ID   IMIM-PC2
AC   CVCL_0345
SY   IMIM-PC-2; IMIM PC-2; IMIMPC2; IM2; Instituto Municipal de Investigacion Medica-Pancreas Cancer 2
DR   MCCL; MCC:0000241
DR   cancercelllines; CVCL_0345
DR   Cosmic; 710859
DR   Cosmic; 948728
DR   IARC_TP53; 16741
DR   Wikidata; Q54897589
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=7723277;
RX   PubMed=8026879;
RX   PubMed=8795137;
RX   PubMed=9665481;
RX   PubMed=11169957;
RX   PubMed=11787853;
RX   PubMed=22585861;
CC   Doubling time: 33.6 hours (PubMed=7723277).
CC   HLA typing: A*25; B*18 (PubMed=8795137).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8026879; PubMed=11787853).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=8026879; PubMed=11787853).
CC   Omics: Transcriptomics; Microarray.
CC   Misspelling: IMM-PC2; Note=Occasionally.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
ST   Source(s): PubMed=22585861
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 8,10
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 14,16
DI   NCIt; C9120; Pancreatic ductal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=11787853; DOI=10.1007/s004280100474;
RA   Moore, Patrick S.
RA   Sipos, Bence
RA   Orlandini, Simonetta
RA   Sorio, Claudio
RA   Real, Francisco X.
RA   Lemoine, Nicholas Robert
RA   Gress, Thomas M.
RA   Bassi, Claudio
RA   Kloppel, Gunter
RA   Kalthoff, Holger
RA   Ungefroren, Hendrik
RA   Lohr, Johannes-Matthias
RA   Scarpa, Aldo
RT   "Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras,
RT   p53, p16 and DPC4/Smad4.";
RL   Virchows Arch. 439:798-802(2001).
//
RX   PubMed=7723277;
RA   Vila, Maya R.
RA   Lloreta, Josep
RA   Schussler, Martina H.
RA   Berrozpe, Georgina
RA   Welt, Sydney
RA   Real, Francisco X.
RT   "New pancreas cancers cell lines that represent distinct stages of
RT   ductal differentiation.";
RL   Lab. Invest. 72:395-404(1995).
//
RX   PubMed=11169957; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1014>3.0.CO;2-U;
RA   Wallrapp, Christine
RA   Hahnel, Susanne
RA   Boeck, Wolfgang
RA   Soder, Anja
RA   Mincheva, Antoaneta
RA   Lichter, Peter
RA   Leder, Gerhard
RA   Gansauge, Frank
RA   Sorio, Claudio
RA   Scarpa, Aldo
RA   Gress, Thomas M.
RT   "Loss of the Y chromosome is a frequent chromosomal imbalance in
RT   pancreatic cancer and allows differentiation to chronic
RT   pancreatitis.";
RL   Int. J. Cancer 91:340-344(2001).
//
RX   PubMed=8795137; DOI=10.1111/j.1399-0039.1996.tb02572.x;
RA   Torres, M.J.
RA   Ruiz-Cabello Osuna, Francisco
RA   Skoudy, Anouchka
RA   Berrozpe, Georgina
RA   Jimenez, Pilar
RA   Serrano, Alfonso
RA   Real, Francisco X.
RA   Garrido, Federico
RT   "Loss of an HLA haplotype in pancreas cancer tissue and its
RT   corresponding tumor derived cell line.";
RL   Tissue Antigens 47:372-381(1996).
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser, Markus Udo
RA   Ruckert, Felix
RA   Niedergethmann, Marco
RA   Grutzmann, Robert
RA   Saeger, Hans-Detlev
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=8026879; DOI=10.1002/ijc.2910580207;
RA   Berrozpe, Georgina
RA   Schaeffer, James
RA   Peinado, Miguel Angel
RA   Real, Francisco X.
RA   Perucho, Manuel
RT   "Comparative analysis of mutations in the p53 and K-ras genes in
RT   pancreatic cancer.";
RL   Int. J. Cancer 58:185-191(1994).
//
RX   PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396;
RA   Marcotte, Richard
RA   Brown, Kevin R.
RA   Suarez Saiz, Fernando Jose
RA   Sayad, Azin
RA   Karamboulas, Konstantina
RA   Krzyzanowski, Paul M.
RA   Sircoulomb, Fabrice
RA   Medrano, Mauricio
RA   Fedyshyn, Yaroslav
RA   Koh, Judice Lie-Yong
RA   van Dyk, Dewald
RA   Fedyshyn, Bohdana
RA   Luhova, Marianna
RA   Brito, Glauber C.
RA   Vizeacoumar, Franco J.
RA   Vizeacoumar, Frederick S.
RA   Datti, Alessandro
RA   Kasimer, Dahlia
RA   Buzina, Alla
RA   Mero, Patricia
RA   Misquitta, Christine
RA   Normand, Josee
RA   Haider, Maliha
RA   Ketela, Troy
RA   Wrana, Jeffrey L.
RA   Rottapel, Robert
RA   Neel, Benjamin G.
RA   Moffat, Jason
RT   "Essential gene profiles in breast, pancreatic, and ovarian cancer
RT   cells.";
RL   Cancer Discov. 2:172-189(2012).
//
RX   PubMed=9665481; DOI=10.1016/S0002-9440(10)65561-7; PMCID=PMC1852940;
RA   Paciucci, Rosanna
RA   Vila, Maya R.
RA   Adell, Teresa
RA   Diaz, Victor M.
RA   Tora, Montserrat
RA   Nakamura, Toshikazu
RA   Real, Francisco X.
RT   "Activation of the urokinase plasminogen activator/urokinase
RT   plasminogen activator receptor system and redistribution of E-cadherin
RT   are associated with hepatocyte growth factor-induced motility of
RT   pancreas tumor cells overexpressing Met.";
RL   Am. J. Pathol. 153:201-212(1998).
//