ID SUP-B15 AC CVCL_0103 SY Sup-B15; SUPB-15; SUPB15; SupB15; SupB15W; SupB15WT DR CLO; CLO_0009161 DR EFO; EFO_0006763 DR AddexBio; C0003019/4892 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-1929 DR BCRJ; 0229 DR BioSample; SAMN03473114 DR BioSample; SAMN10987666 DR cancercelllines; CVCL_0103 DR CCRID; 3101HUMTCHu190 DR Cell_Model_Passport; SIDM01176 DR ChEMBL-Cells; CHEMBL4295393 DR ChEMBL-Targets; CHEMBL4296498 DR Cosmic; 1012120 DR Cosmic; 1130245 DR Cosmic; 1498420 DR Cosmic; 1524821 DR Cosmic; 1630017 DR Cosmic; 2491077 DR Cosmic-CLP; 1247871 DR DepMap; ACH-000059 DR DSMZ; ACC-389 DR DSMZCellDive; ACC-389 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR GDSC; 1247871 DR GEO; GSM236806 DR GEO; GSM236842 DR GEO; GSM887658 DR GEO; GSM888750 DR GEO; GSM1374913 DR GEO; GSM1670490 DR GEO; GSM5137745 DR GEO; GSM5137767 DR IARC_TP53; 30174 DR IZSLER; BS TCL 238 DR LiGeA; CCLE_418 DR LINCS_LDP; LCL-1041 DR PharmacoDB; SUPB15_1518_2019 DR PRIDE; PXD000394 DR PRIDE; PXD023662 DR PRIDE; PXD030304 DR Progenetix; CVCL_0103 DR PubChem_Cell_line; CVCL_0103 DR Wikidata; Q54970859 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=3162827; RX PubMed=7630190; RX PubMed=7888679; RX PubMed=8704231; RX PubMed=9067587; RX PubMed=9108419; RX PubMed=9823951; RX PubMed=10071072; RX PubMed=10576511; RX PubMed=15843827; RX PubMed=16408098; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25576301; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30879952; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35354797; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Doubling time: ~18 hours (PubMed=3162827); ~60 hours (DSMZ=ACC-389). CC HLA typing: A*03:01,11:01; B*51:02,52:01; C*12:02,14:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 1 fused to ABL1 exon 2 (e1a2 transcript) (PubMed=3162827; PubMed=10071072; PubMed=10576511; PubMed=15843827; PubMed=25485619; PubMed=35354797; DepMap=ACH-000059). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; HLA class I peptidome. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.5%; East Asian, North=0.25%; East Asian, South=0.2%; South Asian=1.01%; European, North=70.33%; European, South=27.71% (PubMed=30894373). CC Discontinued: AddexBio; C0003019/4892; probable. CC Discontinued: BCRJ; 0229; probable. CC Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371. ST Source(s): ATCC=CRL-1929; Cosmic-CLP=1247871; DSMZ=ACC-389; PubMed=25877200; PubMed=30879952 ST Amelogenin: X,Y ST CSF1PO: 11,12 ST D13S317: 8,14 ST D16S539: 11,12 ST D18S51: 14 ST D19S433: 13,15 ST D21S11: 28,31 ST D2S1338: 20,23 ST D3S1358: 15,16 ST D5S818: 12,13 ST D7S820: 10,11 ST D8S1179: 11,14 ST FGA: 19,20 ST Penta D: 9,12 ST Penta E: 21 ST TH01: 6,9.3 ST TPOX: 8,9 ST vWA: 15,17 DI NCIt; C68659; Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 DI ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_A308 ! SUP-B13 SX Male AG 9Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 44 CH CVCL_S642 ! SUP-B15/RI CH CVCL_DR65 ! SupB15RT // RX PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468; RA Kailayangiri, Sareetha RA Altvater, Bianca RA Lesch, Stefanie RA Balbach, Sebastian T. RA Gottlich, Claudia RA Kuhnemundt, Johanna RA Mikesch, Jan-Henrik RA Schelhaas, Sonja RA Jamitzky, Silke RA Meltzer, Jutta RA Farwick, Nicole RA Greune, Lea RA Fluegge, Maike RA Kerl, Kornelius RA Lode, Holger N. RA Siebert, Nikolai RA Muller, Ingo RA Walles, Heike RA Hartmann, Wolfgang RA Rossig, Claudia RT "EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for RT targeting with gene-modified T cells."; RL Mol. Ther. 27:933-946(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=3162827; RA Naumovski, Louie RA Morgan, Rodman RA Hecht, Frederick RA Link, Michael P. RA Glader, Bertil E. RA Smith, Stephen D. RT "Philadelphia chromosome-positive acute lymphoblastic leukemia cell RT lines without classical breakpoint cluster region rearrangement."; RL Cancer Res. 48:2876-2879(1988). