ID   BeWo
AC   CVCL_0044
SY   BEWO; Be Wo; Be-Wo
DR   BTO; BTO_0000798
DR   CLO; CLO_0001934
DR   CLO; CLO_0001935
DR   CLO; CLO_0050014
DR   EFO; EFO_0002050
DR   CLDB; cl415
DR   CLDB; cl416
DR   AddexBio; C0030001/4905
DR   ArrayExpress; E-MTAB-38
DR   ATCC; CCL-98
DR   BCRC; 60073
DR   BCRJ; 0048
DR   BioSample; SAMN01821537
DR   BioSample; SAMN01821617
DR   BioSample; SAMN03471293
DR   cancercelllines; CVCL_0044
DR   CCRID; 1101HUM-PUMC000156
DR   CCRID; 4201HUM-CCTCC00072
DR   CCTCC; GDC0072
DR   Cell_Model_Passport; SIDM00692
DR   ChEMBL-Cells; CHEMBL3308359
DR   ChEMBL-Targets; CHEMBL614525
DR   CLS; 300123
DR   DSMZ; ACC-458
DR   DSMZCellDive; ACC-458
DR   ECACC; 86082803
DR   FANTOM5_SSTAR; 10423-106C9
DR   GEO; GSM48269
DR   GEO; GSM48270
DR   GEO; GSM48271
DR   GEO; GSM48272
DR   GEO; GSM48273
DR   GEO; GSM7701452
DR   GEO; GSM7701456
DR   IARC_TP53; 21200
DR   IGRhCellID; BeWo
DR   IPD-IMGT/HLA; 10312
DR   IZSLER; BS TCL 3
DR   JCRB; JCRB9111
DR   KCLB; 10098
DR   LINCS_LDP; LCL-1293
DR   Lonza; 1449
DR   Progenetix; CVCL_0044
DR   PubChem_Cell_line; CVCL_0044
DR   RCB; RCB1644
DR   RCB; RCB3678
DR   TKG; TKG 0567
DR   TOKU-E; 661
DR   Ubigene; YC-D018
DR   Wikidata; Q54796111
RX   DOI=10.1007/0-306-46861-1_8;
RX   PubMed=2720636;
RX   PubMed=2878840;
RX   PubMed=3518877;
RX   PubMed=4038916;
RX   PubMed=4299001;
RX   PubMed=5753554;
RX   PubMed=6174649;
RX   PubMed=6682628;
RX   PubMed=6988327;
RX   PubMed=7153601;
RX   PubMed=7819056;
RX   PubMed=7937597;
RX   PubMed=11897413;
RX   PubMed=16797695;
RX   PubMed=16957166;
RX   PubMed=20215515;
RX   PubMed=28161053;
RX   PubMed=32178868;
RX   PubMed=33096371;
RX   PubMed=33810901;
WW   Info; -; -; https://web.archive.org/web/20141030051820/http://www2.kumc.edu/soalab/LabLinks/recipes/bewo.htm
WW   Info; HPA; -; https://www.proteinatlas.org/learn/cellines
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-163.html
CC   Part of: Human Protein Atlas, Cell Atlas panel.
CC   Population: Caucasian.
CC   Characteristics: Cells were initially transplanted to the cheek pouch of a hamster and maintained by serial passage for 8 years prior to the establishment of the cell line.
CC   Doubling time: ~30 hours (DSMZ=ACC-458).
CC   HLA typing: C*04:01:01:01,07:01 (IPD-IMGT/HLA=10312).
CC   Karyotypic information: Near triploid karyotype (PubMed=33096371).
CC   Omics: Proteomics; Expression; Large antibody panel staining analysis.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Fetal brain; UBERON=UBERON_0006238.
