ID   RT-4
AC   CVCL_0036
SY   RT4; RT4P
DR   BTO; BTO_0002870
DR   CLO; CLO_0008892
DR   EFO; EFO_0006480
DR   CLDB; cl4197
DR   CLDB; cl4198
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-7937
DR   ATCC; HTB-2
DR   BCRC; 60111
DR   BCRJ; 0214
DR   BioGRID_ORCS_Cell_line; 382
DR   BioSample; SAMN03473092
DR   BioSample; SAMN10988330
DR   cancercelllines; CVCL_0036
DR   CCRID; 3101HUMTCHu226
DR   CCRID; 5301HUM-KCB16045YJ
DR   Cell_Model_Passport; SIDM01085
DR   ChEMBL-Cells; CHEMBL3307430
DR   ChEMBL-Targets; CHEMBL614884
DR   CLS; 300326
DR   Cosmic; 687455
DR   Cosmic; 715805
DR   Cosmic; 755396
DR   Cosmic; 760479
DR   Cosmic; 845560
DR   Cosmic; 846283
DR   Cosmic; 867839
DR   Cosmic; 925819
DR   Cosmic; 928816
DR   Cosmic; 943749
DR   Cosmic; 1016881
DR   Cosmic; 1046681
DR   Cosmic; 1068091
DR   Cosmic; 1285125
DR   Cosmic; 1285983
DR   Cosmic; 1819325
DR   Cosmic; 1927301
DR   Cosmic; 2037955
DR   Cosmic; 2050460
DR   Cosmic; 2057455
DR   Cosmic; 2444250
DR   Cosmic; 2686112
DR   Cosmic; 2700996
DR   Cosmic-CLP; 687455
DR   DepMap; ACH-000242
DR   DSMZ; ACC-412
DR   DSMZCellDive; ACC-412
DR   ECACC; 91091914
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 687455
DR   GEO; GSM136232
DR   GEO; GSM763024
DR   GEO; GSM827439
DR   GEO; GSM887553
DR   GEO; GSM888636
DR   GEO; GSM1374859
DR   GEO; GSM1574570
DR   GEO; GSM1670394
DR   GEO; GSM7701369
DR   GEO; GSM7701370
DR   IARC_TP53; 21088
DR   KCB; KCB 2016045YJ
DR   KCLB; 30002
DR   LiGeA; CCLE_210
DR   LINCS_LDP; LCL-1717
DR   PharmacoDB; RT4_1334_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_0036
DR   PubChem_Cell_line; CVCL_0036
DR   SKY/M-FISH/CGH; 1462
DR   Wikidata; Q54951351
RX   PubMed=77569;
RX   PubMed=327080;
RX   PubMed=571047;
RX   PubMed=833871;
RX   PubMed=864752;
RX   PubMed=870558;
RX   PubMed=1114348;
RX   PubMed=3518877;
RX   PubMed=3708594;
RX   PubMed=5503601;
RX   PubMed=6220172;
RX   PubMed=6244232;
RX   PubMed=6582512;
RX   PubMed=6823318;
RX   PubMed=7017212;
RX   PubMed=7459858;
RX   PubMed=7787250;
RX   PubMed=8873383;
RX   PubMed=9850064;
RX   PubMed=11207054;
RX   PubMed=11921286;
RX   PubMed=15846775;
RX   PubMed=16885334;
RX   PubMed=16957166;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=23401075;
RX   PubMed=24018021;
RX   PubMed=24035680;
RX   PubMed=24367658;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=25997541;
RX   PubMed=26055179;
RX   PubMed=26589293;
RX   PubMed=27270441;
RX   PubMed=27397505;
RX   PubMed=28855393;
RX   PubMed=29732388;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31395879;
RX   PubMed=31978347;
RX   PubMed=35839778;
WW   Info; HPA; -; https://www.proteinatlas.org/learn/cellines
WW   Info; Synapse; Bladder Cancer exome; https://www.synapse.org/Synapse:syn4970200
CC   Part of: BLA-40 bladder carcinoma cell line panel.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
CC   Part of: Human Protein Atlas, Cell Atlas panel.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Part of: TCGA-110-CL cell line panel.
CC   Part of: UBC-40 urothelial bladder cancer cell line index.
CC   Population: Caucasian.
CC   Doubling time: 37 hours (PubMed=3708594); 65.8 hours (PubMed=26055179); ~80 hours (DSMZ=ACC-412).
CC   HLA typing: A*01,03; B*12 (PubMed=77569).
CC   HLA typing: A*02:01,03:01; B*44:02,44:02; C*05:01,05:01; DQA1*03:02,03:02; DQB1*05:03,05:03 (PubMed=25960936).
CC   HLA typing: A*02:01,03:01; B*44:02,44:02; C*05:01,05:01; DQA1*01:02,03:02; DQB1*05:03,05:03; DRB1*04:01,14:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=9850064).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3690; FGFR3 + HGNC; HGNC:11524; TACC3; Name(s)=FGFR3-TACC3 (PubMed=28855393).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (PubMed=7787250).
CC   Sequence variation: Mutation; HGNC; HGNC:12362; TSC1; Simple; p.Leu557Cysfs*72 (c.1669delC); ClinVar=VCV000048811; Zygosity=Homozygous (PubMed=23401075; Cosmic-CLP=687455; DepMap=ACH-000242).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Large antibody panel staining analysis.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=2.72%; East Asian, South=0%; South Asian=0.98%; European, North=64.69%; European, South=31.61% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7937; true.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
ST   Source(s): ATCC=HTB-2; CCRID; CLS=300326; Cosmic-CLP=687455; DSMZ=ACC-412; ECACC=91091914; KCLB=30002; PubMed=25877200; PubMed=27270441
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 8
ST   D16S539: 9
ST   D18S51: 15,17
ST   D19S433: 13
ST   D21S11: 30,32.2
ST   D2S1338: 18,19
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 9,12
ST   D8S1179: 13,15
ST   FGA: 22,24
ST   Penta D: 12 (ATCC=HTB-2; CLS=300326; DSMZ=ACC-412)
ST   Penta D: 12,13 (PubMed=25877200)
ST   Penta E: 7,10
ST   TH01: 9,9.3
ST   TPOX: 8,11
ST   vWA: 14,17
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 48
CH   CVCL_2715 ! RT4/31
CH   CVCL_RR19 ! RT4rCDDP1000
CH   CVCL_RR20 ! RT4rGEMCI10
CH   CVCL_T027 ! RT4v6
//
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RA   Stromberg, Sara
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RA   Monteiro, Alvaro N.A.
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RT   ancestry in cancer cell lines.";
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RT   human cancer cell lines.";
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RT   biology and drug response.";
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//
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RA   Orfeo, Thomas
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RT   producing tumors in nude mice.";
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RA   Earl, Julie
RA   Rico, Daniel
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RA   Rodriguez-Santiago, Benjamin
RA   Mendez-Pertuz, Marinela
RA   Auer, Herbert
RA   Gomez, Gonzalo
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RA   Schulz, Wolfgang A.
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RA   Carrato, Alfredo
RA   Theodorescu, Dan
RA   Chanock, Stephen Jacob
RA   Valencia, Alfonso
RA   Real, Francisco X.
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RT   resource for functional studies.";
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//
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RA   Theodorescu, Dan
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RT   cancer cell lines.";
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RA   Sarne, Lena
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RT   human cell lines. Attempts at typing by the mixed hemadsorption
RT   technique.";
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RT   cancer: high frequency across stages, detection in urine, and lack of
RT   association with outcome.";
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//
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//
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//
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//