ID   CHO-K1
AC   CVCL_0214
SY   CHO K1; CHOK1; CHO cell clone K1; GM15452
DR   BTO; BTO:0000457
DR   CLO; CLO_0002427
DR   CLO; CLO_0002462
DR   CLO; CLO_0002463
DR   CLO; CLO_0026669
DR   CLO; CLO_0050409
DR   CLO; CLO_0050420
DR   CLO; CLO_0050423
DR   MCCL; MCC:0000103
DR   CLDB; cl730
DR   CLDB; cl731
DR   CLDB; cl732
DR   CLDB; cl734
DR   CLDB; cl735
DR   CLDB; cl738
DR   CLDB; cl739
DR   CLDB; cl740
DR   CLDB; cl741
DR   CLDB; cl4897
DR   AddexBio; P0017001/33
DR   ATCC; CCL-61
DR   ATCC; CRL-9618
DR   BCRC; 60006
DR   BCRJ; 0069
DR   CCLV; CCLV-RIE 0134
DR   CCLV; CCLV-RIE 0315
DR   CCRID; 1101HAM-PUMC000004
DR   CCRID; 1102HAM-NIFDC00006
DR   CCRID; 3101HAMGNHa7
DR   CCRID; 3101HAMSCSP507
DR   CCRID; 4201HAM-CCTCC00018
DR   CCRID; 4201PAT-CCTCC00006
DR   CCRID; 5301HAM-KCB88028YJ
DR   CCRID; 6101MOU-CERC000111
DR   CCTCC; GDC0018
DR   ChEMBL-Cells; CHEMBL3307512
DR   ChEMBL-Targets; CHEMBL614031
DR   CLS; 603480
DR   Coriell; GM15452
DR   DSMZ; ACC-110
DR   DSMZCellDive; ACC-110
DR   ECACC; 85051005
DR   GEO; GSE92885
DR   GEO; GSM1968555
DR   GEO; GSM1968563
DR   GEO; GSM1968571
DR   GEO; GSM1968572
DR   GEO; GSM1968569
DR   GEO; GSM1968570
DR   GEO; GSM1968594
DR   GEO; GSM1968596
DR   GEO; GSM1968598
DR   GEO; GSM1968589
DR   GEO; GSM1968600
DR   GEO; GSM1968599
DR   GEO; GSM1968591
DR   GEO; GSM1968593
DR   GEO; GSM1968595
DR   GEO; GSM1968597
DR   GEO; GSM1968565
DR   GEO; GSM1968566
DR   GEO; GSM1968560
DR   GEO; GSM1968559
DR   GEO; GSM1968558
DR   GEO; GSM1968561
DR   GEO; GSM1968557
DR   GEO; GSM1968562
DR   GEO; GSM1968564
DR   GEO; GSM1968567
DR   GEO; GSM1968556
DR   GEO; GSM1968568
DR   IBRC; C10136
DR   ICLC; ATL98003
DR   IZSLER; BS CL 15
DR   JCRB; IFO50414
DR   JCRB; JCRB9018
DR   KCB; KCB 88028YJ
DR   KCLB; 10061
DR   Lonza; 44
DR   MetaboLights; MTBLS493
DR   NCBI_Iran; C645
DR   PubChem_Cell_line; CVCL_0214
DR   RCB; RCB0285
DR   RCB; RCB2330
DR   RCB; RCB2869
DR   TKG; TKG 0328
DR   TOKU-E; 949
DR   TOKU-E; 950
DR   Ubigene; YC-C066
DR   Wikidata; Q54812705
RX   DOI=10.3390/pr1030296;
RX   DOI=10.3390/pr5020020;
RX   PubMed=10320750;
RX   PubMed=21804562;
RX   PubMed=21945585;
RX   PubMed=22971049;
RX   PubMed=23873082;
RX   PubMed=26993211;
RX   PubMed=28544881;
RX   PubMed=32078082;
RX   PubMed=32619503;
RX   PubMed=34050613;
RX   PubMed=34737324;
RX   PubMed=36610518;
WW   https://en.wikipedia.org/wiki/Chinese_hamster_ovary_cell
WW   https://www.chogenome.org/
WW   http://genome.ucsc.edu/cgi-bin/hgGateway?db=criGriChoV2&redirect=manual&source=genome.ucsc.edu
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/c/cell-lines-detail-30.html
WW   https://web.archive.org/web/20160506232703/https://www.biotechhistory.org/magazine-article/vital-tools-brief-history-cho-cells/
WW   https://www.phe-culturecollections.org.uk/media/128263/chok1-cell-line-profile.pdf
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9618.
CC   Doubling time: ~24 hours (DSMZ=ACC-110).
CC   Omics: Genome sequenced.
CC   Omics: Metabolome analysis.
CC   Omics: miRNA expression profiling.
CC   Omics: Deep proteome analysis.
CC   Omics: Glycoproteome analysis by proteomics.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0213 ! CHO
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 40
//
RX   DOI=10.3390/pr1030296;
RA   Wurm F.M.;
RT   "CHO quasispecies -- implications for manufacturing processes.";
RL   Processes 1:296-311(2013).
//
RX   DOI=10.3390/pr5020020;
RA   Wurm F.M., Wurm M.J.;
RT   "Cloning of CHO cells, productivity and genetic stability -- a
RT   discussion.";
RL   Processes 5:20.1-20.13(2017).
//
RX   PubMed=10320750; DOI=10.1016/S0027-5107(99)00077-9;
RA   Hu T., Miller C.M., Ridder G.M., Aardema M.J.;
RT   "Characterization of p53 in Chinese hamster cell lines CHO-K1,
RT   CHO-WBL, and CHL: implications for genotoxicity testing.";
RL   Mutat. Res. 426:51-62(1999).
