ID   HeLa S3
AC   CVCL_0058
SY   HeLa s3; HeLa-S3; HELA-S3; HeLa/S3; HeLa.S3; HeLa S 3; HeLa S-3; HeLaS3; HeLa, S3 clone; S3-HeLa; S3 HeLa
DR   BTO; BTO:0000568
DR   CLO; CLO_0003695
DR   CLO; CLO_0003696
DR   CLO; CLO_0003699
DR   CLO; CLO_0050921
DR   CLO; CLO_0050936
DR   EFO; EFO_0002791
DR   MCCL; MCC:0000220
DR   CLDB; cl1616
DR   CLDB; cl1617
DR   CLDB; cl1619
DR   CLDB; cl1620
DR   CLDB; cl1621
DR   CLDB; cl1622
DR   4DN; 4DNSRGTEEYSL
DR   ATCC; CCL-2.2
DR   ATCC; CRL-7924
DR   BCRC; 60101
DR   BioSample; SAMN03472408
DR   BioSample; SAMN03472767
DR   CCRID; 1101HUM-PUMC000188
DR   CCRID; 1102HUM-NIFDC00009
DR   CCRID; 4201HUM-CCTCC00193
DR   CCTCC; GDC0193
DR   ChEMBL-Cells; CHEMBL3886002
DR   ChEMBL-Targets; CHEMBL4296436
DR   CLS; 300384
DR   Cosmic; 846181
DR   Cosmic; 1201780
DR   Cosmic; 1324209
DR   dbGAP; phs000665.v9.p1
DR   DSMZ; ACC-161
DR   DSMZCellDive; ACC-161
DR   ECACC; 87110901
DR   ENCODE; ENCBS031GUL
DR   ENCODE; ENCBS061SJE
DR   ENCODE; ENCBS075PNA
DR   ENCODE; ENCBS094KYE
DR   ENCODE; ENCBS113ENC
DR   ENCODE; ENCBS146YHK
DR   ENCODE; ENCBS163VBG
DR   ENCODE; ENCBS199XIN
DR   ENCODE; ENCBS229UDI
DR   ENCODE; ENCBS254ZSR
DR   ENCODE; ENCBS292TEU
DR   ENCODE; ENCBS352IHZ
DR   ENCODE; ENCBS376OKH
DR   ENCODE; ENCBS403WXR
DR   ENCODE; ENCBS417UAY
DR   ENCODE; ENCBS423QWP
DR   ENCODE; ENCBS424JTA
DR   ENCODE; ENCBS432ENC
DR   ENCODE; ENCBS434SUM
DR   ENCODE; ENCBS450RLH
DR   ENCODE; ENCBS468RLW
DR   ENCODE; ENCBS493MKF
DR   ENCODE; ENCBS500SDW
DR   ENCODE; ENCBS529RSF
DR   ENCODE; ENCBS575PET
DR   ENCODE; ENCBS577WSP
DR   ENCODE; ENCBS580FYL
DR   ENCODE; ENCBS585KIN
DR   ENCODE; ENCBS598ZWC
DR   ENCODE; ENCBS635AAA
DR   ENCODE; ENCBS636AAA
DR   ENCODE; ENCBS637AAA
DR   ENCODE; ENCBS646PGB
DR   ENCODE; ENCBS647UNF
DR   ENCODE; ENCBS655ARO
DR   ENCODE; ENCBS656NDW
DR   ENCODE; ENCBS658BKJ
DR   ENCODE; ENCBS681BHB
DR   ENCODE; ENCBS684AAA
DR   ENCODE; ENCBS685AAA
DR   ENCODE; ENCBS686AAA
DR   ENCODE; ENCBS687AAA
DR   ENCODE; ENCBS688AAA
DR   ENCODE; ENCBS689AAA
DR   ENCODE; ENCBS714AAA
DR   ENCODE; ENCBS735AAA
DR   ENCODE; ENCBS736AAA
DR   ENCODE; ENCBS737AAA
DR   ENCODE; ENCBS738AAA
DR   ENCODE; ENCBS739AAA
DR   ENCODE; ENCBS740AAA
DR   ENCODE; ENCBS748HNU
DR   ENCODE; ENCBS804AAA
DR   ENCODE; ENCBS805AAA
DR   ENCODE; ENCBS812AOY
DR   ENCODE; ENCBS822AAA
DR   ENCODE; ENCBS823AAA
DR   ENCODE; ENCBS833ISA
DR   ENCODE; ENCBS834AAA
DR   ENCODE; ENCBS838AAA
DR   ENCODE; ENCBS839AAA
DR   ENCODE; ENCBS854BZN
DR   ENCODE; ENCBS877WSH
DR   ENCODE; ENCBS890POO
DR   ENCODE; ENCBS899VUW
DR   ENCODE; ENCBS979JZP
DR   GEO; GSM472905
DR   GEO; GSM472916
DR   GEO; GSM472932
DR   GEO; GSM733669
DR   GEO; GSM733682
DR   GEO; GSM733684
DR   GEO; GSM733689
DR   GEO; GSM733696
DR   GEO; GSM733711
DR   GEO; GSM733734
