ID   HL-60/ADR
AC   CVCL_0304
SY   HL60/ADR; HL60/Adr; HL60-ADR
DR   BTO; BTO_0003572
DR   MCCL; MCC:0000196
DR   cancercelllines; CVCL_0304
DR   ChEMBL-Cells; CHEMBL3833762
DR   ChEMBL-Targets; CHEMBL4296430
DR   PubChem_Cell_line; CVCL_0304
DR   Wikidata; Q54889800
RX   PubMed=2425939;
RX   PubMed=2573357;
RX   PubMed=2886122;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C7961; Adult acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0002 ! HL-60
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 26
//
RX   PubMed=2573357; DOI=10.1016/0006-2952(89)90134-2;
RA   McGrath, Tim
RA   Latoud, Chantal
RA   Arnold, Susan T.
RA   Safa, Ahmad R.
RA   Felsted, Ronald LaNay
RA   Center, Melvin S.
RT   "Mechanisms of multidrug resistance in HL60 cells. Analysis of
RT   resistance associated membrane proteins and levels of mdr gene
RT   expression.";
RL   Biochem. Pharmacol. 38:3611-3619(1989).
//
RX   PubMed=2886122; DOI=10.1016/0006-291X(87)91560-9;
RA   McGrath, Tim
RA   Center, Melvin S.
RT   "Adriamycin resistance in HL60 cells in the absence of detectable
RT   P-glycoprotein.";
RL   Biochem. Biophys. Res. Commun. 145:1171-1176(1987).
//
RX   PubMed=2425939;
RA   Marsh, Wallace
RA   Sicheri, Dolores
RA   Center, Melvin S.
RT   "Isolation and characterization of adriamycin-resistant HL-60 cells
RT   which are not defective in the initial intracellular accumulation of
RT   drug.";
RL   Cancer Res. 46:4053-4057(1986).
//