ID   NALM-1
AC   CVCL_0091
SY   Nalm-1; NALM 1; NALM1; Nalm1
DR   CLO; CLO_0007937
DR   EFO; EFO_0002244
DR   CLDB; cl3630
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   ATCC; CRL-1567
DR   BioSample; SAMN01821583
DR   BioSample; SAMN01821650
DR   BioSample; SAMN03471397
DR   BioSample; SAMN10988498
DR   cancercelllines; CVCL_0091
DR   Cell_Model_Passport; SIDM01686
DR   CGH-DB; 9216-4
DR   Cosmic; 787506
DR   Cosmic; 801721
DR   Cosmic; 908157
DR   Cosmic; 999775
DR   Cosmic; 1012105
DR   Cosmic; 1026573
DR   Cosmic; 1498418
DR   Cosmic; 2491099
DR   DepMap; ACH-000462
DR   DSMZ; ACC-131
DR   DSMZCellDive; ACC-131
DR   GEO; GSM887346
DR   GEO; GSM888422
DR   IARC_TP53; 21526
DR   IGRhCellID; NALM1
DR   JCRB; JCRB0064
DR   LiGeA; CCLE_447
DR   PharmacoDB; NALM1_978_2019
DR   Progenetix; CVCL_0091
DR   Wikidata; Q54907391
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=301573;
RX   PubMed=302341;
RX   PubMed=2140233;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3332852;
RX   PubMed=3874327;
RX   PubMed=6582512;
RX   PubMed=6929725;
RX   PubMed=9067587;
RX   PubMed=9680106;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=12506034;
RX   PubMed=15588857;
RX   PubMed=15843827;
RX   PubMed=16408098;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=26589293;
RX   PubMed=29786757;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=35124168;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: African American.
CC   Doubling time: ~48 hours (DSMZ=ACC-131).
CC   HLA typing: A*02:01,33:03; B*52:01,53:01; C*16:01,16:01 (PubMed=26589293).
CC   HLA typing: A*02:01:01,33:03:01; B*52:01:02,53:01:01; C*04:01:01,16:01:01; DPA1*01:03:01,01:03:01; DPB1*18:01,104:01; DQA1*01:05:01,05:05:01; DQB1*03:01:01,05:01:01; DRA*01:01:01,01:02:02; DRB1*12:01:01,13:03:01 (DSMZCellDive=ACC-131).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827; DepMap=ACH-000462).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=77.03%; Native American=6.08%; East Asian, North=2.94%; East Asian, South=0%; South Asian=0%; European, North=4.83%; European, South=9.12% (PubMed=30894373).
CC   Discontinued: JCRB; JCRB0064; probable.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): ATCC=CRL-1567; DSMZ=ACC-131
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 11,15
ST   D18S51: 11,15
ST   D19S433: 11,15
ST   D21S11: 29,30
ST   D2S1338: 17,20
ST   D3S1358: 15,17
ST   D5S818: 11
ST   D7S820: 10,11
ST   D8S1179: 14,15
ST   FGA: 23,26
ST   Penta D: 3
ST   Penta E: 8,9
ST   TH01: 7,9
ST   TPOX: 9,11
ST   vWA: 15,17
DI   NCIt; C7320; Childhood chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   3Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 38
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=301573; DOI=10.1093/jnci/59.1.83;
RA   Minowada, Jun
RA   Tsubota, Teruhiko
RA   Greaves, Melvyn Francis
RA   Walters, Thomas R.
RT   "A non-T, non-B human leukemia cell line (NALM-1): establishment of
RT   the cell line and presence of leukemia-associated antigens.";
RL   J. Natl. Cancer Inst. 59:83-87(1977).
//
RX   PubMed=302341; DOI=10.1093/jnci/59.3.833;
RA   Sonta, Shin-ichi
RA   Minowada, Jun
RA   Tsubota, Teruhiko
RA   Sandberg, Avery Aba
RT   "Cytogenetic study of a new Ph1-positive cell line (NALM-1).";
RL   J. Natl. Cancer Inst. 59:833-837(1977).
