ID   BeWo
AC   CVCL_0044
SY   BEWO; Be Wo; Be-Wo
DR   BTO; BTO:0000798
DR   CLO; CLO_0001934
DR   CLO; CLO_0001935
DR   CLO; CLO_0050014
DR   EFO; EFO_0002050
DR   CLDB; cl415
DR   CLDB; cl416
DR   AddexBio; C0030001/4905
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CCL-98
DR   BCRC; 60073
DR   BCRJ; 0048
DR   BioSample; SAMN01821537
DR   BioSample; SAMN01821617
DR   BioSample; SAMN03471293
DR   cancercelllines; CVCL_0044
DR   CCRID; 1101HUM-PUMC000156
DR   CCRID; 4201HUM-CCTCC00072
DR   CCTCC; GDC0072
DR   Cell_Model_Passport; SIDM00692
DR   ChEMBL-Cells; CHEMBL3308359
DR   ChEMBL-Targets; CHEMBL614525
DR   CLS; 300123
DR   DSMZ; ACC-458
DR   DSMZCellDive; ACC-458
DR   ECACC; 86082803
DR   GEO; GSM48269
DR   GEO; GSM48270
DR   GEO; GSM48271
DR   GEO; GSM48272
DR   GEO; GSM48273
DR   IARC_TP53; 21200
DR   IGRhCellID; BeWo
DR   IPD-IMGT/HLA; 10312
DR   IZSLER; BS TCL 3
DR   JCRB; JCRB9111
DR   KCLB; 10098
DR   LINCS_LDP; LCL-1293
DR   Lonza; 1449
DR   Progenetix; CVCL_0044
DR   PubChem_Cell_line; CVCL_0044
DR   RCB; RCB1644
DR   RCB; RCB3678
DR   TKG; TKG 0567
DR   TOKU-E; 661
DR   Ubigene; YC-D018
DR   Wikidata; Q54796111
RX   DOI=10.1007/0-306-46861-1_8;
RX   PubMed=2720636;
RX   PubMed=2878840;
RX   PubMed=3518877;
RX   PubMed=4038916;
RX   PubMed=4299001;
RX   PubMed=5753554;
RX   PubMed=6174649;
RX   PubMed=6682628;
RX   PubMed=6988327;
RX   PubMed=7153601;
RX   PubMed=7819056;
RX   PubMed=7937597;
RX   PubMed=11897413;
RX   PubMed=14207855;
RX   PubMed=16797695;
RX   PubMed=20215515;
RX   PubMed=28161053;
RX   PubMed=32178868;
RX   PubMed=33096371;
RX   PubMed=33810901;
WW   https://www.proteinatlas.org/learn/cellines
WW   http://www2.kumc.edu/soalab/LabLinks/recipes/bewo.htm
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-163.html
CC   Population: Caucasian.
CC   Characteristics: Cells were initially transplanted to the cheek pouch of a hamster and maintained by serial passage for 8 years prior to the establishment of the cell line.
CC   Doubling time: ~30 hours (DSMZ=ACC-458).
CC   HLA typing: C*04:01:01:01,07:01 (IPD-IMGT/HLA=10312).
CC   Karyotypic information: Near triploid karyotype (PubMed=33096371).
CC   Omics: Deep antibody staining analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Fetal brain; UBERON=UBERON_0006237.
ST   Source(s): AddexBio; ATCC; CCRID; CLS; DSMZ; ECACC; IZSLER; KCLB; PubMed=33810901; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 13,15
ST   D12S391: 17,24
ST   D13S317: 9,11
ST   D16S539: 13,14
ST   D18S51: 14,16
ST   D19S433: 13,15
ST   D1S1656: 14,16
ST   D21S11: 30
ST   D22S1045: 15
ST   D2S1338: 21,24
ST   D2S441: 14
ST   D3S1358: 15
ST   D5S818: 10,11
ST   D7S820: 10,12
ST   D8S1179: 12
ST   FGA: 22,23 (KCLB)
ST   FGA: 22,23,24 (CCRID; CLS; DSMZ; PubMed=33810901)
ST   Penta D: 9,12
ST   Penta E: 8,12
ST   SE33: 15,25.2
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C4646; Gestational choriocarcinoma
DI   ORDO; Orphanet_99926; Gestational choriocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0363 ! JEG-3
SX   Male
AG   Fetus
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 40
//
RX   DOI=10.1007/0-306-46861-1_8;
RA   Ganapathy V., Prasad P.D., Leibach F.H.;
RT   "Choriocarcinoma.";
RL   (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.141-147; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=2720636; DOI=10.1016/0165-4608(89)90664-X;
RA   Surti U., Habibian R.;
RT   "Chromosomal rearrangement in choriocarcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 38:229-240(1989).
//
RX   PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3;
RA   Yamashita K., Nakamura T., Shimizu T., Katagiri M., Ikeda H.;
RT   "Expression of HLA class I and class II antigens in human
RT   choriocarcinoma cell lines.";
RL   Int. J. Gynecol. Obstet. 24:301-307(1986).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=4038916; DOI=10.1016/0165-4608(85)90052-4;
RA   Sheppard D.M., Fisher R.A., Lawler S.D.;
RT   "Karyotypic analysis and chromosome polymorphisms in four
RT   choriocarcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 16:251-258(1985).
