ID   HIT-T15
AC   CVCL_0301
SY   HIT T15; HIT.T15; HIT T-15; HITT15; HIT clone T15; Hamster Islet Transformed-Tioguanine resistant clone 15; HIT
DR   BTO; BTO_0000627
DR   CLO; CLO_0003758
DR   MCCL; MCC:0000192
DR   ATCC; CRL-1777
DR   IZSLER; BS TCL 188
DR   KCB; KCB 200828YJ
DR   KCLB; 21777
DR   Wikidata; Q54889679
RX   PubMed=2569024;
RX   PubMed=3535793;
RX   PubMed=6270673;
RX   PubMed=8697299;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-502.html
CC   Characteristics: Secretes insulin. Maximal stimulation is obtained with glucose, arginine and leucine (PubMed=3535793).
CC   Doubling time: 33-34 hours (PubMed=6270673).
CC   Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Pancreas, islets of Langerhans; UBERON=UBERON_0000006.
OX   NCBI_TaxID=10036; ! Mesocricetus auratus (Golden hamster)
SX   Sex unspecified
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 20
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RX   PubMed=2569024; DOI=10.1677/joe.0.1210479;
RA   Lambert, David George
RA   Atkins, Terence William
RT   "Effects of islet hormones on insulin secretion from cloned B cell
RT   lines, HIT-T15 and RINm5F.";
RL   J. Endocrinol. 121:479-485(1989).
//
RX   PubMed=3535793; DOI=10.1016/0006-291X(86)90776-X;
RA   Lambert, David George
RA   Hughes, K.
RA   Atkins, Terence William
RT   "Insulin release from a cloned hamster B-cell line (HIT-T15). The
RT   effects of glucose, amino acids, sulphonylureas and colchicine.";
RL   Biochem. Biophys. Res. Commun. 140:616-625(1986).
//
RX   PubMed=6270673; DOI=10.1073/pnas.78.7.4339; PMCID=PMC319785;
RA   Santerre, Robert F.
RA   Cook, Roland A.
RA   Crisel, Rae Marie Dodge
RA   Sharp, John D.
RA   Schmidt, Robert J.
RA   Williams, Daniel C.
RA   Wilson, Christine P.
RT   "Insulin synthesis in a clonal cell line of simian virus
RT   40-transformed hamster pancreatic beta cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:4339-4343(1981).
//
RX   PubMed=8697299;
RA   Poitout, Vincent
RA   Olson, Lawrence Karl
RA   Robertson, R. Paul
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//