ID   JEG-3
AC   CVCL_0363
SY   Jeg-3; JEG3; Jeg3; jeg3
DR   BTO; BTO:0002269
DR   CLO; CLO_0007017
DR   EFO; EFO_0002066
DR   MCCL; MCC:0000257
DR   CLDB; cl2935
DR   CLDB; cl2936
DR   AddexBio; C0030003/4940
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HTB-36
DR   BCRC; 60428
DR   BCRJ; 0123
DR   BioSample; SAMN01821538
DR   BioSample; SAMN01821638
DR   cancercelllines; CVCL_0363
DR   CCRID; 1101HUM-PUMC000071
DR   CCRID; 3101HUMTCHu195
DR   CCRID; 4201HUM-CCTCC00320
DR   CCTCC; GDC0320
DR   Cell_Model_Passport; SIDM01218
DR   ChEMBL-Cells; CHEMBL3308202
DR   ChEMBL-Targets; CHEMBL2366348
DR   CLS; 300222
DR   Cosmic; 683654
DR   Cosmic; 907176
DR   Cosmic; 1312288
DR   Cosmic; 2077192
DR   Cosmic-CLP; 907176
DR   DepMap; ACH-001530
DR   DSMZ; ACC-463
DR   DSMZCellDive; ACC-463
DR   ECACC; 92120308
DR   EGA; EGAS00001000978
DR   GDSC; 907176
DR   GEO; GSM48266
DR   GEO; GSM48267
DR   GEO; GSM48268
DR   GEO; GSM1669948
DR   IARC_TP53; 4344
DR   IARC_TP53; 21418
DR   IGRhCellID; JEG3
DR   IZSLER; BS TCL 181
DR   KCLB; 30036
DR   LINCS_LDP; LCL-1492
DR   NCBI_Iran; C544
DR   PharmacoDB; JEG3_677_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0363
DR   PubChem_Cell_line; CVCL_0363
DR   TOKU-E; 2070
DR   Wikidata; Q54898563
RX   DOI=10.1007/0-306-46861-1_8;
RX   PubMed=62839;
RX   PubMed=327080;
RX   PubMed=833871;
RX   PubMed=2878840;
RX   PubMed=3518877;
RX   PubMed=5103722;
RX   PubMed=6220172;
RX   PubMed=7459858;
RX   PubMed=7753552;
RX   PubMed=7819056;
RX   PubMed=7937597;
RX   PubMed=11994546;
RX   PubMed=12966428;
RX   PubMed=16797695;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=28161053;
RX   PubMed=28724925;
RX   PubMed=30894373;
RX   PubMed=33096371;
RX   PubMed=33810901;
RX   PubMed=35839778;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-251.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Characteristics: Established by serial cloning into hamster cheek pouches.
CC   Doubling time: ~36 hours (CLS=300222); ~24 hours (DSMZ=ACC-463).
CC   Karyotypic information: Near tetraploid karyotype (PubMed=33096371).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0.01%; Native American=0.09%; East Asian, North=0.97%; East Asian, South=0%; South Asian=0.9%; European, North=71.88%; European, South=26.16% (PubMed=30894373).
CC   Caution: A TP53 mutation is indicated as being at p.Gln167His (c.501G>T) in PubMed=7819056 but has not been confirmed by CCLE and Cosmic-CLP.
CC   Derived from site: Metastatic; Fetal brain; UBERON=UBERON_0006237.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DepMap; DSMZ; KCLB; PubMed=33810901
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 13,15
ST   D12S391: 17,24
ST   D13S317: 9,11
ST   D16S539: 13,14
ST   D18S51: 14
ST   D19S433: 13,15
ST   D1S1656: 14,16
ST   D21S11: 30
ST   D22S1045: 15
ST   D2S1338: 24
ST   D2S441: 14,15
ST   D3S1358: 15 (CLS)
ST   D3S1358: 15,16 (CCRID; DepMap; DSMZ; KCLB; PubMed=33810901)
ST   D5S818: 10,11
ST   D7S820: 10,12
ST   D8S1179: 12
ST   FGA: 23,24
ST   Penta D: 9,12
ST   Penta E: 8,12
ST   SE33: 15,25.2
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C4646; Gestational choriocarcinoma
DI   ORDO; Orphanet_99926; Gestational choriocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0044 ! BeWo
SX   Male
AG   Fetus
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 43
//
RX   DOI=10.1007/0-306-46861-1_8;
RA   Ganapathy V., Prasad P.D., Leibach F.H.;
RT   "Choriocarcinoma.";
RL   (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=62839; DOI=10.1093/jnci/56.5.911;
RA   Lieblich J.M., Weintraub B.D., Krauth G.H., Kohler P.O., Rabson A.S.,
RA   Rosen S.W.;
RT   "Ectopic and eutopic secretion of chorionic gonadotropin and its
RT   subunits in vitro: comparison of clonal strains from carcinomas of
RT   lung and placenta.";
RL   J. Natl. Cancer Inst. 56:911-917(1976).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3;
RA   Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.;
RT   "Expression of HLA class I and class II antigens in human
RT   choriocarcinoma cell lines.";
RL   Int. J. Gynecol. Obstet. 24:301-307(1986).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=5103722; DOI=10.1210/jcem-32-5-683;
RA   Kohler P.O., Bridson W.E.;
RT   "Isolation of hormone-producing clonal lines of human
RT   choriocarcinoma.";
RL   J. Clin. Endocrinol. Metab. 32:683-687(1971).