DR   GEO; GSM733756
DR   GEO; GSM733785
DR   GEO; GSM736510
DR   GEO; GSM736564
DR   GEO; GSM749721
DR   GEO; GSM749729
DR   GEO; GSM749739
DR   GEO; GSM798322
DR   GEO; GSM803454
DR   GEO; GSM803455
DR   GEO; GSM803478
DR   GEO; GSM803533
DR   GEO; GSM816436
DR   GEO; GSM816643
DR   GEO; GSM816633
DR   GEO; GSM822273
DR   GEO; GSM822285
DR   GEO; GSM822286
DR   GEO; GSM923449
DR   GEO; GSM935272
DR   GEO; GSM935276
DR   GEO; GSM935290
DR   GEO; GSM935302
DR   GEO; GSM935317
DR   GEO; GSM935318
DR   GEO; GSM935320
DR   GEO; GSM935326
DR   GEO; GSM935328
DR   GEO; GSM935341
DR   GEO; GSM935342
DR   GEO; GSM935351
DR   GEO; GSM935362
DR   GEO; GSM935365
DR   GEO; GSM935366
DR   GEO; GSM935367
DR   GEO; GSM935369
DR   GEO; GSM935370
DR   GEO; GSM935383
DR   GEO; GSM935384
DR   GEO; GSM935395
DR   GEO; GSM935405
DR   GEO; GSM935408
DR   GEO; GSM935416
DR   GEO; GSM935432
DR   GEO; GSM935435
DR   GEO; GSM935436
DR   GEO; GSM935459
DR   GEO; GSM935476
DR   GEO; GSM935484
DR   GEO; GSM935486
DR   GEO; GSM935489
DR   GEO; GSM935498
DR   GEO; GSM935500
DR   GEO; GSM935508
DR   GEO; GSM935511
DR   GEO; GSM935552
DR   GEO; GSM935553
DR   GEO; GSM935554
DR   GEO; GSM935555
DR   GEO; GSM935560
DR   GEO; GSM935561
DR   GEO; GSM935570
DR   GEO; GSM935571
DR   GEO; GSM935578
DR   GEO; GSM935582
DR   GEO; GSM935606
DR   GEO; GSM935615
DR   GEO; GSM935625
DR   GEO; GSM935635
DR   GEO; GSM935636
DR   GEO; GSM935637
DR   GEO; GSM935638
DR   GEO; GSM945201
DR   GEO; GSM945208
DR   GEO; GSM945230
DR   GEO; GSM945253
DR   GEO; GSM1003480
DR   GEO; GSM1003483
DR   GEO; GSM1003520
DR   GEO; GSM1003618
DR   GEO; GSM2423737
DR   GEO; GSM2423738
DR   GEO; GSM4224315
DR   GEO; GSM4226257
DR   ICLC; HTL95020
DR   IZSLER; BS TCL 22
DR   JCRB; IFO50011
DR   JCRB; JCRB9010
DR   KCLB; 10002.2
DR   Lonza; 877
DR   NCBI_Iran; C572
DR   PRIDE; PRD000146
DR   PRIDE; PXD000212
DR   PRIDE; PXD000674
DR   PRIDE; PXD000964
DR   PRIDE; PXD001200
DR   PRIDE; PXD001385
DR   PRIDE; PXD001592
DR   PRIDE; PXD002436
DR   PRIDE; PXD002802
DR   PRIDE; PXD003346
DR   PRIDE; PXD003709
DR   PRIDE; PXD004655
DR   PRIDE; PXD006322
DR   PubChem_Cell_line; CVCL_0058
DR   RCB; RCB0191
DR   RCB; RCB1525
DR   RCB; RCB3682
DR   TKG; TKG 0444
DR   TOKU-E; 1437
DR   Wikidata; Q54882556
RX   CelloPub=CLPUB00481;
RX   DOI=10.11418/jtca1981.17.3_101;
RX   PubMed=566722;
RX   PubMed=978597;
RX   PubMed=1180926;
RX   PubMed=1522048;
RX   PubMed=3180844;
RX   PubMed=3756862;
RX   PubMed=3986962;
RX   PubMed=6256643;
RX   PubMed=6825208;
RX   PubMed=9290701;
RX   PubMed=10338214;
RX   PubMed=11416159;
RX   PubMed=13286432;
RX   PubMed=13531635;
RX   PubMed=14518029;
RX   PubMed=16589695;
RX   PubMed=19450234;
RX   PubMed=23325432;
RX   PubMed=23925245;
RX   PubMed=24185095;
RX   PubMed=26550473;
