ID   Hep 3B2.1-7
AC   CVCL_0326
SY   Hep 3B2_1-7; Hep 3B 2.1-7; HEP3B217; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B
DR   BTO; BTO_0000972
DR   CLO; CLO_0003702
DR   CLO; CLO_0003703
DR   CLO; CLO_0003710
DR   EFO; EFO_0002205
DR   MCCL; MCC:0000221
DR   CLDB; cl1627
DR   CLDB; cl1628
DR   CLDB; cl1629
DR   CLDB; cl1630
DR   AddexBio; C0015001/45
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; HB-8064
DR   BCRC; 60434
DR   BCRJ; 0357
DR   BioGRID_ORCS_Cell_line; 810
DR   BioSample; SAMN03473193
DR   BioSample; SAMN10988098
DR   cancercelllines; CVCL_0326
DR   CCRID; 1101HUM-PUMC000376
DR   CCRID; 1101HUM-PUMC000474
DR   CCRID; 1102HUM-NIFDC00059
DR   CCRID; 3101HUMSCSP5045
DR   CCRID; 3101HUMTCHu106
DR   CCRID; 4201HUM-CCTCC00070
DR   CCTCC; GDC0070
DR   Cell_Model_Passport; SIDM00672
DR   CGH-DB; 454-3
DR   CGH-DB; 9069-4
DR   ChEMBL-Cells; CHEMBL4106361
DR   ChEMBL-Targets; CHEMBL4296437
DR   CLS; 305141
DR   Cosmic; 873401
DR   Cosmic; 928140
DR   Cosmic; 934549
DR   Cosmic; 948066
DR   Cosmic; 979729
DR   Cosmic; 999851
DR   Cosmic; 1019316
DR   Cosmic; 1177682
DR   Cosmic; 1351510
DR   Cosmic; 1518225
DR   Cosmic; 1628385
DR   Cosmic; 2023864
DR   Cosmic; 2162536
DR   Cosmic; 2301557
DR   Cosmic; 2321030
DR   Cosmic; 2668282
DR   Cosmic; 2773181
DR   Cosmic; 2816904
DR   Cosmic-CLP; 1240147
DR   DepMap; ACH-000625
DR   DSMZ; ACC-93
DR   DSMZCellDive; ACC-93
DR   ECACC; 86062703
DR   EGA; EGAS00001000978
DR   GDSC; 1240147
DR   GEO; GSM207050
DR   GEO; GSM501778
DR   GEO; GSM565879
DR   GEO; GSM887078
DR   GEO; GSM888148
DR   GEO; GSM936759
DR   GEO; GSM1374531
DR   GEO; GSM1669879
DR   GEO; GSM2551564
DR   IARC_TP53; 30036
DR   IGRhCellID; Hep3B
DR   IZSLER; BS TCL 78
DR   KCB; KCB 200771YJ
DR   KCB; KCB 200942YJ
DR   KCLB; 88064
DR   LiGeA; CCLE_655
DR   LIMORE; Hep3B
DR   LINCS_LDP; LCL-1924
DR   Lonza; 473
DR   PharmacoDB; Hep3B2_17_538_2019
DR   PRIDE; PXD000533
DR   PRIDE; PXD000535
DR   PRIDE; PXD005291
DR   PRIDE; PXD008190
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0326
DR   PubChem_Cell_line; CVCL_0326
DR   RCB; RCB2090
DR   TKG; TKG 0291
DR   TOKU-E; 1439
DR   TOKU-E; 3574
DR   Ubigene; YC-D002
DR   Wikidata; Q54882746
RX   DOI=10.1007/978-4-431-68349-0_4;
RX   DOI=10.11418/jtca1981.16.3_173;
RX   Patent=US4393133;
RX   PubMed=233137;
RX   PubMed=2439335;
RX   PubMed=3023526;
RX   PubMed=3431441;
RX   PubMed=6248960;
RX   PubMed=6275024;
RX   PubMed=6288577;
RX   PubMed=7972006;
RX   PubMed=8050184;
RX   PubMed=8224613;
RX   PubMed=8389256;
RX   PubMed=8835345;
RX   PubMed=9290701;
RX   PubMed=9359923;
RX   PubMed=10523694;
RX   PubMed=11050057;
RX   PubMed=12029633;
RX   PubMed=15767549;
RX   PubMed=20215515;
RX   PubMed=20454443;
RX   PubMed=20937217;
RX   PubMed=22460905;
RX   PubMed=23505090;
RX   PubMed=23887712;
RX   PubMed=24116068;
RX   PubMed=25574106;
RX   PubMed=25877200;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29610054;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31063779;
RX   PubMed=31068700;
RX   PubMed=31378681;
RX   PubMed=31395879;
RX   PubMed=31978347;
RX   PubMed=32899426;
RX   PubMed=34320349;
RX   PubMed=35839778;
WW   Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/Hep3B
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Info; Quora; -; https://www.quora.com/What-is-a-Hep-3B-cell-line
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-106.html
WW   Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/hep3b-xenograft-model/
WW   Provider; BRICS; BRICS0054; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3869
CC   Group: Patented cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: JFCR45 cancer cell line panel.
