ID A-375 AC CVCL_0132 SY A 375; A375; A375-MEL; A375-mel; A375mel; 375 DR BTO; BTO_0002806 DR CLO; CLO_0001544 DR CLO; CLO_0001581 DR CLO; CLO_0001582 DR EFO; EFO_0002103 DR MCCL; MCC:0000024 DR CLDB; cl198 DR CLDB; cl199 DR Abcam; ab275461 DR AddexBio; C0020004/4992 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-1619 DR ATCC; CRL-7904 DR BCRC; 60039 DR BCRJ; 0278 DR BioGRID_ORCS_Cell_line; 44 DR BioSample; SAMN03472142 DR BioSample; SAMN05292441 DR BioSample; SAMN07709998 DR BioSample; SAMN07709999 DR BioSample; SAMN07710000 DR BioSample; SAMN07710001 DR BioSample; SAMN07710002 DR BioSample; SAMN07710003 DR BioSample; SAMN07710004 DR BioSample; SAMN10988347 DR cancercelllines; CVCL_0132 DR CCRID; 1101HUM-PUMC000126 DR CCRID; 1101HUM-PUMC000327 DR CCRID; 3101HUMSCSP533 DR CCRID; 3101HUMTCHu155 DR CCRID; 4201HUM-CCTCC00285 DR CCTCC; GDC0285 DR CCTCC; GDC0314 DR Cell_Model_Passport; SIDM00795 DR CGH-DB; 9313-4 DR ChEMBL-Cells; CHEMBL3308077 DR ChEMBL-Targets; CHEMBL613859 DR CLS; 300110 DR Cosmic; 686480 DR Cosmic; 687431 DR Cosmic; 706114 DR Cosmic; 876698 DR Cosmic; 888861 DR Cosmic; 897482 DR Cosmic; 897735 DR Cosmic; 905226 DR Cosmic; 906793 DR Cosmic; 928688 DR Cosmic; 933003 DR Cosmic; 1006556 DR Cosmic; 1022280 DR Cosmic; 1054855 DR Cosmic; 1132587 DR Cosmic; 1155278 DR Cosmic; 1211162 DR Cosmic; 1303032 DR Cosmic; 1458961 DR Cosmic; 1459655 DR Cosmic; 1477406 DR Cosmic; 1481413 DR Cosmic; 1507620 DR Cosmic; 1537486 DR Cosmic; 1555009 DR Cosmic; 1669118 DR Cosmic; 1812178 DR Cosmic; 1888914 DR Cosmic; 1890486 DR Cosmic; 1989294 DR Cosmic; 1995332 DR Cosmic; 2036699 DR Cosmic; 2230112 DR Cosmic; 2233660 DR Cosmic; 2479252 DR Cosmic; 2791113 DR Cosmic-CLP; 906793 DR DepMap; ACH-000219 DR ECACC; 88113005 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR ENCODE; ENCBS606AAA DR ENCODE; ENCBS607AAA DR GDSC; 906793 DR GEO; GSM206443 DR GEO; GSM218051 DR GEO; GSM274681 DR GEO; GSM276771 DR GEO; GSM555121 DR GEO; GSM555173 DR GEO; GSM827158 DR GEO; GSM886854 DR GEO; GSM887919 DR GEO; GSM952580 DR GEO; GSM1092559 DR GEO; GSM1138787 DR GEO; GSM1177892 DR GEO; GSM1177893 DR GEO; GSM1374382 DR GEO; GSM1669582 DR GEO; GSM1671962 DR GEO; GSM1671967 DR GEO; GSM1671977 DR GEO; GSM1671981 DR GEO; GSM1671982 DR GEO; GSM1671987 DR GEO; GSM1671990 DR GEO; GSM1672001 DR GEO; GSM1672004 DR GEO; GSM1672007 DR GEO; GSM1672011 DR GEO; GSM1672017 DR GEO; GSM1672024 DR GEO; GSM1672027 DR GEO; GSM1672030 DR GEO; GSM1672039 DR GEO; GSM1672051 DR GEO; GSM1672062 DR GEO; GSM1672067 DR GEO; GSM1672078 DR GEO; GSM1672097 DR GEO; GSM1672102 DR GEO; GSM1672119 DR GEO; GSM1672135 DR GEO; GSM3039510 DR GEO; GSM3039516 DR GEO; GSM3039517 DR GEO; GSM3039518 DR IARC_TP53; 21163 DR IBRC; C10141 DR IGRhCellID; A375 DR IZSLER; BS TCL 88 DR KCB; KCB 99003YJ DR LiGeA; CCLE_226 DR LINCS_HMS; 50060 DR LINCS_LDP; LCL-1235 DR Lonza; 970 DR NCBI_Iran; C136 DR