ID   HCT 15
AC   CVCL_0292
SY   HCT-15; HCT.15; HCT15
DR   BTO; BTO:0002201
DR   CLO; CLO_0003666
DR   EFO; EFO_0002188
DR   MCCL; MCC:0000182
DR   CLDB; cl1576
DR   CLDB; cl4985
DR   AddexBio; C0009010/381
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CCL-225
DR   BCRC; 60539
DR   BioGRID_ORCS_Cell_line; 868
DR   BioSample; SAMN01821556
DR   BioSample; SAMN01821630
DR   BioSample; SAMN03471553
DR   BioSample; SAMN10987770
DR   cancercelllines; CVCL_0292
DR   CCRID; 1101HUM-PUMC000247
DR   CCRID; 3101HUMTCHu133
DR   CCRID; 4201HUM-CCTCC00250
DR   CCTCC; GDC0250
DR   Cell_Model_Passport; SIDM00789
DR   ChEMBL-Cells; CHEMBL3307945
DR   ChEMBL-Targets; CHEMBL612263
DR   CLS; 300229
DR   ColonAtlas; HCT15
DR   Cosmic; 711261
DR   Cosmic; 873700
DR   Cosmic; 875902
DR   Cosmic; 887222
DR   Cosmic; 897458
DR   Cosmic; 905007
DR   Cosmic; 905937
DR   Cosmic; 913889
DR   Cosmic; 934567
DR   Cosmic; 947354
DR   Cosmic; 995403
DR   Cosmic; 1044258
DR   Cosmic; 1057756
DR   Cosmic; 1066206
DR   Cosmic; 1092601
DR   Cosmic; 1122324
DR   Cosmic; 1132569
DR   Cosmic; 1175841
DR   Cosmic; 1184092
DR   Cosmic; 1187307
DR   Cosmic; 1218878
DR   Cosmic; 1305354
DR   Cosmic; 1310950
DR   Cosmic; 1312338
DR   Cosmic; 1436020
DR   Cosmic; 1466814
DR   Cosmic; 1479592
DR   Cosmic; 1526922
DR   Cosmic; 1609492
DR   Cosmic; 1676747
DR   Cosmic; 1708403
DR   Cosmic; 1995438
DR   Cosmic; 1998443
DR   Cosmic; 2036655
DR   Cosmic; 2156942
DR   Cosmic; 2301979
DR   Cosmic; 2664053
DR   Cosmic; 2727470
DR   Cosmic; 2760066
DR   Cosmic; 2800585
DR   Cosmic; 2811051
DR   Cosmic-CLP; 905937
DR   DepMap; ACH-000997
DR   DSMZ; ACC-357
DR   DSMZCellDive; ACC-357
DR   ECACC; 91030712
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 905937
DR   GEO; GSM2129
DR   GEO; GSM50189
DR   GEO; GSM50253
DR   GEO; GSM206502
DR   GEO; GSM274763
DR   GEO; GSM274764
DR   GEO; GSM481406
DR   GEO; GSM513816
DR   GEO; GSM514293
DR   GEO; GSM741257
DR   GEO; GSM743444
DR   GEO; GSM750792
DR   GEO; GSM784011
DR   GEO; GSM799332
DR   GEO; GSM799395
DR   GEO; GSM846356
DR   GEO; GSM844554
DR   GEO; GSM887063
DR   GEO; GSM888133
DR   GEO; GSM1153402
DR   GEO; GSM1178151
DR   GEO; GSM1178152
DR   GEO; GSM1178153
DR   GEO; GSM1181251
DR   GEO; GSM1181363
DR   GEO; GSM1346875
DR   GEO; GSM1374519
DR   GEO; GSM1374520
DR   GEO; GSM1374521
DR   GEO; GSM1374522
DR   GEO; GSM1448178
DR   GEO; GSM1669869
DR   GEO; GSM2124665
DR   GEO; GSM2550002
DR   IARC_TP53; 21114
DR   ICLC; HTL00001
DR   IGRhCellID; HCT15
DR   KCB; KCB 2011097YJ
DR   KCLB; 10225
DR   LiGeA; CCLE_761
DR   LINCS_LDP; LCL-1178
DR   Lonza; 492
DR   MetaboLights; MTBLS227
DR   NCI-DTP; HCT-15
DR   PharmacoDB; HCT15_518_2019
DR   PRIDE; PXD005235
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0292
DR   PubChem_Cell_line; CVCL_0292
DR   RCB; RCB1958
DR   SKY/M-FISH/CGH; 2786
DR   TKG; TKG 0504
DR   TOKU-E; 1423
DR   Wikidata; Q54882006
RX   PubMed=427742;
RX   PubMed=2041050;
RX   PubMed=7139607;
RX   PubMed=7247963;
RX   PubMed=7621404;
RX   PubMed=7972006;
RX   PubMed=8197130;
RX   PubMed=8464898;
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=9809040;
RX   PubMed=10700174;
RX   PubMed=10737795;
RX   PubMed=11314036;
RX   PubMed=11414198;
RX   PubMed=11416159;
RX   PubMed=11526487;
RX   PubMed=11668190;
RX   PubMed=12584437;
RX   PubMed=15748285;
RX   PubMed=15900046;
RX   PubMed=16854228;
RX   PubMed=17088437;
RX   PubMed=18167186;
RX   PubMed=19372543;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20570890;
RX   PubMed=20606684;
RX   PubMed=22068913;
