ID   Akata
AC   CVCL_0148
SY   AKATA; Akata-BL; Akata BL; Akata-EC; Akata-Early Culture
DR   MCCL; MCC:0000041
DR   cancercelllines; CVCL_0148
DR   Cosmic; 931094
DR   Cosmic; 2301567
DR   IARC_TP53; 698
DR   JCRB; JCRB1763
DR   NCBI_Iran; C451
DR   TOKU-E; 3580
DR   Wikidata; Q54749080
RX   PubMed=1647567;
RX   PubMed=1915267;
RX   PubMed=9473234;
RX   PubMed=9973220;
RX   PubMed=11559830;
RX   PubMed=23152513;
RX   PubMed=25787276;
RX   PubMed=28960205;
CC   Population: Japanese.
CC   Virology: Contains a complete EBV genome (strain Akata) which has been sequenced (PubMed=23152513; PubMed=25787276).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (PubMed=1915267).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): JCRB=JCRB1763
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 8,12
ST   D16S539: 10,11
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 14,16
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 22
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RX   PubMed=1647567; DOI=10.1007/BF00571929;
RA   Takada K., Horinouchi K., Ono Y., Aya T., Osato T., Takahashi M.,
RA   Hayasaka S.;
RT   "An Epstein-Barr virus-producer line Akata: establishment of the cell
RT   line and analysis of viral DNA.";
RL   Virus Genes 5:147-156(1991).
//
RX   PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x;
RA   Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.;
RT   "p53 is frequently mutated in Burkitt's lymphoma cell lines.";
RL   EMBO J. 10:2879-2887(1991).
//
RX   PubMed=9473234; DOI=10.1182/blood.V91.5.1680;
RA   Klangby U., Okan I., Magnusson K.P., Wendland M., Lind P., Wiman K.G.;
RT   "p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a
RT   mRNA and protein expression in Burkitt's lymphoma.";
RL   Blood 91:1680-1687(1998).
//
RX   PubMed=9973220;
RA   Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G.,
RA   Magrath I.T., Bhatia K.G.;
RT   "Bax is frequently compromised in Burkitt's lymphomas with
RT   irreversible resistance to Fas-induced apoptosis.";
RL   Cancer Res. 59:696-703(1999).
//
RX   PubMed=11559830; DOI=10.1128/JVI.75.20.9977-9982.2001;
RA   Maruo S., Nanbo A., Takada K.;
RT   "Replacement of the Epstein-Barr virus plasmid with the EBER plasmid
RT   in Burkitt's lymphoma cells.";
RL   J. Virol. 75:9977-9982(2001).
//
RX   PubMed=23152513; DOI=10.1128/JVI.02517-12;
RA   Lin Z., Wang X., Strong M.J., Concha M., Baddoo M., Xu G.-R.,
RA   Baribault C., Fewell C., Hulme W., Hedges D., Taylor C.M.,
RA   Flemington E.K.;
RT   "Whole-genome sequencing of the Akata and Mutu Epstein-Barr virus
RT   strains.";
RL   J. Virol. 87:1172-1182(2013).
//
RX   PubMed=25787276; DOI=10.1128/JVI.03614-14;
RA   Palser A.L., Grayson N.E., White R.E., Corton C., Correia S.,
RA   Ba Abdullah M.M., Watson S.J., Cotten M., Arrand J.R., Murray P.G.,
RA   Allday M.J., Rickinson A.B., Young L.S., Farrell P.J., Kellam P.;
RT   "Genome diversity of Epstein-Barr virus from multiple tumor types and
RT   normal infection.";
RL   J. Virol. 89:5222-5237(2015).
//
RX   PubMed=28960205; DOI=10.1038/cdd.2017.150;
RA   Fitzsimmons L., Boyce A.J., Wei W.-B., Chang C., Croom-Carter D.S.G.,
RA   Tierney R.J., Herold M.J., Bell A.I., Strasser A., Kelly G.L.,
RA   Rowe M.;
RT   "Coordinated repression of BIM and PUMA by Epstein-Barr virus latent
RT   genes maintains the survival of Burkitt lymphoma cells.";
RL   Cell Death Differ. 25:241-254(2018).
//