PharmacoDB; A375_42_2019 DR PRIDE; PXD001485 DR PRIDE; PXD004343 DR PRIDE; PXD005912 DR PRIDE; PXD007265 DR PRIDE; PXD021877 DR PRIDE; PXD022992 DR PRIDE; PXD025255 DR PRIDE; PXD025881 DR PRIDE; PXD026952 DR PRIDE; PXD027886 DR PRIDE; PXD028863 DR PRIDE; PXD030304 DR Progenetix; CVCL_0132 DR PubChem_Cell_line; CVCL_0132 DR Ubigene; YC-C036 DR Wikidata; Q54605986 RX DOI=10.1007/BF00199208; RX DOI=10.1007/BF00205883; RX PubMed=77569; RX PubMed=265522; RX PubMed=327080; RX PubMed=375235; RX PubMed=833871; RX PubMed=1832891; RX PubMed=3518877; RX PubMed=4357758; RX PubMed=6220172; RX PubMed=6500159; RX PubMed=6584666; RX PubMed=6954533; RX PubMed=9670966; RX PubMed=9973934; RX PubMed=10497214; RX PubMed=12068308; RX PubMed=14871852; RX PubMed=15009714; RX PubMed=15467732; RX PubMed=17308088; RX PubMed=18172304; RX PubMed=19727395; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=21343389; RX PubMed=21424129; RX PubMed=21673604; RX PubMed=21857157; RX PubMed=22178978; RX PubMed=22282976; RX PubMed=22460905; RX PubMed=23039341; RX PubMed=24581590; RX PubMed=25056119; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25960936; RX PubMed=26405815; RX PubMed=26589293; RX PubMed=26673621; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=29275043; RX PubMed=29492214; RX PubMed=29605720; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31978347; RX PubMed=35128241; RX PubMed=35839778; WW Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=A375 WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544560 WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/melanoma-xenograft/a375-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). CC Population: Caucasian. CC Doubling time: 26.9 +- 6.9 hours (PubMed=29275043); ~32 hours (PBCF). CC HLA typing: A*01,02; B*12,13 (PubMed=77569). CC HLA typing: A*01:01,02:01; B*44:03,57:01; C*06:02,16:02; DQA1*03:02,02:01; DQB1*03:03,03:03; DRB1*04:05,07:01 (PubMed=25960936). CC HLA typing: A*01:01,02:01; B*44:03,57:01; C*06:02,16:01; DQA1*03:02,02:01; DQB1*03:02,03:02; DRB1*04:05,07:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=12068308; PubMed=15467732; PubMed=26405815; PubMed=29492214; ATCC=CRL-1619; Cosmic-CLP=906793; DepMap=ACH-000219). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (PubMed=29492214; ATCC=CRL-1619; Cosmic-CLP=906793; DepMap=ACH-000219). CC Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (PubMed=29492214; ATCC=CRL-1619; Cosmic-CLP=906793; DepMap=ACH-000219). CC Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; 2DE-MS. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; PTM; Phosphorylation. CC Omics: Proteomics; Quantitative. CC Omics: Proteomics; Subcellular; Secretome. