ID   HCT 116
AC   CVCL_0291
SY   HCT-116; HCT.116; HCT_116; HCT116; HCT116wt; HCT-116/P; HCT-116/parental; CoCL2
DR   BTO; BTO_0001109
DR   CLO; CLO_0003665
DR   EFO; EFO_0002824
DR   MCCL; MCC:0000181
DR   CLDB; cl1574
DR   CLDB; cl1575
DR   CLDB; cl5198
DR   4DN; 4DNSRMYUIVGD
DR   Abcam; ab255451
DR   Abcam; ab273730
DR   Abcam; ab288559
DR   ABM; T8240
DR   AddexBio; C0009005/41
DR   ArrayExpress; E-MEXP-2623
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-5197
DR   ATCC; CCL-247
DR   BCRC; 60349
DR   BCRJ; 0288
DR   BioGRID_ORCS_Cell_line; 97
DR   BioSample; SAMN03470980
DR   BioSample; SAMN03471481
DR   BioSample; SAMN03473487
DR   BioSample; SAMN05292433
DR   BioSample; SAMN10988251
DR   cancercelllines; CVCL_0291
DR   CCRID; 1101HUM-PUMC000158
DR   CCRID; 1101HUM-PUMC000331
DR   CCRID; 3101HUMTCHu99
DR   CCRID; 4201HUM-CCTCC00625
DR   Cell_Model_Passport; SIDM00783
DR   ChEMBL-Cells; CHEMBL3308372
DR   ChEMBL-Targets; CHEMBL394
DR   CLS; 300195
DR   ColonAtlas; HCT116
DR   Cosmic; 711257
DR   Cosmic; 720329
DR   Cosmic; 724840
DR   Cosmic; 869794
DR   Cosmic; 870449
DR   Cosmic; 873701
DR   Cosmic; 875296
DR   Cosmic; 875425
DR   Cosmic; 875847
DR   Cosmic; 876644
DR   Cosmic; 876706
DR   Cosmic; 887223
DR   Cosmic; 889535
DR   Cosmic; 897457
DR   Cosmic; 902790
DR   Cosmic; 905936
DR   Cosmic; 913887
DR   Cosmic; 934564
DR   Cosmic; 947355
DR   Cosmic; 948126
DR   Cosmic; 948861
DR   Cosmic; 985996
DR   Cosmic; 995410
DR   Cosmic; 1043815
DR   Cosmic; 1044257
DR   Cosmic; 1045410
DR   Cosmic; 1057752
DR   Cosmic; 1066205
DR   Cosmic; 1067220
DR   Cosmic; 1092600
DR   Cosmic; 1102383
DR   Cosmic; 1122325
DR   Cosmic; 1131683
DR   Cosmic; 1132568
DR   Cosmic; 1132689
DR   Cosmic; 1154644
DR   Cosmic; 1175840
DR   Cosmic; 1176588
DR   Cosmic; 1183769
DR   Cosmic; 1184080
DR   Cosmic; 1184333
DR   Cosmic; 1187306
DR   Cosmic; 1218874
DR   Cosmic; 1223141
DR   Cosmic; 1305353
DR   Cosmic; 1310945
DR   Cosmic; 1332008
DR   Cosmic; 1436021
DR   Cosmic; 1466804
DR   Cosmic; 1466815
DR   Cosmic; 1479594
DR   Cosmic; 1486132
DR   Cosmic; 1519359
DR   Cosmic; 1524003
DR   Cosmic; 1524333
DR   Cosmic; 1552179
DR   Cosmic; 1571772
DR   Cosmic; 1609495
DR   Cosmic; 1672408
DR   Cosmic; 1676727
DR   Cosmic; 1708402
DR   Cosmic; 1805253
DR   Cosmic; 1927246
DR   Cosmic; 1945865
DR   Cosmic; 1995437
DR   Cosmic; 1998442
DR   Cosmic; 2036656
DR   Cosmic; 2046556
DR   Cosmic; 2052593
DR   Cosmic; 2145576
DR   Cosmic; 2301978
DR   Cosmic; 2389569
DR   Cosmic; 2433755
DR   Cosmic; 2464667
DR   Cosmic; 2550353
DR   Cosmic; 2646766
DR   Cosmic; 2651864
DR   Cosmic; 2667881
DR   Cosmic; 2667972
DR   Cosmic; 2668248
DR   Cosmic; 2727479
DR   Cosmic; 2760068
DR   Cosmic; 2787545
DR   Cosmic; 2811054
DR   Cosmic-CLP; 905936
DR   DepMap; ACH-000971
DR   DSMZ; ACC-581
DR   DSMZCellDive; ACC-581
DR   ECACC; 91091005
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   ENCODE; ENCBS004UZY
DR   ENCODE; ENCBS009DQE
DR   ENCODE; ENCBS257IHV
DR   ENCODE; ENCBS378ENC
DR   ENCODE; ENCBS389ENC
DR   ENCODE; ENCBS409ENC
DR   ENCODE; ENCBS409MTT