CC   Part of: Liver Cancer Model Repository (LIMORE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: TCGA-110-CL cell line panel.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); HB-8064.
CC   Population: African American.
CC   Doubling time: 28.05 hours (PubMed=31378681); ~40-50 hours (DSMZ=ACC-93).
CC   Karyotypic information: Has lost chromosome Y.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Arg146Ter (c.436C>T); Zygosity=Homozygous (PubMed=31395879; Cosmic-CLP=1240147; DepMap=ACH-000625).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (PubMed=31395879; Cosmic-CLP=1240147; DepMap=ACH-000625).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=71.82%; Native American=0.52%; East Asian, North=3.16%; East Asian, South=0%; South Asian=0%; European, North=8.8%; European, South=15.69% (PubMed=30894373).
CC   Misspelling: Hep_3B1_1-7; Cosmic=2773181.
CC   Discontinued: RCB; RCB2090; true.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): AddexBio=C0015001/45; ATCC=HB-8064; CCRID; Cosmic-CLP=1240147; DSMZ=ACC-93; ECACC=86062703; KCLB=88064; PubMed=24116068; PubMed=25877200; PubMed=31378681
ST   Amelogenin: X
ST   CSF1PO: 8
ST   D13S317: 12,14
ST   D16S539: 10
ST   D18S51: 20
ST   D19S433: 12.2,14
ST   D21S11: 30,31
ST   D2S1338: 21,25
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 8,10
ST   D8S1179: 12
ST   FGA: 18
ST   Penta D: 12,14
ST   Penta E: 5,16 (ATCC=HB-8064; CCRID; PubMed=25877200)
ST   Penta E: 16 (DSMZ=ACC-93)
ST   TH01: 6,7
ST   TPOX: 9
ST   vWA: 17
DI   NCIt; C7955; Childhood hepatocellular carcinoma
DI   ORDO; Orphanet_33402; Pediatric hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 50
CH   CVCL_B6FG ! F6D2
CH   CVCL_C8YA ! Hep 3B-Luc
CH   CVCL_C8Q9 ! Hep3B-c1
CH   CVCL_XE51 ! Hep3b-Cas9-741
CH   CVCL_XE52 ! Hep3b-Cas9-742
CH   CVCL_XE53 ! Hep3b-Cas9-743
CH   CVCL_XE54 ! Hep3b-Cas9-744
CH   CVCL_XE55 ! Hep3b-Cas9-745
CH   CVCL_DI39 ! Hep3BLAP-I
CH   CVCL_DI40 ! Hep3BLAP-II
CH   CVCL_DI41 ! Hep3BLIP-I
CH   CVCL_DI42 ! Hep3BLIP-II
CH   CVCL_F1PZ ! HyCyte Hep 3B2.1-7 KO-hMFSD2A
CH   CVCL_E3HF ! HyCyte Hep 3B2.1-7-Luc
CH   CVCL_W815 ! REPC
CH   CVCL_D9W5 ! Ubigene Hep 3B2.1-7 LZTR1 KO
CH   CVCL_D9W6 ! Ubigene Hep 3B2.1-7 NR1H4 KO
//
RX   PubMed=23887712; DOI=10.1038/ncomms3218; PMCID=PMC3731665;
RA   Nault, Jean-Charles
RA   Mallet, Maxime
RA   Pilati, Camilla
RA   Calderaro, Julien
RA   Bioulac-Sage, Paulette
RA   Laurent, Christophe
RA   Laurent, Alexis
RA   Cherqui, Daniel
RA   Balabaud, Charles
RA   Zucman-Rossi, Jessica
RT   "High frequency of telomerase reverse-transcriptase promoter somatic
RT   mutations in hepatocellular carcinoma and preneoplastic lesions.";
RL   Nat. Commun. 4:2218.1-2218.7(2013).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=20937217; DOI=10.1170/149;