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.84%; Native American=0.49%; East Asian, North=1.69%; East Asian, South=0%; South Asian=0%; European, North=67.22%; European, South=29.75% (PubMed=30894373). CC Misspelling: A-735; Note=Occasionally. CC Discontinued: ATCC; CRL-7904; true. CC Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511. ST Source(s): AddexBio=C0020004/4992; ATCC=CRL-1619; CCRID; CLS=300110; Cosmic-CLP=906793; ECACC=88113005; IZSLER=BS TCL 88; PubMed=25056119; PubMed=25877200; Technion Genomics Center ST Amelogenin: X ST CSF1PO: 11,12 ST D10S1248: 16 ST D12S391: 18,21 ST D13S317: 11,14 ST D16S539: 9 ST D18S51: 12,17 ST D19S433: 13,14.2 ST D1S1656: 16,17.3 ST D21S11: 29,30 ST D22S1045: 16 ST D2S1338: 16,24 ST D2S441: 11 ST D3S1358: 15,17 ST D5S818: 12 ST D7S820: 9 ST D8S1179: 11,14 ST FGA: 23 ST Penta D: 9,15 ST Penta E: 10,12 ST TH01: 8 ST TPOX: 8,10 ST vWA: 16,17 DI NCIt; C3802; Amelanotic melanoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 54Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 49 CH CVCL_6546 ! 4-1.10 CH CVCL_E8SQ ! A-375 Human CD228 CH CVCL_E8SR ! A-375 Human CLDN18.2 CH CVCL_XZ66 ! A-375 Human EGFR vIII CH CVCL_UD29 ! A-375 KRAS p.G13D CH CVCL_UD28 ! A-375 MEK1 p.Q56P CH CVCL_JF22 ! A-375 NRAS p.Q61K CH CVCL_C8WV ! A-375-Luc CH CVCL_LC86 ! A375 NRAS (Q61K/+/+) CH CVCL_C3D8 ! A375 NY-ESO-1 Knockout CH CVCL_C0Q6 ! A375 PLX/AZD-resistant CH CVCL_E8FX ! A375 RL CH CVCL_C3EX ! A375 Safe Harbor Landing Pad CH CVCL_C4RR ! A375 XPA-mutated clone A3 CH CVCL_C4RS ! A375 XPA-mutated clone A9 CH CVCL_C4RT ! A375 XPA-mutated clone B1 CH CVCL_2294 ! A375-C5 CH CVCL_2295 ! A375-C6 CH CVCL_QZ67 ! A375-eGFP-Puro CH CVCL_C8YB ! A375-ER-2 CH CVCL_QZ68 ! A375-Fluc-Neo/eGFP-Puro CH CVCL_QZ69 ! A375-Fluc-Neo/hNIS-Puro CH CVCL_QZ70 ! A375-Fluc-Puro CH CVCL_QZ71 ! A375-hNIS-Neo/eGFP-Puro CH CVCL_QZ72 ! A375-hNIS-Puro CH CVCL_QZ73 ! A375-iRFP-Neo CH CVCL_QZ74 ! A375-iRFP-Neo/Fluc-Puro CH CVCL_QZ75 ! A375-iRFP-Neo/hNIS-Puro CH CVCL_B7NR ! A375-Luc-RFP CH CVCL_UR32 ! A375-Luc2 CH CVCL_B222 ! A375-M CH CVCL_X494 ! A375-MA1 CH CVCL_C7GI ! A375-NTP-R CH CVCL_6233 ! A375-P CH CVCL_6234 ! A375-R CH CVCL_A2CR ! A375-R1 CH CVCL_A1VP ! A375-RMR CH CVCL_5649 ! A375-SM CH CVCL_AP96 ! A375-VR [2014] CH CVCL_AQ00 ! A375-VR [2015] CH CVCL_0136 ! A375.S2 CH CVCL_IW10 ! A375/R CH CVCL_R745 ! A375PF11 CH CVCL_Y439 ! A375S1 CH CVCL_XE59 ! A375sci CH CVCL_B0ZF ! Abcam A-375 IL13RA2 KO CH CVCL_B7V4 ! Abcam A-375 NT5E KO CH CVCL_KS59 ! CellSensor AP1-bla A375 CH CVCL_KS16 ! CellSensor SBE-bla A375 CH CVCL_6286 ! DRO CH CVCL_D6AF ! HyCyte A-375 KO-hSETD2 CH CVCL_E3GK ! HyCyte A-375-Luc CH CVCL_ZJ05 ! LanthaScreen ERK2 A375 CH CVCL_YJ74 ! LINTERNA A375 CH CVCL_D7J3 ! Ubigene A-375 B2M KO CH CVCL_D7J4 ! Ubigene A-375 B3GNT2 KO CH CVCL_D7J5 ! Ubigene A-375 IGF2BP1 KO CH CVCL_D7J6 ! Ubigene A-375 MAGEA4 KO CH CVCL_D7J7 ! Ubigene A-375 PRAME KO CH CVCL_D7J9 ! Ubigene A-375 USP7 KO // RX PubMed=6584666; DOI=10.1093/jnci/72.4.913; RA Kozlowski, James M. RA Hart, Ian R. RA Fidler, Isaiah Joshua RA Hanna, Nabil RT "A human melanoma line heterogeneous with respect to metastatic RT capacity in athymic nude mice."; RL J. Natl. Cancer Inst. 72:913-917(1984). