ID   WM115
AC   CVCL_0040
SY   WM-115; WM 115; WM115F; WM115-mel; WM115mel; WC00079
DR   BTO; BTO:0003075
DR   CLO; CLO_0009613
DR   EFO; EFO_0002390
DR   CLDB; cl4727
DR   CLDB; cl4728
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1675
DR   BioGRID_ORCS_Cell_line; 345
DR   BioSample; SAMN10987773
DR   cancercelllines; CVCL_0040
DR   Cell_Model_Passport; SIDM01000
DR   CGH-DB; 9323-4
DR   ChEMBL-Cells; CHEMBL3308813
DR   ChEMBL-Targets; CHEMBL1075611
DR   Coriell; WC00079
DR   Cosmic; 886835
DR   Cosmic; 888868
DR   Cosmic; 897480
DR   Cosmic; 905236
DR   Cosmic; 909784
DR   Cosmic; 932717
DR   Cosmic; 972277
DR   Cosmic; 1155268
DR   Cosmic; 1155547
DR   Cosmic; 1238102
DR   Cosmic; 1238104
DR   Cosmic-CLP; 909784
DR   DepMap; ACH-000304
DR   ECACC; 91061232
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 909784
DR   GEO; GSM109022
DR   GEO; GSM827472
DR   GEO; GSM887735
DR   GEO; GSM888830
DR   GEO; GSM1670576
DR   IARC_TP53; 21271
DR   IARC_TP53; 24992
DR   IGRhCellID; WM115
DR   LiGeA; CCLE_370
DR   LINCS_HMS; 50567
DR   Lonza; 584
DR   PharmacoDB; WM115_1662_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0040
DR   PubChem_Cell_line; CVCL_0040
DR   Rockland; WM115-01-0001
DR   Wikidata; Q54994157
RX   PubMed=2253310;
RX   PubMed=3020539;
RX   PubMed=3856042;
RX   PubMed=4053039;
RX   PubMed=11121133;
RX   PubMed=15009714;
RX   PubMed=15467732;
RX   PubMed=15592718;
RX   PubMed=16827748;
RX   PubMed=18632627;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=21424129;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Population: Caucasian.
CC   HLA typing: A*02:01,29:02; B*13:02,44:03:01; C*06:02,16:01; DPB1*02:01:02,02:01:02; DQB1*02:01,02:01; DRB1*07:01,07:01 (PubMed=15592718).
CC   HLA typing: A*02:01,29:02; B*13:02,44:03; C*06:02,16:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (Wistar).
CC   Sequence variation: Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Homozygous (Wistar).
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Hemizygous (Wistar).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Asp (c.1799_1800delTGinsAT); ClinVar=VCV000375939; Zygosity=Heterozygous (PubMed=15009714; PubMed=15467732; Wistar).
CC   Omics: Deep antibody staining analysis.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.17%; East Asian, North=0%; East Asian, South=0%; South Asian=0.85%; European, North=67.47%; European, South=31.51% (PubMed=30894373).
CC   Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: CSF1PO: 11,12->12, D18S51: 17->17,21 and D8S1179: 8,13->13,15.
CC   Misspelling: WH115mel; CGH-DB=9323-4.
CC   Discontinued: ATCC; CRL-1675; true.
CC   Discontinued: Coriell; WC00079; probable.
CC   Discontinued: ECACC; 91061232; probable.
CC   Derived from site: Metastatic; Right anterior leg, skin; UBERON=UBERON_0001511.
ST   Source(s): ATCC=CRL-1675; Cosmic-CLP=909784; ESTDAB=ESTDAB-066; Wistar
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 12,13
ST   D16S539: 11,12
ST   D18S51: 17,21
ST   D19S433: 13
ST   D21S11: 29
ST   D2S1338: 19
ST   D3S1358: 15,18
ST   D5S818: 13
ST   D7S820: 8
ST   D8S1179: 13,15
ST   FGA: 21,23
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_L033 ! WM165-1
OI   CVCL_RN55 ! WM165-2
OI   CVCL_6795 ! WM239A
OI   CVCL_RN56 ! WM239B
OI   CVCL_RN57 ! WM266-1
OI   CVCL_RN58 ! WM266-2
OI   CVCL_RN59 ! WM266-3
OI   CVCL_2765 ! WM266-4
SX   Female
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 46
RX   PubMed=2253310; DOI=10.1007/BF00046337;
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RT   "Induction of arginosuccinate synthetase (ASS) expression affects the
RT   antiproliferative activity of arginine deiminase (ADI) in melanoma
RT   cells.";
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RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
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RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
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RT   predicted neo-epitopes, virus and gene expression.";
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RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
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RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
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RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
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RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023;
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RA   Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K.,
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