ID   J.CaM1.6
AC   CVCL_0354
SY   J CaM 1.6; J-CaM-1.6; JCam-1.6; JCaM 1.6; JCAM 1.6; JCaM1.6; Jcam clone 1.6; J.CaM1; JCaM-1; JCaM1; JCAM1; Jurkat-derived Ca2+ mutant no. 1
DR   BTO; BTO:0003314
DR   CLO; CLO_0006983
DR   MCCL; MCC:0000248
DR   CLDB; cl2934
DR   ATCC; CRL-2063
DR   BioSample; SAMN03471427
DR   cancercelllines; CVCL_0354
DR   ECACC; 96060401
DR   Wikidata; Q54898427
RX   PubMed=3263650;
RX   PubMed=3309950;
RX   PubMed=7592872;
RX   PubMed=8626636;
RX   PubMed=11231305;
RX   PubMed=33562083;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/j/cell-lines-detail-80.html
CC   Population: Caucasian.
CC   Characteristics: Deficient for LCK activity due to a deletion of exon 7.
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (PubMed=7592872).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): ATCC=CRL-2063; ECACC=96060401
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 8,12
ST   D16S539: 10,11
ST   D18S51: 13,22
ST   D19S433: 14.2,15
ST   D21S11: 31.2,33.2
ST   D2S1338: 19,23
ST   D3S1358: 15,17
ST   D5S818: 9
ST   D7S820: 8,10
ST   D8S1179: 13,14
ST   FGA: 20,21
ST   Penta D: 11,13
ST   Penta E: 10,11
ST   TH01: 6,9.3
ST   TPOX: 8,10
ST   vWA: 18,19
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0367 ! Jurkat E6.1
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 28
//
RX   PubMed=3263650; DOI=10.1073/pnas.85.22.8613;
RA   Goldsmith M.A., Dazin P.F., Weiss A.;
RT   "At least two non-antigen-binding molecules are required for signal
RT   transduction by the T-cell antigen receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:8613-8617(1988).
//
RX   PubMed=3309950; DOI=10.1073/pnas.84.19.6879;
RA   Goldsmith M.A., Weiss A.;
RT   "Isolation and characterization of a T-lymphocyte somatic mutant with
RT   altered signal transduction by the antigen receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:6879-6883(1987).
//
RX   PubMed=7592872; DOI=10.1074/jbc.270.44.26533;
RA   Fargnoli J., Burkhardt A.L., Laverty M., Kut S.A., van Oers N.S.C.,
RA   Weiss A., Bolen J.B.;
RT   "Syk mutation in Jurkat E6-derived clones results in lack of p72syk
RT   expression.";
RL   J. Biol. Chem. 270:26533-26537(1995).
//
RX   PubMed=8626636; DOI=10.1074/jbc.271.17.9976;
RA   Straus D.B., Chan A.C.-Y., Patai B., Weiss A.;
RT   "SH2 domain function is essential for the role of the Lck tyrosine
RT   kinase in T cell receptor signal transduction.";
RL   J. Biol. Chem. 271:9976-9981(1996).
//
RX   PubMed=11231305; DOI=10.1046/j.1432-1327.2001.02028.x;
RA   Livolsi A., Busuttil V., Imbert V., Abraham R.T., Peyron J.-F.;
RT   "Tyrosine phosphorylation-dependent activation of NF-kappa B.
RT   Requirement for p56 LCK and ZAP-70 protein tyrosine kinases.";
RL   Eur. J. Biochem. 268:1508-1515(2001).
//
RX   PubMed=33562083; DOI=10.3390/cells10020343;
RA   Vico-Barranco I., de Arbulo-Echevarria M.M., Serrano-Garcia I.,
RA   Perez-Linaza A., Miranda-Sayago J.M., Miazek A., Narbona-Sanchez I.,
RA   Aguado E.;
RT   "A novel, LAT/Lck double deficient T cell subline J.CaM1.7 for
RT   combined analysis of early TCR signaling.";
RL   Cells 10:343.1-343.20(2021).
//