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=22178978; DOI=10.1016/j.freeradbiomed.2011.11.019; RA Swalwell, Helen RA Latimer, Jennifer RA Haywood, Rachel M. RA Birch-Machin, Mark Anthony RT "Investigating the role of melanin in UVA/UVB- and hydrogen RT peroxide-induced cellular and mitochondrial ROS production and RT mitochondrial DNA damage in human melanoma cells."; RL Free Radic. Biol. Med. 52:626-634(2012). // RX PubMed=23039341; DOI=10.1186/1476-4598-11-75; PMCID=PMC3554420; RA Byron, Sara A. RA Loch, David C. RA Wellens, Candice L. RA Wortmann, Andreas RA Wu, Jia-Yi RA Wang, John RA Nomoto, Kenichi RA Pollock, Pamela M. RT "Sensitivity to the MEK inhibitor E6201 in melanoma cells is RT associated with mutant BRAF and wildtype PTEN status."; RL Mol. Cancer 11:75.1-75.15(2012). // RX PubMed=15467732; DOI=10.1038/sj.onc.1208152; RA Tanami, Hideaki RA Imoto, Issei RA Hirasawa, Akira RA Yuki, Yasuhiro RA Sonoda, Itaru RA Inoue, Jun RA Yasui, Kohichiroh RA Misawa-Furihata, Akiko RA Kawakami, Yutaka RA Inazawa, Johji RT "Involvement of overexpressed wild-type BRAF in the growth of RT malignant melanoma cell lines."; RL Oncogene 23:8796-8804(2004). // RX PubMed=375235; DOI=10.1073/pnas.76.3.1288; PMCID=PMC383236; RA Sherwin, Stephen A. RA Sliski, Ann H. RA Todaro, George J. RT "Human melanoma cells have both nerve growth factor and nerve growth RT factor-specific receptors on their cell surfaces."; RL Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981; RA Boegel, Sebastian RA Lower, Martin RA Bukur, Thomas RA Sahin, Ugur RA Castle, John C. RT "A catalog of HLA type, HLA expression, and neo-epitope candidates in RT human cancer cell lines."; RL OncoImmunology 3:e954893.1-e954893.12(2014). // RX PubMed=29605720; DOI=10.1016/j.neo.2018.02.009; PMCID=PMC5915992; RA Mologni, Luca RA Costanza, Mariantonia RA Sharma, Geeta Geeta RA Viltadi, Michela RA Massimino, Luca RA Citterio, Stefania RA Purgante, Stefania RA Raman, Hima RA Pirola, Alessandra RA Zucchetti, Massimo RA Piazza, Rocco RA Gambacorti-Passerini, Carlo RT "Concomitant BCORL1 and BRAF mutations in vemurafenib-resistant RT melanoma cells."; RL Neoplasia 20:467-477(2018). // RX PubMed=35128241; DOI=10.1021/acsomega.1c05361; PMCID=PMC8811929; RA Martinez, Ramon 3rd RA Huang, Wei-Liang RA Buck, Heather RA Rea, Samantha RA Defnet, Amy E. RA Kane, Maureen A. RA Shapiro, Paul RT "Proteomic changes in the monolayer and spheroid melanoma cell models RT of acquired resistance to BRAF and MEK1/2 inhibitors."; RL ACS Omega 7:3293-3311(2022). // RX PubMed=21673604; DOI=10.1097/CMR.0b013e32834495c3; PMCID=PMC3131479; RA Orgaz, Jose L. RA Benguria, Alberto RA Sanchez-Martinez, Cristina RA Ladhani, Omar RA Volpert, Olga V. RA Jimenez, Benilde RT "Changes in the