RX   PubMed=30175587;
RX   PubMed=30778230;
RX   PubMed=33205894;
WW   http://genome.ucsc.edu/ENCODE/protocols/cell/human/HeLa-S3_protocol.pdf
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-157.html
WW   http://immortalcells.blogspot.ch/2011/12/hela-vs-hela-s3.html
CC   Part of: ENCODE project common cell types; tier 2.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: African American.
CC   Virology: Has at least 4 five HPV18 integration sites in the genome (PubMed=26550473).
CC   Doubling time: ~48 hours (DSMZ=ACC-161).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: ChIP-seq epigenome analysis.
CC   Omics: CTCF ChIP-seq epigenome analysis.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K36me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me2 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: H3K79me2 ChIP-seq epigenome analysis.
CC   Omics: H3K9ac ChIP-seq epigenome analysis.
CC   Omics: H4K20me1 ChIP-seq epigenome analysis.
CC   Omics: Hi-C chromosome conformation analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Genome sequenced.
CC   Omics: scRNAseq analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Anecdotal: The 'S' series of HeLa clones was named after Dr. Florence Sabin.
CC   Discontinued: ATCC; CRL-7924; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; CCRID; CLS; DSMZ; ECACC; JCRB; KCLB; PubMed=11416159; PubMed=14518029; RCB; TKG
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 12 (RCB)
ST   D13S317: 12,13.3 (DSMZ; JCRB_IFO50011)
ST   D13S317: 13.3 (ATCC; CCRID; CLS; JCRB_JCRB9010; KCLB; TKG)
ST   D13S317: 14 (ECACC; PubMed=14518029)
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11 (JCRB_IFO50011)
ST   D5S818: 11,12 (ATCC; CCRID; CLS; DSMZ; ECACC; JCRB_JCRB9010; KCLB; PubMed=14518029; RCB; TKG)
ST   D7S820: 8 (JCRB_JCRB9010)
ST   D7S820: 8,12 (ATCC; CCRID; CLS; DSMZ; ECACC; JCRB_IFO50011; KCLB; PubMed=14518029; RCB; TKG)
ST   D8S1179: 12,13
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,17,18 (JCRB_JCRB9010)
ST   vWA: 16,18 (ATCC; CCRID; CLS; DSMZ; ECACC; KCLB; PubMed=11416159; PubMed=14518029; RCB; TKG)
ST   vWA: 17,18 (JCRB_IFO50011)
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 41
//
RX   CelloPub=CLPUB00481;
RA   Kuno H., Yoshida T.;
RT   "Detection of human papillomavirus types 16, 18, and 33 in cell lines
RT   derived from human genital organs by polymerase chain reaction.";
RL   Res. Commun. Inst. Ferment. Osaka 18:6-12(1997).
//
RX   DOI=10.11418/jtca1981.17.3_101;
RA   Itami C., Ishida R., Utsumi K.R., Nakabayashi T.;
RT   "Variation in three groups of HeLa cell sublines as revealed by
RT   karyotype analysis and O6-methylguaninedna-methyltransferase
RT   activity.";
RL   Tissue Cult. Res. Commun. 17:101-106(1998).
