ID   COLO 357
AC   CVCL_0221
SY   COLO-357; Colo-357; Colo 357; COLO #357; COLO357; Colo357; Colorado 357
DR   BTO; BTO_0003440
DR   CLO; CLO_0002548
DR   EFO; EFO_0002710
DR   MCCL; MCC:0000506
DR   CLDB; cl5052
DR   cancercelllines; CVCL_0221
DR   Cell_Model_Passport; SIDM01654
DR   ChEMBL-Cells; CHEMBL3307702
DR   ChEMBL-Targets; CHEMBL614778
DR   Cosmic; 685615
DR   Cosmic; 724642
DR   Cosmic; 736272
DR   Cosmic; 808167
DR   Cosmic; 922258
DR   Cosmic; 933529
DR   Cosmic; 949233
DR   Cosmic; 1006371
DR   Cosmic; 1198206
DR   ECACC; 94072245
DR   GEO; GSM621898
DR   PubChem_Cell_line; CVCL_0221
DR   Wikidata; Q54814099
RX   DOI=10.4172/2324-9293.1000104;
RX   PubMed=1764370;
RX   PubMed=3815343;
RX   PubMed=6277475;
RX   PubMed=6435863;
RX   PubMed=6989766;
RX   PubMed=8426738;
RX   PubMed=11169959;
RX   PubMed=12692724;
RX   PubMed=12800145;
RX   PubMed=14695172;
RX   PubMed=16912165;
RX   PubMed=18298655;
RX   PubMed=20037478;
WW   Info; Pawefish; -; https://www.cellosaurus.org/pawefish/PancCellLineDescriptions/Colo%20357.html
CC   Population: African American.
CC   Doubling time: 21 hours (PubMed=6989766).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (PubMed=8426738; PubMed=11169959).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Discontinued: ECACC; 94072245; true.
CC   Derived from site: Metastatic; Celiac axis lymph node; UBERON=UBERON_0002508.
ST   Source(s): Technion Genomics Center
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D10S1248: 13,15
ST   D12S391: 18
ST   D13S317: 11
ST   D16S539: 9,12
ST   D18S51: 13
ST   D19S433: 11,13
ST   D1S1656: 15
ST   D21S11: 29,32.2
ST   D22S1045: 11
ST   D2S1338: 21,24
ST   D2S441: 11
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 8,10
ST   D8S1179: 14
ST   FGA: 25
ST   Penta D: 5,9
ST   Penta E: 8,9
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18
DI   NCIt; C5721; Pancreatic adenosquamous carcinoma
DI   ORDO; Orphanet_424039; Squamous cell carcinoma of pancreas
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 35
CH   CVCL_RL60 ! COLO 357-TRS4
CH   CVCL_8196 ! COLO 357/FG
CH   CVCL_IP74 ! COLO 357/SG
//
RX   PubMed=6435863;
RA   Chang, Barbara K.
RA   Black, Owen Jr.
RA   Gutman, Robert
RT   "Inhibition of growth of human or hamster pancreatic cancer cell lines
RT   by alpha-difluoromethylornithine alone and combined with
RT   cis-diamminedichloroplatinum(II).";
RL   Cancer Res. 44:5100-5104(1984).
//
RX   PubMed=11169959; DOI=10.1002/1097-0215(200002)9999:9999<::AID-IJC1049>3.0.CO;2-C;
RA   Sirivatanauksorn, Vorapan
RA   Sirivatanauksorn, Yongyut
RA   Gorman, Patricia A.
RA   Davidson, Jeffrey M.
RA   Sheer, Denise
RA   Moore, Patrick S.
RA   Scarpa, Aldo
RA   Edwards, Paul A.W.
RA   Lemoine, Nicholas Robert
RT   "Non-random chromosomal rearrangements in pancreatic cancer cell lines
RT   identified by spectral karyotyping.";
RL   Int. J. Cancer 91:350-358(2001).
//
RX   PubMed=12692724; DOI=10.1007/s00428-003-0784-4;
RA   Sipos, Bence
RA   Moser, Simone
RA   Kalthoff, Holger
RA   Torok, Virag
RA   Lohr, Johannes-Matthias
RA   Kloppel, Gunter
RT   "A comprehensive characterization of pancreatic ductal carcinoma cell
RT   lines: towards the establishment of an in vitro research platform.";
RL   Virchows Arch. 442:444-452(2003).
//
RX   PubMed=12800145; DOI=10.1002/gcc.10218;
RA   Adelaide, Jose
RA   Huang, Huai-En
RA   Murati, Anne
RA   Alsop, Amber E.
RA   Orsetti, Beatrice
RA   Mozziconacci, Marie-Joelle
RA   Popovici, Cornel
RA   Ginestier, Christophe
RA   Letessier, Anne
RA   Basset, Celine
RA   Courtay-Cahen, Celine
RA   Jacquemier, Jocelyne
RA   Theillet, Charles
RA   Birnbaum, Daniel
RA   Edwards, Paul A.W.
RA   Chaffanet, Max
RT   "A recurrent chromosome translocation breakpoint in breast and
RT   pancreatic cancer cell lines targets the neuregulin/NRG1 gene.";
RL   Genes Chromosomes Cancer 37:333-345(2003).
//
RX   PubMed=8426738;
RA   Kalthoff, Holger
RA   Schmiegel, Wolff Helmut
RA   Roeder, Christian
RA   Kasche, Daniela
RA   Schmidt, Andreas
RA   Lauer, Georg
RA   Thiele, Heinz-Gunter
RA   Honold, Georg
RA   Pantel, Klaus
RA   Riethmuller, Gert
RA   Scherer, Ewalt
RA   Maurer, Julian
RA   Maacke, Heiko
RA   Deppert, Wolfgang
RT   "p53 and K-RAS alterations in pancreatic epithelial cell lesions.";
RL   Oncogene 8:289-298(1993).