gene expression profile of A375 human melanoma cells RT induced by overexpression of multifunctional pigment RT epithelium-derived factor."; RL Melanoma Res. 21:285-297(2011). // RX PubMed=265522; DOI=10.1073/pnas.74.2.565; PMCID=PMC392331; RA Fabricant, Robert Neal RA De Larco, Joseph E. RA Todaro, George J. RT "Nerve growth factor receptors on human melanoma cells in culture."; RL Proc. Natl. Acad. Sci. U.S.A. 74:565-569(1977). // RX PubMed=327080; DOI=10.1093/jnci/59.1.221; RA Fogh, Jorgen RA Fogh, Jens M. RA Orfeo, Thomas RT "One hundred and twenty-seven cultured human tumor cell lines RT producing tumors in nude mice."; RL J. Natl. Cancer Inst. 59:221-226(1977). // RX PubMed=4357758; DOI=10.1093/jnci/51.5.1417; RA Giard, Donald J. RA Aaronson, Stuart A. RA Todaro, George J. RA Arnstein, Paul RA Kersey, John H. RA Dosik, Harvey RA Parks, Wade P. RT "In vitro cultivation of human tumors: establishment of cell lines RT derived from a series of solid tumors."; RL J. Natl. Cancer Inst. 51:1417-1423(1973). // RX PubMed=19727395; DOI=10.1371/journal.pone.0006888; PMCID=PMC2731225; RA Wadlow, Raymond Couric RA Wittner, Ben S. RA Finley, S. Aidan RA Bergquist, Henry RA Upadhyay, Rabi RA Finn, Stephen P. RA Loda, Massimo RA Mahmood, Umar RA Ramaswamy, Sridhar RT "Systems-level modeling of cancer-fibroblast interaction."; RL PLoS ONE 4:e6888.1-e6888.10(2009). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=29275043; DOI=10.1016/j.jprot.2017.12.013; RA Liberato, Tarcisio RA Pessotti, Dayelle S. RA Fukushima, Isabella RA Kitano, Eduardo S. RA Serrano, Solange M.T. RA Zelanis, Andre RT "Signatures of protein expression revealed by secretome analyses of RT cancer associated fibroblasts and melanoma cell lines."; RL J. Proteomics 174:1-8(2018). // RX PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x; RA Espmark, Jons Ake RA Ahlqvist-Roth, Lena RA Sarne, Lena RA Persson, Anita RT "Tissue typing of cells in culture. III. HLA antigens of established RT human cell lines. Attempts at typing by the mixed hemadsorption RT technique."; RL Tissue Antigens 11:279-286(1978). // RX PubMed=25056119; DOI=10.1158/0008-5472.CAN-14-1232-T; PMCID=PMC4167745; RA Watson, Ian R. RA Li, Li-Ren RA Cabeceiras, Peter K. RA Mahdavi, Mozhdeh RA Gutschner, Tony RA Genovese, Giannicola RA Wang, Guo-Can RA Fang, Zhuang-Na RA Tepper, James M. RA Stemke-Hale, Katherine RA Tsai, Kenneth Y. RA Davies, Michael A. RA Mills, Gordon B. RA Chin, Lynda RT "The RAC1 P29S hotspot mutation in melanoma confers resistance to RT pharmacological inhibition of RAF."; RL Cancer Res. 74:4845-4852(2014). