ID NALM-1 AC CVCL_0091 SY Nalm-1; NALM 1; NALM1; Nalm1 DR CLO; CLO_0007937 DR EFO; EFO_0002244 DR CLDB; cl3630 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR ATCC; CRL-1567 DR BioSample; SAMN01821583 DR BioSample; SAMN01821650 DR BioSample; SAMN03471397 DR BioSample; SAMN10988498 DR cancercelllines; CVCL_0091 DR Cell_Model_Passport; SIDM01686 DR CGH-DB; 9216-4 DR Cosmic; 787506 DR Cosmic; 801721 DR Cosmic; 908157 DR Cosmic; 999775 DR Cosmic; 1012105 DR Cosmic; 1026573 DR Cosmic; 1498418 DR Cosmic; 2491099 DR DepMap; ACH-000462 DR DSMZ; ACC-131 DR DSMZCellDive; ACC-131 DR GEO; GSM887346 DR GEO; GSM888422 DR IARC_TP53; 21526 DR IGRhCellID; NALM1 DR JCRB; JCRB0064 DR LiGeA; CCLE_447 DR PharmacoDB; NALM1_978_2019 DR Progenetix; CVCL_0091 DR Wikidata; Q54907391 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=301573; RX PubMed=302341; RX PubMed=2140233; RX PubMed=2985879; RX PubMed=3159941; RX PubMed=3332852; RX PubMed=3874327; RX PubMed=6582512; RX PubMed=6929725; RX PubMed=9067587; RX PubMed=9680106; RX PubMed=10071072; RX PubMed=10576511; RX PubMed=12506034; RX PubMed=15588857; RX PubMed=15843827; RX PubMed=16408098; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=26589293; RX PubMed=29786757; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=35124168; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: LL-100 blood cancer cell line panel. CC Population: African American. CC Doubling time: ~48 hours (DSMZ=ACC-131). CC HLA typing: A*02:01,33:03; B*52:01,53:01; C*16:01,16:01 (PubMed=26589293). CC HLA typing: A*02:01:01,33:03:01; B*52:01:02,53:01:01; C*04:01:01,16:01:01; DPA1*01:03:01,01:03:01; DPB1*18:01,104:01; DQA1*01:05:01,05:05:01; DQB1*03:01:01,05:01:01; DRA*01:01:01,01:02:02; DRB1*12:01:01,13:03:01 (DSMZCellDive=ACC-131). CC Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=15843827; DepMap=ACH-000462). CC Omics: Genomics; Whole exome sequencing. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=77.03%; Native American=6.08%; East Asian, North=2.94%; East Asian, South=0%; South Asian=0%; European, North=4.83%; European, South=9.12% (PubMed=30894373). CC Discontinued: JCRB; JCRB0064; probable. CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. ST Source(s): ATCC=CRL-1567; DSMZ=ACC-131 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 11,12 ST D16S539: 11,15 ST D18S51: 11,15 ST D19S433: 11,15 ST D21S11: 29,30 ST D2S1338: 17,20 ST D3S1358: 15,17 ST D5S818: 11 ST D7S820: 10,11 ST D8S1179: 14,15 ST FGA: 23,26 ST Penta D: 3 ST Penta E: 8,9 ST TH01: 7,9 ST TPOX: 9,11 ST vWA: 15,17 DI NCIt; C7320; Childhood chronic myelogenous leukemia, BCR-ABL1 positive DI ORDO; Orphanet_521; Chronic myeloid leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 3Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 38 // RX PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068; RA Tamai, Minori RA Kasai, Shin RA Akahane, Koshi RA Thu, Thao Nguyen RA Kagami, Keiko RA Komatsu, Chiaki RA Abe, Masako RA Watanabe, Atsushi RA Goi, Kumiko RA Miyake, Kunio RA Inaba, Toshiya RA Takita, Junko RA Goto, Hiroaki RA Minegishi, Masayoshi RA Iwamoto, Shotaro RA Sugita, Kanji RA Inukai, Takeshi RT "Glucocorticoid receptor gene mutations confer glucocorticoid RT resistance in B-cell precursor acute lymphoblastic leukemia."; RL J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646; RA Quentmeier, Hilmar RA Pommerenke, Claudia RA Dirks, Wilhelm Gerhard RA Eberth, Sonja RA Koeppel, Max RA MacLeod, Roderick A.F. RA Nagel, Stefan RA Steube, Klaus G. RA Uphoff, Cord C. RA Drexler, Hans Gunther RT "The LL-100 panel: 100 cell lines for blood cancer studies."; RL Sci. Rep. 9:8218.1-8218.14(2019). // RX PubMed=301573; DOI=10.1093/jnci/59.1.83; RA Minowada, Jun RA Tsubota, Teruhiko RA Greaves, Melvyn Francis RA Walters, Thomas R. RT "A non-T, non-B human leukemia cell line (NALM-1): establishment of RT the cell line and presence of leukemia-associated antigens."; RL J. Natl. Cancer Inst. 59:83-87(1977). // RX PubMed=15588857; DOI=10.1016/j.cancergencyto.2004.04.021; RA Pelz, Antje-Friederike RA Weilepp, Gisela RA Wieacker, Peter F. RT "Re-analysis of the cell line NALM-1 karyotype by GTG-banding, RT spectral karyotyping, and whole chromosome painting."; RL Cancer Genet. Cytogenet. 