ID SNU-398 AC CVCL_0077 SY SNU398; NCI-SNU-398 DR BTO; BTO_0003170 DR CLO; CLO_0009098 DR EFO; EFO_0002347 DR MCCL; MCC:0000435 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2233 DR BioGRID_ORCS_Cell_line; 368 DR BioSample; SAMN03473191 DR BioSample; SAMN10987942 DR cancercelllines; CVCL_0077 DR Cell_Model_Passport; SIDM01181 DR ChEMBL-Cells; CHEMBL3307619 DR ChEMBL-Targets; CHEMBL614454 DR CLS; 305274 DR Cosmic; 873393 DR Cosmic; 928143 DR Cosmic; 1187337 DR Cosmic; 1995640 DR Cosmic; 2009538 DR Cosmic; 2023868 DR Cosmic; 2162531 DR Cosmic; 2321036 DR Cosmic; 2771606 DR Cosmic-CLP; 1240217 DR DepMap; ACH-000221 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 1240217 DR GEO; GSM481448 DR GEO; GSM565922 DR GEO; GSM827415 DR GEO; GSM887623 DR GEO; GSM888708 DR GEO; GSM936780 DR GEO; GSM1374890 DR GEO; GSM1670468 DR GEO; GSM2551587 DR IARC_TP53; 6307 DR IGRhCellID; SNU398 DR KCLB; 00398 DR LiGeA; CCLE_422 DR LIMORE; SNU398 DR LINCS_LDP; LCL-1934 DR PharmacoDB; SNU398_1458_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_0077 DR PubChem_Cell_line; CVCL_0077 DR Wikidata; Q54955184 RX PubMed=7543080; RX PubMed=8824565; RX PubMed=19956504; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=23505090; RX PubMed=23887712; RX PubMed=25485619; RX PubMed=25574106; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=31063779; RX PubMed=31068700; RX PubMed=31378681; RX PubMed=35839778; WW Info; LCCL; -; https://lccl.zucmanlab.com/hcc/cellLines/SNU398 WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/liver-cancer-xenograft/snu-398-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: Liver Cancer Model Repository (LIMORE). CC Part of: MD Anderson Cell Lines Project. CC Part of: Seoul National University (SNU) cell line collection. CC Population: Korean. CC Doubling time: 39 hours (PubMed=7543080); 25.49 hours (PubMed=31378681). CC HLA typing: A*02:01,24:02; B*15:32,40:02; C*01:02,04:01 (PubMed=26589293). CC Karyotypic information: Has lost chromosome Y. CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser37Cys (c.110C>G); ClinVar=VCV000017579; Zygosity=Heterozygous (PubMed=31378681; Cosmic-CLP=1240217; DepMap=ACH-000221). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Ile (c.644G>T); ClinVar=VCV000376660; Zygosity=Heterozygous (PubMed=8824565). CC Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; miRNA profiling; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.33%; Native American=0.85%; East Asian, North=66.35%; East Asian, South=28.86%; South Asian=0%; European, North=0%; European, South=2.61% (PubMed=30894373). CC Derived from site: In situ; Liver; UBERON=UBERON_0002107. ST Source(s): ATCC=CRL-2233; Cosmic-CLP=1240217; KCLB=00398; PubMed=25877200; PubMed=31378681 ST Amelogenin: X,Y ST CSF1PO: 13 ST D13S317: 11 ST D16S539: 10,14 ST D18S51: 15 (PubMed=25877200) ST D18S51: 15,19 (ATCC=CRL-2233) ST D19S433: 14,14.1 ST D21S11: 29 ST D2S1338: 19 ST D3S1358: 17 ST D5S818: 12 ST D7S820: 10,11 ST D8S1179: 12 ST FGA: 22,23 (KCLB=00398) ST FGA: 23 (ATCC=CRL-2233; PubMed=25877200) ST Penta D: 14 ST Penta E: 12 ST TH01: 7,9 (ATCC=CRL-2233; Cosmic-CLP=1240217; PubMed=25877200) ST TH01: 8,9 (KCLB=00398) ST TH01: 9 (PubMed=31378681) ST TPOX: 11 ST vWA: 17,18 DI NCIt; C7956; Adult hepatocellular carcinoma DI ORDO; Orphanet_210159; Adult hepatocellular carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 42Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 