ID Caco-2/TC-7 AC CVCL_0233 SY Caco-2/TC7; Caco2/TC7; TC-7; TC7 DR BTO; BTO_0002571 DR EFO; EFO_0002817 DR MCCL; MCC:0000122 DR cancercelllines; CVCL_0233 DR ChEMBL-Cells; CHEMBL4483155 DR ChEMBL-Targets; CHEMBL4483233 DR ColonAtlas; TC7 DR Lonza; 1105 DR Millipore; SCC209 DR PubChem_Cell_line; CVCL_0233 DR Wikidata; Q54808328 RX DOI=10.1016/0378-5173(94)00280-I; RX PubMed=8175910; RX PubMed=14599474; RX PubMed=15868485; CC Population: Caucasian. CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line). CC Derived from site: In situ; Colon; UBERON=UBERON_0001155. ST Source(s): Millipore=SCC209 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 11,13,14 ST D16S539: 12,13 ST D18S51: 12 ST D21S11: 30 ST D3S1358: 17 ST D5S818: 12,13 ST D7S820: 11,12 ST D8S1179: 12 ST FGA: 19 ST Penta D: 9 ST Penta E: 7 ST TH01: 6 ST TPOX: 9,11 ST vWA: 16,18 DI NCIt; C4349; Colon adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_0025 ! Caco-2 SX Male AG 72Y CA Cancer cell line DT Created: 04-04-12; Last updated: 19-12-24; Version: 24 // RX DOI=10.1016/0378-5173(94)00280-I; RA Caro I., Boulenc X., Rousset M., Meunier V., Bourrie M., Julian B., RA Joyeux H., Roques C., Berger Y., Zweibaum A., Fabre G.; RT "Characterisation of a newly isolated Caco-2 clone (TC-7), as a model RT of transport processes and biotransformation of drugs."; RL Int. J. Pharm. 116:147-158(1995). // RX PubMed=8175910; DOI=10.1242/jcs.107.1.213; RA Chantret I., Rodolosse A., Barbat A., Dussaulx E., Brot-Laroche E., RA Zweibaum A., Rousset M.; RT "Differential expression of sucrase-isomaltase in clones isolated from RT early and late passages of the cell line Caco-2: evidence for RT glucose-dependent negative regulation."; RL J. Cell Sci. 107:213-225(1994). // RX PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X; RA Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.; RT "Permeability characteristics of parental and clonal human intestinal RT Caco-2 cell lines differentiated in serum-supplemented and serum-free RT media."; RL Toxicol. In Vitro 17:761-767(2003). // RX PubMed=15868485; DOI=10.1007/s10565-005-0085-6; RA Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., RA Zucco F.; RT "The Caco-2 cell line as a model of the intestinal barrier: influence RT of cell and culture-related factors on Caco-2 cell functional RT characteristics."; RL Cell Biol. Toxicol. 21:1-26(2005). //