ID Hs 746.T AC CVCL_0333 SY Hs 746T; HS 746T; Hs-746T; HS-746T; Hs746T; HS746T; Hs746-T; 746T DR CLO; CLO_0004094 DR EFO; EFO_0006589 DR MCCL; MCC:0000229 DR AddexBio; C0023003/4957 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; HTB-135 DR BioSample; SAMN03470907 DR BioSample; SAMN03472714 DR BioSample; SAMN10987647 DR cancercelllines; CVCL_0333 DR CCRID; 4201HUM-CCTCC00069 DR CCTCC; GDC0069 DR Cell_Model_Passport; SIDM00665 DR ChEMBL-Cells; CHEMBL3307498 DR ChEMBL-Targets; CHEMBL614579 DR CLS; 305121 DR Cosmic; 1187275 DR Cosmic; 1329184 DR Cosmic; 1460704 DR Cosmic; 1479630 DR Cosmic; 1482075 DR Cosmic; 1995447 DR Cosmic; 2069776 DR Cosmic; 2484963 DR Cosmic-CLP; 1240151 DR DepMap; ACH-000616 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 1240151 DR GEO; GSM267418 DR GEO; GSM267425 DR GEO; GSM267432 DR GEO; GSM267439 DR GEO; GSM552359 DR GEO; GSM562402 DR GEO; GSM827402 DR GEO; GSM844566 DR GEO; GSM887115 DR GEO; GSM888186 DR GEO; GSM1237674 DR GEO; GSM1237699 DR GEO; GSM1374552 DR GEO; GSM1669898 DR KCB; KCB 2013048YJ DR LiGeA; CCLE_544 DR LINCS_LDP; LCL-1883 DR PharmacoDB; Hs746T_594_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0333 DR PubChem_Cell_line; CVCL_0333 DR Wikidata; Q54895986 RX PubMed=283258; RX PubMed=761205; RX PubMed=6500159; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=24807215; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=29435981; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/gastric-xenograft-model/hs746t-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MET genetic alteration cell panel (ATCC TCP-1036). CC Population: Caucasian. CC Characteristics: MET-amplified, contains 13-14 copies of the gene (PubMed=29435981). CC Doubling time: 41 hours (PubMed=29435981). CC HLA typing: A*25:01,25:01; B*18:01,18:01; C*12:03,12:03; DQA1*01:02,01:02; DQB1*05:01,05:01; DRB1*01:01,01:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.16%; East Asian, North=2.9%; East Asian, South=0%; South Asian=0.58%; European, North=65.13%; European, South=31.23% (PubMed=30894373). CC Derived from site: Metastatic; Left leg, skeletal muscle; UBERON=UBERON_0001383. ST Source(s): AddexBio=C0023003/4957; ATCC=HTB-135; Cosmic-CLP=1240151; PubMed=25877200 ST Amelogenin: X,Y ST CSF1PO: 10,12 ST D13S317: 10 ST D16S539: 11 ST D18S51: 15,16 ST D19S433: 14 ST D21S11: 29 ST D2S1338: 23 ST D3S1358: 14,15 ST D5S818: 11,13 ST D7S820: 8 ST D8S1179: 13,14 ST FGA: 25 ST Penta D: 9 ST Penta E: 7,9 ST TH01: 9 ST TPOX: 8,10 ST vWA: 15,17 (AddexBio=C0023003/4957; ATCC=HTB-135; Cosmic-CLP=1240151) ST vWA: 17 (PubMed=25877200) DI NCIt; C4004; Gastric adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_S315 ! Hs 746.Sk OI CVCL_ZX69 ! Hs 750.M OI CVCL_N486 ! Hs 750.T SX Male AG 74Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 40 // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=6500159; DOI=10.1159/000163283; RA Gershwin, Merrill Eric RA Lentz, Daniel RA Owens, Robert B. RT "Relationship between karyotype of tissue culture lines and RT tumorigenicity in nude mice."; RL Exp. Cell Biol. 52:361-370(1984). // RX PubMed=761205; RA Smith, Helene S. RA Springer, E. Louise RA Hackett, Adeline Johnson RT "Nuclear ultrastructure of epithelial cell lines derived from human RT carcinomas and nonmalignant tissues."; RL Cancer Res. 39:332-344(1979). // RX PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760; RA Liu, Jin-Feng RA McCleland, Mark L. RA Stawiski, Eric W. RA Gnad, Florian RA Mayba, Oleg RA Haverty, Peter M. RA Durinck, Steffen RA Chen, Ying-Jiun RA Klijn, Christiaan RA Jhunjhunwala, Suchit RA Lawrence, Michael RA Liu, Han-Bin RA Wan, Yi-Nan RA Chopra, Vivek S. RA Yaylaoglu, Murat Burat RA Yuan, Wen-Lin RA Ha, Connie RA Gilbert, Houston N. RA Reeder, Jens RA Pau, Gregoire RA Stinson, Jeremy RA Stern, Howard M. RA Manning, Gerard RA Wu, Thomas D. RA Neve, Richard M. RA de Sauvage, Frederic J. RA Modrusan, Zora RA Seshagiri, Somasekar RA Firestein, Ron RA Zhang, Ze-Min RT "Integrated exome and transcriptome sequencing reveals ZAK isoform RT usage in gastric cancer."; RL Nat. Commun. 5:3830.1-3830.8(2014). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=29435981; DOI=10.1002/ijc.31304; RA Kim, Hyun Jeong RA Kang, Sun Kyoung RA Kwon, Woo Sun RA Kim, Tae Soo RA Jeong, Inhye RA Jeung, Hei-Cheul RA Kragh, Michael RA Horak, Ivan D. RA Chung, Hyun Cheol RA Rha, Sun Young RT "Forty-nine gastric cancer cell lines with integrative genomic RT profiling for development of c-MET inhibitor."; RL Int. J. Cancer 143:151-159(2018). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=283258; DOI=10.1093/jnci/62.2.225; RA Smith, Helene S. RT "In vitro properties of epithelial cell lines established from human RT carcinomas and nonmalignant tissue."; RL J. Natl. Cancer Inst. 62:225-230(1979). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). //