ID 4T1 AC CVCL_0125 SY 4T1-A; 4T1.0; 4T1/WT DR BTO; BTO_0004311 DR CLO; CLO_0001401 DR EFO; EFO_0002037 DR MCCL; MCC:0000017 DR AddexBio; C0006004/13 DR ATCC; CRL-2539 DR BCRJ; 0022 DR BioGRID_ORCS_Cell_line; 1260 DR BioSample; SAMN11397647 DR CCRID; 3101MOUSCSP5056 DR CCRID; 3101MOUTCM32 DR CCRID; 4201MOU-CCTCC00294 DR CCRID; 6101MOU-CERC000107 DR CCTCC; GDC0294 DR ChEMBL-Cells; CHEMBL3307995 DR ChEMBL-Targets; CHEMBL612589 DR CLS; 300300 DR GEO; GSM1529765 DR GEO; GSM1529766 DR GEO; GSM1529767 DR GEO; GSM1847461 DR GEO; GSM1847462 DR KCB; KCB 200967YJ DR Lonza; 481 DR NCBI_Iran; C604 DR PRIDE; PXD013948 DR PRIDE; PXD016112 DR PRIDE; PXD021413 DR PRIDE; PXD024762 DR PRIDE; PXD027822 DR PubChem_Cell_line; CVCL_0125 DR Ubigene; YC-B004 DR Wikidata; Q42802273 RX PubMed=10411109; RX PubMed=26857856; RX PubMed=27177471; RX PubMed=31220119; RX PubMed=37712227; WW Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/4/cell-lines-detail-66.html WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/4T1 WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/breast-cancer-xenograft/4t1-xenograft-model/ CC Characteristics: Metastatic. CC Characteristics: Widely used model in cancer research due to its high similarity to human breast cancer. The tumor growth and metastatic spread of 4T1 cells closely mimic the behavior of human breast cancer. The 4T1 cell line is considered an animal model for stage IV human breast cancer, as it is able to spontaneously metastasize in both post-operative and non-surgical models (CLS=300300). CC Doubling time: 12.6 hours (ATCC=CRL-2539). CC Selected for resistance to: ChEBI; CHEBI_9555; Tioguanine (6-thioguanine; 6-TG). CC Omics: Transcriptomics; Microarray. CC Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911. CC Breed/subspecies: BALB/cfC3H. ST Source(s): PubMed=31220119; PubMed=37712227; Ubigene=YC-B004 ST Mouse STR 1-1: 15,16 ST Mouse STR 1-2: 17 ST Mouse STR 2-1: 16,17 ST Mouse STR 3-2: 14,15 ST Mouse STR 4-2: 21.3 ST Mouse STR 5-5: 14 ST Mouse STR 6-4: 18 ST Mouse STR 6-7: 12 ST Mouse STR 7-1: 25.2 ST Mouse STR 8-1: 13 ST Mouse STR 11-2: 18,19,20 ST Mouse STR 12-1: 16 ST Mouse STR 13-1: 16.2 ST Mouse STR 15-3: 22.3 ST Mouse STR 17-2: 15 ST Mouse STR 18-3: 18,19 ST Mouse STR 19-2: 13 ST Mouse STR X-1: 25 DI NCIt; C21678; Malignant neoplasms of the mouse mammary gland OX NCBI_TaxID=10090; ! Mus musculus (Mouse) HI CVCL_W343 ! 410.4 SX Female AG Age unspecified CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 35 CH CVCL_QZ56 ! 4T1-eGFP-Puro CH CVCL_QZ57 ! 4T1-Fluc-Neo CH CVCL_QZ58 ! 4T1-Fluc-Neo/eGFP-Puro CH CVCL_QZ59 ! 4T1-Fluc-Neo/iRFP-Puro CH CVCL_QZ60 ! 4T1-iRFP-Puro CH CVCL_J239 ! 4T1-Luc [JCRB] CH CVCL_C8UY ! 4T1-Luc [Ubigene] CH CVCL_A4BM ! 4T1-Luc2 [ATCC] CH CVCL_L899 ! 4T1-luc2 [Caliper] CH CVCL_5J28 ! 4T1-luc2-GFP CH CVCL_5J46 ! 4T1-luc2-tdTomato CH CVCL_C8UZ ! 4T1-mCherry CH CVCL_QZ61 ! 4T1-mNIS (monoclonal) CH CVCL_QZ62 ! 4T1-mNIS-Neo/eGFP-Puro CH CVCL_QZ63 ! 4T1-mNIS-Neo/iRFP-Puro CH CVCL_QZ64 ! 4T1-mNIS-Puro CH CVCL_QZ65 ! 4T1-mNIS-Puro/Fluc-Neo CH CVCL_5I84 ! 4T1-Red-FLuc CH CVCL_5I85 ! 4T1-Red-FLuc-GFP CH CVCL_HE47 ! 4T1-S CH CVCL_E7FZ ! 4T1-SIINFEKL/H-2Kb CH CVCL_5J45 ! 4T1-tdTomato CH CVCL_GR31 ! 4T1.13 CH CVCL_GR32 ! 4T1.2 CH CVCL_B3QZ ! 4T1.3 CH CVCL_C9FJ ! 4T1/Cas9-hyg CH CVCL_JG34 ! 4T1/CMV-Luc #6 CH CVCL_C0U6 ! 4T1/EPB CH CVCL_XG69 ! 