156:59-61(2005). // RX PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- III. RT Beta-hexosaminidase (E.C. 3.2.1.30)."; RL Leuk. Res. 9:549-559(1985). // RX PubMed=15843827; DOI=10.1038/sj.leu.2403749; RA Hagstrom-Andersson, Anna K. RA Eden, Patrik RA Lindgren, David RA Nilsson, Jens RA Lassen, Carin RA Heldrup, Jesper RA Fontes, Magnus RA Borg, Ake RA Mitelman, Felix RA Johansson, Bertil RA Hoglund, Mattias RA Fioretos, Thoas RT "Gene expression profiling of leukemic cell lines reveals conserved RT molecular signatures among subtypes with specific genetic RT aberrations."; RL Leukemia 19:1042-1050(2005). // RX PubMed=6929725; DOI=10.1002/1097-0142(19800501)45:9<2324::AID-CNCR2820450915>3.0.CO;2-J; RA Kubonishi, Ichiro RA Freeman, Arnold I. RA Minowada, Jun RT "Heterotransplantation and clonal growth of human RT Ph'-chromosome-positive leukemia-cell (NALM-1) and B-cell RT leukemia-cell (BALM-2) lines."; RL Cancer 45:2324-2329(1980). // RX PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4; RA Drexler, Hans Gunther RA MacLeod, Roderick A.F. RA Uphoff, Cord C. RT "Leukemia cell lines: in vitro models for the study of Philadelphia RT chromosome-positive leukemia."; RL Leuk. Res. 23:207-215(1999). // RX PubMed=12506034; DOI=10.1182/blood-2002-06-1770; RA Uno, Kanako RA Inukai, Takeshi RA Kayagaki, Nobuhiko RA Goi, Kumiko RA Sato, Hiroki RA Nemoto, Atsushi RA Takahashi, Kazuya RA Kagami, Keiko RA Yamaguchi, Noriko RA Yagita, Hideo RA Okumura, Ko RA Koyama-Okazaki, Toshiko RA Suzuki, Toshio RA Sugita, Kanji RA Nakazawa, Shinpei RT "TNF-related apoptosis-inducing ligand (TRAIL) frequently induces RT apoptosis in Philadelphia chromosome-positive leukemia cells."; RL Blood 101:3658-3667(2003). // RX PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720; RA Mattes, Michael Jules RA Cordon-Cardo, Carlos RA Lewis, John L. Jr. RA Old, Lloyd John RA Lloyd, Kenneth Oliver RT "Cell surface antigens of human ovarian and endometrial carcinoma RT defined by mouse monoclonal antibodies."; RL Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984). // RX PubMed=9067587; DOI=10.1038/sj.leu.2400571; RA Uphoff, Cord C. RA MacLeod, Roderick A.F. RA Denkmann, Sabine A. RA Golub, Todd Robert RA Borkhardt, Arndt RA Janssen, Johannes W.G. RA Drexler, Hans Gunther RT "Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in RT human early B-lineage leukemia cell lines."; RL Leukemia 11:441-447(1997). // RX PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2; RA Matsuo, Yoshinobu RA Drexler, Hans Gunther RT "Establishment and characterization of human B cell precursor-leukemia RT cell lines."; RL Leuk. Res. 22:567-579(1998). // RX PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1. RT Carboxylic esterase."; RL Leuk. Res. 9:209-229(1985). // RX PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9; RA Uphoff, Cord C. RA Habig, Silke RA Fombonne, Severine RA Matsuo, Yoshinobu RA Drexler, Hans Gunther RT "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines."; RL Leuk. Res. 23:1055-1060(1999). // RX PubMed=16408098; DOI=10.1038/sj.leu.2404081; RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RA Zaborski, Margarete RA Drexler, Hans Gunther RT "JAK2 V617F tyrosine kinase mutation in cell lines derived from RT myeloproliferative disorders."; RL Leukemia 20:471-476(2006). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=302341; DOI=10.1093/jnci/59.3.833; RA Sonta, Shin-ichi RA Minowada, Jun RA Tsubota, Teruhiko RA Sandberg, Avery Aba RT "Cytogenetic study of a new Ph1-positive cell line (NALM-1)."; RL J. Natl. Cancer Inst. 59:833-837(1977). // RX PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x; RA Nakano, Akinobu RA Harada, Takayuki RA Morikawa, Shigeru RA Kato, Yuzuru RT "Expression of leukocyte common antigen (CD45) on various human RT leukemia/lymphoma cell lines."; RL Acta Pathol. Jpn. 40:107-115(1990). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=29786757; DOI=10.1007/s12185-018-2474-7; RA Tomoyasu, Chihiro RA Imamura, Toshihiko RA Tomii, Toshihiro RA Yano, Mio RA Asai, Daisuke RA Goto, Hiroaki RA Shimada, Akira RA Sanada, Masashi RA Iwamoto, Shotaro RA Takita, Junko RA Minegishi, Masayoshi RA Inukai, Takeshi RA Sugita, Kanji RA Hosoi, Hajime RT "Copy number abnormality of acute lymphoblastic leukemia cell lines RT based on their genetic subtypes."; RL Int. J. Hematol. 108:312-318(2018). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9; RA Keating, Armand RT "Ph positive CML cell lines."; RL Baillieres Clin. Haematol. 1:1021-1029(1987). // RX PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x; RA Drexler, Hans Gunther RA Gaedicke, Gerhard RA Minowada, Jun RT "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid RT phosphatase."; RL Leuk. Res. 9:537-548(1985). //