RX   PubMed=22336246;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22460905;
RX   PubMed=22628656;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24042735;
RX   PubMed=24279929;
RX   PubMed=24670534;
RX   PubMed=24755471;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25926053;
RX   PubMed=25944804;
RX   PubMed=26169745;
RX   PubMed=26537799;
RX   PubMed=26589293;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=28179481;
RX   PubMed=28192450;
RX   PubMed=28196595;
RX   PubMed=28683746;
RX   PubMed=28854368;
RX   PubMed=29444439;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=20
WW   https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/HCT15.html
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: JFCR39 cancer cell line panel.
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Part of: NCI-60 cancer cell line panel.
CC   Part of: PI3K genetic alteration cell panel (ATCC TCP-1028).
CC   Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
CC   Population: Caucasian.
CC   Doubling time: 19 hours (PubMed=427742); ~20 hours (PubMed=7139607); 29.57 hours (PubMed=25944804); 15 hours (CLS=300229); ~20-25 hours (DSMZ=ACC-357); 20.6 hours (NCI-DTP=HCT-15).
CC   HLA typing: A*02,24; B*08,35:01:01; C*04,07; DPB1*01:01:01,04:01; DQB1*02,05:03:01; DRB1*03,14 (PubMed=15748285).
CC   HLA typing: A*02:01,24:02; B*08:01,35:01; C*04:01,07:06; DQB1*05:03,05:03 (PubMed=26589293).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=11526487; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746; PubMed=31068700; Sanger).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Arg727Met (c.2180G>T); Zygosity=Heterozygous (PubMed=17088437; PubMed=24755471; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Lys993Asn (c.2979G>T); Zygosity=Heterozygous (PubMed=17088437; PubMed=24755471; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Ile1417Leufs*2 (c.4248delC); Zygosity=Heterozygous (PubMed=17088437; PubMed=24755471; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Arg2166Ter (c.6496C>T); ClinVar=VCV000438883; Zygosity=Heterozygous (PubMed=17088437; PubMed=24755471; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; c.68-1G>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=8197130; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 914; B2M; Simple; p.Tyr30Ter (c.90C>A); Zygosity=Heterozygous (PubMed=8197130; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Cys1200Terfs (c.3599_3600delGT) (3827delGT); Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 16627; CHEK2; Simple; p.Arg145Trp (c.433C>T); ClinVar=VCV000005592; Zygosity=Heterozygous (PubMed=18167186; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=17088437; PubMed=20570890; PubMed=24755471; PubMed=28683746; ATCC=CCL-225; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (PubMed=17088437; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Asp549Asn (c.1645G>A); ClinVar=VCV000375900; Zygosity=Heterozygous (PubMed=17088437; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (PubMed=9000147; PubMed=15900046; PubMed=17088437; PubMed=28683746; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.1101-2A>C; ClinVar=VCV000635383; Zygosity=Heterozygous; Note=Splice acceptor mutation (PubMed=9000147; PubMed=15900046; PubMed=17088437; PubMed=28683746; Cosmic-CLP=905937; DepMap=ACH-000997).
CC   Omics: Array-based CGH.
CC   Omics: CNV analysis.
CC   Omics: CRISPR phenotypic screen.
CC   Omics: Deep exome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Fluorescence phenotype profiling.
CC   Omics: lncRNA expression profiling.
