ID   IB3-1
AC   CVCL_0338
SY   IB3
DR   BTO; BTO_0004445
DR   CLO; CLO_0004329
DR   EFO; EFO_0001194
DR   MCCL; MCC:0000234
DR   ATCC; CRL-2777
DR   ATCC; JHU-52
DR   BCRJ; 0114
DR   ChEMBL-Cells; CHEMBL4295410
DR   ChEMBL-Targets; CHEMBL4296439
DR   PubChem_Cell_line; CVCL_0338
DR   Wikidata; Q54897163
RX   PubMed=1380129;
RX   PubMed=1849726;
RX   PubMed=7679117;
RX   PubMed=15463957;
RX   PubMed=16512671;
RX   PubMed=18441018;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/i/cell-lines-detail-527.html
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Phe508del (c.1521_1523delCTT); ClinVar=VCV000007105; Zygosity=Heterozygous (PubMed=15463957).
CC   Sequence variation: Mutation; HGNC; HGNC:1884; CFTR; Simple; p.Trp1282Ter (c.3846G>A); ClinVar=VCV000007129; Zygosity=Heterozygous (PubMed=15463957).
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Omics: Proteomics; 2DE-MS.
CC   Discontinued: ATCC; CRL-2777; true.
CC   Discontinued: ATCC; JHU-52; true.
ST   Source(s): ATCC=CRL-2777
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8,12,13
ST   D16S539: 9,11
ST   D5S818: 11,12,13
ST   D7S820: 11,12
ST   TH01: 8,9.3
ST   TPOX: 8,9
ST   vWA: 15,18
DI   NCIt; C2975; Cystic fibrosis
DI   ORDO; Orphanet_586; Cystic fibrosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   7Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 23
CH   CVCL_4462 ! IB3-1/C38
CH   CVCL_4461 ! IB3-1/S9
//
RX   PubMed=7679117; DOI=10.1016/S0021-9258(18)53762-5;
RA   Flotte, Terence R.
RA   Afione, Sandra A.
RA   Solow, Rikki
RA   Drumm, Mitchell L.
RA   Markakis, Diane
RA   Guggino, William B.
RA   Zeitlin, Pamela L.
RA   Carter, Barrie J.
RT   "Expression of the cystic fibrosis transmembrane conductance regulator
RT   from a novel adeno-associated virus promoter.";
RL   J. Biol. Chem. 268:3781-3790(1993).
//
RX   PubMed=16512671; DOI=10.1021/pr050319o;
RA   Singh, Om V.
RA   Vij, Neeraj
RA   Mogayzel, Peter Joseph Jr.
RA   Jozwik, Catherine Edith
RA   Pollard, Harvey B.
RA   Zeitlin, Pamela L.
RT   "Pharmacoproteomics of 4-phenylbutyrate-treated IB3-1 cystic fibrosis
RT   bronchial epithelial cells.";
RL   J. Proteome Res. 5:562-571(2006).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert, Dieter C.
RA   Willems, Marjolaine
RA   Cassiman, Jean-Jacques
RA   Frizzell, Raymond A.
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=1380129; DOI=10.1038/358581a0;
RA   Egan, Marie
RA   Flotte, Terence R.
RA   Afione, Sandra A.
RA   Solow, Rikki
RA   Zeitlin, Pamela L.
RA   Carter, Barrie J.
RA   Guggino, William B.
RT   "Defective regulation of outwardly rectifying Cl- channels by protein
RT   kinase A corrected by insertion of CFTR.";
RL   Nature 358:581-584(1992).
//
RX   PubMed=1849726; DOI=10.1165/ajrcmb/4.4.313;
RA   Zeitlin, Pamela L.
RA   Lu, Luo
RA   Rhim, Johng Sik
RA   Cutting, Garry R.
RA   Stetten, Gail
RA   Kieffer, K.A.
RA   Craig, Robert
RA   Guggino, William B.
RT   "A cystic fibrosis bronchial epithelial cell line: immortalization by
RT   adeno-12-SV40 infection.";
RL   Am. J. Respir. Cell Mol. Biol. 4:313-319(1991).
//
RX   PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200; PMCID=PMC2444007;
RA   Andersson, Charlotte
RA   Al-Turkmani, M. Rabie
RA   Savaille, Juanito E.
RA   Alturkmani, Ragheed
RA   Katrangi, Waddah
RA   Cluette-Brown, Joanne E.
RA   Zaman, Munir M.
RA   Laposata, Michael
RA   Freedman, Steven D.
RT   "Cell culture models demonstrate that CFTR dysfunction leads to
RT   defective fatty acid composition and metabolism.";
RL   J. Lipid Res. 49:1692-1700(2008).
//