DR   ENCODE; ENCBS431ENC
DR   ENCODE; ENCBS471AAA
DR   ENCODE; ENCBS472AAA
DR   ENCODE; ENCBS475AAA
DR   ENCODE; ENCBS476AAA
DR   ENCODE; ENCBS494OPB
DR   ENCODE; ENCBS615KTO
DR   ENCODE; ENCBS626JHZ
DR   ENCODE; ENCBS650OZU
DR   ENCODE; ENCBS847SOB
DR   ENCODE; ENCBS851PYB
DR   GDSC; 905936
DR   GEO; GSM810
DR   GEO; GSM2143
DR   GEO; GSM50188
DR   GEO; GSM50252
DR   GEO; GSM115118
DR   GEO; GSM206501
DR   GEO; GSM274713
DR   GEO; GSM274714
DR   GEO; GSM274726
DR   GEO; GSM383862
DR   GEO; GSM383867
DR   GEO; GSM383868
DR   GEO; GSM384091
DR   GEO; GSM384092
DR   GEO; GSM481405
DR   GEO; GSM513818
DR   GEO; GSM514292
DR   GEO; GSM580039
DR   GEO; GSM580040
DR   GEO; GSM741266
DR   GEO; GSM743443
DR   GEO; GSM749774
DR   GEO; GSM750773
DR   GEO; GSM750793
DR   GEO; GSM784012
DR   GEO; GSM799331
DR   GEO; GSM799394
DR   GEO; GSM827446
DR   GEO; GSM846355
DR   GEO; GSM887062
DR   GEO; GSM888132
DR   GEO; GSM945287
DR   GEO; GSM945304
DR   GEO; GSM1022651
DR   GEO; GSM1022652
DR   GEO; GSM1153399
DR   GEO; GSM1178133
DR   GEO; GSM1178134
DR   GEO; GSM1178135
DR   GEO; GSM1181250
DR   GEO; GSM1181367
DR   GEO; GSM1346874
DR   GEO; GSM1374516
DR   GEO; GSM1374517
DR   GEO; GSM1374518
DR   GEO; GSM1404391
DR   GEO; GSM1404392
DR   GEO; GSM1448092
DR   GEO; GSM1669868
DR   GEO; GSM2124655
DR   GEO; GSM2550001
DR   GEO; GSM3145712
DR   GEO; GSM3591761
DR   IARC_TP53; 21064
DR   ICLC; HTL95025
DR   IZSLER; BS TCL 100
DR   KCB; KCB 200706YJ
DR   KCLB; 10247
DR   LiGeA; CCLE_168
DR   LINCS_LDP; LCL-1161
DR   Lonza; 691
DR   MeSH; D045325
DR   MetaboLights; MTBLS227
DR   NCBI_Iran; C570
DR   NCI-DTP; HCT-116
DR   PharmacoDB; HCT116_517_2019
DR   PRIDE; PXD000089
DR   PRIDE; PXD000394
DR   PRIDE; PXD001352
DR   PRIDE; PXD001426
DR   PRIDE; PXD001546
DR   PRIDE; PXD001550
DR   PRIDE; PXD002453
DR   PRIDE; PXD002793
DR   PRIDE; PXD004452
DR   PRIDE; PXD005235
DR   PRIDE; PXD005354
DR   PRIDE; PXD005355
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD025898
DR   PRIDE; PXD030304
DR   PRIDE; PXD032264
DR   PRIDE; PXD037651
DR   Progenetix; CVCL_0291
DR   PubChem_Cell_line; CVCL_0291
DR   RCB; RCB2979
DR   SKY/M-FISH/CGH; 1687
DR   SKY/M-FISH/CGH; 2778
DR   SKY/M-FISH/CGH; 2785
DR   SKY/M-FISH/CGH; 3883
DR   TOKU-E; 1422
DR   Ubigene; YC-C004
DR   Wikidata; Q28334584
RX   PubMed=2041050;
RX   PubMed=2835152;
RX   PubMed=3335022;
RX   PubMed=3955419;
RX   PubMed=6437669;
RX   PubMed=7214343;
RX   PubMed=7761852;
RX   PubMed=7824277;
RX   PubMed=7972006;
RX   PubMed=9000147;
RX   PubMed=9000572;
RX   PubMed=9023415;
RX   PubMed=9174048;
RX   PubMed=9178645;
RX   PubMed=9294210;
RX   PubMed=9331090;
RX   PubMed=9515795;
RX   PubMed=9563901;
RX   PubMed=9715273;
RX   PubMed=10612807;
RX   PubMed=10674020;
RX   PubMed=10700174;
RX   PubMed=10700188;
RX   PubMed=10737795;
RX   PubMed=11226274;
RX   PubMed=11314036;
RX   PubMed=11414198;
RX   PubMed=11416159;
RX   PubMed=11526487;
RX   PubMed=11687795;
RX   PubMed=12068308;
RX   PubMed=12584437;
RX   PubMed=12615714;
RX   PubMed=12671075;
RX   PubMed=12714694;
RX   PubMed=15748285;
RX   PubMed=15900046;