//
RX   PubMed=566722; DOI=10.1007/BF02616110;
RA   Lavappa K.S.;
RT   "Survey of ATCC stocks of human cell lines for HeLa contamination.";
RL   In Vitro 14:469-475(1978).
//
RX   PubMed=978597; DOI=10.1269/jrr.17.154;
RA   Nikaido O., Horikawa M.;
RT   "Analysis of the factors in determining radiosensitivity in mammalian
RT   cells by using radio-sensitive and -resistant clones isolated from
RT   HeLa S3 cells in vitro.";
RL   J. Radiat. Res. 17:154-173(1976).
//
RX   PubMed=1180926; DOI=10.1016/0006-291x(75)90551-3;
RA   Fujiwara Y., Tatsumi M.;
RT   "Repair of mitomycin C damage to DNA in mammalian cells and its
RT   impairment in Fanconi's anemia cells.";
RL   Biochem. Biophys. Res. Commun. 66:592-598(1975).
//
RX   PubMed=1522048; DOI=10.1007/BF02634140;
RA   Kataoka E., Honma M., Ohnishi K., Sofuni T., Mizusawa H.;
RT   "Application of highly polymorphic DNA markers to the identification
RT   of HeLa cell sublines.";
RL   In Vitro Cell. Dev. Biol. Anim. 28:553-556(1992).
//
RX   PubMed=3180844; DOI=10.1159/000132579;
RA   Chen T.-R.;
RT   "Re-evaluation of HeLa, HeLa S3, and HEp-2 karyotypes.";
RL   Cytogenet. Cell Genet. 48:19-24(1988).
//
RX   PubMed=3756862;
RA   Maynard K., Parsons P.G.;
RT   "Cross-sensitivity of methylating agents, hydroxyurea, and
RT   methotrexate in human tumor cells of the Mer- phenotype.";
RL   Cancer Res. 46:5009-5013(1986).
//
RX   PubMed=3986962; DOI=10.1093/carcin/6.4.549;
RA   Watatani M., Ikenaga M., Hatanaka T., Kinuta M., Takai S.-i., Mori T.,
RA   Kondo S.;
RT   "Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA
RT   damage in tumor cell strains from Japanese patients and demonstration
RT   of MNNG hypersensitivity of Mer xenografts in athymic nude mice.";
RL   Carcinogenesis 6:549-553(1985).
//
RX   PubMed=6256643; DOI=10.1038/288724a0;
RA   Day R.S. III, Ziolkowski C.H.J., Scudiero D.A., Meyer S.A.,
RA   Lubiniecki A.S., Girardi A.J., Galloway S.M., Bynum G.D.;
RT   "Defective repair of alkylated DNA by human tumour and
RT   SV40-transformed human cell strains.";
RL   Nature 288:724-727(1980).
//
RX   PubMed=6825208; DOI=10.1093/carcin/4.2.199;
RA   Yarosh D.B., Foote R.S., Mitra S., Day R.S. III;
RT   "Repair of O6-methylguanine in DNA by demethylation is lacking in Mer-
RT   human tumor cell strains.";
RL   Carcinogenesis 4:199-205(1983).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=10338214; DOI=10.1016/s0092-8674(00)80760-6;
RA   Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A.,
RA   Moss H., de Lange T.;
RT   "Mammalian telomeres end in a large duplex loop.";
RL   Cell 97:503-514(1999).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198;
RA   Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G.,
RA   Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R.,
RA   Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.;
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=13286432; DOI=10.1084/jem.103.2.273;
RA   Puck T.T., Marcus P.I., Cieciura S.J.;
RT   "Clonal growth of mammalian cells in vitro; growth characteristics of
RT   colonies from single HeLa cells with and without a feeder layer.";
RL   J. Exp. Med. 103:273-283(1956).
//
RX   PubMed=13531635; DOI=10.1007/BF00340146;
RA   Pomerat C.M., Kent S.P., Logie L.C.;
RT   "Irradiation of cells in tissue culture. I. Giant cell induction in
RT   strain cultures versus elements from primary explants.";
RL   Z. Zellforsch. Mikrosk. Anat. 47:158-174(1957).
//
RX   PubMed=14518029; DOI=10.1002/pros.10290;
RA   van Bokhoven A., Varella-Garcia M., Korch C.T., Johannes W.U.,
RA   Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.;
RT   "Molecular characterization of human prostate carcinoma cell lines.";
RL   Prostate 57:205-225(2003).
