ID   Caki-2
AC   CVCL_0235
SY   CAKI-2; CaKi-2; caki-2; CAKI 2; Caki 2; Caki2; CAKI2
DR   BTO; BTO:0006204
DR   CLO; CLO_0002177
DR   EFO; EFO_0002150
DR   MCCL; MCC:0000124
DR   CLDB; cl625
DR   CLDB; cl626
DR   CLDB; cl627
DR   CLDB; cl629
DR   4DN; 4DNSRDD5W2FZ
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-47
DR   BCRJ; 0408
DR   BioGRID_ORCS_Cell_line; 583
DR   BioSample; SAMN01821542
DR   BioSample; SAMN01821619
DR   BioSample; SAMN03471873
DR   BioSample; SAMN10988361
DR   cancercelllines; CVCL_0235
DR   CCRID; 1101HUM-PUMC000337
DR   Cell_Model_Passport; SIDM01546
DR   ChEMBL-Cells; CHEMBL3308071
DR   ChEMBL-Targets; CHEMBL613852
DR   CLS; 300140
DR   Cosmic; 687941
DR   Cosmic; 874612
DR   Cosmic; 877458
DR   Cosmic; 979706
DR   Cosmic; 982278
DR   Cosmic; 1152536
DR   Cosmic; 2520633
DR   DepMap; ACH-000234
DR   DSMZ; ACC-54
DR   DSMZCellDive; ACC-54
DR   ECACC; 93120819
DR   EGA; EGAS00001000610
DR   ENCODE; ENCBS074UKQ
DR   ENCODE; ENCBS461KDA
DR   ENCODE; ENCBS611WID
DR   ENCODE; ENCBS768KGZ
DR   ENCODE; ENCBS787YGO
DR   GEO; GSM374478
DR   GEO; GSM886903
DR   GEO; GSM887968
DR   IARC_TP53; 30022
DR   ICLC; HTL95029
DR   IGRhCellID; Caki2
DR   IZSLER; BS TCL 8
DR   KCLB; 30047
DR   LiGeA; CCLE_157
DR   PharmacoDB; Caki2_164_2019
DR   PRIDE; PXD000335
DR   PRIDE; PXD003105
DR   Progenetix; CVCL_0235
DR   PubChem_Cell_line; CVCL_0235
DR   Wikidata; Q54808377
RX   DOI=10.1007/978-1-4757-1647-4_5;
RX   PubMed=327080;
RX   PubMed=571047;
RX   PubMed=833871;
RX   PubMed=3518877;
RX   PubMed=6244232;
RX   PubMed=6582512;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=7591954;
RX   PubMed=10723130;
RX   PubMed=10929426;
RX   PubMed=15585611;
RX   PubMed=17409424;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=22949125;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=26972028;
RX   PubMed=27141528;
RX   PubMed=27993170;
RX   PubMed=28196595;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
WW   https://www.mskcc.org/research-advantage/support/technology/tangible-material/caki-2-human-renal-cell-line
WW   https://tcpaportal.org/mclp/
CC   Problematic cell line: Misclassified. Originally thought to be a clear cell renal cell carcinoma but shown to be from a papillary renal cell carcinoma (PubMed=17409424; PubMed=27993170).
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   From: Memorial Sloan Kettering Cancer Center; New York; USA.
CC   Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2010-068.
CC   Population: Caucasian.
CC   Doubling time: ~30-40 hours (DSMZ=ACC-54).
CC   HLA typing: A*01,11; B*08,51; C*07,12 (PubMed=15585611).
