ID   COLO 357
AC   CVCL_0221
SY   COLO-357; Colo-357; Colo 357; COLO #357; COLO357; Colo357; Colorado 357
DR   BTO; BTO:0003440
DR   CLO; CLO_0002548
DR   EFO; EFO_0002710
DR   MCCL; MCC:0000506
DR   CLDB; cl5052
DR   cancercelllines; CVCL_0221
DR   Cell_Model_Passport; SIDM01654
DR   ChEMBL-Cells; CHEMBL3307702
DR   ChEMBL-Targets; CHEMBL614778
DR   Cosmic; 685615
DR   Cosmic; 724642
DR   Cosmic; 736272
DR   Cosmic; 808167
DR   Cosmic; 922258
DR   Cosmic; 933529
DR   Cosmic; 949233
DR   Cosmic; 1006371
DR   Cosmic; 1198206
DR   ECACC; 94072245
DR   GEO; GSM621898
DR   PubChem_Cell_line; CVCL_0221
DR   Wikidata; Q54814099
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=1764370;
RX   PubMed=3815343;
RX   PubMed=6277475;
RX   PubMed=6435863;
RX   PubMed=6989766;
RX   PubMed=8426738;
RX   PubMed=11169959;
RX   PubMed=12692724;
RX   PubMed=12800145;
RX   PubMed=14695172;
RX   PubMed=16912165;
RX   PubMed=18298655;
WW   https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/Colo%20357.html
CC   Population: African American.
CC   Doubling time: 21 hours (PubMed=6989766).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959).
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: ECACC; 94072245; probable.
CC   Derived from site: Metastatic; Celiac axis lymph node; UBERON=UBERON_0002508.
ST   Source(s): Technion Genomics Center BCF
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D10S1248: 13,15
ST   D12S391: 18
ST   D13S317: 11
ST   D16S539: 9,12
ST   D18S51: 13
ST   D19S433: 11,13
ST   D1S1656: 15
ST   D21S11: 29,32.2
ST   D22S1045: 11
ST   D2S1338: 21,24
ST   D2S441: 11
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 14
ST   FGA: 25
ST   Penta D: 5,9
ST   Penta E: 8,9
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C5721; Pancreatic adenosquamous carcinoma
DI   ORDO; Orphanet_424039; Squamous cell carcinoma of pancreas
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 31
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser M.U., Ruckert F., Niedergethmann M., Grutzmann R.,
RA   Saeger H.-D.;
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=1764370; DOI=10.1038/bjc.1991.467;
RA   Barton C.M., Staddon S.L., Hughes C.M., Hall P.A., O'Sullivan C.,
RA   Kloppel G., Theis B., Russell R.C.G., Neoptolemos J., Williamson R.C.N.,
RA   Lane D.P., Lemoine N.R.;
RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
RL   Br. J. Cancer 64:1076-1082(1991).
//
RX   PubMed=3815343;
RA   Kajiji S.M., Davceva B., Quaranta V.;
RT   "Six monoclonal antibodies to human pancreatic cancer antigens.";
RL   Cancer Res. 47:1367-1376(1987).
//
RX   PubMed=6277475;
RA   Frampton R.J., Suva L.J., Eisman J.A., Findlay D.M., Moore G.E.,
RA   Moseley J.M., Martin T.J.;
RT   "Presence of 1,25-dihydroxyvitamin D3 receptors in established human
RT   cancer cell lines in culture.";
RL   Cancer Res. 42:1116-1119(1982).
//
RX   PubMed=6435863;
RA   Chang B.K., Black O. Jr., Gutman R.;
RT   "Inhibition of growth of human or hamster pancreatic cancer cell lines
RT   by alpha-difluoromethylornithine alone and combined with
RT   cis-diamminedichloroplatinum(II).";
RL   Cancer Res. 44:5100-5104(1984).
//
RX   PubMed=6989766; DOI=10.1002/ijc.2910250507;
RA   Morgan R.T., Woods L.K., Moore G.E., Quinn L.A., McGavran L.,
RA   Gordon S.G.;
RT   "Human cell line (COLO 357) of metastatic pancreatic adenocarcinoma.";
RL   Int. J. Cancer 25:591-598(1980).
//
RX   PubMed=8426738;
RA   Kalthoff H., Schmiegel W.H., Roeder C., Kasche D., Schmidt A., Lauer G.,
RA   Thiele H.-G., Honold G., Pantel K., Riethmuller G., Scherer E.,
RA   Maurer J., Maacke H., Deppert W.;
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn V., Sirivatanauksorn Y., Gorman P.A., Davidson J.M.,
RA   Sheer D., Moore P.S., Scarpa A., Edwards P.A.W., Lemoine N.R.;
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos B., Moser S., Kalthoff H., Torok V., Lohr J.-M., Kloppel G.;
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B.,
RA   Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A.,
RA   Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D.,
RA   Edwards P.A.W., Chaffanet M.;
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=14695172;
RA   Iacobuzio-Donahue C.A., Ashfaq R., Maitra A., Adsay N.V.,
RA   Shen-Ong G.L.-C., Berg K., Hollingsworth M.A., Cameron J.L., Yeo C.J.,
RA   Kern S.E., Goggins M.G., Hruban R.H.;
RT   "Highly expressed genes in pancreatic ductal adenocarcinomas: a
RT   comprehensive characterization and comparison of the transcription
RT   profiles obtained from three major technologies.";
RL   Cancer Res. 63:8614-8622(2003).
//
RX   PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721;
RA   Calhoun E.S., Hucl T., Gallmeier E., West K.M., Arking D.E.,
RA   Maitra A., Iacobuzio-Donahue C.A., Chakravarti A., Hruban R.H.,
RA   Kern S.E.;
RT   "Identifying allelic loss and homozygous deletions in pancreatic
RT   cancer without matched normals using high-density single-nucleotide
RT   polymorphism arrays.";
RL   Cancer Res. 66:7920-7928(2006).
//
RX   PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x;
RA   Pilarsky C., Ammerpohl O., Sipos B., Dahl E., Hartmann A.,
RA   Wellmann A., Braunschweig T., Lohr J.-M., Jesenofsky R., Friess H.,
RA   Wente M.N., Kristiansen G., Jahnke B., Denz A., Ruckert F.,
RA   Schackert H.K., Kloppel G., Kalthoff H., Saeger H.-D., Grutzmann R.;
RT   "Activation of Wnt signalling in stroma from pancreatic cancer
RT   identified by gene expression profiling.";
RL   J. Cell. Mol. Med. 12:2823-2835(2008).
//