//
RX   PubMed=16589695; DOI=10.1073/pnas.41.7.432;
RA   Puck T.T., Marcus P.I.;
RT   "A rapid method for viable cell titration and clone production with
RT   HeLa cells in tissue culture: the use of X-irradiated cells to supply
RT   conditioning factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 41:432-437(1955).
//
RX   PubMed=19450234; DOI=10.2144/000113089;
RA   Rahbari R., Sheahan T., Modes V., Collier P., Macfarlane C.M.,
RA   Badge R.M.;
RT   "A novel L1 retrotransposon marker for HeLa cell line
RT   identification.";
RL   BioTechniques 46:277-284(2009).
//
RX   PubMed=23325432; DOI=10.1101/gr.147942.112;
RA   Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E.,
RA   Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A.,
RA   Crawford G.E., Absher D.M., Wold B.J., Myers R.M.;
RT   "Dynamic DNA methylation across diverse human cell lines and
RT   tissues.";
RL   Genome Res. 23:555-567(2013).
//
RX   PubMed=23925245; DOI=10.1038/nature12064;
RA   Adey A., Burton J.N., Kitzman J.O., Hiatt J.B., Lewis A.P.,
RA   Martin B.K., Qiu R.-L., Lee C., Shendure J.;
RT   "The haplotype-resolved genome and epigenome of the aneuploid HeLa
RT   cancer cell line.";
RL   Nature 500:207-211(2013).
//
RX   PubMed=24185095; DOI=10.1038/nbt.2727;
RA   Burton J.N., Adey A., Patwardhan R.P., Qiu R.-L., Kitzman J.O.,
RA   Shendure J.;
RT   "Chromosome-scale scaffolding of de novo genome assemblies based on
RT   chromatin interactions.";
RL   Nat. Biotechnol. 31:1119-1125(2013).
//
RX   PubMed=26550473; DOI=10.1186/s13742-015-0091-4;
RA   Wu L., Zhang X.-L., Zhao Z.-K., Wang L., Li B., Li G.-B., Dean M.,
RA   Yu Q.-C., Wang Y.-H., Lin X.-X., Rao W.-J., Mei Z.-L., Li Y.,
RA   Jiang R.-Z., Yang H., Li F.-Q., Xie G.-Y., Xu L.-Q., Wu K., Zhang J.,
RA   Chen J.-H., Wang T., Kristiansen K., Zhang X.-Q., Li Y.-R.,
RA   Yang H.-M., Wang J., Hou Y., Xu X.;
RT   "Full-length single-cell RNA-seq applied to a viral human cancer:
RT   applications to HPV expression and splicing analysis in HeLa S3
RT   cells.";
RL   GigaScience 4:51.1-51.17(2015).
//
RX   PubMed=30175587; DOI=10.1021/acs.jproteome.8b00392;
RA   Robin T., Bairoch A., Muller M., Lisacek F., Lane L.;
RT   "Large-scale reanalysis of publicly available HeLa cell proteomics
RT   data in the context of the Human Proteome Project.";
RL   J. Proteome Res. 17:4160-4170(2018).
//
RX   PubMed=30778230; DOI=10.1038/s41587-019-0037-y;
RA   Liu Y.-S., Mi Y., Mueller T., Kreibich S., Williams E.G., Van Drogen A.,
RA   Borel C., Frank M., Germain P.-L., Bludau I., Mehnert M., Seifert M.,
RA   Emmenlauer M., Sorg I., Bezrukov F., Sloan-Bena F., Zhou H., Dehio C.,
RA   Testa G., Saez-Rodriguez J., Antonarakis S.E., Hardt W.-D.,
RA   Aebersold R.;
RT   "Multi-omic measurements of heterogeneity in HeLa cells across
RT   laboratories.";
RL   Nat. Biotechnol. 37:314-322(2019).
//
RX   PubMed=33205894; DOI=10.15252/msb.20209946;
RA   Schwabe D., Formichetti S., Junker J.P., Falcke M., Rajewsky N.;
RT   "The transcriptome dynamics of single cells during the cell cycle.";
RL   Mol. Syst. Biol. 16:e9946.1-e9946.20(2020).
//