ID   Caco-2/15
AC   CVCL_0232
SY   Caco2/15
DR   BTO; BTO:0005279
DR   MCCL; MCC:0000121
DR   cancercelllines; CVCL_0232
DR   Wikidata; Q54808322
RX   PubMed=1764023;
RX   PubMed=9827699;
RX   PubMed=14599474;
RX   PubMed=15868485;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0025 ! Caco-2
SX   Male
AG   72Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 19
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RX   PubMed=1764023; DOI=10.1042/bj2800599;
RA   Beaulieu J.-F., Quaroni A.;
RT   "Clonal analysis of sucrase-isomaltase expression in the human colon
RT   adenocarcinoma Caco-2 cells.";
RL   Biochem. J. 280:599-608(1991).
//
RX   PubMed=9827699; DOI=10.1002/(SICI)1097-4644(19981215)71:4<536::AID-JCB8>3.0.CO;2-1;
RA   Desloges N., Basora N., Perreault N., Bouatrouss Y., Sheppard D.,
RA   Beaulieu J.-F.;
RT   "Regulated expression of the integrin alpha9beta1 in the epithelium of
RT   the developing human gut and in intestinal cell lines: relation with
RT   cell proliferation.";
RL   J. Cell. Biochem. 71:536-545(1998).
//
RX   PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X;
RA   Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.;
RT   "Permeability characteristics of parental and clonal human intestinal
RT   Caco-2 cell lines differentiated in serum-supplemented and serum-free
RT   media.";
RL   Toxicol. In Vitro 17:761-767(2003).
//
RX   PubMed=15868485; DOI=10.1007/s10565-005-0085-6;
RA   Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A.,
RA   Zucco F.;
RT   "The Caco-2 cell line as a model of the intestinal barrier: influence
RT   of cell and culture-related factors on Caco-2 cell functional
RT   characteristics.";
RL   Cell Biol. Toxicol. 21:1-26(2005).
//