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=26673621; DOI=10.18632/oncotarget.6548; PMCID=PMC4823068; RA Roller, Devin Grimm RA Capaldo, Brian J. RA Bekiranov, Stefan RA Mackey, Aaron J. RA Conaway, Mark Robert RA Petricoin, Emanuel F. 3rd RA Gioeli, Daniel RA Weber, Michael J. RT "Combinatorial drug screening and molecular profiling reveal diverse RT mechanisms of intrinsic and adaptive resistance to BRAF inhibition in RT V600E BRAF mutant melanomas."; RL Oncotarget 7:2734-2753(2016). // RX PubMed=17308088; DOI=10.1158/0008-5472.CAN-06-3311; RA Shields, Janiel M. RA Thomas, Nancy E. RA Cregger, Melissa RA Berger, Aaron J. RA Leslie, Michael RA Torrice, Chad RA Hao, Hong-Lin RA Penland, Shannon RA Arbiser, Jack Leonard RA Scott, Glynis A. RA Zhou, Tong RA Bar-Eli, Menashe RA Bear, James E. RA Der, Channing Joseph RA Kaufmann, William K. RA Rimm, David L. RA Sharpless, Norman Edward RT "Lack of extracellular signal-regulated kinase mitogen-activated RT protein kinase signaling shows a new type of melanoma."; RL Cancer Res. 67:1502-1512(2007). // RX PubMed=14871852; DOI=10.1158/0008-5472.CAN-03-2209; RA Hogan, Kevin T. RA Coppola, Michael A. RA Gatlin, Christine L. RA Thompson, Lee W. RA Shabanowitz, Jeffrey RA Hunt, Donald Frederick RA Engelhard, Victor H. RA Ross, Mark M. RA Slingluff, Craig L. Jr. RT "Identification of novel and widely expressed cancer/testis gene RT isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to RT melanoma."; RL Cancer Res. 64:1157-1163(2004). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin K. RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=22282976; DOI=10.1093/carcin/1.1.21; RA Day, Rufus S. 3rd RA Ziolkowski, Chuck H.J. RA Scudiero, Dominic A. RA Meyer, Sharon A. RA Mattern, Michael R. RT "Human tumor cell strains defective in the repair of alkylation RT damage."; RL Carcinogenesis 1:21-32(1980). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157; RA Westin, Eric H. RA Gallo, Robert Charles RA Arya, Suresh K. RA Eva, Alessandra RA Souza, Lawrence M. RA Baluda, Marcel Albert RA Aaronson, Stuart A. RA Wong-Staal, Flossie RT "Differential expression of the amv gene in human hematopoietic RT cells."; RL Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982). // RX PubMed=3518877; DOI=10.3109/07357908609038260; RA Fogh, Jorgen RT "Human tumor lines for cancer research."; RL Cancer Invest. 4:157-184(1986). // RX PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783; RA Rose, Amy E. RA Poliseno, Laura RA Wang, Jin-Hua RA Clark, Michael RA Pearlman, Alexander RA Wang, Gui-Min RA Vega y Saenz de Miera, Eleazar Carmelo RA Medicherla, Ratna RA Christos, Paul J. RA Shapiro, Richard RA Pavlick, Anna RA Darvishian, Farbod RA Zavadil, Jiri RA Polsky, David RA Hernando, Eva RA Ostrer, Harry RA Osman, Iman RT "Integrative genomics identifies molecular alterations that challenge RT the linear model of melanoma progression."; RL Cancer Res. 71:2561-2571(2011). // RX PubMed=9973934; DOI=10.1016/S0165-4608(98)00122-8; RA Nelson, Mark A. RA Ariza, Maria E. RA Yang, Jin-Ming RA Thompson, Floyd H. RA Taetle, Raymond RA Trent, Jeffrey M. RA Wymer, Julie RA Massey-Brown, Kathy S. RA Broome-Powell, Marianne RA Easton, John RA Lahti, Jill M. RA Kidd, Vincent J. RT "Abnormalities in the p34cdc2-related PITSLRE protein kinase gene RT complex (CDC2L) on chromosome band 1p36 in melanoma."; RL Cancer Genet. Cytogenet. 