CC   Omics: Metabolome analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: N-glycan profiling.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=2.68%; Native American=0%; East Asian, North=5.84%; East Asian, South=0%; South Asian=0%; European, North=49.17%; European, South=42.32% (PubMed=30894373).
CC   Misspelling: HTC-15; Note=Occasionally.
CC   Misspelling: HTC15; Note=Occasionally.
CC   Discontinued: RCB; RCB1958; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
ST   Source(s): AddexBio=C0009010/381; ATCC=CCL-225; CCRID; CLS=300229; Cosmic-CLP=905937; DSMZ=ACC-357; ECACC=91030712; KCLB=10225; PubMed=11416159; PubMed=19372543; PubMed=25877200; PubMed=25926053; Technion Genomics Center; TKG=TKG 0504
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D10S1248: 13,15
ST   D12S391: 19,22
ST   D13S317: 8,11
ST   D16S539: 12,13
ST   D18S51: 11,17
ST   D19S433: 14,16
ST   D1S1656: 17.3,19.3
ST   D21S11: 29,32.2
ST   D22S1045: 17
ST   D2S1338: 17,25
ST   D2S441: 13,15
ST   D3S1358: 17
ST   D5S818: 13
ST   D7S820: 10,12
ST   D8S1179: 15
ST   DYS391: 11
ST   FGA: 15,22 (DSMZ=ACC-357)
ST   FGA: 22 (ATCC=CCL-225; CCRID; CLS=300229; PubMed=11416159; PubMed=19372543; PubMed=25877200; Technion Genomics Center)
ST   Penta D: 9,14
ST   Penta E: 7,14
ST   TH01: 7,9.3
ST   TPOX: 8,11
ST   vWA: 18,19
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3449 ! __Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-09-24; Version: 49
//
RX   PubMed=427742;
RA   Dexter D.L., Barbosa J.A., Calabresi P.;
RT   "N,N-dimethylformamide-induced alteration of cell culture
RT   characteristics and loss of tumorigenicity in cultured human colon
RT   carcinoma cells.";
RL   Cancer Res. 39:1020-1025(1979).
//
RX   PubMed=2041050; DOI=10.1093/jnci/83.11.757;
RA   Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D.,
RA   Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A.,
RA   Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.;
RT   "Feasibility of a high-flux anticancer drug screen using a diverse
RT   panel of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 83:757-766(1991).
//
RX   PubMed=7139607;
RA   Dexter D.L., Spremulli E.N., Matook G.M., Diamond I., Calabresi P.;
RT   "Inhibition of the growth of human colon cancer xenografts by polar
RT   solvents.";
RL   Cancer Res. 42:5018-5022(1982).
//
RX   PubMed=7247963; DOI=10.1016/0006-2952(81)90167-2;
RA   Crabtree G.W., Dexter D.L., Stoeckler J.D., Savarese T.M., Ghoda L.Y.,
RA   Rogler-Brown T.L., Calabresi P., Parks R.E. Jr.;
RT   "Activities of purine-metabolizing enzymes in human colon carcinoma
RT   cell lines and xenograft tumors.";
RL   Biochem. Pharmacol. 30:793-798(1981).
//
RX   PubMed=7621404; DOI=10.1016/0165-4608(94)00225-z;
RA   Chen T.-R., Dorotinsky C.S., McGuire L.J., Macy M.L., Hay R.J.;
RT   "DLD-1 and HCT-15 cell lines derived separately from colorectal
RT   carcinomas have totally different chromosome changes but the same
RT   genetic origin.";
RL   Cancer Genet. Cytogenet. 81:103-108(1995).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8197130; DOI=10.1073/pnas.91.11.4751; PMCID=PMC43866;
RA   Bicknell D.C., Rowan A.J., Bodmer W.F.;
RT   "Beta 2-microglobulin gene mutations: a study of established
RT   colorectal cell lines and fresh tumors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:4751-4755(1994).
//
RX   PubMed=8464898; DOI=10.1073/pnas.90.7.2842; PMCID=PMC46192;
RA   Browning M.J., Krausa P., Rowan A.J., Bicknell D.C., Bodmer J.G.,
RA   Bodmer W.F.;
RT   "Tissue typing the HLA-A locus from genomic DNA by sequence-specific
RT   PCR: comparison of HLA genotype and surface expression on colorectal
RT   tumor cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2842-2845(1993).