RX   PubMed=16418264;
RX   PubMed=16854228;
RX   PubMed=17088437;
RX   PubMed=17178751;
RX   PubMed=17363507;
RX   PubMed=18258742;
RX   PubMed=18340113;
RX   PubMed=19372543;
RX   PubMed=19927377;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20570890;
RX   PubMed=20606684;
RX   PubMed=21912889;
RX   PubMed=22068913;
RX   PubMed=22336246;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22460905;
RX   PubMed=22628656;
RX   PubMed=23272949;
RX   PubMed=23546019;
RX   PubMed=23631600;
RX   PubMed=23649806;
RX   PubMed=23671654;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24042735;
RX   PubMed=24279929;
RX   PubMed=24670534;
RX   PubMed=24755471;
RX   PubMed=25485619;
RX   PubMed=25576301;
RX   PubMed=25841592;
RX   PubMed=25877200;
RX   PubMed=25926053;
RX   PubMed=25944804;
RX   PubMed=25960936;
RX   PubMed=25984343;
RX   PubMed=26169745;
RX   PubMed=26537799;
RX   PubMed=26589293;
RX   PubMed=26719794;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=28179481;
RX   PubMed=28192450;
RX   PubMed=28196595;
RX   PubMed=28601559;
RX   PubMed=28683746;
RX   PubMed=28854368;
RX   PubMed=29101300;
RX   PubMed=29207035;
RX   PubMed=29444439;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=32172478;
RX   PubMed=32927768;
RX   PubMed=34320349;
RX   PubMed=35839778;
RX   PubMed=36648961;
RX   PubMed=38861359;
WW   Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/HCT-116_protocol.pdf
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/ColonCellLineDescriptions/HCT116.html
WW   Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=17
WW   Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544583
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-88.html
WW   Info; Wikipedia; -; https://en.wikipedia.org/wiki/HCT116_cells
WW   Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/colon-cancer-xenograft/hct116-xenograft-model/
WW   Provider; BRICS; BRICS0098; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3904
CC   Part of: AstraZeneca Colorectal cell line (AZCL) panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: ENCODE project common cell types; tier 3.
CC   Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
CC   Part of: JFCR39 cancer cell line panel.
CC   Part of: KuDOS 95 cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI RAS program mutant KRAS cell line panel.
CC   Part of: NCI-60 cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 27 hours (PubMed=9563901); 17.1 hours (PubMed=22628656); 22 hours (PubMed=23546019); 25.02 hours (PubMed=25944804); 36 hours (PubMed=25984343); 18.14 +- 0.051 hours (PubMed=32927768); ~25-48 hours (DSMZ=ACC-581); 17.4 hours (NCI-DTP=HCT-116); ~21 hours (PBCF).
CC   HLA typing: A*01,02; B*18,45:01; C*05,07; DPB1*03:01:01,04:02; DQB1*02,03 (PubMed=15748285).
CC   HLA typing: A*01:01,02:01; B*45:01; C*05:01,07:01 (PubMed=9178645).
CC   HLA typing: A*01:01,02:01; B*18:01,45:01; C*05:01,07:01; DQA1*05:02,05:02; DQB1*03:09,02:02; DRB1*03:05,11:02 (PubMed=25960936).
CC   HLA typing: A*01:01,02:01; B*18:01,45:01; C*05:01,07:01 (PubMed=26589293).