//
RX   PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x;
RA   Nakano, Akinobu
RA   Harada, Takayuki
RA   Morikawa, Shigeru
RA   Kato, Yuzuru
RT   "Expression of leukocyte common antigen (CD45) on various human
RT   leukemia/lymphoma cell lines.";
RL   Acta Pathol. Jpn. 40:107-115(1990).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9;
RA   Keating, Armand
RT   "Ph positive CML cell lines.";
RL   Baillieres Clin. Haematol. 1:1021-1029(1987).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=6929725; DOI=10.1002/1097-0142(19800501)45:9<2324::AID-CNCR2820450915>3.0.CO;2-J;
RA   Kubonishi, Ichiro
RA   Freeman, Arnold I.
RA   Minowada, Jun
RT   "Heterotransplantation and clonal growth of human
RT   Ph'-chromosome-positive leukemia-cell (NALM-1) and B-cell
RT   leukemia-cell (BALM-2) lines.";
RL   Cancer 45:2324-2329(1980).
//
RX   PubMed=9067587; DOI=10.1038/sj.leu.2400571;
RA   Uphoff, Cord C.
RA   MacLeod, Roderick A.F.
RA   Denkmann, Sabine A.
RA   Golub, Todd Robert
RA   Borkhardt, Arndt
RA   Janssen, Johannes W.G.
RA   Drexler, Hans Gunther
RT   "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in
RT   human early B-lineage leukemia cell lines.";
RL   Leukemia 11:441-447(1997).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=12506034; DOI=10.1182/blood-2002-06-1770;
RA   Uno, Kanako
RA   Inukai, Takeshi
RA   Kayagaki, Nobuhiko
RA   Goi, Kumiko
RA   Sato, Hiroki
RA   Nemoto, Atsushi
RA   Takahashi, Kazuya
RA   Kagami, Keiko
RA   Yamaguchi, Noriko
RA   Yagita, Hideo
RA   Okumura, Ko
RA   Koyama-Okazaki, Toshiko
RA   Suzuki, Toshio
RA   Sugita, Kanji
RA   Nakazawa, Shinpei
RT   "TNF-related apoptosis-inducing ligand (TRAIL) frequently induces
RT   apoptosis in Philadelphia chromosome-positive leukemia cells.";
RL   Blood 101:3658-3667(2003).
//
RX   PubMed=15588857; DOI=10.1016/j.cancergencyto.2004.04.021;
RA   Pelz, Antje-Friederike
RA   Weilepp, Gisela
RA   Wieacker, Peter F.
RT   "Re-analysis of the cell line NALM-1 karyotype by GTG-banding,
RT   spectral karyotyping, and whole chromosome painting.";
RL   Cancer Genet. Cytogenet. 156:59-61(2005).
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=16408098; DOI=10.1038/sj.leu.2404081;
RA   Quentmeier, Hilmar
RA   MacLeod, Roderick A.F.
RA   Zaborski, Margarete
RA   Drexler, Hans Gunther
RT   "JAK2 V617F tyrosine kinase mutation in cell lines derived from
RT   myeloproliferative disorders.";
RL   Leukemia 20:471-476(2006).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu, Chihiro
RA   Imamura, Toshihiko
RA   Tomii, Toshihiro
RA   Yano, Mio
RA   Asai, Daisuke
RA   Goto, Hiroaki
RA   Shimada, Akira
RA   Sanada, Masashi
RA   Iwamoto, Shotaro
RA   Takita, Junko
RA   Minegishi, Masayoshi
RA   Inukai, Takeshi
RA   Sugita, Kanji
RA   Hosoi, Hajime
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai, Minori
RA   Kasai, Shin
RA   Akahane, Koshi
RA   Thu, Thao Nguyen
RA   Kagami, Keiko
RA   Komatsu, Chiaki
RA   Abe, Masako
RA   Watanabe, Atsushi
RA   Goi, Kumiko
RA   Miyake, Kunio
RA   Inaba, Toshiya
RA   Takita, Junko
RA   Goto, Hiroaki
RA   Minegishi, Masayoshi
RA   Iwamoto, Shotaro
RA   Sugita, Kanji
RA   Inukai, Takeshi
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//