//
RX   PubMed=4299001;
RA   Pattillo R.A., Gey G.O.;
RT   "The establishment of a cell line of human hormone-synthesizing
RT   trophoblastic cells in vitro.";
RL   Cancer Res. 28:1231-1236(1968).
//
RX   PubMed=5753554; DOI=10.1126/science.159.3822.1467;
RA   Pattillo R.A., Gey G.O., Delfs E., Mattingly R.F.;
RT   "Human hormone production in vitro.";
RL   Science 159:1467-1469(1968).
//
RX   PubMed=6174649;
RA   Sekiya S., Kawata M., Inaba N., Takamizawa H.;
RT   "Studies on marker substances in cell lines derived from various human
RT   gynecologic tumors.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 34:37-42(1982).
//
RX   PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4;
RA   Sekiya S., Kaiho T., Shirotake S., Iwasawa H., Takeda B.,
RA   Takamizawa H.;
RT   "Effect of methotrexate on the growth and human chorionic gonadotropin
RT   secretion of human choriocarcinoma cell lines in vitro.";
RL   Am. J. Obstet. Gynecol. 146:57-64(1983).
//
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien S.J., Shannon J.E., Gail M.H.;
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
//
RX   PubMed=7153601;
RA   Sasaki S., Katayama P.K., Roesler M., Pattillo R.A., Mattingly R.F.,
RA   Ohkawa K.;
RT   "Cytogenetic analysis of choriocarcinoma cell lines.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 34:2253-2256(1982).
//
RX   PubMed=7819056; DOI=10.1038/bjc.1995.3;
RA   Yaginuma Y., Yamashita T., Takuma N., Katayama H., Ishikawa M.;
RT   "Analysis of the p53 gene in human choriocarcinoma cell lines.";
RL   Br. J. Cancer 71:9-12(1995).
//
RX   PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6;
RA   Grummer R., Hohn H.-P., Mareel M.M., Denker H.-W.;
RT   "Adhesion and invasion of three human choriocarcinoma cell lines into
RT   human endometrium in a three-dimensional organ culture system.";
RL   Placenta 15:411-429(1994).
//
RX   PubMed=11897413; DOI=10.1016/S0378-5173(01)00929-2;
RA   Ampasavate C., Chandorkar G.A., Vander Velde D.G., Stobaugh J.F.,
RA   Audus K.L.;
RT   "Transport and metabolism of opioid peptides across BeWo cells, an in
RT   vitro model of the placental barrier.";
RL   Int. J. Pharm. 233:85-98(2002).
//
RX   PubMed=14207855; DOI=10.1093/jnci/33.3.441;
RA   Dawe C.J., Banfield W.G. II, Morgan W.D., Slatick M.S.,
RA   Ollendorf-Curth H.;
RT   "Growth in continuous culture, and in hamsters, of cells from a
RT   neoplasm associated with acanthosis nigricans.";
RL   J. Natl. Cancer Inst. 33:441-456(1964).
//
RX   PubMed=16797695; DOI=10.1016/j.placenta.2006.05.001;
RA   Burleigh D.W., Kendziorski C.M., Choi Y.J., Grindle K.M.,
RA   Grendell R.L., Magness R.R., Golos T.G.;
RT   "Microarray analysis of BeWo and JEG3 trophoblast cell lines:
RT   identification of differentially expressed transcripts.";
RL   Placenta 28:383-389(2007).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007;
RA   Abou-Kheir W., Barrak J., Hadadeh O., Daoud G.;
RT   "HTR-8/SVneo cell line contains a mixed population of cells.";
RL   Placenta 50:1-7(2017).
//
RX   PubMed=32178868; DOI=10.1016/j.bbrc.2020.03.031;
RA   Li Z.-S., Kurosawa O., Iwata H.;
RT   "A comparative study of key physiological stem cell parameters between
RT   three human trophoblast cell lines.";
RL   Biochem. Biophys. Res. Commun. 525:1038-1045(2020).
//
RX   PubMed=33096371; DOI=10.1016/j.placenta.2020.10.011;
RA   Weber M., Weise A., Vasheghani F., Gohner C., Fitzgerald J.S.,
RA   Liehr T., Markert U.R.;
RT   "Cytogenomics of six human trophoblastic cell lines.";
RL   Placenta 103:72-75(2021).
//
RX   PubMed=33810901; DOI=10.1016/j.placenta.2021.02.022;
RA   Pastuschek J., Nonn O., Gutierrez-Samudio R.N., Murrieta-Coxca J.M.,
RA   Muller J., Sanft J., Huppertz B., Markert U.R., Groten T.,
RA   Morales-Prieto D.M.;
RT   "Molecular characteristics of established trophoblast-derived cell
RT   lines.";
RL   Placenta 108:122-133(2021).
//