CC   HLA typing: A*01:01:01,02:01:01; B*18:01:01,21:01:01; C*05:01:01,07:01:01; DPB1*03:01:01G,04:02:01G; DQA1*05:01:01,05:05:01; DQB1*02:01:01,03:19:01; DRB1*03:01:01,11:02:01 (CLS=300195).
CC   Microsatellite instability: Instable (MSI-high) (PubMed=9000147; PubMed=10674020; PubMed=12714694; PubMed=23671654; PubMed=24042735; PubMed=24755471; PubMed=25926053; PubMed=28683746; PubMed=31068700; Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (PubMed=12615714; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (PubMed=17088437; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (PubMed=17088437; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu33Argfs*20 (c.97delG); Zygosity=Heterozygous (DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Asp74fs*21 (c.220delG); Zygosity=Heterozygous (PubMed=17088437).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (PubMed=9294210; PubMed=24755471; ATCC=CCL-247; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (PubMed=10700188; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (PubMed=12068308; PubMed=17088437; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (PubMed=17088437; PubMed=20570890; PubMed=24755471; PubMed=28683746; Cosmic-CLP=905936; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (PubMed=23649806; DepMap=ACH-000971).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (PubMed=12615714).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=9715273; PubMed=15900046; PubMed=16418264).
CC   Omics: Genomics; ChIP-seq; CTCF.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Glycomics; N-glycan profiling.
CC   Omics: Metabolomics.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Phenotyping; Fluorescent probe library screening.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; HLA class I peptidome.
CC   Omics: Proteomics; PTM; Phosphorylation.
CC   Omics: Proteomics; PTM; Phosphorylation; Quantitative.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Proteomics; Subcellular; Extracellular vesicles.
CC   Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
CC   Omics: Transcriptomics; Massively parallel signature sequencing (MPSS).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.08%; East Asian, North=1.16%; East Asian, South=0%; South Asian=0.97%; European, North=64.85%; European, South=32.93% (PubMed=30894373).
CC   Misspelling: HCT-166; Note=In a BTO entry (BTO_0004743) now obsoleted.
CC   Misspelling: HTC 116; Note=Occasionally.
CC   Misspelling: HTC-116; Note=Occasionally.
CC   Misspelling: Htc-116; Note=Occasionally.
CC   Misspelling: HTC116; Note=Occasionally.
CC   Misspelling: HTC1116; Note=Occasionally.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; Cosmic-CLP=905936; DSMZ=ACC-581; ECACC=91091005; KCLB=10247; PubMed=11416159; PubMed=19372543; PubMed=25877200; PubMed=25926053
ST   Amelogenin: X (CLS=300195; PubMed=11416159; PubMed=19372543; PubMed=25877200; PubMed=25926053)
ST   Amelogenin: X,Y (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; Cosmic-CLP=905936; DSMZ=ACC-581; ECACC=91091005; KCLB=10247)
ST   CSF1PO: 7,9,10,11 (Cosmic-CLP=905936)
ST   CSF1PO: 7,10 (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; DSMZ=ACC-581; ECACC=91091005; KCLB=10247; PubMed=19372543; PubMed=25877200; PubMed=25926053)
ST   D13S317: 10,12
ST   D16S539: 11,12,13,14 (DSMZ=ACC-581)
ST   D16S539: 11,13 (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; Cosmic-CLP=905936; ECACC=91091005; PubMed=19372543; PubMed=25877200; PubMed=25926053)
ST   D18S51: 16,17 (ATCC=CCL-247; CCRID; CLS=300195; DSMZ=ACC-581; PubMed=19372543)
ST   D18S51: 17 (PubMed=25877200)
ST   D19S433: 12 (ATCC=CCL-247)
ST   D19S433: 12,13 (CCRID; DSMZ=ACC-581)
ST   D21S11: 29,30
ST   D2S1338: 16
ST   D3S1358: 12,18,19 (ATCC=CCL-247; CCRID; CLS=300195; DSMZ=ACC-581)
ST   D3S1358: 12,19 (PubMed=19372543; PubMed=25877200)
ST   D5S818: 10,11
ST   D7S820: 11,12
ST   D8S1179: 10,12,14,15 (CLS=300195)
ST   D8S1179: 11,12,13,14 (DSMZ=ACC-581)
ST   D8S1179: 11,12,14 (ATCC=CCL-247)
ST   D8S1179: 12,14 (CCRID; PubMed=19372543; PubMed=25877200)
ST   FGA: 18,23
ST   Penta D: 9,13
ST   Penta E: 12,13,14 (CLS=300195)
ST   Penta E: 13,14 (ATCC=CCL-247; DSMZ=ACC-581; PubMed=25877200)
ST   TH01: 8,9 (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; Cosmic-CLP=905936; DSMZ=ACC-581; ECACC=91091005; KCLB=10247; PubMed=11416159; PubMed=19372543; PubMed=25877200)
ST   TH01: 8,9,10 (PubMed=25926053)
ST   TPOX: 8 (ECACC=91091005; KCLB=10247; PubMed=19372543; PubMed=25877200; PubMed=25926053)
ST   TPOX: 8,9 (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; Cosmic-CLP=905936; DSMZ=ACC-581)
ST   vWA: 17 (PubMed=11416159; PubMed=19372543)
ST   vWA: 17,21,22,23 (DSMZ=ACC-581)
