ID   BEAS-2B
AC   CVCL_0168
SY   Beas-2B; BEAS 2B; BEAS2B; Beas2B; Bronchial Epithelium transformed with Ad12-SV40 2B
DR   BTO; BTO_0002923
DR   CLO; CLO_0001925
DR   EFO; EFO_0001089
DR   MCCL; MCC:0000060
DR   AddexBio; T0007001/26
DR   ATCC; CRL-3588
DR   ATCC; CRL-9609
DR   BCRJ; 0395
DR   BioSample; SAMN03471073
DR   BioSample; SAMN03472862
DR   cancercelllines; CVCL_0168
DR   CCRID; 3101HUMSCSP5067
DR   CCRID; 5301HUM-KCB09022YJ
DR   CCTCC; GDC0139
DR   ChEMBL-Cells; CHEMBL4295386
DR   ChEMBL-Targets; CHEMBL4296403
DR   CLS; 300311
DR   ECACC; 95102433
DR   GEO; GSE33520
DR   GEO; GSM139654
DR   GEO; GSM139655
DR   GEO; GSM139656
DR   GEO; GSM139657
DR   GEO; GSM139659
DR   GEO; GSM139660
DR   GEO; GSM139661
DR   GEO; GSM139663
DR   GEO; GSM139664
DR   GEO; GSM139666
DR   GEO; GSM171836
DR   GEO; GSM171837
DR   GEO; GSM253389
DR   GEO; GSM827258
DR   GEO; GSM3138797
DR   GEO; GSM3138798
DR   GEO; GSM3138799
DR   GEO; GSM3138800
DR   GEO; GSM3138801
DR   GEO; GSM3138802
DR   GEO; GSM3138803
DR   GEO; GSM3138804
DR   GEO; GSM3138805
DR   IARC_TP53; 23556
DR   KCB; KCB 200922YJ
DR   Kerafast; ENH021-FP
DR   Lonza; 343
DR   NCBI_Iran; C561
DR   PRIDE; PXD003503
DR   Progenetix; CVCL_0168
DR   PubChem_Cell_line; CVCL_0168
DR   Ubigene; YC-B005
DR   Wikidata; Q54795940
RX   DOI=10.1007/978-1-4612-0411-4_25;
RX   Patent=US4885238;
RX   Patent=US5506131;
RX   PubMed=2450641;
RX   PubMed=2539488;
RX   PubMed=2846394;
RX   PubMed=7972006;
RX   PubMed=8504475;
RX   PubMed=12894236;
RX   PubMed=15463957;
RX   PubMed=17331233;
RX   PubMed=20215515;
RX   PubMed=22521957;
RX   PubMed=25524072;
RX   PubMed=25877200;
RX   PubMed=31156620;
RX   PubMed=31900469;
WW   Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/crl-9609-growth-and-morphology
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-39.html
CC   Group: Patented cell line.
CC   Part of: Small cell lung cancer p53 hotspot mutation cell panel (ATCC TCP-2040).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-9609.
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ATCC; CRL-9609; true.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
ST   Source(s): ATCC=CRL-3588; CCRID; ECACC=95102433; PubMed=25877200; Technion Genomics Center
ST   Amelogenin: X,Y
ST   CSF1PO: 9,12
ST   D10S1248: 14,15
ST   D12S391: 17,18
ST   D13S317: 13
ST   D16S539: 11,12 (PubMed=25877200)
ST   D16S539: 12 (ATCC=CRL-3588; CCRID; ECACC=95102433; Technion Genomics Center)
ST   D18S51: 18,19
ST   D19S433: 13.2 (PubMed=25877200)
ST   D19S433: 13.2,15.2 (CCRID; Technion Genomics Center)
ST   D1S1656: 14,15
ST   D21S11: 28,30
ST   D22S1045: 14,16
ST   D2S1338: 22,23
ST   D2S441: 11,11.3
ST   D3S1358: 15,17
ST   D5S818: 12,13
ST   D7S820: 10,13
ST   D8S1179: 13,15
ST   DYS391: 10
ST   FGA: 20,24
ST   Penta D: 2.2,13
ST   Penta E: 5,8
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 17,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0171 ! BET-1A
SX   Male
AG   Age unspecified
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 39
//
RX   DOI=10.1007/978-1-4612-0411-4_25;
RA   Lehman T.A., Harris C.C.;
RT   "Neoplastic transformation and suppression of transformation of human
RT   bronchial epithelial cells in vitro.";
RL   (In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.251-258; Humana Press; New York; USA (1990).
//
RX   Patent=US4885238;
RA   Reddel R.R., Yang K., Rhim J.S., Brash D.E., Su R.T., Lechner J.F.,
RA   Gerwin B.I., Harris C.C., Amstad P.A.;
RT   "Immortalized human bronchial epithelial mesothelial cell lines.";
RL   Patent number US4885238, 05-Dec-1989.