ST   Source(s): AddexBio=C0030001/4905; ATCC=CCL-98; CCRID; CLS=300123; DSMZ=ACC-458; ECACC=86082803; IZSLER=BS TCL 3; KCLB=10098; PubMed=33810901; RCB=RCB1644; TKG=TKG 0567
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 13,15
ST   D12S391: 17,24
ST   D13S317: 9,11
ST   D16S539: 13,14
ST   D18S51: 14,16
ST   D19S433: 13,15
ST   D1S1656: 14,16
ST   D21S11: 30
ST   D22S1045: 15
ST   D2S1338: 21,24
ST   D2S441: 14
ST   D3S1358: 15
ST   D5S818: 10,11
ST   D7S820: 10,12
ST   D8S1179: 12
ST   FGA: 22,23 (KCLB=10098)
ST   FGA: 22,23,24 (ATCC=CCL-98; CCRID; CLS=300123; DSMZ=ACC-458; PubMed=33810901)
ST   Penta D: 9,12
ST   Penta E: 8,12
ST   SE33: 15,25.2
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C4646; Gestational choriocarcinoma
DI   ORDO; Orphanet_99926; Gestational choriocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0363 ! JEG-3
SX   Male
AG   Fetus
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 46
CH   CVCL_LB82 ! BeWo b24
CH   CVCL_LB83 ! BeWo b30
CH   CVCL_XF88 ! Bewo31
CH   CVCL_R702 ! Hs 630.T
CH   CVCL_E1JD ! HyCyte Bewo KO-hABCC1
CH   CVCL_E1JE ! HyCyte Bewo KO-hABCG2
CH   CVCL_D8ES ! Ubigene BeWo ERVFRD-1 KO
CH   CVCL_D8ET ! Ubigene BeWo TRPV6 KO
//
RX   PubMed=4299001;
RA   Pattillo, Roland Anthony
RA   Gey, George Otto
RT   "The establishment of a cell line of human hormone-synthesizing
RT   trophoblastic cells in vitro.";
RL   Cancer Res. 28:1231-1236(1968).
//
RX   PubMed=7819056; DOI=10.1038/bjc.1995.3; PMCID=PMC2033447;
RA   Yaginuma, Yuji
RA   Yamashita, Tsuyoshi
RA   Takuma, Naoyuki
RA   Katayama, Hideto
RA   Ishikawa, Mutsuo
RT   "Analysis of the p53 gene in human choriocarcinoma cell lines.";
RL   Br. J. Cancer 71:9-12(1995).
//
RX   PubMed=2720636; DOI=10.1016/0165-4608(89)90664-X;
RA   Surti, Urvashi
RA   Habibian, Rezvan
RT   "Chromosomal rearrangement in choriocarcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 38:229-240(1989).
//
RX   PubMed=6174649;
RA   Sekiya, Souei
RA   Kawata, Makoto
RA   Inaba, Noriyuki
RA   Takamizawa, Hiroyoshi
RT   "Studies on marker substances in cell lines derived from various human
RT   gynecologic tumors.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 34:37-42(1982).
//
RX   PubMed=2878840; DOI=10.1016/0020-7292(86)90088-3;
RA   Yamashita, Kohki
RA   Nakamura, Takafumi
RA   Shimizu, Tetsuya
RA   Katagiri, Makoto
RA   Ikeda, Hisami
RT   "Expression of HLA class I and class II antigens in human
RT   choriocarcinoma cell lines.";
RL   Int. J. Gynaecol. Obstet. 24:301-307(1986).
//
RX   PubMed=33810901; DOI=10.1016/j.placenta.2021.02.022;
RA   Pastuschek, Jana
RA   Nonn, Olivia
RA   Gutierrez-Samudio, Ruby N.
RA   Murrieta-Coxca, Jose Martin
RA   Muller, Jasmin
RA   Sanft, Juliane
RA   Huppertz, Berthold
RA   Markert, Udo R.
RA   Groten, Tanja
RA   Morales-Prieto, Diana M.
RT   "Molecular characteristics of established trophoblast-derived cell
RT   lines.";
RL   Placenta 108:122-133(2021).
//
RX   PubMed=4038916; DOI=10.1016/0165-4608(85)90052-4;
RA   Sheppard, David M.
RA   Fisher, Rosemary A.
RA   Lawler, Sylvia Dorothy
RT   "Karyotypic analysis and chromosome polymorphisms in four
RT   choriocarcinoma cell lines.";
RL   Cancer Genet. Cytogenet. 16:251-258(1985).
//
RX   PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123;
RA   Andersson, Ann-Catrin
RA   Stromberg, Sara
RA   Backvall, Helena
RA   Kampf, Caroline
RA   Uhlen, Mathias
RA   Wester, Kenneth
RA   Ponten, Fredrik
RT   "Analysis of protein expression in cell microarrays: a tool for
RT   antibody-based proteomics.";
RL   J. Histochem. Cytochem. 54:1413-1423(2006).