RA   Di Masi, Alessandra
RA   Viganotti, Mara
RA   Antoccia, Antonio
RA   Magrelli, Armando
RA   Salvatore, Marco
RA   Azzalin, Gianluca
RA   Tosto, Fabrizio
RA   Lorenzetti, Stefano
RA   Maranghi, Francesca
RA   Mantovani, Alberto
RA   Macino, Giuseppe
RA   Tanzarella, Caterina
RA   Taruscio, Domenica
RT   "Characterization of HuH6, Hep3B, HepG2 and HLE liver cancer cell
RT   lines by WNT/beta-catenin pathway, microRNA expression and protein
RT   expression profile.";
RL   Cell. Mol. Biol. 56:OL1299-OL1317(2010).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=6275024; DOI=10.1099/0022-1317-57-1-95;
RA   Koshy, Rajen
RA   Maupas, Philippe
RA   Muller, R.
RA   Hofschneider, Peter Hans
RT   "Detection of hepatitis B virus-specific DNA in the genomes of human
RT   hepatocellular carcinoma and liver cirrhosis tissues.";
RL   J. Gen. Virol. 57:95-102(1981).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang, Kai
RA   Lim, Ho Yeong
RA   Shi, Stephanie
RA   Lee, Jeeyun
RA   Deng, Shi-Bing
RA   Xie, Tao
RA   Zhu, Zhou
RA   Wang, Yu-Li
RA   Pocalyko, David
RA   Yang, Wei Jennifer
RA   Rejto, Paul A.
RA   Mao, Mao
RA   Park, Cheol-Keun
RA   Xu, Jiang-Chun
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=29610054; DOI=10.1016/j.dmpk.2018.03.003; PMCID=PMC6309175;
RA   Shi, Jian
RA   Wang, Xin-Wen
RA   Lyu, Ling-Yun
RA   Jiang, Hui
RA   Zhu, Hao-Jie
RT   "Comparison of protein expression between human livers and the hepatic
RT   cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics:
RT   Focusing on drug-metabolizing enzymes.";
RL   Drug Metab. Pharmacokinet. 33:133-140(2018).
//
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu, Noriyuki
RA   Yoshida, Yoko
RA   Yamazaki, Kanami
RA   Nakamura, Tomoki
RA   Dan, Shingo
RA   Fukui, Yasuhisa
RA   Yamori, Takao
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
//
RX   PubMed=6248960; DOI=10.1126/science.6248960;
RA   Knowles, Barbara B.
RA   Howe, Chin C.
RA   Aden, David P.
RT   "Human hepatocellular carcinoma cell lines secrete the major plasma
RT   proteins and hepatitis B surface antigen.";
RL   Science 209:497-499(1980).
//
RX   PubMed=2439335; DOI=10.1111/j.1432-1033.1987.tb11497.x;
RA   Vincent, Claude
RA   Marceau, Marianne
RA   Blangarin, Pascale
RA   Bouic, Patrick
RA   Madjar, Jean-Jacques
RA   Revillard, Jean-Pierre
RT   "Purification of alpha 1-microglobulin produced by human hepatoma cell
RT   lines. Biochemical characterization and comparison with alpha
RT   1-microglobulin synthesized by human hepatocytes.";
RL   Eur. J. Biochem. 165:699-704(1987).
//
RX   DOI=10.1007/978-4-431-68349-0_4;
RA   Alexander, Jennifer J.
RT   "Human hepatoma cell lines.";
RL   (In book chapter) Neoplasms of the liver; Okuda, Kunio & Ishak, Kamal George (eds.); pp.47-56; Springer; Tokyo; Japan (1987).
