR   JCRB; JCRB1029
DR   JCRB; NIHS0279
DR   LiGeA; CCLE_881
DR   LIMORE; JHH5
DR   PharmacoDB; JHH5_683_2019
DR   Progenetix; CVCL_0364
DR   Wikidata; Q54898642
RX   DOI=10.11418/jtca1981.16.3_173;
RX   PubMed=1701409;
RX   PubMed=8835345;
RX   PubMed=9359923;
RX   PubMed=10523694;
RX   PubMed=10933057;
RX   PubMed=17241388;
RX   PubMed=22460905;
RX   PubMed=23505090;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31063779;
RX   PubMed=31068700;
RX   PubMed=31378681;
RX   PubMed=31395879;
RX   PubMed=31978347;
RX   PubMed=36724073;
WW   Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/JHH5
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Liver Cancer Model Repository (LIMORE).
CC   Part of: TCGA-110-CL cell line panel.
CC   Population: Japanese.
CC   Doubling time: 30.39 hours (PubMed=31378681); ~40 hours (Note=Lot 03112003), ~2 days (Note=Lot 03022011), ~29 hours (Note=Lot 09272018), ~1 day (Note=Lot 08252021) (JCRB=JCRB1029).
CC   HLA typing: A*24:02,24:02; B*08:01,67:02; C*01:02,12:02; DQA1*01:02,01:02; DQB1*03:02,03:02; DRB1*11:12,15:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Gln6Argfs*22 (c.17_18delAG); Zygosity=Unspecified (PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700; PubMed=31378681).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro190_His193del (c.569_580del12); Zygosity=Unspecified (DepMap=ACH-000734).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.41%; Native American=0.04%; East Asian, North=81.84%; East Asian, South=17.72%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; NIHS0279; true.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): JCRB=JCRB1029; PubMed=25877200; PubMed=31378681
ST   Amelogenin: X,Y
ST   CSF1PO: 9
ST   D13S317: 9
ST   D16S539: 9,10
ST   D18S51: 13
ST   D21S11: 31.2
ST   D3S1358: 15,17
ST   D5S818: 13
ST   D7S820: 10,12
ST   D8S1179: 12
ST   FGA: 19
ST   Penta D: 11
ST   Penta E: 17,20
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 17,19
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
CH   CVCL_JF88 ! JHH-5-Luc
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001;
RA   Caruso, Stefano
RA   Calatayud, Anna-Line
RA   Pilet, Jill
RA   La Bella, Tiziana
RA   Rekik, Samia
RA   Imbeaud, Sandrine
RA   Letouze, Eric
RA   Meunier, Lea
RA   Bayard, Quentin
RA   Rohr-Udilova, Nataliya
RA   Peneau, Camille
RA   Grasl-Kraupp, Bettina
RA   de Koning, Leanne
RA   Ouine, Berengere
RA   Bioulac-Sage, Paulette
RA   Couchy, Gabrielle
RA   Calderaro, Julien
RA   Nault, Jean-Charles
RA   Zucman-Rossi, Jessica
RA   Rebouissou, Sandra
RT   "Analysis of liver cancer cell lines identifies agents with likely
RT   efficacy against hepatocellular carcinoma and markers of response.";
RL   Gastroenterology 157:760-776(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   DOI=10.11418/jtca1981.16.3_173;
RA   Mihara, Koichiro
RA   Miyazaki, Masahiro
RA   Fushimi, Kazuo
RA   Tsuji, Toshiya
RA   Inoue, Yusuke
RA   Fukaya, Ken-ichi
RA   Ohashi, Ryuichiro
RA   Namba, Masayoshi
RT   "The p53 gene status and other cellular characteristics of human cell
RT   lines maintained in our laboratory.";
RL   Tissue Cult. Res. Commun. 16:173-178(1997).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang, Kai
RA   Lim, Ho Yeong
RA   Shi, Stephanie
RA   Lee, Jeeyun
RA   Deng, Shi-Bing
RA   Xie, Tao
RA   Zhu, Zhou
RA   Wang, Yu-Li
RA   Pocalyko, David
RA   Yang, Wei Jennifer
RA   Rejto, Paul A.
RA   Mao, Mao
RA   Park, Cheol-Keun
RA   Xu, Jiang-Chun
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=17241388; DOI=10.1111/j.1478-3231.2006.01410.x;
RA   Kosuge, Makoto
RA   Takizawa, Hiroko
RA   Maehashi, Haruka
RA   Matsuura, Tomokazu
RA   Matsufuji, Senya
RT   "A comprehensive gene expression analysis of human hepatocellular
RT   carcinoma cell lines as components of a bioartificial liver using a
RT   radial flow bioreactor.";
RL   Liver Int. 27:101-108(2007).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785;
RA   Yu, Katharine
RA   Chen, Bin
RA   Aran, Dvir
RA   Charalel, Joe
RA   Yau, Christina
RA   Wolf, Douglas M.