//
RX   PubMed=32178868; DOI=10.1016/j.bbrc.2020.03.031;
RA   Li, Zhuo-Si
RA   Kurosawa, Osamu
RA   Iwata, Hiroo
RT   "A comparative study of key physiological stem cell parameters between
RT   three human trophoblast cell lines.";
RL   Biochem. Biophys. Res. Commun. 525:1038-1045(2020).
//
RX   PubMed=6682628; DOI=10.1016/0002-9378(83)90927-4;
RA   Sekiya, Souei
RA   Kaiho, Teruyo
RA   Shirotake, Syoichi
RA   Iwasawa, Hiroshi
RA   Takeda, Bin
RA   Takamizawa, Hiroyoshi
RT   "Effect of methotrexate on the growth and human chorionic gonadotropin
RT   secretion of human choriocarcinoma cell lines in vitro.";
RL   Am. J. Obstet. Gynecol. 146:57-64(1983).
//
RX   DOI=10.1007/0-306-46861-1_8;
RA   Ganapathy, Vadivel
RA   Prasad, Puttur D.
RA   Leibach, Frederick H.
RT   "Choriocarcinoma.";
RL   (In book chapter) Human cell culture. Vol. 2. Cancer cell lines part 2; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.141-147; Kluwer Academic Publishers; New York; USA (1999).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=11897413; DOI=10.1016/S0378-5173(01)00929-2;
RA   Ampasavate, Chadarat
RA   Chandorkar, Gurudatt A.
RA   Vander Velde, David G.
RA   Stobaugh, John F.
RA   Audus, Kenneth L.
RT   "Transport and metabolism of opioid peptides across BeWo cells, an in
RT   vitro model of the placental barrier.";
RL   Int. J. Pharm. 233:85-98(2002).
//
RX   PubMed=28161053; DOI=10.1016/j.placenta.2016.12.007;
RA   Abou-Kheir, Wassim
RA   Barrak, Joanna
RA   Hadadeh, Ola
RA   Daoud, Georges
RT   "HTR-8/SVneo cell line contains a mixed population of cells.";
RL   Placenta 50:1-7(2017).
//
RX   PubMed=7937597; DOI=10.1016/0143-4004(94)90008-6;
RA   Grummer, Ruth
RA   Hohn, Hans-Peter
RA   Mareel, Marc M.
RA   Denker, Hans-Werner
RT   "Adhesion and invasion of three human choriocarcinoma cell lines into
RT   human endometrium in a three-dimensional organ culture system.";
RL   Placenta 15:411-429(1994).
//
RX   PubMed=33096371; DOI=10.1016/j.placenta.2020.10.011;
RA   Weber, Maja
RA   Weise, Anja
RA   Vasheghani, Faezeh
RA   Gohner, Claudia
RA   Fitzgerald, Justine Sayuri
RA   Liehr, Thomas
RA   Markert, Udo R.
RT   "Cytogenomics of six human trophoblastic cell lines.";
RL   Placenta 103:72-75(2021).
//
RX   PubMed=5753554; DOI=10.1126/science.159.3822.1467;
RA   Pattillo, Roland Anthony
RA   Gey, George Otto
RA   Delfs, Eleanor Mary
RA   Mattingly, Richard F.
RT   "Human hormone production in vitro.";
RL   Science 159:1467-1469(1968).
//
RX   PubMed=6988327; DOI=10.1007/BF02831503;
RA   O'Brien, Stephen James
RA   Shannon, John E.
RA   Gail, Mitchell H.
RT   "A molecular approach to the identification and individualization of
RT   human and animal cells in culture: isozyme and allozyme genetic
RT   signatures.";
RL   In Vitro 16:119-135(1980).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=7153601;
RA   Sasaki, Shigeru
RA   Katayama, Paul K.
RA   Roesler, Mark
RA   Pattillo, Roland Anthony
RA   Mattingly, Richard F.
RA   Ohkawa, Kimiyasu
RT   "Cytogenetic analysis of choriocarcinoma cell lines.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 34:2253-2256(1982).
//
RX   PubMed=16797695; DOI=10.1016/j.placenta.2006.05.001;
RA   Burleigh, David W.
RA   Kendziorski, Christina Marie
RA   Choi, Yun Jung
RA   Grindle, Kreg M.
RA   Grendell, Richard L.
RA   Magness, Ronald R.
RA   Golos, Thaddeus G.
RT   "Microarray analysis of BeWo and JEG3 trophoblast cell lines:
RT   identification of differentially expressed transcripts.";
RL   Placenta 28:383-389(2007).
//