CH CVCL_E1CC ! Ubigene SNU-398 LZTR1 KO // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724; RA Qiu, Zhi-Xin RA Li, Hong RA Zhang, Zheng-Tao RA Zhu, Zhen-Feng RA He, Sheng RA Wang, Xu-Jun RA Wang, Peng-Cheng RA Qin, Jian-Jie RA Zhuang, Li-Ping RA Wang, Wei RA Xie, Fu-Bo RA Gu, Ying RA Zou, Ke-Ke RA Li, Chao RA Li, Chun RA Wang, Chen-Hua RA Cen, Jin RA Chen, Xiao-Tao RA Shu, Ya-Jing RA Zhang, Zhao RA Sun, Lu-Lu RA Min, Li-Hua RA Fu, Yong RA Huang, Xiao-Wu RA Lv, Hui RA Zhou, He RA Ji, Yuan RA Zhang, Zhi-Gang RA Meng, Zhi-Qiang RA Shi, Xiao-Lei RA Zhang, Hai-Bin RA Li, Yi-Xue RA Hui, Li-Jian RT "A pharmacogenomic landscape in human liver cancers."; RL Cancer Cell 36:179-193.e11(2019). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. 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RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=25574106; DOI=10.3748/wjg.v21.i1.311; PMCID=PMC4284350; RA Cevik, Dilek RA Yildiz, Gokhan RA Ozturk, Mehmet RT "Common telomerase reverse transcriptase promoter mutations in RT hepatocellular carcinomas from different geographical locations."; RL World J. Gastroenterol. 21:311-317(2015). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=7543080; DOI=10.1002/ijc.2910620308; RA Park, Jae-Gahb RA Lee, Jae-Ho RA Kang, Myung-Soo RA Park, Kyu-Joo RA Jeon, You-Me RA Lee, Hyun-Ju RA Kwon, Hae-Sung RA Park, Hyun-Sook RA Yeo, Kyong-Sook RA Lee, Kuhn-Uk RA Kim, Soo-Tae RA Chung, June-Key RA Hwang, You-Jin RA Lee, Hyo-Suk RA Kim, Chung Yong RA Lee, Young Ik RA Chen, Tchaw-Ren RA Hay, Robert J. RA Song, Sang-Yong RA Kim, Woo-Ho RA Ki, Chul-Woo RA Kim, Young-Il RT "Characterization of cell lines established from human hepatocellular RT carcinoma."; RL Int. J. Cancer 62:276-282(1995). // RX PubMed=23505090; DOI=10.1002/hep.26402; RA Wang, Kai RA Lim, Ho Yeong RA Shi, Stephanie RA Lee, Jeeyun RA Deng, Shi-Bing RA Xie, Tao RA Zhu, Zhou RA Wang, Yu-Li RA Pocalyko, David RA Yang, Wei Jennifer RA Rejto, Paul A. RA Mao, Mao RA Park, Cheol-Keun RA Xu, Jiang-Chun RT "Genomic landscape of copy number aberrations enables the RT identification of oncogenic drivers in hepatocellular carcinoma."; RL Hepatology 58:706-717(2013). // RX PubMed=8824565; DOI=10.1002/(SICI)1097-0215(19960917)67:6<898::AID-IJC22>3.0.CO;2-X; RA Kang, Myung-Soo RA Lee, Hong-Joo RA Lee, Jae-Ho RA Ku, Ja-Lok RA Lee, Kathreen P. RA Kelley, Michael J. RA Won, Yong-Jin RA Kim, Soo-Tae RA Park, Jae-Gahb RT "Mutation of p53 gene in hepatocellular carcinoma cell lines with HBX RT DNA."; RL Int. J. Cancer 67:898-902(1996). // RX PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416; RA Ku, Ja-Lok RA Park, Jae-Gahb RT "Biology of SNU cell lines."; RL Cancer Res. Treat. 37:1-19(2005). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=31063779; DOI=10.1053/j.gastro.2019.05.001; RA Caruso, Stefano RA Calatayud, Anna-Line RA Pilet, Jill RA La Bella, Tiziana RA Rekik, Samia RA Imbeaud, Sandrine RA Letouze, Eric RA Meunier, Lea RA Bayard, Quentin RA Rohr-Udilova, Nataliya RA Peneau, Camille RA Grasl-Kraupp, Bettina RA de Koning, Leanne RA Ouine, Berengere RA Bioulac-Sage, Paulette RA Couchy, Gabrielle RA Calderaro, Julien RA Nault, Jean-Charles RA Zucman-Rossi, Jessica RA Rebouissou, Sandra RT "Analysis of liver cancer cell lines identifies agents with likely RT efficacy against hepatocellular carcinoma and markers of response."; RL Gastroenterology 157:760-776(2019). //