//
RX   PubMed=9000147;
RA   Cottu P.-H., Muzeau F., Estreicher A., Flejou J.-F., Iggo R.D.,
RA   Thomas G., Hamelin R.;
RT   "Inverse correlation between RER+ status and p53 mutation in
RT   colorectal cancer cell lines.";
RL   Oncogene 13:2727-2730(1996).
//
RX   PubMed=9000572;
RA   Hoang J.-M., Cottu P.-H., Thuille B., Salmon R.J., Thomas G.,
RA   Hamelin R.;
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8;
RA   Vermeulen S.J., Chen T.-R., Speleman F., Nollet F., Van Roy F.M.,
RA   Mareel M.M.;
RT   "Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18
RT   originate from one and the same patient?";
RL   Cancer Genet. Cytogenet. 107:76-79(1998).
//
RX   PubMed=10700174; DOI=10.1038/73432;
RA   Ross D.T., Scherf U., Eisen M.B., Perou C.M., Rees C., Spellman P.T.,
RA   Iyer V.R., Jeffrey S.S., van de Rijn M., Waltham M.C., Pergamenschikov A.,
RA   Lee J.C.F., Lashkari D., Shalon D., Myers T.G., Weinstein J.N.,
RA   Botstein D., Brown P.O.;
RT   "Systematic variation in gene expression patterns in human cancer cell
RT   lines.";
RL   Nat. Genet. 24:227-235(2000).
//
RX   PubMed=10737795; DOI=10.1073/pnas.97.7.3352; PMCID=PMC16243;
RA   Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J.,
RA   Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.;
RT   "APC mutations in sporadic colorectal tumors: a mutational 'hotspot'
RT   and interdependence of the 'two hits'.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000).
//
RX   PubMed=11314036; DOI=10.1038/sj.onc.1204211;
RA   Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L.,
RA   Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R.,
RA   Minna J.D.;
RT   "Searching for microsatellite mutations in coding regions in lung,
RT   breast, ovarian and colorectal cancers.";
RL   Oncogene 20:1005-1009(2001).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H.,
RA   Wolf E., Gabius H.-J.;
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet J., Zhou X.-P., Duval A., Rolland S., Hoang J.-M., Cottu P.-H.,
RA   Hamelin R.;
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=12584437; DOI=10.1159/000068544;
RA   Melcher R., Koehler S., Steinlein C., Schmid M., Mueller C.R.,
RA   Luehrs H., Menzel T., Scheppach W., Moerk H., Scheurlen M.,
RA   Koehrle J., Al-Taie O.;
RT   "Spectral karyotype analysis of colon cancer cell lines of the tumor
RT   suppressor and mutator pathway.";
RL   Cytogenet. Genome Res. 98:22-28(2002).
//
RX   PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742;
RA   Adams S., Robbins F.-M., Chen D., Wagage D., Holbeck S.L.,
RA   Morse H.C. 3rd, Stroncek D., Marincola F.M.;
RT   "HLA class I and II genotype of the NCI-60 cell lines.";
RL   J. Transl. Med. 3:11.1-11.8(2005).
//
RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
RA   Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y.,
RA   Yamazaki K., Hamada J.-i., Tada M., Moriuchi T., Ishikawa Y., Kato Y.,
RA   Tomoda H., Yamori T., Tsuruo T.;
RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
RT   new therapeutic target.";
RL   J. Natl. Cancer Inst. 97:765-777(2005).
//
RX   PubMed=16854228; DOI=10.1186/1476-4598-5-29; PMCID=PMC1550420;
RA   Bandres Elizalde E.M., Cubedo E., Agirre X., Malumbres R., Zarate R.,
RA   Ramirez N., Abajo A., Navarro A., Moreno I., Monzo M.,
RA   Garcia-Foncillas J.;
RT   "Identification by real-time PCR of 13 mature microRNAs differentially
RT   expressed in colorectal cancer and non-tumoral tissues.";
RL   Mol. Cancer 5:29.1-29.10(2006).
//
RX   PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832;
RA   Ikediobi O.N., Davies H.R., Bignell G.R., Edkins S., Stevens C.,
RA   O'Meara S., Santarius T., Avis T., Barthorpe S., Brackenbury L.,
RA   Buck G., Butler A.P., Clements J., Cole J., Dicks E., Forbes S.,
RA   Gray K., Halliday K., Harrison R., Hills K., Hinton J., Hunter C.,
RA   Jenkinson A., Jones D., Kosmidou V., Lugg R., Menzies A.,
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