//
RX   PubMed=12029633; DOI=10.1053/jhep.2002.33683;
RA   Yasui, Kohichiroh
RA   Arii, Shigeki
RA   Zhao, Chen
RA   Imoto, Issei
RA   Ueda, Masakazu
RA   Nagai, Hisaki
RA   Emi, Mitsuru
RA   Inazawa, Johji
RT   "TFDP1, CUL4A, and CDC16 identified as targets for amplification at
RT   13q34 in hepatocellular carcinomas.";
RL   Hepatology 35:1476-1484(2002).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724;
RA   Qiu, Zhi-Xin
RA   Li, Hong
RA   Zhang, Zheng-Tao
RA   Zhu, Zhen-Feng
RA   He, Sheng
RA   Wang, Xu-Jun
RA   Wang, Peng-Cheng
RA   Qin, Jian-Jie
RA   Zhuang, Li-Ping
RA   Wang, Wei
RA   Xie, Fu-Bo
RA   Gu, Ying
RA   Zou, Ke-Ke
RA   Li, Chao
RA   Li, Chun
RA   Wang, Chen-Hua
RA   Cen, Jin
RA   Chen, Xiao-Tao
RA   Shu, Ya-Jing
RA   Zhang, Zhao
RA   Sun, Lu-Lu
RA   Min, Li-Hua
RA   Fu, Yong
RA   Huang, Xiao-Wu
RA   Lv, Hui
RA   Zhou, He
RA   Ji, Yuan
RA   Zhang, Zhi-Gang
RA   Meng, Zhi-Qiang
RA   Shi, Xiao-Lei
RA   Zhang, Hai-Bin
RA   Li, Yi-Xue
RA   Hui, Li-Jian
RT   "A pharmacogenomic landscape in human liver cancers.";
RL   Cancer Cell 36:179-193.e11(2019).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia, Li-Qun
RA   Osada, Motonobu
RA   Ishioka, Chikashi
RA   Gamo, Makio
RA   Ikawa, Shuntaro
RA   Suzuki, Takao
RA   Shimodaira, Hideki
RA   Niitani, Tomohito
RA   Kudo, Toshio
RA   Akiyama, Mitoshi
RA   Kimura, Narimiti
RA   Matsuo, Mitsuyoshi
RA   Mizusawa, Hiroshi
RA   Tanaka, Noriho
RA   Koyama, Hideki
RA   Namba, Masayoshi
RA   Kanamaru, Ryunosuke
RA   Kuroki, Toshio
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785;
RA   Yu, Katharine
RA   Chen, Bin
RA   Aran, Dvir
RA   Charalel, Joe
RA   Yau, Christina
RA   Wolf, Douglas M.
RA   van 't Veer, Laura J.
RA   Butte, Atul Janardhan
RA   Goldstein, Ted
RA   Sirota, Marina
RT   "Comprehensive transcriptomic analysis of cell lines as models of
RT   primary tumors across 22 tumor types.";
RL   Nat. Commun. 10:3574.1-3574.11(2019).
//
RX   Patent=US4393133;
RA   Knowles, Barbara B.
RA   Aden, David P.
RT   "Human hepatoma derived cell line, process for preparation thereof,
RT   and uses therefor.";
RL   Patent number US4393133, 12-Jul-1983.
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=3023526; DOI=10.1099/0022-1317-67-11-2315;
RA   Aspinall, Sanet
RA   Alexander, Jennifer J.
RA   Bos, Pieter
RT   "Comparative expression of hepatitis B virus antigens in several cell
RT   model systems.";
RL   J. Gen. Virol. 67:2315-2323(1986).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin Karl
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=11050057; DOI=10.1053/jhep.2000.19349;
RA   Wong, Nathalie
RA   Lai, Paul Bo-San
RA   Pang, Elizabeth
RA   Leung, Thomas Wai-Tong
RA   Lau, Joseph Wan-Yee
RA   Johnson, Philip James
RT   "A comprehensive karyotypic study on human hepatocellular carcinoma by
RT   spectral karyotyping.";
RL   Hepatology 32:1060-1068(2000).
//
RX   PubMed=6288577; DOI=10.1002/ijc.2910300106;
RA   Simon, Daniela
RA   Aden, David P.
RA   Knowles, Barbara B.
