ID   BCP-1
AC   CVCL_0107
SY   BCP1
DR   BTO; BTO_0002728
DR   CLO; CLO_0001905
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; CRL-2294
DR   BioSample; SAMN03471861
DR   BioSample; SAMN10987880
DR   cancercelllines; CVCL_0107
DR   Cell_Model_Passport; SIDM01530
DR   Cosmic; 683661
DR   Cosmic; 1238079
DR   Cosmic; 1588555
DR   DepMap; ACH-000923
DR   GEO; GSM634737
DR   GEO; GSM710423
DR   GEO; GSM710439
DR   GEO; GSM886874
DR   GEO; GSM887939
DR   GEO; GSM3150239
DR   IARC_TP53; 26981
DR   LiGeA; CCLE_346
DR   PharmacoDB; BCP1_81_2019
DR   PRIDE; PXD012087
DR   Progenetix; CVCL_0107
DR   Wikidata; Q4835216
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8705864;
RX   PubMed=9473233;
RX   PubMed=9766492;
RX   PubMed=15613351;
RX   PubMed=17121789;
RX   PubMed=19608668;
RX   PubMed=21685375;
RX   PubMed=22460905;
RX   PubMed=25355872;
RX   PubMed=26589293;
RX   PubMed=30285677;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; COPE; -; http://www.cells-talk.com/index.php/page/copelibrary?key=BCP-1
WW   Info; Wikipedia; -; https://en.wikipedia.org/wiki/BCP-1_cells
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   HLA typing: A*24:02,68:01; B*38:01,44:02; C*05:01,12:03 (PubMed=26589293).
CC   Sequence variation: Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Homozygous (PubMed=19608668).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (PubMed=19608668).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp259Asn (c.775G>A); Zygosity=Heterozygous (PubMed=19608668; DepMap=ACH-000923).
CC   Transformant: NCBI_TaxID; 37296; Human herpesvirus 8 (HHV-8/KSHV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq virome analysis.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.81%; Native American=0.07%; East Asian, North=2%; East Asian, South=0.6%; South Asian=8.1%; European, North=24.92%; European, South=62.51% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-2294
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11,13
ST   D16S539: 10,11
ST   D18S51: 13,17
ST   D19S433: 14,15
ST   D21S11: 28,31.2
ST   D2S1338: 23,24
ST   D3S1358: 16,17
ST   D5S818: 12
ST   D7S820: 10,11
ST   D8S1179: 14
ST   FGA: 20,22.2
ST   Penta D: 8,13
ST   Penta E: 10
ST   TH01: 7,9
ST   TPOX: 8,9
ST   vWA: 17,18
DI   NCIt; C6915; Primary effusion lymphoma
DI   ORDO; Orphanet_48686; Primary effusion lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   94Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8705864; DOI=10.1038/nm0896-925;
RA   Gao S.-J., Kingsley L., Li M., Zheng W., Parravicini C., Ziegler J.,
RA   Newton R., Rinaldo C.R., Saah A., Phair J.P., Detels R., Chang Y.,
RA   Moore P.S.;
RT   "KSHV antibodies among Americans, Italians and Ugandans with and
RT   without Kaposi's sarcoma.";
RL   Nat. Med. 2:925-928(1996).
//
RX   PubMed=9473233; DOI=10.1182/blood.V91.5.1671;
RA   Boshoff C., Gao S.-J., Healy L.E., Matthews S., Thomas A.J.,
RA   Coignet L.J.A., Warnke R.A., Strauchen J.A., Matutes E., Kamel O.W.,
RA   Moore P.S., Weiss R.A., Chang Y.;
RT   "Establishing a KSHV+ cell line (BCP-1) from peripheral blood and
RT   characterizing its growth in Nod/SCID mice.";
RL   Blood 91:1671-1679(1998).
//
RX   PubMed=9766492; DOI=10.1038/sj.leu.2401160;
RA   Drexler H.G., Uphoff C.C., Gaidano G., Carbone A.;
RT   "Lymphoma cell lines: in vitro models for the study of HHV-8+ primary
RT   effusion lymphomas (body cavity-based lymphomas).";
RL   Leukemia 12:1507-1517(1998).
//
RX   PubMed=15613351; DOI=10.1128/JVI.79.2.1244-1251.2005; PMCID=PMC538532;
RA   Fan W., Bubman D., Chadburn A., Harrington W.J. Jr., Cesarman E.,
RA   Knowles D.M.;
RT   "Distinct subsets of primary effusion lymphoma can be identified based
RT   on their cellular gene expression profile and viral association.";
RL   J. Virol. 79:1244-1251(2005).
//
RX   PubMed=17121789; DOI=10.1128/JVI.01757-06; PMCID=PMC1797584;
RA   Burd C.E., Sin S.-H., Dittmer D.P.;
RT   "Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus
RT   lymphomas: implications for therapy.";
RL   J. Virol. 81:1912-1922(2007).
//
RX   PubMed=19608668; DOI=10.3324/haematol.2009.007260; PMCID=PMC2719041;
RA   Boulanger E., Marchio A., Hong S.-S., Pineau P.;
RT   "Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin
RT   genes in human herpesvirus 8-associated primary effusion lymphoma.";
RL   Haematologica 94:1170-1174(2009).
//
RX   PubMed=21685375; DOI=10.1182/blood-2010-12-323659; PMCID=PMC3158728;
RA   Roy D., Sin S.-H., Damania B., Dittmer D.P.;
RT   "Tumor suppressor genes FHIT and WWOX are deleted in primary effusion
RT   lymphoma (PEL) cell lines.";
RL   Blood 118:e32-e39(2011).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25355872; DOI=10.1128/JVI.02570-14; PMCID=PMC4301145;
RA   Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z.,
RA   O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.;
RT   "High-throughput RNA sequencing-based virome analysis of 50 lymphoma
RT   cell lines from the Cancer Cell Line Encyclopedia project.";
RL   J. Virol. 89:713-729(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X.,
RA   Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C.,
RA   Yang H.H., Koeffler H.P.;
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//