4T1/GFP/FlucII CH CVCL_E1IL ! HyCyte 4T1 KO-mBtn1a1 CH CVCL_F1LJ ! HyCyte 4T1 KO-mCd200 CH CVCL_D6AA ! HyCyte 4T1 KO-mEhd4 CH CVCL_E1IM ! HyCyte 4T1 KO-mEnpp1 CH CVCL_D6AB ! HyCyte 4T1 KO-mInhba CH CVCL_F1LK ! HyCyte 4T1 KO-mLdha CH CVCL_F1LL ! HyCyte 4T1 KO-mStk11 CH CVCL_E1IN ! HyCyte 4T1 KO-mTmem176b CH CVCL_D6AC ! HyCyte 4T1 KO-mUsp22 CH CVCL_D6AD ! HyCyte 4T1 KO-mZdhhc20 CH CVCL_E3GH ! HyCyte 4T1-Luc CH CVCL_D7HW ! Ubigene 4T1 Ar KO CH CVCL_D7HX ! Ubigene 4T1 Arid1a KO CH CVCL_D7HY ! Ubigene 4T1 Arid2 KO CH CVCL_D7HZ ! Ubigene 4T1 Atg5 KO CH CVCL_D7I0 ! Ubigene 4T1 Atrx KO CH CVCL_D7I1 ! Ubigene 4T1 Ccar1 KO CH CVCL_D7I2 ! Ubigene 4T1 Cgas KO CH CVCL_D7I3 ! Ubigene 4T1 Ciita KO CH CVCL_D7I4 ! Ubigene 4T1 Ddr1 KO CH CVCL_D7I5 ! Ubigene 4T1 Drd1 KO CH CVCL_D7I6 ! Ubigene 4T1 Fat1 KO CH CVCL_D7I7 ! Ubigene 4T1 Grik1 KO CH CVCL_D7I8 ! Ubigene 4T1 Ifi35 KO CH CVCL_D7I9 ! Ubigene 4T1 Il17ra KO CH CVCL_D7IA ! Ubigene 4T1 Kmt2c KO CH CVCL_D7IB ! Ubigene 4T1 Kmt2d KO CH CVCL_D7IC ! Ubigene 4T1 Lamtor5 KO CH CVCL_D7ID ! Ubigene 4T1 Lats2 KO CH CVCL_D7IE ! Ubigene 4T1 Mctp1 KO CH CVCL_D7IF ! Ubigene 4T1 Nlgn4l KO CH CVCL_D7IG ! Ubigene 4T1 Pigr KO CH CVCL_D7IH ! Ubigene 4T1 Rad51c KO CH CVCL_D7II ! Ubigene 4T1 Rb1 KO CH CVCL_D7IJ ! Ubigene 4T1 Smarca4 KO CH CVCL_D7IK ! Ubigene 4T1 Spp1 KO CH CVCL_D7IL ! Ubigene 4T1 Sting1 KO CH CVCL_D7IM ! Ubigene 4T1 Tnfrsf1b KO CH CVCL_D7IN ! Ubigene 4T1 Ttc14 KO CH CVCL_D7IP ! Ubigene 4T1 Ythdf1 KO CH CVCL_D7IQ ! Ubigene 4T1 Zbtb33 KO // RX PubMed=37712227; DOI=10.1242/dmm.050150; PMCID=PMC10618599; RA Chen, Yi-Hsien RA Connelly, Jon P. RA Florian, Colin P. RA Cui, Xiao-Xia RA Pruett-Miller, Shondra M. RT "Short tandem repeat profiling via next-generation sequencing for cell RT line authentication."; RL Dis. Model. Mech. 16:dmm050150.1-dmm050150.10(2023). // RX PubMed=27177471; DOI=10.1016/j.canlet.2016.05.005; RA Sasaki, So-ichiro RA Baba, Tomohisa RA Nishimura, Tatsunori RA Hayakawa, Yoshihiro RA Hashimoto, Shin-ichi RA Gotoh, Noriko RA Mukaida, Naofumi RT "Essential roles of the interaction between cancer cell-derived RT chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast RT cancer bone metastasis."; RL Cancer Lett. 378:23-32(2016). // RX PubMed=26857856; DOI=10.1007/s13577-015-0127-1; RA Abe, Hirotake RA Wada, Haruka RA Baghdadi, Muhammad RA Nakanishi, Sayaka RA Usui, Yuu RA Tsuchikawa, Takahiro RA Shichinohe, Toshiaki RA Hirano, Satoshi RA Seino, Ken-ichiro RT "Identification of a highly immunogenic mouse breast cancer sub cell RT line, 4T1-S."; RL Hum. Cell 29:58-66(2016). // RX PubMed=31220119; DOI=10.1371/journal.pone.0218412; PMCID=PMC6586308; RA Almeida, Jamie L. RA Dakic, Aleksandra RA Kindig, Karin RA Kone, Maikan RA Letham, Deborah Lee Dormady RA Langdon, Scott RA Peat, Ruth RA Holding-Pillai, Jayamalini RA Hall, Erin M. RA Ladd, Mark RA Shaffer, Megan D. RA Berg, Heath RA Li, Jin-Liang RA Wigger, Georges RA Lund, Steve RA Steffen, Carolyn R. RA Fransway, Barbara B. RA Geraghty, Bob RA Natoli, Manuela RA Bauer, Beth A. RA Gollin, Susanne M. RA Lewis, Dale W. RA Reid, Yvonne A. RT "Interlaboratory study to validate a STR profiling method for RT intraspecies identification of mouse cell lines."; RL PLoS ONE 14:e0218412.1-e0218412.24(2019). // RX PubMed=10411109; DOI=10.1023/A:1006689719505; RA Lelekakis, Maria RA Moseley, Jane M. RA Martin, Thomas John RA Hards, Daphne RA Williams, Elizabeth Deborah RA Ho, Patricia W.M. RA Lowen, Darren RA Javni, Jeannie RA Miller, Fred R. RA Slavin, John RA Anderson, Robin L. RT "A novel orthotopic model of breast cancer metastasis to bone."; RL Clin. Exp. Metastasis 17:163-170(1999). //