//
RX   PubMed=6277475;
RA   Frampton, Richard J.
RA   Suva, Larry J.
RA   Eisman, John Allan
RA   Findlay, David M.
RA   Moore, George Eugene
RA   Moseley, Jane M.
RA   Martin, Thomas John
RT   "Presence of 1,25-dihydroxyvitamin D3 receptors in established human
RT   cancer cell lines in culture.";
RL   Cancer Res. 42:1116-1119(1982).
//
RX   PubMed=6989766; DOI=10.1002/ijc.2910250507;
RA   Morgan, Robert T.
RA   Woods, Linda K.
RA   Moore, George Eugene
RA   Quinn, Laurie A.
RA   McGavran, Loris
RA   Gordon, Stuart G.
RT   "Human cell line (COLO 357) of metastatic pancreatic adenocarcinoma.";
RL   Int. J. Cancer 25:591-598(1980).
//
RX   PubMed=18298655; DOI=10.1111/j.1582-4934.2008.00289.x; PMCID=PMC3828895;
RA   Pilarsky, Christian
RA   Ammerpohl, Ole
RA   Sipos, Bence
RA   Dahl, Edgar
RA   Hartmann, Arndt
RA   Wellmann, Axel
RA   Braunschweig, Till
RA   Lohr, Johannes-Matthias
RA   Jesenofsky, Ralf
RA   Friess, Helmut
RA   Wente, Moritz Nicolas
RA   Kristiansen, Glen
RA   Jahnke, Beatrix
RA   Denz, Axel
RA   Ruckert, Felix
RA   Schackert, Hans Konrad
RA   Kloppel, Gunter
RA   Kalthoff, Holger
RA   Saeger, Hans-Detlev
RA   Grutzmann, Robert
RT   "Activation of Wnt signalling in stroma from pancreatic cancer
RT   identified by gene expression profiling.";
RL   J. Cell. Mol. Med. 12:2823-2835(2008).
//
RX   PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721;
RA   Calhoun, Eric S.
RA   Hucl, Tomas
RA   Gallmeier, Eike
RA   West, Kristen M.
RA   Arking, Dan E.
RA   Maitra, Anirban
RA   Iacobuzio-Donahue, Christine A.
RA   Chakravarti, Aravinda
RA   Hruban, Ralph H.
RA   Kern, Scott E.
RT   "Identifying allelic loss and homozygous deletions in pancreatic
RT   cancer without matched normals using high-density single-nucleotide
RT   polymorphism arrays.";
RL   Cancer Res. 66:7920-7928(2006).
//
RX   PubMed=20037478; DOI=10.4161/cbt.8.21.9685; PMCID=PMC2824894;
RA   Kent, Oliver A.
RA   Mullendore, Michael E.
RA   Wentzel, Eric A.
RA   Lopez-Romero, Pedro
RA   Tan, Aik-Choon
RA   Alvarez, Hector
RA   West, Kristen M.
RA   Ochs, Michael F.
RA   Hidalgo, Manuel
RA   Arking, Dan E.
RA   Maitra, Anirban
RA   Mendell, Joshua T.
RT   "A resource for analysis of microRNA expression and function in
RT   pancreatic ductal adenocarcinoma cells.";
RL   Cancer Biol. Ther. 8:2013-2024(2009).
//
RX   PubMed=3815343;
RA   Kajiji, Shama M.
RA   Davceva, Biljana
RA   Quaranta, Vito
RT   "Six monoclonal antibodies to human pancreatic cancer antigens.";
RL   Cancer Res. 47:1367-1376(1987).
//
RX   PubMed=14695172;
RA   Iacobuzio-Donahue, Christine A.
RA   Ashfaq, Raheela
RA   Maitra, Anirban
RA   Adsay, Nazmi Volkan
RA   Shen-Ong, Grace L.-C.
RA   Berg, Karin
RA   Hollingsworth, Michael Anthony
RA   Cameron, John Lemuel
RA   Yeo, Charles J.
RA   Kern, Scott E.
RA   Goggins, Michael Gilbert
RA   Hruban, Ralph H.
RT   "Highly expressed genes in pancreatic ductal adenocarcinomas: a
RT   comprehensive characterization and comparison of the transcription
RT   profiles obtained from three major technologies.";
RL   Cancer Res. 63:8614-8622(2003).
//
RX   DOI=10.4172/2324-9293.1000104;
RA   Wagenhauser, Markus Udo
RA   Ruckert, Felix
RA   Niedergethmann, Marco
RA   Grutzmann, Robert
RA   Saeger, Hans-Detlev
RT   "Distribution of characteristic mutations in native ductal
RT   adenocarcinoma of the pancreas and pancreatic cancer cell lines.";
RL   Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013).
//
RX   PubMed=1764370; DOI=10.1038/bjc.1991.467; PMCID=PMC1977874;
RA   Barton, Claire M.
RA   Staddon, Susan Louise
RA   Hughes, Christine M.
RA   Hall, Peter A.
RA   O'Sullivan, Catriona
RA   Kloppel, Gunter
RA   Theis, Belinda
RA   Russell, Ronald Christopher Gordon
RA   Neoptolemos, John P.
RA   Williamson, Robin Charles Noel
RA   Lane, David Philip
RA   Lemoine, Nicholas Robert
RT   "Abnormalities of the p53 tumour suppressor gene in human pancreatic
RT   cancer.";
RL   Br. J. Cancer 64:1076-1082(1991).
//