//
RX   PubMed=6220172;
RA   Dracopoli N.C., Fogh J.;
RT   "Polymorphic enzyme analysis of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 70:469-476(1983).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=7753552;
RA   Brown A.D., Lopez-Terrada D.H., Denny C., Lee K.A.W.;
RT   "Promoters containing ATF-binding sites are de-regulated in cells that
RT   express the EWS/ATF1 oncogene.";
RL   Oncogene 10:1749-1756(1995).
//
RX   PubMed=7819056; DOI=10.1038/bjc.1995.3;
RA   Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.;
RT   "Analysis of the p53 gene in human choriocarcinoma cell lines.";
RL   Br. J. Cancer 71:9-12(1995).
//
RX   PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6;
RA   Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.;
RT   "Adhesion and invasion of three human choriocarcinoma cell lines into
RT   human endometrium in a three-dimensional organ culture system.";
RL   Placenta 15:411-429(1994).
//
RX   PubMed=11994546; DOI=10.1093/molehr/8.5.485;
RA   Blanchon L., Sauvant P., Bavik C., Gallot D., Charbonne F.,
RA   Alexandre-Gouabau M.-C., Lemery D., Jacquetin B., Dastugue B., Ward S.,
RA   Sapin V.;
RT   "Human choriocarcinoma cell line JEG-3 produces and secretes active
RT   retinoids from retinol.";
RL   Mol. Hum. Reprod. 8:485-493(2002).
//
RX   PubMed=12966428; DOI=10.1038/sj.bjc.6601212;
RA   Li K.K.C., Goodall J., Goding C.R., Liao S.-K., Wang C.-H., Lin Y.-C.,
RA   Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.;
RT   "The melanocyte inducing factor MITF is stably expressed in cell lines
RT   from human clear cell sarcoma.";
RL   Br. J. Cancer 89:1072-1078(2003).
//
RX   PubMed=16797695; DOI=10.1016/j.placenta.2006.05.001;
RA   Burleigh D.W., Kendziorski C.M., Choi Y.J., Grindle K.M.,
RA   Grendell R.L., Magness R.R., Golos T.G.;
RT   "Microarray analysis of BeWo and JEG3 trophoblast cell lines:
RT   identification of differentially expressed transcripts.";
RL   Placenta 28:383-389(2007).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007;
RA   Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.;
RT   "HTR-8/SVneo cell line contains a mixed population of cells.";
RL   Placenta 50:1-7(2017).
//
RX   PubMed=28724925; DOI=10.1038/s41598-017-06364-z;
RA   Rothbauer M., Patel N., Gondola H., Siwetz M., Huppertz B., Ertl P.;
RT   "A comparative study of five physiological key parameters between four
RT   different human trophoblast-derived cell lines.";
RL   Sci. Rep. 7:5892-5892(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=33096371; DOI=10.1016/j.placenta.2020.10.011;
RA   Weber M., Weise A., Vasheghani F., Gohner C., Fitzgerald J.S.,
RA   Liehr T., Markert U.R.;
RT   "Cytogenomics of six human trophoblastic cell lines.";
RL   Placenta 103:72-75(2021).
//
RX   PubMed=33810901; DOI=10.1016/j.placenta.2021.02.022;
RA   Pastuschek J., Nonn O., Gutierrez-Samudio R.N., Murrieta-Coxca J.M.,
RA   Muller J., Sanft J., Huppertz B., Markert U.R., Groten T.,
RA   Morales-Prieto D.M.;
RT   "Molecular characteristics of established trophoblast-derived cell
RT   lines.";
RL   Placenta 108:122-133(2021).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//