//
RX   Patent=US5506131;
RA   Harris C.C., Gelboin H.V., Gonzalez F.J., Mace K., Pfeifer A.M.A.;
RT   "Immortalized human cell lines containing exogenous cytochrome P450
RT   genes.";
RL   Patent number US5506131, 09-Apr-1996.
//
RX   PubMed=2450641;
RA   Reddel R.R., Ke Y., Gerwin B.I., McMenamin M.G., Lechner J.F.,
RA   Su R.T., Brash D.E., Park J.-B., Rhim J.S., Harris C.C.;
RT   "Transformation of human bronchial epithelial cells by infection with
RT   SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium
RT   phosphate coprecipitation with a plasmid containing SV40 early region
RT   genes.";
RL   Cancer Res. 48:1904-1909(1988).
//
RX   PubMed=2539488; DOI=10.1093/jnci/81.8.587;
RA   Bonfil R.D., Reddel R.R., Ura H., Reich R., Fridman R., Harris C.C.,
RA   Klein-Szanto A.J.P.;
RT   "Invasive and metastatic potential of a v-Ha-ras-transformed human
RT   bronchial epithelial cell line.";
RL   J. Natl. Cancer Inst. 81:587-594(1989).
//
RX   PubMed=2846394; DOI=10.1111/j.1432-0436.1988.tb00592.x;
RA   Ke Y., Reddel R.R., Gerwin B.I., Miyashita M., McMenamin M.G.,
RA   Lechner J.F., Harris C.C.;
RT   "Human bronchial epithelial cells with integrated SV40 virus T antigen
RT   genes retain the ability to undergo squamous differentiation.";
RL   Differentiation 38:60-66(1988).
//
RX   PubMed=7972006; DOI=10.1073/pnas.91.23.11045; PMCID=PMC45163;
RA   Okamoto A., Demetrick D.J., Spillare E.A., Hagiwara K., Hussain S.P.,
RA   Bennett W.P., Forrester K., Gerwin B.I., Serrano M., Beach D.H.,
RA   Harris C.C.;
RT   "Mutations and altered expression of p16INK4 in human cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11045-11049(1994).
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman T.A., Modali R.V., Boukamp P., Stanek J., Bennett W.P.,
RA   Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M.,
RA   Harris C.C.;
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//
RX   PubMed=12894236; DOI=10.1038/sj.onc.1206728;
RA   Ma Y., Koza-Taylor P.H., DiMattia D.A., Hames L., Fu H.-N.,
RA   Dragnev K.H., Turi T., Beebe J.S. Jr., Freemantle S.J., Dmitrovsky E.;
RT   "Microarray analysis uncovers retinoid targets in human bronchial
RT   epithelial cells.";
RL   Oncogene 22:4924-4932(2003).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=17331233; DOI=10.1186/1471-2164-8-62; PMCID=PMC1821332;
RA   Nymark P., Lindholm P.M., Korpela M.V., Lahti L., Ruosaari S.,
RA   Kaski S., Hollmen J., Anttila S., Kinnula V.L., Knuutila S.;
RT   "Gene expression profiles in asbestos-exposed epithelial and
RT   mesothelial lung cell lines.";
RL   BMC Genomics 8:62.1-62.14(2007).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22521957; DOI=10.1016/j.taap.2012.04.003; PMCID=PMC3358533;
RA   Stueckle T.A., Lu Y.-J., Davis M.E., Wang L.-Y., Jiang B.-H.,
RA   Holaskova I., Schafer R., Barnett J.B., Rojanasakul Y.;
RT   "Chronic occupational exposure to arsenic induces carcinogenic gene
RT   signaling networks and neoplastic transformation in human lung
RT   epithelial cells.";
RL   Toxicol. Appl. Pharmacol. 261:204-216(2012).
//
RX   PubMed=25524072; DOI=10.1002/jat.3094; PMCID=PMC4474793;
RA   Zhao F., Klimecki W.T.;
RT   "Culture conditions profoundly impact phenotype in BEAS-2B, a human
RT   pulmonary epithelial model.";
RL   J. Appl. Toxicol. 35:945-951(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=31156620; DOI=10.3389/fimmu.2019.01019; PMCID=PMC6529937;
RA   Panda D., Gjinaj E., Bachu M., Squire E., Novatt H., Ozato K.,
RA   Rabin R.L.;
RT   "IRF1 maintains optimal constitutive expression of antiviral genes and
RT   regulates the early antiviral response.";
RL   Front. Immunol. 10:1019.1-1019.16(2019).
//
RX   PubMed=31900469; DOI=10.1371/journal.pone.0227174; PMCID=PMC6941928;
RA   Han X.-Y., Na T., Wu T.-T., Yuan B.-Z.;
RT   "Human lung epithelial BEAS-2B cells exhibit characteristics of
RT   mesenchymal stem cells.";
RL   PLoS ONE 15:e0227174.1-e0227174.18(2020).
//