ID   Caco-2/TC-7
AC   CVCL_0233
SY   Caco-2/TC7; Caco2/TC7; TC-7; TC7
DR   BTO; BTO_0002571
DR   EFO; EFO_0002817
DR   MCCL; MCC:0000122
DR   cancercelllines; CVCL_0233
DR   ChEMBL-Cells; CHEMBL4483155
DR   ChEMBL-Targets; CHEMBL4483233
DR   ColonAtlas; TC7
DR   Lonza; 1105
DR   Millipore; SCC209
DR   PubChem_Cell_line; CVCL_0233
DR   Wikidata; Q54808328
RX   DOI=10.1016/0378-5173(94)00280-I;
RX   PubMed=8175910;
RX   PubMed=14599474;
RX   PubMed=15868485;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): Millipore=SCC209
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,13,14
ST   D16S539: 12,13
ST   D18S51: 12
ST   D21S11: 30
ST   D3S1358: 17
ST   D5S818: 12,13
ST   D7S820: 11,12
ST   D8S1179: 12
ST   FGA: 19
ST   Penta D: 9
ST   Penta E: 7
ST   TH01: 6
ST   TPOX: 9,11
ST   vWA: 16,18
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 24
//
RX   DOI=10.1016/0378-5173(94)00280-I;
RA   Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B.,
RA   Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G.;
RT   "Characterisation of a newly isolated Caco-2 clone (TC-7), as a model
RT   of transport processes and biotransformation of drugs.";
RL   Int. J. Pharm. 116:147-158(1995).
//
RX   PubMed=8175910; DOI=10.1242/jcs.107.1.213;
RA   Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E.,
RA   Zweibaum A., Rousset M.;
RT   "Differential expression of sucrase-isomaltase in clones isolated from
RT   early and late passages of the cell line Caco-2: evidence for
RT   glucose-dependent negative regulation.";
RL   J. Cell Sci. 107:213-225(1994).
//
RX   PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X;
RA   Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.;
RT   "Permeability characteristics of parental and clonal human intestinal
RT   Caco-2 cell lines differentiated in serum-supplemented and serum-free
RT   media.";
RL   Toxicol. In Vitro 17:761-767(2003).
//
RX   PubMed=15868485; DOI=10.1007/s10565-005-0085-6;
RA   Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A.,
RA   Zucco F.;
RT   "The Caco-2 cell line as a model of the intestinal barrier: influence
RT   of cell and culture-related factors on Caco-2 cell functional
RT   characteristics.";
RL   Cell Biol. Toxicol. 21:1-26(2005).
//