ST   vWA: 17,22 (AddexBio=C0009005/41; ATCC=CCL-247; CCRID; CLS=300195; Cosmic-CLP=905936; ECACC=91091005; KCLB=10247; PubMed=25877200; PubMed=25926053)
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_R729 ! HCT 116a
OI   CVCL_R730 ! HCT 116b
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 50
//
RX   PubMed=2041050; DOI=10.1093/jnci/83.11.757;
RA   Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D.,
RA   Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A.,
RA   Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.;
RT   "Feasibility of a high-flux anticancer drug screen using a diverse
RT   panel of cultured human tumor cell lines.";
RL   J. Natl. Cancer Inst. 83:757-766(1991).
//
RX   PubMed=2835152;
RA   Boyd D., Florent G., Kim P., Brattain M.G.;
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RT   "Evidence of selection for clones having genetic inactivation of the
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RT   "Comprehensive sampling of gene expression in human cell lines with
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RL   Proc. Natl. Acad. Sci. U.S.A. 100:4702-4705(2003).
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RX   PubMed=12714694; DOI=10.1093/mutage/18.3.277;
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RT   "Variation in the extent of microsatellite instability in human cell
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RL   Mutagenesis 18:277-282(2003).
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RL   J. Transl. Med. 3:11.1-11.8(2005).
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RX   PubMed=15900046; DOI=10.1093/jnci/dji133;
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RT   "p53-defective tumors with a functional apoptosome-mediated pathway: a
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RL   J. Natl. Cancer Inst. 97:765-777(2005).
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RA   Liu Y., Bodmer W.F.;
RT   "Analysis of p53 mutations and their expression in 56 colorectal
RT   cancer cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006).
//
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RT   "Identification by real-time PCR of 13 mature microRNAs differentially
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RT   "Mutation analysis of 24 known cancer genes in the NCI-60 cell line
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RT   "Colon carcinoma cells harboring PIK3CA mutations display resistance
RT   to growth factor deprivation induced apoptosis.";
RL   Mol. Cancer Ther. 6:1143-1150(2007).
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RA   Emaduddin M., Bicknell D.C., Bodmer W.F., Feller S.M.;
RT   "Cell growth, global phosphotyrosine elevation, and c-Met
RT   phosphorylation through Src family kinases in colorectal cancer
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RL   Proc. Natl. Acad. Sci. U.S.A. 105:2358-2362(2008).
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RT   "Altered expression of cell proliferation-related and
RT   interferon-stimulated genes in colon cancer cells resistant to SN38.";
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RT   "DNA fingerprinting of the NCI-60 cell line panel.";
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//
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RT   cancer cell lines.";
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RT   "A genome-wide screen for microdeletions reveals disruption of
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//
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RA   Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.;
RT   "5-fluorouracil response in a large panel of colorectal cancer cell
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RT   study of mechanisms of clinical anti-cancer drug resistance.";
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RT   "JFCR39, a panel of 39 human cancer cell lines, and its application in
RT   the discovery and development of anticancer drugs.";
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RT   "Mass homozygotes accumulation in the NCI-60 cancer cell lines as
RT   compared to HapMap trios, and relation to fragile site location.";
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RA   Flobak A., Laegreid A., Thommesen L.;
RT   "Characterisation of colorectal cancer cell lines through proteomic
RT   profiling of their extracellular vesicles.";
RL   Proteomes 11:3.1-3.20(2023).
//
RX   PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194;
RA   Kunkel M.W., Coussens N.P., Morris J., Taylor R.C., Dexheimer T.S.,
RA   Jones E.M., Doroshow J.H., Teicher B.A.;
RT   "HTS384 NCI60: the next phase of the NCI60 screen.";
RL   Cancer Res. 84:2403-2416(2024).
//