RT   "Chromosomes of human hepatoma cell lines.";
RL   Int. J. Cancer 30:27-33(1982).
//
RX   PubMed=24116068; DOI=10.1371/journal.pone.0075692; PMCID=PMC3792989;
RA   Weiskirchen, Ralf
RA   Weimer, Jorg
RA   Meurer, Steffen K.
RA   Kron, Anja
RA   Seipel, Barbara
RA   Vater, Inga
RA   Arnold, Norbert
RA   Siebert, Reiner
RA   Xu, Lie-Ming
RA   Friedman, Scott Laurence
RA   Bergmann, Carsten
RT   "Genetic characteristics of the human hepatic stellate cell line LX-2.";
RL   PLoS ONE 8:e75692.1-e75692.9(2013).
//
RX   PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001;
RA   Caruso, Stefano
RA   Calatayud, Anna-Line
RA   Pilet, Jill
RA   La Bella, Tiziana
RA   Rekik, Samia
RA   Imbeaud, Sandrine
RA   Letouze, Eric
RA   Meunier, Lea
RA   Bayard, Quentin
RA   Rohr-Udilova, Nataliya
RA   Peneau, Camille
RA   Grasl-Kraupp, Bettina
RA   de Koning, Leanne
RA   Ouine, Berengere
RA   Bioulac-Sage, Paulette
RA   Couchy, Gabrielle
RA   Calderaro, Julien
RA   Nault, Jean-Charles
RA   Zucman-Rossi, Jessica
RA   Rebouissou, Sandra
RT   "Analysis of liver cancer cell lines identifies agents with likely
RT   efficacy against hepatocellular carcinoma and markers of response.";
RL   Gastroenterology 157:760-776(2019).
//
RX   PubMed=8389256; DOI=10.1093/carcin/14.5.987;
RA   Hsu, Ih-Chang
RA   Tokiwa, Takayoshi
RA   Bennett, William P.
RA   Metcalf, Robert A.
RA   Welsh, Judith A.
RA   Sun, Tsung-Tang
RA   Harris, Curtis Craig
RT   "p53 gene mutation and integrated hepatitis B viral DNA sequences in
RT   human liver cancer cell lines.";
RL   Carcinogenesis 14:987-992(1993).
//
RX   PubMed=3431441; DOI=10.1016/s0076-6879(87)51006-0;
RA   Darlington, Gretchen J.
RT   "Liver cell lines.";
RL   Methods Enzymol. 151:19-38(1987).
//
RX   PubMed=233137; DOI=10.1038/282615a0;
RA   Aden, David P.
RA   Fogel, Alice
RA   Plotkin, Stanley Alan
RA   Damjanov, Ivan
RA   Knowles, Barbara B.
RT   "Controlled synthesis of HBsAg in a differentiated human liver
RT   carcinoma-derived cell line.";
RL   Nature 282:615-616(1979).
//
RX   PubMed=8224613; DOI=10.1096/fasebj.7.14.8224613;
RA   Puisieux, Alain
RA   Galvin, Katherine
RA   Troalen, Frederic
RA   Bressac, Brigitte
RA   Marcais, Christophe
RA   Galun, Eithan
RA   Ponchel, Frederique
RA   Yakicier, Cengiz
RA   Ji, Jing-Wei
RA   Ozturk, Mehmet
RT   "Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell
RT   lines.";
RL   FASEB J. 7:1407-1413(1993).
//
RX   PubMed=34320349; DOI=10.1016/j.celrep.2021.109441; PMCID=PMC8333195;
RA   Jochems, Fleur
RA   Thijssen, Bram
RA   De Conti, Giulia
RA   Jansen, Robin
RA   Pogacar, Ziva
RA   Groot, Kelvin
RA   Wang, Li-Qin
RA   Schepers, Arnout
RA   Wang, Cun
RA   Jin, Hao-Jie
RA   Beijersbergen, Roderick L.
RA   Leite de Oliveira, Rodrigo
RA   Wessels, Lodewyk F.A.
RA   Bernards, Rene
RT   "The cancer SENESCopedia: a delineation of cancer cell senescence.";
RL   Cell Rep. 36:109441.1-109441.22(2021).