108:91-99(1999). // RX PubMed=6220172; RA Dracopoli, Nicholas C. RA Fogh, Jorgen RT "Polymorphic enzyme analysis of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 70:469-476(1983). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX DOI=10.1007/BF00199208; RA Bruggen, Josef RA Sorg, Clemens RA Macher, Egon RT "Membrane associated antigens of human malignant melanoma V: RT Serological typing of cell lines using antisera from nonhuman RT primates."; RL Cancer Immunol. Immunother. 5:53-62(1978). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=9670966; DOI=10.4049/jimmunol.161.2.877; RA Bettinotti, Maria P. RA Kim, Christina J. RA Lee, Kang-Hun RA Roden, Matthew RA Cormier, Janice N. RA Panelli, Monica C. RA Parker, Kenneth K. RA Marincola, Francesco M. RT "Stringent allele/epitope requirements for MART-1/Melan A RT immunodominance: implications for peptide-based immunotherapy."; RL J. Immunol. 161:877-889(1998). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, A. Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=10497214; DOI=10.1074/jbc.274.40.28505; RA Ariza, Maria E. RA Broome-Powell, Marianne RA Lahti, Jill M. RA Kidd, Vincent J. RA Nelson, Mark A. RT "Fas-induced apoptosis in human malignant melanoma cell lines is RT associated with the activation of the p34(cdc2)-related PITSLRE RT protein kinases."; RL J. Biol. Chem. 274:28505-28513(1999). // RX PubMed=15009714; DOI=10.1046/j.0022-202X.2004.22243.x; PMCID=PMC2586668; RA Tsao, Hensin RA Goel, Vikas RA Wu, Heng RA Yang, Guang RA Haluska, Frank G. RT "Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 RT inactivation in melanoma."; RL J. Invest. Dermatol. 122:337-341(2004). // RX PubMed=1832891; DOI=10.1016/0277-5379(91)90277-K; RA Hansson, Johan RA Fichtinger-Schepman, Anne Marie Josephine RA Edgren, Margareta R. RA Ringborg, Ulrik RT "Comparative study of two human melanoma cell lines with different RT sensitivities to mustine and cisplatin."; RL Eur. J. Cancer 27:1039-1045(1991). // RX PubMed=24581590; DOI=10.1016/j.jdermsci.2014.01.006; RA Gehrke, Samuel RA Otsuka, Atsushi RA Huber, Roman RA Meier, Barbara RA Kistowska, Magdalena RA Fenini, Gabriele RA Cheng, Phil RA Dummer, Reinhard RA Kerl, Katrin RA Contassot, Emmanuel RA French, Lars Einar RT "Metastatic melanoma cell lines do not secrete IL-1beta but promote RT IL-1beta production from macrophages."; RL J. Dermatol. Sci. 74:167-169(2014). // RX PubMed=21424129; DOI=10.3892/or.2011.1220; RA Manca, Antonella RA Sini, Maria Cristina RA Izzo, Francesco RA Ascierto, Paolo Antonio RA Tatangelo, Fabiana RA Botti, Gerardo RA Gentilcore, Giusy RA Capone, Marilena RA Mozzillo, Nicola