CC   HLA typing: A*01:01,11:01; B*08:01,52:01; C*07:01,12:02 (PubMed=26589293).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: GPI-anchored proteins analysis by proteomics.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.61%; East Asian, North=1.28%; East Asian, South=0%; South Asian=0%; European, North=64.34%; European, South=33.76% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): ATCC; CCRID; CLS; COG; DSMZ; ECACC; KCLB; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 10
ST   D16S539: 9,13
ST   D18S51: 17
ST   D19S433: 13,14
ST   D21S11: 27,31
ST   D2S1338: 17,20
ST   D3S1358: 14
ST   D5S818: 11
ST   D7S820: 12
ST   D8S1179: 10
ST   FGA: 22
ST   Penta D: 10,13
ST   Penta E: 7,17
ST   TH01: 6
ST   TPOX: 9,11
ST   vWA: 16,17
DI   NCIt; C6975; Papillary renal cell carcinoma
DI   ORDO; Orphanet_319298; Papillary renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 37
//
RX   DOI=10.1007/978-1-4757-1647-4_5;
RA   Fogh J., Trempe G.L.;
RT   "New human tumor cell lines.";
RL   (In) Human tumor cells in vitro; Fogh J. (eds.); pp.115-159; Springer; New York (1975).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=571047;
RA   Fogh J.;
RT   "Cultivation, characterization, and identification of human tumor
RT   cells with emphasis on kidney, testis, and bladder tumors.";
RL   Natl. Cancer Inst. Monogr. 49:5-9(1978).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6244232;
RA   Williams R.D.;
RT   "Human urologic cancer cell lines.";
RL   Invest. Urol. 17:359-363(1980).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568;
RA   Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.;
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=7591954; DOI=10.1111/j.1349-7006.1995.tb03087.x;
RA   Kinoshita H., Yamada H., Ogawa O., Kakehi Y., Osaka M., Nakamura E.,
RA   Mishina M., Habuchi T., Takahashi R., Sugiyama T., Yoshida O.;
RT   "Contribution of chromosome 9p21-22 deletion to the progression of
RT   human renal cell carcinoma.";
RL   Jpn. J. Cancer Res. 86:795-799(1995).
//
RX   PubMed=10723130; DOI=10.1038/sj.onc.1203449;
RA   Alimov A., Kost-Alimova M., Liu J., Li C.-D., Bergerheim U.S.R.,
RA   Imreh S., Klein G., Zabarovsky E.R.;
RT   "Combined LOH/CGH analysis proves the existence of interstitial 3p
RT   deletions in renal cell carcinoma.";
RL   Oncogene 19:1392-1399(2000).
//
RX   PubMed=10929426; DOI=10.1007/s002400000103;
RA   Shintaku I., Kawagoe N., Yutani S., Hoshi S., Orikasa S.,
RA   Yoshizumi O., Itoh K.;
RT   "Expression of the SART1 tumor rejection antigen in renal cell
RT   carcinoma.";
RL   Urol. Res. 28:178-184(2000).
//
RX   PubMed=15585611; DOI=10.1158/1078-0432.CCR-04-0072;
RA   Tykodi S.S., Warren E.H., Thompson J.A., Riddell S.R., Childs R.W.,
RA   Otterud B.E., Leppert M.F., Storb R., Sandmaier B.M.;
RT   "Allogeneic hematopoietic cell transplantation for metastatic renal
RT   cell carcinoma after nonmyeloablative conditioning: toxicity,
RT   clinical response, and immunological response to minor
RT   histocompatibility antigens.";
RL   Clin. Cancer Res. 10:7799-7811(2004).
//
RX   PubMed=17409424; DOI=10.1158/0008-5472.CAN-06-4571;
RA   Furge K.A., Chen J.-D., Koeman J., Swiatek P.J., Dykema K., Lucin K.,
RA   Kahnoski R., Yang X.-M.J., Teh B.T.;
RT   "Detection of DNA copy number changes and oncogenic signaling
RT   abnormalities from gene expression data reveals MYC activation in
RT   high-grade papillary renal cell carcinoma.";
RL   Cancer Res. 67:3171-3176(2007).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.;
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008;
RA   Masuishi Y., Kimura Y., Arakawa N., Hirano H.;
RT   "Identification of glycosylphosphatidylinositol-anchored proteins and
RT   omega-sites using TiO2-based affinity purification followed by
RT   hydrogen fluoride treatment.";
RL   J. Proteomics 139:77-83(2016).
//
RX   PubMed=27141528; DOI=10.1016/j.dib.2016.04.001;
RA   Masuishi Y., Kimura Y., Arakawa N., Hirano H.;
RT   "Data for identification of GPI-anchored peptides and omega-sites in
RT   cancer cell lines.";
RL   Data Brief 7:1302-1305(2016).
//
RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8;
RA   Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C.,
RA   Czarnecka A.M.;
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165;
RA   Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y.,
RA   Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J.-D., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
RA   Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III,
RA   Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K.,
RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
RA   Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A.,
RA   Sellers W.R., Gygi S.P.;
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//