ID   BV-2
AC   CVCL_0182
SY   BV2
DR   BTO; BTO_0003350
DR   EFO; EFO_0022792
DR   MCCL; MCC:0000073
DR   CLDB; cl7130
DR   BCRJ; 0356
DR   BioGRID_ORCS_Cell_line; 765
DR   CCRID; 1101MOU-PUMC000063
DR   CCRID; 4201MOU-CCTCC00311
DR   CCTCC; GDC0311
DR   ChEMBL-Cells; CHEMBL3307704
DR   ChEMBL-Targets; CHEMBL614781
DR   CLS; 305156
DR   GEO; GSM635468
DR   GEO; GSM635469
DR   GEO; GSM635470
DR   GEO; GSM635471
DR   ICLC; ATL03001
DR   KCB; KCB 200770YJ
DR   Lonza; 118
DR   PRIDE; PXD001597
DR   PRIDE; PXD004984
DR   PubChem_Cell_line; CVCL_0182
DR   Ubigene; YC-C035
DR   Wikidata; Q54798657
RX   CelloPub=CLPUB00788;
RX   DOI=10.1007/s13273-019-00057-6;
RX   PubMed=2110186;
RX   PubMed=19565166;
RX   PubMed=21214938;
RX   PubMed=21961028;
RX   PubMed=22651808;
RX   PubMed=26227174;
CC   Transformant: Recombinant retrovirus J2.
CC   Omics: Proteomics; Subcellular; Secretome.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
CC   Cell type: Microglial cell; CL=CL_0000129.
CC   Breed/subspecies: C57BL/6.
ST   Source(s): Ubigene=YC-C035
ST   Mouse STR 4-2: 20.3
ST   Mouse STR 5-5: 17
ST   Mouse STR 6-4: 17.3
ST   Mouse STR 6-7: 15
ST   Mouse STR 12-1: 16
ST   Mouse STR 15-3: 22.3,23.3,24.3
ST   Mouse STR 18-3: 16,17
ST   Mouse STR X-1: 27
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   1W
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
CH   CVCL_ZJ35 ! BV-2 PU.1 KO
CH   CVCL_XD67 ! BV2-EGFP
CH   CVCL_C8UX ! BV2-Luc
CH   CVCL_WJ28 ! BV2-mCherry
CH   CVCL_XD66 ! BV2-tDT
CH   CVCL_E1JF ! HyCyte BV-2 KO-mAgo2
CH   CVCL_E1JG ! HyCyte BV-2 KO-mCadm1
CH   CVCL_E1JH ! HyCyte BV-2 KO-mCd83
CH   CVCL_F1N6 ! HyCyte BV-2 KO-mDhrs3
CH   CVCL_F1N7 ! HyCyte BV-2 KO-mIkzf1
CH   CVCL_F1N8 ! HyCyte BV-2 KO-mLy96
CH   CVCL_F1N9 ! HyCyte BV-2 KO-mMapt
CH   CVCL_F1NA ! HyCyte BV-2 KO-mMir124a-3
CH   CVCL_E1JI ! HyCyte BV-2 KO-mNpc1
CH   CVCL_F1NB ! HyCyte BV-2 KO-mRgs1
CH   CVCL_F1NC ! HyCyte BV-2 KO-mSlc2a5
CH   CVCL_F1ND ! HyCyte BV-2 KO-mSqstm1
CH   CVCL_F1NE ! HyCyte BV-2 KO-mStat3
CH   CVCL_E1JJ ! HyCyte BV-2 KO-mTrem2
CH   CVCL_F1NF ! HyCyte BV-2 KO-mTxnip
CH   CVCL_E3GW ! HyCyte BV-2-Luc
CH   CVCL_D8EW ! Ubigene BV-2 Ifngr1 KO
CH   CVCL_D8EX ! Ubigene BV-2 Lpl KO
CH   CVCL_D8EY ! Ubigene BV-2 Plin2 KO
CH   CVCL_D8EZ ! Ubigene BV-2 Syk KO
CH   CVCL_D8F0 ! Ubigene BV-2 Usp7 KO
//
RX   PubMed=19565166; DOI=10.14573/altex.2009.2.83;
RA   Henn, Anja
RA   Lund, Soren
RA   Hedtjarn, Maj
RA   Schrattenholz, Andre
RA   Porzgen, Peter
RA   Leist, Marcel
RT   "The suitability of BV2 cells as alternative model system for primary
RT   microglia cultures or for animal experiments examining brain
RT   inflammation.";
RL   ALTEX 26:83-94(2009).
//
RX   PubMed=22651808; DOI=10.1186/1742-2094-9-115; PMCID=PMC3407712;
RA   Stansley, Branden
RA   Post, Jan
RA   Hensley, Kenneth
RT   "A comparative review of cell culture systems for the study of
RT   microglial biology in Alzheimer's disease.";
RL   J. Neuroinflammation 9:115.1-115.8(2012).
//
RX   DOI=10.1007/s13273-019-00057-6;
RA   Mandal, Chanchal
RA   Yoon, Taeho
RA   Park, Ji Yoon
RA   Jung, Kyoung Hwa
RA   Chai, Young Gyu
RT   "Lipopolysaccharide-dependent transcriptional regulation of PU.1 in
RT   microglial cells.";
RL   Mol. Cell. Toxicol. 16:51-61(2020).
//
RX   PubMed=2110186; DOI=10.1016/0165-5728(90)90073-V;
RA   Blasi, Elisabetta
RA   Barluzzi, Roberta
RA   Bocchini, Virginia
RA   Mazzolla, Rosanna
RA   Bistoni, Francesco
RT   "Immortalization of murine microglial cells by a v-raf/v-myc carrying
RT   retrovirus.";
RL   J. Neuroimmunol. 27:229-237(1990).
//
RX   PubMed=21961028; DOI=10.2174/1877381801002010148; PMCID=PMC3180920;
RA   Crain, Jessica M.
RA   Watters, Jyoti J.
RT   "Estrogen and P2 purinergic receptor systems in microglia: therapeutic
RT   targets for neuroprotection.";
RL   Open Drug Discov. J. 2:148-167(2010).
//
RX   CelloPub=CLPUB00788;
RA   Do, Jin Hwan
RA   Ko, Hyun Myung
RA   Suk, Kyoungho
RA   Park, Eun Jung
RA   Choi, Dong-Kug
RT   "Genome-wide inspection of chromosomal aberrations in microglia BV-2
RT   cells by array-based comparative genomic hybridization.";
RL   BioChip J. 3:28-36(2009).
//
RX   PubMed=21214938; DOI=10.1186/1471-2164-12-14; PMCID=PMC3024950;
RA   Atwood, Brady K.
RA   Lopez, Jacqueline
RA   Wager-Miller, James
RA   Mackie, Kenneth P.
RA   Straiker, Alex
RT   "Expression of G protein-coupled receptors and related proteins in
RT   HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray
RT   analysis.";
RL   BMC Genomics 12:14.1-14.14(2011).
//
RX   PubMed=26227174; DOI=10.1002/pmic.201400623;
RA   Woo, Jong-Min
RA   Han, Do-Hyun
RA   Park, Joonho
RA   Kim, Sang Jeong
RA   Kim, Youngsoo
RT   "In-depth characterization of the secretome of mouse CNS cell lines by
RT   LC-MS/MS without prefractionation.";
RL   Proteomics 15:3617-3622(2015).
//