RA Rozzo, Carla RA Cossu, Antonio RA Tanda, Francesco RA Palmieri, Giuseppe RT "Induction of arginosuccinate synthetase (ASS) expression affects the RT antiproliferative activity of arginine deiminase (ADI) in melanoma RT cells."; RL Oncol. Rep. 25:1495-1502(2011). // RX PubMed=26405815; DOI=10.1371/journal.pone.0138210; PMCID=PMC4583389; RA Capaldo, Brian J. RA Roller, Devin Grimm RA Axelrod, Mark J. RA Koeppel, Alexander F. RA Petricoin, Emanuel F. 3rd RA Slingluff, Craig L. Jr. RA Weber, Michael J. RA Mackey, Aaron J. RA Gioeli, Daniel RA Bekiranov, Stefan RT "Systems analysis of adaptive responses to MAP kinase pathway blockade RT in BRAF mutant melanoma."; RL PLoS ONE 10:e0138210.1-e0138210.25(2015). // RX PubMed=6500159; DOI=10.1159/000163283; RA Gershwin, Merrill Eric RA Lentz, Daniel RA Owens, Robert B. RT "Relationship between karyotype of tissue culture lines and RT tumorigenicity in nude mice."; RL Exp. Cell Biol. 52:361-370(1984). // RX DOI=10.1007/BF00205883; RA Bruggen, Josef RA Macher, Egon RA Sorg, Clemens RT "Expression of surface antigens and its relation to parameters of RT malignancy in human malignant melanoma."; RL Cancer Immunol. Immunother. 10:121-127(1981). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathy RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne M. RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=18172304; DOI=10.1158/0008-5472.CAN-07-1939; RA Sabatino, Marianna RA Zhao, Ying-Dong RA Voiculescu, Sonia RA Monaco, Alessandro RA Robbins, Paul F. RA Karai, Laszlo RA Nickoloff, Brian J. RA Maio, Michele RA Selleri, Silvia RA Marincola, Francesco M. RA Wang, Ena RT "Conservation of genetic alterations in recurrent melanoma supports RT the melanoma stem cell hypothesis."; RL Cancer Res. 68:122-131(2008). // RX PubMed=29492214; DOI=10.18632/oncotarget.23989; PMCID=PMC5823576; RA Sini, Maria Cristina RA Doneddu, Valentina RA Paliogiannis, Panagiotis RA Casula, Milena RA Colombino, Maria RA Manca, Antonella RA Botti, Gerardo RA Ascierto, Paolo Antonio RA Lissia, Amelia RA Cossu, Antonio RA Palmieri, Giuseppe RT "Genetic alterations in main candidate genes during melanoma RT progression."; RL Oncotarget 9:8531-8541(2018). // RX PubMed=833871; DOI=10.1093/jnci/58.2.209; RA Fogh, Jorgen RA Wright, William C. RA Loveless, James D. RT "Absence of HeLa cell contamination in 169 cell lines derived from RT human tumors."; RL J. Natl. Cancer Inst. 58:209-214(1977). // RX PubMed=21857157; DOI=10.4161/cc.10.17.17068; PMCID=PMC5479465; RA Caputo, Emilia RA Maiorana, Luigi RA Vasta, Valeria RA Pezzino, Franca Maria RA Sunkara, Sudhir RA Wynne, Kieran RA Elia, Giuliano RA Marincola, Francesco M. RA McCubrey, James Andrew RA Libra, Massimo RA Travali, Salvatore RA Kane, Marian RT "Characterization of human melanoma cell lines and melanocytes by RT proteome analysis."; RL Cell Cycle 10:2924-2936(2011). //