//
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S.-K., Cai Z.-M., Liu X.,
RA   Chen W.-B., Xie M., Wang W.-L., Hammond S., Andersen M.R., Neff N.,
RA   Passarelli B., Koh W., Fan H.C., Wang J.-B., Gui Y.-T., Lee K.H.,
RA   Betenbaugh M.J., Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
//
RX   PubMed=21945585; DOI=10.1016/j.jbiotec.2011.09.014;
RA   Becker J., Hackl M., Rupp O., Jakobi T., Schneider J.,
RA   Szczepanowski R., Bekel T., Borth N., Goesmann A., Grillari J.,
RA   Kaltschmidt C., Noll T., Puhler A., Tauch A., Brinkrolf K.;
RT   "Unraveling the Chinese hamster ovary cell line transcriptome by
RT   next-generation sequencing.";
RL   J. Biotechnol. 156:227-235(2011).
//
RX   PubMed=22971049; DOI=10.1021/pr300476w;
RA   Baycin-Hizal D., Tabb D.L., Chaerkady R., Chen L., Lewis N.E.,
RA   Nagarajan H., Sarkaria V., Kumar A., Wolozny D., Colao J.,
RA   Jacobson E., Tian Y., O'Meally R.N., Krag S.S., Cole R.N.,
RA   Palsson B.O., Zhang H., Betenbaugh M.J.;
RT   "Proteomic analysis of Chinese hamster ovary cells.";
RL   J. Proteome Res. 11:5265-5276(2012).
//
RX   PubMed=23873082; DOI=10.1038/nbt.2624;
RA   Lewis N.E., Liu X., Li Y.-X., Nagarajan H., Yerganian G., O'Brien E.,
RA   Bordbar A., Roth A.M., Rosenbloom J., Bian C., Xie M., Chen W.-B.,
RA   Li N., Baycin-Hizal D., Latif H., Forster J., Betenbaugh M.J.,
RA   Famili I., Xu X., Wang J., Palsson B.O.;
RT   "Genomic landscapes of Chinese hamster ovary cell lines as revealed by
RT   the Cricetulus griseus draft genome.";
RL   Nat. Biotechnol. 31:759-765(2013).
//
RX   PubMed=26993211; DOI=10.1016/j.jbiotec.2016.03.022;
RA   Klanert G., Jadhav V., Shanmukam V., Diendorfer A.B., Karbiener M.,
RA   Scheideler M., Hernandez-Bort J.A., Grillari J., Hackl M., Borth N.;
RT   "A signature of 12 microRNAs is robustly associated with growth rate
RT   in a variety of CHO cell lines.";
RL   J. Biotechnol. 235:150-161(2016).
//
RX   PubMed=28544881; DOI=10.1016/j.cels.2017.04.009;
RA   Yusufi F.N.K., Lakshmanan M., Ho Y.-S., Loo B.L.-W., Ariyaratne P.,
RA   Yang Y.-S., Ng S.K., Tan T.R.-M., Yeo H.C., Lim H.L., Ng S.W., Hiu A.-P.,
RA   Chow C.P., Wan C., Chen S.-W., Teo G., Song G., Chin J.-X., Ruan X.-A.,
RA   Sung K.W.-K., Hu W.-S., Yap M.G.-S., Bardor M., Nagarajan N., Lee D.-Y.;
RT   "Mammalian systems biotechnology reveals global cellular adaptations
RT   in a recombinant CHO cell line.";
RL   Cell Syst. 4:530-542.e6(2017).
//
RX   PubMed=32078082; DOI=10.1007/s10529-020-02841-0;
RA   Capella Roca B., Doolan P., Barron N., O'Neill F., Clynes M.;
RT   "Altered gene expression in CHO cells following polyamine
RT   starvation.";
RL   Biotechnol. Lett. 42:927-936(2020).
//
RX   PubMed=32619503; DOI=10.1016/j.ymben.2020.06.002;
RA   Szeliova D., Ruckerbauer D.E., Galleguillos S.N., Petersen L.B.,
RA   Natter K., Hanscho M., Troyer C., Causon T., Schoeny H.,
RA   Christensen H.B., Lee D.-Y., Lewis N.E., Koellensperger G., Hann S.,
RA   Nielsen L.K., Borth N., Zanghellini J.;
RT   "What CHO is made of: variations in the biomass composition of Chinese
RT   hamster ovary cell lines.";
RL   Metab. Eng. 61:288-300(2020).
//
RX   PubMed=34050613; DOI=10.1002/biot.202100165;
RA   Wurm M.J., Wurm F.M.;
RT   "Naming CHO cells for bio-manufacturing: genome plasticity and variant
RT   phenotypes of cell populations in bioreactors question the relevance
RT   of old names.";
RL   Biotechnol. J. 16:e2100165.1-e2100165.13(2021).
//
RX   PubMed=34737324; DOI=10.1038/s41598-021-00779-5;
RA   Lung O., Candlish R.C., Nebroski M., Kruckiewicz P., Buchanan C.,
RA   Moniwa M.;
RT   "High-throughput sequencing for species authentication and
RT   contamination detection of 63 cell lines.";
RL   Sci. Rep. 11:21657-21657(2021).
//
RX   PubMed=36610518; DOI=10.1016/j.ymben.2022.12.009;
RA   Kotidis P., Donini R., Arnsdorf J., Hansen A.H., Voldborg B.G.R.,
RA   Chiang A.W.T., Haslam S.M., Betenbaugh M.J., Jimenez del Val I.,
RA   Lewis N.E., Krambeck F.J., Kontoravdi C.;
RT   "CHOGlycoNET: comprehensive glycosylation reaction network for CHO
RT   cells.";
RL   Metab. Eng. 76:87-96(2023).
//