RA   van 't Veer, Laura J.
RA   Butte, Atul Janardhan
RA   Goldstein, Ted
RA   Sirota, Marina
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574.1-3574.11(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin K.
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=10523694; DOI=10.3892/or.6.6.1267;
RA   Gao, Chong
RA   Ohashi, Ryuichiro
RA   Pu, Hong
RA   Inoue, Yusuke
RA   Tsuji, Toshiya
RA   Miyazaki, Masahiro
RA   Namba, Masayoshi
RT   "Yeast functional assay of the p53 gene status in 11 cell lines and 26
RT   surgical specimens of human hepatocellular carcinoma.";
RL   Oncol. Rep. 6:1267-1271(1999).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=1701409;
RA   Fujise, Kiyotaka
RA   Nagamori, Seishi
RA   Hasumura, Satoshi
RA   Homma, Sadamu
RA   Sujino, Hajime
RA   Matsuura, Tomokazu
RA   Shimizu, Keiichiro
RA   Niiya, Minoru
RA   Kameda, Haruo
RA   Fujita, Kazunobu
RA   Ohno, Tsuneya
RT   "Integration of hepatitis B virus DNA into cells of six established
RT   human hepatocellular carcinoma cell lines.";
RL   Hepato-Gastroenterol. 37:457-460(1990).
//
RX   PubMed=36724073; DOI=10.1016/j.celrep.2023.112065;
RA   Yang, Ji-Cheng
RA   Guo, Fu-Sheng
RA   Chin, Hui-San
RA   Chen, Gao-Bin
RA   Ang, Chow-Hiang
RA   Lin, Qing-Song
RA   Hong, Wan-Jin
RA   Fu, Nai-Yang
RT   "Sequential genome-wide CRISPR-Cas9 screens identify genes regulating
RT   cell-surface expression of tetraspanins.";
RL   Cell Rep. 42:112065.1-112065.26(2023).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724;
RA   Qiu, Zhi-Xin
RA   Li, Hong
RA   Zhang, Zheng-Tao
RA   Zhu, Zhen-Feng
RA   He, Sheng
RA   Wang, Xu-Jun
RA   Wang, Peng-Cheng
RA   Qin, Jian-Jie
RA   Zhuang, Li-Ping
RA   Wang, Wei
RA   Xie, Fu-Bo
RA   Gu, Ying
RA   Zou, Ke-Ke
RA   Li, Chao
RA   Li, Chun
RA   Wang, Chen-Hua
RA   Cen, Jin
RA   Chen, Xiao-Tao
RA   Shu, Ya-Jing
RA   Zhang, Zhao
RA   Sun, Lu-Lu
RA   Min, Li-Hua
RA   Fu, Yong
RA   Huang, Xiao-Wu
RA   Lv, Hui
RA   Zhou, He
RA   Ji, Yuan
RA   Zhang, Zhi-Gang
RA   Meng, Zhi-Qiang
RA   Shi, Xiao-Lei
RA   Zhang, Hai-Bin
RA   Li, Yi-Xue
RA   Hui, Li-Jian
RT   "A pharmacogenomic landscape in human liver cancers.";
RL   Cancer Cell 36:179-193.e11(2019).
//
RX   PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A;
RA   Tsuboi, So
RA   Nagamori, Seishi
RA   Miyazaki, Masahiro
RA   Mihara, Koichiro
RA   Fukaya, Ken-ichi
RA   Teruya, Kiichiro
RA   Kosaka, Tsunenori
RA   Tsuji, Takao
RA   Namba, Masayoshi
RT   "Persistence of hepatitis C virus RNA in established human
RT   hepatocellular carcinoma cell lines.";
RL   J. Med. Virol. 48:133-140(1996).
//
RX   PubMed=9359923; DOI=10.18926/AMO/30789;
RA   Mihara, Koichiro
RA   Miyazaki, Masahiro
RA   Kondo, Tadashi
RA   Fushimi, Kazuo
RA   Tsuji, Toshiya
RA   Inoue, Yusuke
RA   Fukaya, Ken-ichi
RA   Ishioka, Chikashi
RA   Namba, Masayoshi
RT   "Yeast functional assay of the p53 gene status in human cell lines
RT   maintained in our laboratory.";
RL   Acta Med. Okayama 51:261-265(1997).
//
RX   PubMed=10933057; DOI=10.1038/sj.neo.7900046; PMCID=PMC1508115;
RA   Murakami, Koji
RA   Sakukawa, Rieko
RA   Ikeda, Takashi
RA   Matsuura, Tomokazu
RA   Hasumura, Satoshi
RA   Nagamori, Seishi
RA   Yamada, Yuji
RA   Saiki, Ikuo
RT   "Invasiveness of hepatocellular carcinoma cell lines: contribution of
RT   membrane-type 1 matrix metalloproteinase.";
RL   Neoplasia 1:424-430(1999).
//