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=8704231; DOI=10.1182/blood.V88.3.785.785; RA Kim, Do-Hyun RA Moldwin, Richard L. RA Vignon, Clementine RA Bohlander, Stefan Klaus RA Suto, Yoshimasa RA Giordano, Lisa RA Gupta, Rajat RA Fears, Scott RA Nucifora, Giuseppina RA Rowley, Janet Davison RA Smith, Stephen D. RT "TEL-AML1 translocations with TEL and CDKN2 inactivation in acute RT lymphoblastic leukemia cell lines."; RL Blood 88:785-794(1996). // RX PubMed=7630190; RA Zhou, Mu-Xiang RA Gu, Lu-Bing RA James, Charles David RA He, Ju RA Yeager, Andrew M. RA Smith, Stephen D. RA Findley, Harry W. Jr. RT "Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines RT established from children with acute lymphoblastic leukemia."; RL Leukemia 9:1159-1161(1995). // RX PubMed=7888679; DOI=10.1182/blood.V85.6.1608.bloodjournal8561608; RA Zhou, Mu-Xiang RA Yeager, Andrew M. RA Smith, Stephen D. RA Findley, Harry W. Jr. RT "Overexpression of the MDM2 gene by childhood acute lymphoblastic RT leukemia cells expressing the wild-type p53 gene."; RL Blood 85:1608-1614(1995). // RX PubMed=9823951; DOI=10.1038/sj.leu.2401198; RA Zhou, Mu-Xiang RA Gu, Lu-Bing RA Yeager, Andrew M. RA Findley, Harry W. Jr. RT "Sensitivity to Fas-mediated apoptosis in pediatric acute RT lymphoblastic leukemia is associated with a mutant p53 phenotype and RT absence of Bcl-2 expression."; RL Leukemia 12:1756-1763(1998). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=15843827; DOI=10.1038/sj.leu.2403749; RA Hagstrom-Andersson, Anna K. RA Eden, Patrik RA Lindgren, David RA Nilsson, Jens RA Lassen, Carin RA Heldrup, Jesper RA Fontes, Magnus RA Borg, Ake RA Mitelman, Felix RA Johansson, Bertil RA Hoglund, Mattias RA Fioretos, Thoas RT "Gene expression profiling of leukemic cell lines reveals conserved RT molecular signatures among subtypes with specific genetic RT aberrations."; RL Leukemia 19:1042-1050(2005). // RX PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4; RA Drexler, Hans Gunther RA MacLeod, Roderick A.F. RA Uphoff, Cord C. RT "Leukemia cell lines: in vitro models for the study of Philadelphia RT chromosome-positive leukemia."; RL Leuk. Res. 23:207-215(1999). // RX PubMed=9067587; DOI=10.1038/sj.leu.2400571; RA Uphoff, Cord C. RA MacLeod, Roderick A.F. RA Denkmann, Sabine A. RA Golub, Todd Robert RA Borkhardt, Arndt RA Janssen, Johannes W.G. RA Drexler, Hans Gunther RT "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in RT human early B-lineage leukemia cell lines."; RL Leukemia 11:441-447(1997). // RX PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9; RA Uphoff, Cord C. RA Habig, Silke RA Fombonne, Severine RA Matsuo, Yoshinobu RA Drexler, Hans Gunther RT "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines."; RL Leuk. Res. 23:1055-1060(1999). // RX PubMed=25576301; DOI=10.1074/mcp.M114.042812; PMCID=PMC4349985; RA Bassani-Sternberg, Michal RA Pletscher-Frankild, Sune RA Jensen, Lars Juhl RA Mann, Matthias RT "Mass spectrometry of human leukocyte antigen class I peptidomes RT reveals strong effects of protein abundance and turnover on antigen RT presentation."; RL Mol. Cell. Proteomics 14:658-673(2015). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=16408098; DOI=10.1038/sj.leu.2404081; RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RA Zaborski, Margarete RA Drexler, Hans Gunther RT "JAK2 V617F tyrosine kinase mutation in cell lines derived from RT myeloproliferative disorders."; RL Leukemia 20:471-476(2006). // RX PubMed=9108419; DOI=10.1182/blood.V89.8.2986; RA Findley, Harry W. Jr. RA Gu, Lu-Bing RA Yeager, Andrew M. RA Zhou, Mu-Xiang RT "Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with RT p53 status and sensitivity to apoptosis in childhood acute RT lymphoblastic leukemia."; RL Blood 89:2986-2993(1997). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900; RA Leo, Isabelle Rose RA Aswad, Luay RA Stahl, Matthias RA Kunold, Elena RA Post, Frederik RA Erkers, Tom RA Struyf, Nona RA Mermelekas, Georgios RA Joshi, Rubin Narayan RA Gracia-Villacampa, Eva RA Ostling, Paivi RA Kallioniemi, Olli-Pekka RA Pokrovskaja Tamm, Katja RA Siavelis, Ioannis RA Lehtio, Janne RA Vesterlund, Mattias RA Jafari, Rozbeh RT "Integrative multi-omics and drug response profiling of childhood RT acute lymphoblastic leukemia cell lines."; RL Nat. Commun. 13:1691.1-1691.19(2022). //