ID   BV-173
AC   CVCL_0181
SY   BV173
DR   BTO; BTO_0004950
DR   CLO; CLO_0002052
DR   EFO; EFO_0002118
DR   MCCL; MCC:0000072
DR   CLDB; cl510
DR   CLDB; cl4968
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473373
DR   BioSample; SAMN10988488
DR   cancercelllines; CVCL_0181
DR   CCTCC; GDC0607
DR   Cell_Model_Passport; SIDM00962
DR   ChEMBL-Cells; CHEMBL3308228
DR   ChEMBL-Targets; CHEMBL2366145
DR   CLS; 300133
DR   Cosmic; 798672
DR   Cosmic; 910710
DR   Cosmic; 922164
DR   Cosmic; 994184
DR   Cosmic; 996292
DR   Cosmic; 998702
DR   Cosmic; 999741
DR   Cosmic; 1019833
DR   Cosmic; 1026570
DR   Cosmic; 1037734
DR   Cosmic; 1070701
DR   Cosmic; 1071881
DR   Cosmic; 1127249
DR   Cosmic; 1176600
DR   Cosmic; 1191703
DR   Cosmic; 1524792
DR   Cosmic-CLP; 910710
DR   DepMap; ACH-000432
DR   DSMZ; ACC-20
DR   DSMZCellDive; ACC-20
DR   EGA; EGAS00001000978
DR   GDSC; 910710
DR   GEO; GSM236779
DR   GEO; GSM236815
DR   GEO; GSM886895
DR   GEO; GSM887960
DR   GEO; GSM1374414
DR   GEO; GSM1669633
DR   IARC_TP53; 21199
DR   ICLC; HTL99018
DR   IGRhCellID; BV173
DR   LiGeA; CCLE_631
DR   LINCS_LDP; LCL-1111
DR   Lonza; 117
DR   PharmacoDB; BV173_148_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0181
DR   PubChem_Cell_line; CVCL_0181
DR   Wikidata; Q54798653
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1720549;
RX   PubMed=3098690;
RX   PubMed=3332852;
RX   PubMed=3856862;
RX   PubMed=6572735;
RX   PubMed=9680106;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=14504097;
RX   PubMed=16523483;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=20809971;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 30-35 hours (PubMed=6572735); ~48 hours (DSMZ=ACC-20).
CC   HLA typing: A*02:01,30:01; B*15:10,18:01; C*03:04,12:03 (PubMed=26589293).
CC   HLA typing: A*02:01:01,30:01:01; B*15:10:01,18:01:01; C*03:04:02,12:03:01; DPA1*01:03:01,02:01:02; DPB1*02:01:02,01:01:01; DQA1*01:02:01,01:02:02; DQB1*05:02:01,06:03:01; DRA*01:01:01,01:02:02; DRB1*13:02:01,16:01:01 (DSMZCellDive=ACC-20).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=20809971; DepMap=ACH-000432).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln4045Ter (c.12133C>T); Zygosity=Heterozygous (Cosmic-CLP=910710; DepMap=ACH-000432).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.38%; Native American=0%; East Asian, North=2.14%; East Asian, South=0%; South Asian=2.51%; European, North=52.2%; European, South=41.77% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): CLS=300133; Cosmic-CLP=910710; DSMZ=ACC-20
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,10
ST   D16S539: 11,13
ST   D18S51: 12,16
ST   D19S433: 13
ST   D21S11: 30,32
ST   D2S1338: 24,25
ST   D3S1358: 16,17
ST   D5S818: 10,12
ST   D7S820: 10,11
ST   D8S1179: 11,12,13 (CLS=300133)
ST   D8S1179: 12,13 (DSMZ=ACC-20)
ST   FGA: 20,24
ST   Penta D: 11
ST   Penta E: 12,16
ST   TH01: 6,9.3
ST   TPOX: 8,10
ST   vWA: 16
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 46
CH   CVCL_5K95 ! BV-173/E255K
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
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RT   Encyclopedia.";
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//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
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RA   Richardson, Laura
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RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
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RA   Williams, Steven G.
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RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
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RL   Cancer Cell 40:835-849.e8(2022).
//
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RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
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RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=1720549; DOI=10.1073/pnas.88.23.10735; PMCID=PMC53005;
RA   Ziemin-van der Poel, Sheryl
RA   McCabe, Norah R.
RA   Gill, Heidi J.
RA   Espinosa, Rafael 3rd
RA   Patel, Yogesh
RA   Harden, Alanna M.
RA   Rubinelli, Peter Marius
RA   Smith, Stephen D.
RA   Le Beau, Michelle M.
RA   Rowley, Janet Davison
RA   Diaz, Manuel O.
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RT   translocations associated with human leukemias.";
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//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
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RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
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RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
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//
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RA   Pegoraro, Luigi
RA   Matera, Lina
RA   Ritz, Jerome
RA   Levis, Alessandro
RA   Palumbo, Antonio
RA   Biagini, Graziella
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//
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RA   Taketani, Takeshi
RA   Taki, Tomohiko
RA   Sugita, Kanji
RA   Furuichi, Yoshiyuki
RA   Ishii, Eiichi
RA   Hanada, Ryoji
RA   Tsuchida, Masahiro
RA   Sugita, Kenichi
RA   Ida, Kohmei
RA   Hayashi, Yasuhide
RT   "FLT3 mutations in the activation loop of tyrosine kinase domain are
RT   frequently found in infant ALL with MLL rearrangements and pediatric
RT   ALL with hyperdiploidy.";
RL   Blood 103:1085-1088(2004).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=16523483; DOI=10.1002/gcc.20317;
RA   Horsley, Sharon W.
RA   Mackay, Alan
RA   Iravani, Marjan
RA   Fenwick, Kerry
RA   Valgeirsson, Haukur
RA   Dexter, Tim J.
RA   Ashworth, Alan
RA   Kearney, Lyndal
RT   "Array CGH of fusion gene-positive leukemia-derived cell lines reveals
RT   cryptic regions of genomic gain and loss.";
RL   Genes Chromosomes Cancer 45:554-564(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
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RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=3856862; DOI=10.1073/pnas.82.6.1810; PMCID=PMC397362;
RA   Konopka, James B.
RA   Watanabe, Susan M.
RA   Singer, Jack W.
RA   Collins, Steven J.
RA   Witte, Owen Neil
RT   "Cell lines and clinical isolates derived from Ph1-positive chronic
RT   myelogenous leukemia patients express c-abl proteins with a common
RT   structural alteration.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=20809971; DOI=10.1186/1755-8166-3-15; PMCID=PMC2944125;
RA   Virgili, Anna
RA   Nacheva, Elisabeth
RT   "Genomic amplification of BCR/ABL1 and a region downstream of ABL1 in
RT   chronic myeloid leukaemia: a FISH mapping study of CML patients and
RT   cell lines.";
RL   Mol. Cytogenet. 3:15.1-15.12(2010).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=3098690; DOI=10.1002/ijc.2910390116;
RA   Th'ng, Kang Hock
RA   Garewal, Gurjivan
RA   Kearney, Lyndal
RA   Rassool, Feyruz V.
RA   Vaz de Melo, Junia
RA   White, H.
RA   Catovsky, Daniel
RA   Foroni, Letizia
RA   Luzzatto, Lucio
RA   Goldman, John Michael
RT   "Establishment and characterization of three new malignant lymphoid
RT   cell lines.";
RL   Int. J. Cancer 39:89-93(1987).
//
RX   PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9;
RA   Keating, Armand
RT   "Ph positive CML cell lines.";
RL   Baillieres Clin. Haematol. 1:1021-1029(1987).
//