ID   16HBE14o-
AC   CVCL_0112
SY   16-HBE14o; 16HBE140; 16-HBEo; 16HBEo-; 16-HBE; 16HBE
DR   BTO; BTO_0002734
DR   MCCL; MCC:0000003
DR   ArrayExpress; E-MTAB-4194
DR   ChEMBL-Cells; CHEMBL4295404
DR   ChEMBL-Targets; CHEMBL4296395
DR   CLS; 305234
DR   Millipore; SCC150
DR   PRIDE; PXD006933
DR   PubChem_Cell_line; CVCL_0112
DR   TOKU-E; 4023
DR   Wikidata; Q54582314
RX   PubMed=1282304;
RX   PubMed=7507342;
RX   PubMed=9614386;
RX   PubMed=10498856;
RX   PubMed=12711171;
RX   PubMed=15463957;
RX   PubMed=18441018;
RX   PubMed=28970102;
WW   Info; Dartmouth; -; https://web.archive.org/web/20190126194809/http://www.dartmouth.edu/~cysfib/cell-lines.html
CC   Characteristics: Widely used to model barrier function of the airway epithelium and to study respiratory ion transport as well as the function of CFTR (Millipore=SCC150).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSVori-).
CC   Omics: Proteomics; 2DE-MS.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
CC   Cell type: Epithelial cell of bronchus; CL=CL_0002328.
ST   Source(s): Millipore=SCC150
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 14
ST   D21S11: 28,30.2
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 10,11
ST   FGA: 21,22
ST   Penta D: 9
ST   Penta E: 5,14
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 16,18
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=1282304; DOI=10.1152/ajplung.1992.263.6.L692;
RA   Haws C., Krouse M.E., Xia Y.-F., Gruenert D.C., Wine J.J.;
RT   "CFTR channels in immortalized human airway cells.";
RL   Am. J. Physiol. 263:L692-L707(1992).
//
RX   PubMed=7507342; DOI=10.1165/ajrcmb.10.1.7507342;
RA   Cozens A.L., Yezzi M.J., Kunzelmann K., Ohrui T., Chin L., Eng K.,
RA   Finkbeiner W.E., Widdicombe J.H., Gruenert D.C.;
RT   "CFTR expression and chloride secretion in polarized immortal human
RT   bronchial epithelial cells.";
RL   Am. J. Respir. Cell Mol. Biol. 10:38-47(1994).
//
RX   PubMed=9614386; DOI=10.1002/(SICI)1096-9896(199803)184:3<323::AID-PATH2>3.0.CO;2-2;
RA   Meng Q.-H., Springall D.R., Bishop A.E., Morgan K., Evans T.J.,
RA   Habib S., Gruenert D.C., Gyi K.M., Hodson M.E., Yacoub M.H.,
RA   Polak J.M.;
RT   "Lack of inducible nitric oxide synthase in bronchial epithelium: a
RT   possible mechanism of susceptibility to infection in cystic
RT   fibrosis.";
RL   J. Pathol. 184:323-331(1998).
//
RX   PubMed=10498856; DOI=10.1038/sj.bjp.0702772; PMCID=PMC1571611;
RA   Goncz K.K., Feeney L., Gruenert D.C.;
RT   "Differential sensitivity of normal and cystic fibrosis airway
RT   epithelial cells to epinephrine.";
RL   Br. J. Pharmacol. 128:227-233(1999).
//
RX   PubMed=12711171; DOI=10.1016/S0378-5173(03)00129-7;
RA   Forbes B., Shah A., Martin G.P., Lansley A.B.;
RT   "The human bronchial epithelial cell line 16HBE14o- as a model system
RT   of the airways for studying drug transport.";
RL   Int. J. Pharm. 257:161-167(2003).
//
RX   PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040;
RA   Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.;
RT   "Established cell lines used in cystic fibrosis research.";
RL   J. Cyst. Fibros. 3:191-196(2004).
//
RX   PubMed=18441018; DOI=10.1194/jlr.M700388-JLR200; PMCID=PMC2444007;
RA   Andersson C., Al-Turkmani M.R., Savaille J.E., Alturkmani R.,
RA   Katrangi W., Cluette-Brown J.E., Zaman M.M., Laposata M.,
RA   Freedman S.D.;
RT   "Cell culture models demonstrate that CFTR dysfunction leads to
RT   defective fatty acid composition and metabolism.";
RL   J. Lipid Res. 49:1692-1700(2008).
//
RX   PubMed=28970102; DOI=10.1016/j.jprot.2017.09.013;
RA   Puglia M., Landi C., Gagliardi A., Breslin L., Armini A., Brunetti J.,
RA   Pini A., Bianchi L., Bini L.;
RT   "The proteome speciation of an immortalized cystic fibrosis cell line:
RT   new perspectives on the pathophysiology of the disease.";
RL   J. Proteomics 170:28-42(2018).
//