//
RX   PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350;
RA   Cevik, Dilek
RA   Yildiz, Gokhan
RA   Ozturk, Mehmet
RT   "Common telomerase reverse transcriptase promoter mutations in
RT   hepatocellular carcinomas from different geographical locations.";
RL   World J. Gastroenterol. 21:311-317(2015).
//
RX   DOI=10.11418/jtca1981.16.3_173;
RA   Mihara, Koichiro
RA   Miyazaki, Masahiro
RA   Fushimi, Kazuo
RA   Tsuji, Toshiya
RA   Inoue, Yusuke
RA   Fukaya, Ken-ichi
RA   Ohashi, Ryuichiro
RA   Namba, Masayoshi
RT   "The p53 gene status and other cellular characteristics of human cell
RT   lines maintained in our laboratory.";
RL   Tissue Cult. Res. Commun. 16:173-178(1997).
//
RX   PubMed=10523694; DOI=10.3892/or.6.6.1267;
RA   Gao, Chong
RA   Ohashi, Ryuichiro
RA   Pu, Hong
RA   Inoue, Yusuke
RA   Tsuji, Toshiya
RA   Miyazaki, Masahiro
RA   Namba, Masayoshi
RT   "Yeast functional assay of the p53 gene status in 11 cell lines and 26
RT   surgical specimens of human hepatocellular carcinoma.";
RL   Oncol. Rep. 6:1267-1271(1999).
//
RX   PubMed=8835345; DOI=10.1002/(SICI)1096-9071(199602)48:2<133::AID-JMV3>3.0.CO;2-A;
RA   Tsuboi, So
RA   Nagamori, Seishi
RA   Miyazaki, Masahiro
RA   Mihara, Koichiro
RA   Fukaya, Ken-ichi
RA   Teruya, Kiichiro
RA   Kosaka, Tsunenori
RA   Tsuji, Takao
RA   Namba, Masayoshi
RT   "Persistence of hepatitis C virus RNA in established human
RT   hepatocellular carcinoma cell lines.";
RL   J. Med. Virol. 48:133-140(1996).
//
RX   PubMed=9359923; DOI=10.18926/AMO/30789;
RA   Mihara, Koichiro
RA   Miyazaki, Masahiro
RA   Kondo, Tadashi
RA   Fushimi, Kazuo
RA   Tsuji, Toshiya
RA   Inoue, Yusuke
RA   Fukaya, Ken-ichi
RA   Ishioka, Chikashi
RA   Namba, Masayoshi
RT   "Yeast functional assay of the p53 gene status in human cell lines
RT   maintained in our laboratory.";
RL   Acta Med. Okayama 51:261-265(1997).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163;
RA   Okamoto, Aikou
RA   Demetrick, Douglas J.
RA   Spillare, Elisa A.
RA   Hagiwara, Koichi
RA   Hussain, S. Perwez
RA   Bennett, William P.
RA   Forrester, Kathleen
RA   Gerwin, Brenda Isen
RA   Serrano, Manuel
RA   Beach, David H.
RA   Harris, Curtis Craig
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=32899426; DOI=10.3390/cancers12092510; PMCID=PMC7565451;
RA   Scherer, Dominique
RA   Davila-Lopez, Marcela
RA   Goeppert, Benjamin
RA   Abrahamsson, Sanna
RA   Gonzalez Silos, Rosa
RA   Nova, Igor
RA   Marcelain, Katherine
RA   Roa, Juan Carlos
RA   Ibberson, David
RA   Umu, Sinan U.
RA   Rounge, Trine Ballestad
RA   Roessler, Stephanie
RA   Lorenzo-Bermejo, Justo
RT   "RNA sequencing of hepatobiliary cancer cell lines: data and
RT   applications to mutational and transcriptomic profiling.";
RL   Cancers (Basel) 12:2510.1-2510.14(2020).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=8050184; DOI=10.1111/j.1365-2249.1994.tb06089.x; PMCID=PMC1534706;
RA   Wadee, Ahmed Abdulhay
RA   Paterson, Alan
RA   Coplan, Keren Anne
RA   Reddy, Selvan G.
RT   "HLA expression in hepatocellular carcinoma cell lines.";
RL   Clin. Exp. Immunol. 97:328-333(1994).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//